Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05

AUTHORS

Unnur Styrkarsdottir, Hannes Helgason, Asgeir Sigurdsson, Gudmundur L Norddahl, Arna B Agustsdottir, Louise N Reynard, Amanda Villalvilla, Gisli H Halldorsson, Aslaug Jonasdottir, Audur Magnusdottir, Asmundur Oddson, Gerald Sulem, Florian Zink, Gardar Sveinbjornsson, Agnar Helgason, Hrefna S Johannsdottir, Anna Helgadottir, Hreinn Stefansson, Solveig Gretarsdottir, Thorunn Rafnar, Ina S Almdahl, Anne Brækhus, Tormod Fladby, Geir Selbæk, Farhad Hosseinpanah, Fereidoun Azizi, Jung Min Koh, Nelson L S Tang, Maryam S Daneshpour, Jose I Mayordomo, Corrine Welt, Peter S Braund, Nilesh J Samani, Lambertus A Kiemeney, L Stefan Lohmander, Claus Christiansen, Ole A Andreassen, OGEN consortium, Olafur Magnusson, Gisli Masson, Augustine Kong, Ingileif Jonsdottir, Daniel Gudbjartsson, Patrick Sulem, Helgi Jonsson, John Loughlin, Thorvaldur Ingvarsson, Unnur Thorsteinsdottir, Kari Stefansson

ABSTRACT

We performed a genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, which included 4,657 Icelandic patients and 207,514 population controls. We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P = 4.0 × 10-12, odds ratio (OR) = 16.7) and a frameshift mutation, rs532464664 (p.Val330Glyfs*106), in the CHADL gene that associates through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 × 10-18, OR = 7.71). On average, c.1141G>C heterozygotes and individuals homozygous for rs532464664 had their hip replacement operation 13.5 years and 4.9 years earlier than others (P = 0.0020 and P = 0.0026), respectively. We show that the full-length CHADL transcript is expressed in cartilage. Furthermore, the premature stop codon introduced by the CHADL frameshift mutation results in nonsense-mediated decay of the mutant transcripts. More... »

PAGES

801-805

References to SciGraph publications

  • 2009-02. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types in NATURE GENETICS
  • 2015-05. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease in NATURE GENETICS
  • 2015-07. Method for quantitative analysis of nonsense-mediated mRNA decay at the single cell level in SCIENTIFIC REPORTS
  • 2014-08. Intracellular calcium regulates nonsense-mediated mRNA decay in NATURE MEDICINE
  • 2010-06. Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study in ARTHRITIS RESEARCH & THERAPY
  • 2007-02-28. Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se? in OSTEOPOROSIS INTERNATIONAL
  • 2008-09. Detection of sharing by descent, long-range phasing and haplotype imputation in NATURE GENETICS
  • 2007-04. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis in NATURE GENETICS
  • 2015-05. Large-scale whole-genome sequencing of the Icelandic population in NATURE GENETICS
  • 2010-03. A scaling normalization method for differential expression analysis of RNA-seq data in GENOME BIOLOGY
  • 2016-03. Weighting sequence variants based on their annotation increases power of whole-genome association studies in NATURE GENETICS
  • 2009-12. Parental origin of sequence variants associated with complex diseases in NATURE
  • 2007-09. Age- and gender-specific reference values of estimated GFR in Caucasians: The Nijmegen Biomedical Study in KIDNEY INTERNATIONAL
  • 2004-03. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke in NATURE GENETICS
  • 2016-08. Analysis of protein-coding genetic variation in 60,706 humans in NATURE
  • 2014-11. Genotype to phenotype correlations in cartilage oligomeric matrix protein associated chondrodysplasias in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2014-05. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31 in NATURE GENETICS
  • 2015-12. Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591 in BMC MEDICAL GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3816

    DOI

    http://dx.doi.org/10.1038/ng.3816

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084129154

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28319091


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Arthroplasty, Replacement, Hip", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cartilage Oligomeric Matrix Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Codon, Nonsense", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Extracellular Matrix Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Frameshift Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Frequency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Iceland", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kaplan-Meier Estimate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation, Missense", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteoarthritis, Hip", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reverse Transcriptase Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, DNA", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Styrkarsdottir", 
            "givenName": "Unnur", 
            "id": "sg:person.01205523707.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205523707.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.", 
                "School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Helgason", 
            "givenName": "Hannes", 
            "id": "sg:person.01273401363.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273401363.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sigurdsson", 
            "givenName": "Asgeir", 
            "id": "sg:person.01067302737.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067302737.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Norddahl", 
            "givenName": "Gudmundur L", 
            "id": "sg:person.0771421022.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771421022.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agustsdottir", 
            "givenName": "Arna B", 
            "id": "sg:person.01067375637.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067375637.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Newcastle University", 
              "id": "https://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reynard", 
            "givenName": "Louise N", 
            "id": "sg:person.0647426411.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647426411.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Newcastle University", 
              "id": "https://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Villalvilla", 
            "givenName": "Amanda", 
            "id": "sg:person.01213256746.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213256746.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Halldorsson", 
            "givenName": "Gisli H", 
            "id": "sg:person.01334675114.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334675114.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jonasdottir", 
            "givenName": "Aslaug", 
            "id": "sg:person.0726475763.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726475763.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Magnusdottir", 
            "givenName": "Audur", 
            "id": "sg:person.0724300310.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724300310.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oddson", 
            "givenName": "Asmundur", 
            "id": "sg:person.0736713725.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736713725.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sulem", 
            "givenName": "Gerald", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zink", 
            "givenName": "Florian", 
            "id": "sg:person.01121255525.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121255525.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sveinbjornsson", 
            "givenName": "Gardar", 
            "id": "sg:person.0700374216.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700374216.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.", 
                "Department of Anthropology, University of Iceland, Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Helgason", 
            "givenName": "Agnar", 
            "id": "sg:person.01071376774.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071376774.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johannsdottir", 
            "givenName": "Hrefna S", 
            "id": "sg:person.011605274603.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011605274603.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Helgadottir", 
            "givenName": "Anna", 
            "id": "sg:person.01242432070.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242432070.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stefansson", 
            "givenName": "Hreinn", 
            "id": "sg:person.0611467633.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611467633.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gretarsdottir", 
            "givenName": "Solveig", 
            "id": "sg:person.013775616203.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013775616203.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rafnar", 
            "givenName": "Thorunn", 
            "id": "sg:person.0651363747.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651363747.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Akershus University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411279.8", 
              "name": [
                "Department of Neurology, Akershus University Hospital, L\u00f8renskog, Norway."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Almdahl", 
            "givenName": "Ina S", 
            "id": "sg:person.0620626735.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620626735.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oslo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, T\u00f8nsberg, Norway.", 
                "Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Br\u00e6khus", 
            "givenName": "Anne", 
            "id": "sg:person.01074111130.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074111130.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oslo", 
              "id": "https://www.grid.ac/institutes/grid.5510.1", 
              "name": [
                "Department of Neurology, Akershus University Hospital, L\u00f8renskog, Norway.", 
                "Institute of Clinical Medicine, University of Oslo, Oslo, Norway."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fladby", 
            "givenName": "Tormod", 
            "id": "sg:person.01055436526.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055436526.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Innlandet Hospital Trust", 
              "id": "https://www.grid.ac/institutes/grid.412929.5", 
              "name": [
                "Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, T\u00f8nsberg, Norway.", 
                "Faculty of Medicine, University of Oslo, Oslo, Norway.", 
                "Centre for Old Age Psychiatry Research, Innlandet Hospital Trust, Ottestad, Norway."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Selb\u00e6k", 
            "givenName": "Geir", 
            "id": "sg:person.01044411633.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044411633.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shahid Beheshti University of Medical Sciences", 
              "id": "https://www.grid.ac/institutes/grid.411600.2", 
              "name": [
                "Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hosseinpanah", 
            "givenName": "Farhad", 
            "id": "sg:person.0576334543.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576334543.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shahid Beheshti University of Medical Sciences", 
              "id": "https://www.grid.ac/institutes/grid.411600.2", 
              "name": [
                "Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Azizi", 
            "givenName": "Fereidoun", 
            "id": "sg:person.0734152634.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734152634.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Asan Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.413967.e", 
              "name": [
                "Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koh", 
            "givenName": "Jung Min", 
            "id": "sg:person.0712764112.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712764112.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chinese University of Hong Kong", 
              "id": "https://www.grid.ac/institutes/grid.10784.3a", 
              "name": [
                "Department of Chemical Pathology and Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "Nelson L S", 
            "id": "sg:person.0757733351.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757733351.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shahid Beheshti University of Medical Sciences", 
              "id": "https://www.grid.ac/institutes/grid.411600.2", 
              "name": [
                "Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Daneshpour", 
            "givenName": "Maryam S", 
            "id": "sg:person.01033273244.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033273244.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Medical Oncology, Lozano Blesa University Hospital, Zaragoza, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mayordomo", 
            "givenName": "Jose I", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Utah", 
              "id": "https://www.grid.ac/institutes/grid.223827.e", 
              "name": [
                "Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Welt", 
            "givenName": "Corrine", 
            "id": "sg:person.01276025677.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276025677.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glenfield Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412925.9", 
              "name": [
                "Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.", 
                "NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Braund", 
            "givenName": "Peter S", 
            "id": "sg:person.01232734734.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232734734.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glenfield Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412925.9", 
              "name": [
                "Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.", 
                "NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Samani", 
            "givenName": "Nilesh J", 
            "id": "sg:person.0606704334.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606704334.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radboud University Nijmegen Medical Centre", 
              "id": "https://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Radboud University Medical Center, Radboud Institute for Health Science, Nijmegen, the Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kiemeney", 
            "givenName": "Lambertus A", 
            "id": "sg:person.016033704317.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016033704317.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lund University", 
              "id": "https://www.grid.ac/institutes/grid.4514.4", 
              "name": [
                "Orthopaedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lohmander", 
            "givenName": "L Stefan", 
            "id": "sg:person.01246072341.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246072341.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nordic Bioscience (Denmark)", 
              "id": "https://www.grid.ac/institutes/grid.436559.8", 
              "name": [
                "Nordic Bioscience, Herlev, Denmark."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Christiansen", 
            "givenName": "Claus", 
            "id": "sg:person.0641377366.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641377366.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andreassen", 
            "givenName": "Ole A", 
            "id": "sg:person.01263457230.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263457230.91"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "consortium", 
            "givenName": "OGEN", 
            "id": "sg:person.010671263757.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010671263757.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Magnusson", 
            "givenName": "Olafur", 
            "id": "sg:person.0743534613.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743534613.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Masson", 
            "givenName": "Gisli", 
            "id": "sg:person.01366065163.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366065163.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kong", 
            "givenName": "Augustine", 
            "id": "sg:person.010001043302.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010001043302.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.410540.4", 
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.", 
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland.", 
                "Department of Immunology, Landspitali\u2013The National University Hospital of Iceland, Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jonsdottir", 
            "givenName": "Ingileif", 
            "id": "sg:person.01220643160.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220643160.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.", 
                "School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gudbjartsson", 
            "givenName": "Daniel", 
            "id": "sg:person.0637651205.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637651205.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sulem", 
            "givenName": "Patrick", 
            "id": "sg:person.0773127601.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773127601.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.410540.4", 
              "name": [
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland.", 
                "Department of Medicine, Landspitali\u2013The National University Hospital of Iceland, Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jonsson", 
            "givenName": "Helgi", 
            "id": "sg:person.0575412557.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575412557.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Newcastle University", 
              "id": "https://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Loughlin", 
            "givenName": "John", 
            "id": "sg:person.01305125451.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305125451.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Akureyri", 
              "id": "https://www.grid.ac/institutes/grid.16977.3e", 
              "name": [
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland.", 
                "Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland.", 
                "Institution of Health Science, University of Akureyri, Akureyri, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ingvarsson", 
            "givenName": "Thorvaldur", 
            "id": "sg:person.01256544557.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256544557.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.", 
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thorsteinsdottir", 
            "givenName": "Unnur", 
            "id": "sg:person.01277776417.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277776417.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.", 
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stefansson", 
            "givenName": "Kari", 
            "id": "sg:person.0723426172.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723426172.10"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.2957", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000294613", 
              "https://doi.org/10.1038/ng.2957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0255-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005968105", 
              "https://doi.org/10.1007/s00198-006-0255-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0255-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005968105", 
              "https://doi.org/10.1007/s00198-006-0255-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar3033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007003574", 
              "https://doi.org/10.1186/ar3033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmedgenet-2013-101754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007837655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkl679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008829533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.maturitas.2015.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009103185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010958400", 
              "https://doi.org/10.1038/ng.296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2012-203182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017383505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017956321", 
              "https://doi.org/10.1038/nature08625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017956321", 
              "https://doi.org/10.1038/nature08625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1529-0131(200111)44:11<2548::aid-art435>3.0.co;2-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020058171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5002374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020065676", 
              "https://doi.org/10.1038/sj.ki.5002374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m114.593541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020070261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020692466", 
              "https://doi.org/10.1038/ng.3247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12881-015-0215-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020791919", 
              "https://doi.org/10.1186/s12881-015-0215-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0006-341x.1999.00997.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021081768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature19057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022281897", 
              "https://doi.org/10.1038/nature19057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep07729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024324417", 
              "https://doi.org/10.1038/srep07729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bone.2009.09.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031268204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1359/jbmr.050320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031556622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031965116", 
              "https://doi.org/10.1038/2005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.107524.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032096953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032746554", 
              "https://doi.org/10.1038/nm.3620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.matbio.2014.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034205816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1968411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034829410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2014.30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035165019", 
              "https://doi.org/10.1038/ejhg.2014.30"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/17453679908997798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036446703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2011.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038661579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043168111", 
              "https://doi.org/10.1038/ng.3507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045032711", 
              "https://doi.org/10.1038/ng.216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045287472", 
              "https://doi.org/10.1038/ng.3246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.joca.2012.05.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045289277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050287806", 
              "https://doi.org/10.1038/ng1311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050287806", 
              "https://doi.org/10.1038/ng1311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2010-11-3-r25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050509557", 
              "https://doi.org/10.1186/gb-2010-11-3-r25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)60681-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051411617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.34453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052578912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2012-203114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053235870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btu638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053282140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2006-1191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064289385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5435/jaaos-d-13-00173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072860349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5435/jaaos-d-13-00173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072860349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5435/jaaos-d-13-00173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072860349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5435/jaaos-d-13-00173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072860349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2196/resprot.6050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083861911"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-05", 
        "datePublishedReg": "2017-05-01", 
        "description": "We performed a genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, which included 4,657 Icelandic patients and 207,514 population controls. We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P = 4.0 \u00d7 10-12, odds ratio (OR) = 16.7) and a frameshift mutation, rs532464664 (p.Val330Glyfs*106), in the CHADL gene that associates through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 \u00d7 10-18, OR = 7.71). On average, c.1141G>C heterozygotes and individuals homozygous for rs532464664 had their hip replacement operation 13.5 years and 4.9 years earlier than others (P = 0.0020 and P = 0.0026), respectively. We show that the full-length CHADL transcript is expressed in cartilage. Furthermore, the premature stop codon introduced by the CHADL frameshift mutation results in nonsense-mediated decay of the mutant transcripts.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ng.3816", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2756221", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2763785", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2786210", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5137296", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5141610", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2770073", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2767197", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2772903", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "49"
          }
        ], 
        "name": "Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis", 
        "pagination": "801-805", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2429f5b9e08c1855faa751dc51b0a1266a0ed3270b1cceacbe1f798cd0f123f2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28319091"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.3816"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084129154"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.3816", 
          "https://app.dimensions.ai/details/publication/pub.1084129154"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:26", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87109_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ng/journal/v49/n5/full/ng.3816.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.3816'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.3816'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.3816'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.3816'


     

    This table displays all metadata directly associated to this object as RDF triples.

    744 TRIPLES      21 PREDICATES      90 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.3816 schema:about N066ea7cb81ab40df97f3fcc3300531d7
    2 N07d79699dc8f45699dbb10859b0c8764
    3 N09ee993b2d9d400ea7540a71719ae57c
    4 N145f58239695410789fd5123c4b64fb2
    5 N1fae46a9dc5f4a069079c58961c8825b
    6 N225800f261724b2592e10f2e81e7ebd0
    7 N3df68e9b1403443cb2eb1d8cbfb88c25
    8 N3ff43d9d4d8c41a0828cfb6429f7652f
    9 N40ac3db3ba414959bbdc37170631fd2c
    10 N52e8b3ecbb4242d9811369733dc9933d
    11 N53865cb803bd4b0fafc35c4abcefae1b
    12 N5f9434195b4f4e2b995f8ae437dd0905
    13 N61588dec871d47d18171f20f6f77995a
    14 N6c811aafdfd3476b86522ad73db6359d
    15 N7566e01ae70b42b38b668d1fc29cf3e8
    16 N9656243d9e044bd388f7f20a462f0dac
    17 N998d934d45524c80840775a0f5c8f283
    18 N9cf9875988ec414680c595eb0963971f
    19 Nbde709d2839c4a0c9048af7c917b376f
    20 Nca56dfae239d4f0293b49c0ed8d641fe
    21 Ndc22c291e8774c0d93552b6b38b86094
    22 anzsrc-for:06
    23 anzsrc-for:0604
    24 schema:author N02556f7e16cd44e79bfb787c55afa7a3
    25 schema:citation sg:pub.10.1007/s00198-006-0255-2
    26 sg:pub.10.1038/2005
    27 sg:pub.10.1038/ejhg.2014.30
    28 sg:pub.10.1038/nature08625
    29 sg:pub.10.1038/nature19057
    30 sg:pub.10.1038/ng.216
    31 sg:pub.10.1038/ng.2957
    32 sg:pub.10.1038/ng.296
    33 sg:pub.10.1038/ng.3246
    34 sg:pub.10.1038/ng.3247
    35 sg:pub.10.1038/ng.3507
    36 sg:pub.10.1038/ng1311
    37 sg:pub.10.1038/nm.3620
    38 sg:pub.10.1038/sj.ki.5002374
    39 sg:pub.10.1038/srep07729
    40 sg:pub.10.1186/ar3033
    41 sg:pub.10.1186/gb-2010-11-3-r25
    42 sg:pub.10.1186/s12881-015-0215-9
    43 https://doi.org/10.1002/1529-0131(200111)44:11<2548::aid-art435>3.0.co;2-s
    44 https://doi.org/10.1002/art.34453
    45 https://doi.org/10.1016/j.ajhg.2011.08.001
    46 https://doi.org/10.1016/j.bone.2009.09.012
    47 https://doi.org/10.1016/j.joca.2012.05.006
    48 https://doi.org/10.1016/j.matbio.2014.06.001
    49 https://doi.org/10.1016/j.maturitas.2015.04.004
    50 https://doi.org/10.1016/s0140-6736(12)60681-3
    51 https://doi.org/10.1074/jbc.m114.593541
    52 https://doi.org/10.1093/bioinformatics/btu638
    53 https://doi.org/10.1093/nar/gkl679
    54 https://doi.org/10.1101/gad.1968411
    55 https://doi.org/10.1101/gr.107524.110
    56 https://doi.org/10.1111/j.0006-341x.1999.00997.x
    57 https://doi.org/10.1136/annrheumdis-2012-203114
    58 https://doi.org/10.1136/annrheumdis-2012-203182
    59 https://doi.org/10.1136/jmedgenet-2013-101754
    60 https://doi.org/10.1210/jc.2006-1191
    61 https://doi.org/10.1359/jbmr.050320
    62 https://doi.org/10.2196/resprot.6050
    63 https://doi.org/10.3109/17453679908997798
    64 https://doi.org/10.5435/jaaos-d-13-00173
    65 schema:datePublished 2017-05
    66 schema:datePublishedReg 2017-05-01
    67 schema:description We performed a genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, which included 4,657 Icelandic patients and 207,514 population controls. We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G&gt;C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P = 4.0 × 10<sup>-12</sup>, odds ratio (OR) = 16.7) and a frameshift mutation, rs532464664 (p.Val330Glyfs*106), in the CHADL gene that associates through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 × 10<sup>-18</sup>, OR = 7.71). On average, c.1141G&gt;C heterozygotes and individuals homozygous for rs532464664 had their hip replacement operation 13.5 years and 4.9 years earlier than others (P = 0.0020 and P = 0.0026), respectively. We show that the full-length CHADL transcript is expressed in cartilage. Furthermore, the premature stop codon introduced by the CHADL frameshift mutation results in nonsense-mediated decay of the mutant transcripts.
    68 schema:genre research_article
    69 schema:inLanguage en
    70 schema:isAccessibleForFree false
    71 schema:isPartOf N4078e4244ce64c1ebe08bf81fd8adea8
    72 Nebea0594f1bd45c2ae0673cd9902351d
    73 sg:journal.1103138
    74 schema:name Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
    75 schema:pagination 801-805
    76 schema:productId N3b71b8be8d0242ac9ef386eec03f9bd3
    77 Nb9bae937b2b74f2182c238d9f58189dc
    78 Nb9dd121b06c04aafba1912bf48b4e859
    79 Nba4a18f2e7804558830a6d27e6e199f9
    80 Nf8b8f1a01fd743b894980b87edd5f31a
    81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129154
    82 https://doi.org/10.1038/ng.3816
    83 schema:sdDatePublished 2019-04-11T12:26
    84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    85 schema:sdPublisher N570b5cfea1d24c7b988aa83a9329dd43
    86 schema:url http://www.nature.com/ng/journal/v49/n5/full/ng.3816.html
    87 sgo:license sg:explorer/license/
    88 sgo:sdDataset articles
    89 rdf:type schema:ScholarlyArticle
    90 N015cffd98df04dd697c0e90b7e5a842e schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    91 rdf:type schema:Organization
    92 N02556f7e16cd44e79bfb787c55afa7a3 rdf:first sg:person.01205523707.73
    93 rdf:rest Nf0b976c4a5984fa1b6ce3ba5148d5d02
    94 N05e7106c6c1a405a8bf9086b8fe54360 rdf:first sg:person.0773127601.34
    95 rdf:rest N6e56c76f50e940298c9b56661c18cce6
    96 N066ea7cb81ab40df97f3fcc3300531d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Sequence Analysis, DNA
    98 rdf:type schema:DefinedTerm
    99 N07d79699dc8f45699dbb10859b0c8764 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Osteoarthritis, Hip
    101 rdf:type schema:DefinedTerm
    102 N09ee993b2d9d400ea7540a71719ae57c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Humans
    104 rdf:type schema:DefinedTerm
    105 N0b5c268343884f30af7270f4c068a27c rdf:first sg:person.013775616203.68
    106 rdf:rest N70095445410b4cd29e8cafb4d75379b7
    107 N0e4b47100da842f2a4b56f81efe9afd3 rdf:first sg:person.0723426172.10
    108 rdf:rest rdf:nil
    109 N133c263ae4fb45b2ba11cea29cd3c778 rdf:first sg:person.0700374216.54
    110 rdf:rest N26b4569e20214480847506b9cb3f407e
    111 N145f58239695410789fd5123c4b64fb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Genome-Wide Association Study
    113 rdf:type schema:DefinedTerm
    114 N14bcb1fbe7f3466f94e28957d045725d rdf:first sg:person.0743534613.73
    115 rdf:rest Na2d3ebc45cda48eab0f5365888db8d32
    116 N164c7a5a045f4a9db0e312c4cbec9c1e rdf:first sg:person.01220643160.06
    117 rdf:rest Ne7ee19266f4d472a982adf217dfe51bf
    118 N178b1b5ee07745c8a8dd639b14289e82 rdf:first sg:person.01334675114.72
    119 rdf:rest N23c20b0a8fe441be8f110b0205793aa8
    120 N1f02541e79ec4499ad0aa4dfba2225c5 rdf:first sg:person.01067302737.32
    121 rdf:rest N3eb8b0b7b4774407875fcc938cabbce0
    122 N1fae46a9dc5f4a069079c58961c8825b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Frameshift Mutation
    124 rdf:type schema:DefinedTerm
    125 N225800f261724b2592e10f2e81e7ebd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Polymorphism, Single Nucleotide
    127 rdf:type schema:DefinedTerm
    128 N23c20b0a8fe441be8f110b0205793aa8 rdf:first sg:person.0726475763.17
    129 rdf:rest Nbbc96fc4fe654196845411b938f05b34
    130 N26b4569e20214480847506b9cb3f407e rdf:first sg:person.01071376774.64
    131 rdf:rest Nc84888a94e7945079823f31661bd2833
    132 N290a85e8489341c591ce3e21e025141c schema:name Division of Medical Oncology, Lozano Blesa University Hospital, Zaragoza, Spain.
    133 rdf:type schema:Organization
    134 N29769fa66a0b4867b2bf6e3f3533f5fe rdf:first sg:person.01033273244.97
    135 rdf:rest N97ed389bc04849c58af0c09e3ab70094
    136 N2a109ea4febd4134aa7762a21906fe96 rdf:first N94ac4d895c7b420684f212b4dd078916
    137 rdf:rest N664c069b1b15451faf06d82fe3b1cb7a
    138 N35742afd783849f5a374d8100129c000 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    139 rdf:type schema:Organization
    140 N3b71b8be8d0242ac9ef386eec03f9bd3 schema:name readcube_id
    141 schema:value 2429f5b9e08c1855faa751dc51b0a1266a0ed3270b1cceacbe1f798cd0f123f2
    142 rdf:type schema:PropertyValue
    143 N3d636e6b6ab64e3ca1826351cc3adab9 rdf:first sg:person.01246072341.19
    144 rdf:rest N7e7007b5eefc4d34a1d84e75dd4e8064
    145 N3df68e9b1403443cb2eb1d8cbfb88c25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Cartilage Oligomeric Matrix Protein
    147 rdf:type schema:DefinedTerm
    148 N3eb8b0b7b4774407875fcc938cabbce0 rdf:first sg:person.0771421022.72
    149 rdf:rest Ne1c713d636ce4cacb3854958c3d396e7
    150 N3ff43d9d4d8c41a0828cfb6429f7652f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Reverse Transcriptase Polymerase Chain Reaction
    152 rdf:type schema:DefinedTerm
    153 N4078e4244ce64c1ebe08bf81fd8adea8 schema:volumeNumber 49
    154 rdf:type schema:PublicationVolume
    155 N40ac3db3ba414959bbdc37170631fd2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Genetic Predisposition to Disease
    157 rdf:type schema:DefinedTerm
    158 N44ba758944474aa5b8d96580833ea001 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    159 rdf:type schema:Organization
    160 N503559dae25d45b392d798466fb695a7 rdf:first sg:person.01276025677.23
    161 rdf:rest Nb2babac3fff84523bfddbd8485ffa56a
    162 N52e8b3ecbb4242d9811369733dc9933d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Gene Expression
    164 rdf:type schema:DefinedTerm
    165 N53865cb803bd4b0fafc35c4abcefae1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Extracellular Matrix Proteins
    167 rdf:type schema:DefinedTerm
    168 N54d0ce2c998b4e8cb95b1166af400421 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    169 rdf:type schema:Organization
    170 N570b5cfea1d24c7b988aa83a9329dd43 schema:name Springer Nature - SN SciGraph project
    171 rdf:type schema:Organization
    172 N595295d18d284e4c976524fb7f983862 schema:name NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    173 rdf:type schema:Organization
    174 N5e866596198e47b3b4c6e56936d858fd rdf:first sg:person.01044411633.86
    175 rdf:rest Nb9c1b629e3fa4da7be612b50c5bcefdd
    176 N5f6d5a0bf49a49debe969dc2874fdb4e rdf:first sg:person.01242432070.38
    177 rdf:rest N6c9381e5dccf47028893dd4641ff5b13
    178 N5f9434195b4f4e2b995f8ae437dd0905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Risk Factors
    180 rdf:type schema:DefinedTerm
    181 N61588dec871d47d18171f20f6f77995a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Codon, Nonsense
    183 rdf:type schema:DefinedTerm
    184 N64cd01b752214d5ab35b9adcf060179e rdf:first sg:person.01074111130.38
    185 rdf:rest N6a5e979ccd7644599e6da8f5cb0afb26
    186 N650b0a0324d44dba8e87bef2d8d86f1c rdf:first sg:person.016033704317.28
    187 rdf:rest N3d636e6b6ab64e3ca1826351cc3adab9
    188 N664c069b1b15451faf06d82fe3b1cb7a rdf:first sg:person.01121255525.11
    189 rdf:rest N133c263ae4fb45b2ba11cea29cd3c778
    190 N6a5e979ccd7644599e6da8f5cb0afb26 rdf:first sg:person.01055436526.26
    191 rdf:rest N5e866596198e47b3b4c6e56936d858fd
    192 N6c811aafdfd3476b86522ad73db6359d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Kaplan-Meier Estimate
    194 rdf:type schema:DefinedTerm
    195 N6c9381e5dccf47028893dd4641ff5b13 rdf:first sg:person.0611467633.09
    196 rdf:rest N0b5c268343884f30af7270f4c068a27c
    197 N6e56c76f50e940298c9b56661c18cce6 rdf:first sg:person.0575412557.89
    198 rdf:rest Nbe8730b8731c4a3f82921625882bc9a0
    199 N70095445410b4cd29e8cafb4d75379b7 rdf:first sg:person.0651363747.00
    200 rdf:rest N7f6d1a3514324d56868ca9d5a18a9396
    201 N7566e01ae70b42b38b668d1fc29cf3e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Iceland
    203 rdf:type schema:DefinedTerm
    204 N7b086771585642d3b95f815e00d23de5 rdf:first sg:person.0606704334.54
    205 rdf:rest N650b0a0324d44dba8e87bef2d8d86f1c
    206 N7e7007b5eefc4d34a1d84e75dd4e8064 rdf:first sg:person.0641377366.34
    207 rdf:rest Nff343d59d50040f68c527a172798bfeb
    208 N7f6d1a3514324d56868ca9d5a18a9396 rdf:first sg:person.0620626735.30
    209 rdf:rest N64cd01b752214d5ab35b9adcf060179e
    210 N7f9d4aab34e34c4b86d20a914eddfee6 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    211 rdf:type schema:Organization
    212 N81a3d6e6b2d04496b0c10fca04986d20 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    213 rdf:type schema:Organization
    214 N81a56371bf4e422f95ac2a8121d64b3d rdf:first sg:person.01213256746.16
    215 rdf:rest N178b1b5ee07745c8a8dd639b14289e82
    216 N8cd425db7c4a4b7fb5058d2a36727cdb schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    217 rdf:type schema:Organization
    218 N8d4eaa73d2cc4361b2ee194cd102bb12 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    219 rdf:type schema:Organization
    220 N8e9603f442ac42fc85db51bdcc30bbe8 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    221 rdf:type schema:Organization
    222 N9398947a7e52485f85aa2534f5be849f rdf:first sg:person.0647426411.14
    223 rdf:rest N81a56371bf4e422f95ac2a8121d64b3d
    224 N94ac4d895c7b420684f212b4dd078916 schema:affiliation Ne57a6b01f74943d09c6b72c695c6d3d2
    225 schema:familyName Sulem
    226 schema:givenName Gerald
    227 rdf:type schema:Person
    228 N9656243d9e044bd388f7f20a462f0dac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Genotype
    230 rdf:type schema:DefinedTerm
    231 N97ed389bc04849c58af0c09e3ab70094 rdf:first Ndc3ff01e4b0a44dd9bb4e6b21c0bc13b
    232 rdf:rest N503559dae25d45b392d798466fb695a7
    233 N98ca4ef7bd0b4c32845d63a5f43dcbf3 rdf:first sg:person.0712764112.84
    234 rdf:rest Nc9ccffbcd5704ddd9b7454812cb23b07
    235 N998d934d45524c80840775a0f5c8f283 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Cells, Cultured
    237 rdf:type schema:DefinedTerm
    238 N99acbc7290b649e186064f07b7ce358f rdf:first sg:person.010001043302.06
    239 rdf:rest N164c7a5a045f4a9db0e312c4cbec9c1e
    240 N9cf9875988ec414680c595eb0963971f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    241 schema:name Gene Frequency
    242 rdf:type schema:DefinedTerm
    243 Na2d3ebc45cda48eab0f5365888db8d32 rdf:first sg:person.01366065163.97
    244 rdf:rest N99acbc7290b649e186064f07b7ce358f
    245 Na5521396eaa24319b58ed0c0201b5ef8 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    246 rdf:type schema:Organization
    247 Na5c2b0f532e94315a10985ef6fca2023 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    248 rdf:type schema:Organization
    249 Na732f73028dc412c9ae4fd4de8df9c68 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    250 rdf:type schema:Organization
    251 Nabbf5963c3964c7b99d618fbfcd1d95b schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    252 rdf:type schema:Organization
    253 Nb2babac3fff84523bfddbd8485ffa56a rdf:first sg:person.01232734734.11
    254 rdf:rest N7b086771585642d3b95f815e00d23de5
    255 Nb7d766bc9d8d4f6790950932903aad83 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    256 rdf:type schema:Organization
    257 Nb98e71be30b64ea0940cd4f2300d9087 rdf:first sg:person.01256544557.44
    258 rdf:rest Nf6d0f726950d4b9c96b518bdb9e631af
    259 Nb9bae937b2b74f2182c238d9f58189dc schema:name nlm_unique_id
    260 schema:value 9216904
    261 rdf:type schema:PropertyValue
    262 Nb9c1b629e3fa4da7be612b50c5bcefdd rdf:first sg:person.0576334543.32
    263 rdf:rest Nc3741cd1769e4726b80dd12483e132f3
    264 Nb9dd121b06c04aafba1912bf48b4e859 schema:name doi
    265 schema:value 10.1038/ng.3816
    266 rdf:type schema:PropertyValue
    267 Nba4a18f2e7804558830a6d27e6e199f9 schema:name pubmed_id
    268 schema:value 28319091
    269 rdf:type schema:PropertyValue
    270 Nbbc96fc4fe654196845411b938f05b34 rdf:first sg:person.0724300310.21
    271 rdf:rest Nc45dc25fe688411fa0df29d126adc387
    272 Nbde709d2839c4a0c9048af7c917b376f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    273 schema:name Arthroplasty, Replacement, Hip
    274 rdf:type schema:DefinedTerm
    275 Nbe8730b8731c4a3f82921625882bc9a0 rdf:first sg:person.01305125451.09
    276 rdf:rest Nb98e71be30b64ea0940cd4f2300d9087
    277 Nc3741cd1769e4726b80dd12483e132f3 rdf:first sg:person.0734152634.26
    278 rdf:rest N98ca4ef7bd0b4c32845d63a5f43dcbf3
    279 Nc45dc25fe688411fa0df29d126adc387 rdf:first sg:person.0736713725.41
    280 rdf:rest N2a109ea4febd4134aa7762a21906fe96
    281 Nc84888a94e7945079823f31661bd2833 rdf:first sg:person.011605274603.77
    282 rdf:rest N5f6d5a0bf49a49debe969dc2874fdb4e
    283 Nc9ccffbcd5704ddd9b7454812cb23b07 rdf:first sg:person.0757733351.08
    284 rdf:rest N29769fa66a0b4867b2bf6e3f3533f5fe
    285 Nca56dfae239d4f0293b49c0ed8d641fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    286 schema:name Mutation, Missense
    287 rdf:type schema:DefinedTerm
    288 Nd249b1c7fbc84df48734bc9f64bc4838 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    289 rdf:type schema:Organization
    290 Nda428a80529040afb07e194e791f0322 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    291 rdf:type schema:Organization
    292 Ndc016e3109494fc2944c61c7d7e2e797 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    293 rdf:type schema:Organization
    294 Ndc22c291e8774c0d93552b6b38b86094 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    295 schema:name Genome, Human
    296 rdf:type schema:DefinedTerm
    297 Ndc3ff01e4b0a44dd9bb4e6b21c0bc13b schema:affiliation N290a85e8489341c591ce3e21e025141c
    298 schema:familyName Mayordomo
    299 schema:givenName Jose I
    300 rdf:type schema:Person
    301 Ne1c713d636ce4cacb3854958c3d396e7 rdf:first sg:person.01067375637.38
    302 rdf:rest N9398947a7e52485f85aa2534f5be849f
    303 Ne57a6b01f74943d09c6b72c695c6d3d2 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    304 rdf:type schema:Organization
    305 Ne7aae2abc32b475fb0f6112893448a79 schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    306 rdf:type schema:Organization
    307 Ne7ee19266f4d472a982adf217dfe51bf rdf:first sg:person.0637651205.48
    308 rdf:rest N05e7106c6c1a405a8bf9086b8fe54360
    309 Ne9dda9893f3d4793829bcc6c2f1a6470 rdf:first sg:person.010671263757.14
    310 rdf:rest N14bcb1fbe7f3466f94e28957d045725d
    311 Nebea0594f1bd45c2ae0673cd9902351d schema:issueNumber 5
    312 rdf:type schema:PublicationIssue
    313 Nf0724f632383484d8787a5c89ad85a4e schema:name deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    314 rdf:type schema:Organization
    315 Nf0b976c4a5984fa1b6ce3ba5148d5d02 rdf:first sg:person.01273401363.65
    316 rdf:rest N1f02541e79ec4499ad0aa4dfba2225c5
    317 Nf6d0f726950d4b9c96b518bdb9e631af rdf:first sg:person.01277776417.51
    318 rdf:rest N0e4b47100da842f2a4b56f81efe9afd3
    319 Nf8b8f1a01fd743b894980b87edd5f31a schema:name dimensions_id
    320 schema:value pub.1084129154
    321 rdf:type schema:PropertyValue
    322 Nff343d59d50040f68c527a172798bfeb rdf:first sg:person.01263457230.91
    323 rdf:rest Ne9dda9893f3d4793829bcc6c2f1a6470
    324 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    325 schema:name Biological Sciences
    326 rdf:type schema:DefinedTerm
    327 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    328 schema:name Genetics
    329 rdf:type schema:DefinedTerm
    330 sg:grant.2756221 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3816
    331 rdf:type schema:MonetaryGrant
    332 sg:grant.2763785 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3816
    333 rdf:type schema:MonetaryGrant
    334 sg:grant.2767197 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3816
    335 rdf:type schema:MonetaryGrant
    336 sg:grant.2770073 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3816
    337 rdf:type schema:MonetaryGrant
    338 sg:grant.2772903 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3816
    339 rdf:type schema:MonetaryGrant
    340 sg:grant.2786210 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3816
    341 rdf:type schema:MonetaryGrant
    342 sg:grant.5137296 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3816
    343 rdf:type schema:MonetaryGrant
    344 sg:grant.5141610 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3816
    345 rdf:type schema:MonetaryGrant
    346 sg:journal.1103138 schema:issn 1061-4036
    347 1546-1718
    348 schema:name Nature Genetics
    349 rdf:type schema:Periodical
    350 sg:person.010001043302.06 schema:affiliation N7f9d4aab34e34c4b86d20a914eddfee6
    351 schema:familyName Kong
    352 schema:givenName Augustine
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010001043302.06
    354 rdf:type schema:Person
    355 sg:person.01033273244.97 schema:affiliation https://www.grid.ac/institutes/grid.411600.2
    356 schema:familyName Daneshpour
    357 schema:givenName Maryam S
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033273244.97
    359 rdf:type schema:Person
    360 sg:person.01044411633.86 schema:affiliation https://www.grid.ac/institutes/grid.412929.5
    361 schema:familyName Selbæk
    362 schema:givenName Geir
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044411633.86
    364 rdf:type schema:Person
    365 sg:person.01055436526.26 schema:affiliation https://www.grid.ac/institutes/grid.5510.1
    366 schema:familyName Fladby
    367 schema:givenName Tormod
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055436526.26
    369 rdf:type schema:Person
    370 sg:person.010671263757.14 schema:familyName consortium
    371 schema:givenName OGEN
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010671263757.14
    373 rdf:type schema:Person
    374 sg:person.01067302737.32 schema:affiliation Na5521396eaa24319b58ed0c0201b5ef8
    375 schema:familyName Sigurdsson
    376 schema:givenName Asgeir
    377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067302737.32
    378 rdf:type schema:Person
    379 sg:person.01067375637.38 schema:affiliation Ndc016e3109494fc2944c61c7d7e2e797
    380 schema:familyName Agustsdottir
    381 schema:givenName Arna B
    382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067375637.38
    383 rdf:type schema:Person
    384 sg:person.01071376774.64 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    385 schema:familyName Helgason
    386 schema:givenName Agnar
    387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071376774.64
    388 rdf:type schema:Person
    389 sg:person.01074111130.38 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
    390 schema:familyName Brækhus
    391 schema:givenName Anne
    392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074111130.38
    393 rdf:type schema:Person
    394 sg:person.01121255525.11 schema:affiliation Nd249b1c7fbc84df48734bc9f64bc4838
    395 schema:familyName Zink
    396 schema:givenName Florian
    397 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121255525.11
    398 rdf:type schema:Person
    399 sg:person.011605274603.77 schema:affiliation Na5c2b0f532e94315a10985ef6fca2023
    400 schema:familyName Johannsdottir
    401 schema:givenName Hrefna S
    402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011605274603.77
    403 rdf:type schema:Person
    404 sg:person.01205523707.73 schema:affiliation Nf0724f632383484d8787a5c89ad85a4e
    405 schema:familyName Styrkarsdottir
    406 schema:givenName Unnur
    407 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205523707.73
    408 rdf:type schema:Person
    409 sg:person.01213256746.16 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
    410 schema:familyName Villalvilla
    411 schema:givenName Amanda
    412 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213256746.16
    413 rdf:type schema:Person
    414 sg:person.01220643160.06 schema:affiliation https://www.grid.ac/institutes/grid.410540.4
    415 schema:familyName Jonsdottir
    416 schema:givenName Ingileif
    417 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220643160.06
    418 rdf:type schema:Person
    419 sg:person.01232734734.11 schema:affiliation https://www.grid.ac/institutes/grid.412925.9
    420 schema:familyName Braund
    421 schema:givenName Peter S
    422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232734734.11
    423 rdf:type schema:Person
    424 sg:person.01242432070.38 schema:affiliation N35742afd783849f5a374d8100129c000
    425 schema:familyName Helgadottir
    426 schema:givenName Anna
    427 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242432070.38
    428 rdf:type schema:Person
    429 sg:person.01246072341.19 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
    430 schema:familyName Lohmander
    431 schema:givenName L Stefan
    432 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246072341.19
    433 rdf:type schema:Person
    434 sg:person.01256544557.44 schema:affiliation https://www.grid.ac/institutes/grid.16977.3e
    435 schema:familyName Ingvarsson
    436 schema:givenName Thorvaldur
    437 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256544557.44
    438 rdf:type schema:Person
    439 sg:person.01263457230.91 schema:affiliation N595295d18d284e4c976524fb7f983862
    440 schema:familyName Andreassen
    441 schema:givenName Ole A
    442 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263457230.91
    443 rdf:type schema:Person
    444 sg:person.01273401363.65 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    445 schema:familyName Helgason
    446 schema:givenName Hannes
    447 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273401363.65
    448 rdf:type schema:Person
    449 sg:person.01276025677.23 schema:affiliation https://www.grid.ac/institutes/grid.223827.e
    450 schema:familyName Welt
    451 schema:givenName Corrine
    452 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276025677.23
    453 rdf:type schema:Person
    454 sg:person.01277776417.51 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    455 schema:familyName Thorsteinsdottir
    456 schema:givenName Unnur
    457 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277776417.51
    458 rdf:type schema:Person
    459 sg:person.01305125451.09 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
    460 schema:familyName Loughlin
    461 schema:givenName John
    462 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305125451.09
    463 rdf:type schema:Person
    464 sg:person.01334675114.72 schema:affiliation Na732f73028dc412c9ae4fd4de8df9c68
    465 schema:familyName Halldorsson
    466 schema:givenName Gisli H
    467 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334675114.72
    468 rdf:type schema:Person
    469 sg:person.01366065163.97 schema:affiliation N8e9603f442ac42fc85db51bdcc30bbe8
    470 schema:familyName Masson
    471 schema:givenName Gisli
    472 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366065163.97
    473 rdf:type schema:Person
    474 sg:person.013775616203.68 schema:affiliation Nb7d766bc9d8d4f6790950932903aad83
    475 schema:familyName Gretarsdottir
    476 schema:givenName Solveig
    477 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013775616203.68
    478 rdf:type schema:Person
    479 sg:person.016033704317.28 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
    480 schema:familyName Kiemeney
    481 schema:givenName Lambertus A
    482 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016033704317.28
    483 rdf:type schema:Person
    484 sg:person.0575412557.89 schema:affiliation https://www.grid.ac/institutes/grid.410540.4
    485 schema:familyName Jonsson
    486 schema:givenName Helgi
    487 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575412557.89
    488 rdf:type schema:Person
    489 sg:person.0576334543.32 schema:affiliation https://www.grid.ac/institutes/grid.411600.2
    490 schema:familyName Hosseinpanah
    491 schema:givenName Farhad
    492 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576334543.32
    493 rdf:type schema:Person
    494 sg:person.0606704334.54 schema:affiliation https://www.grid.ac/institutes/grid.412925.9
    495 schema:familyName Samani
    496 schema:givenName Nilesh J
    497 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606704334.54
    498 rdf:type schema:Person
    499 sg:person.0611467633.09 schema:affiliation N44ba758944474aa5b8d96580833ea001
    500 schema:familyName Stefansson
    501 schema:givenName Hreinn
    502 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611467633.09
    503 rdf:type schema:Person
    504 sg:person.0620626735.30 schema:affiliation https://www.grid.ac/institutes/grid.411279.8
    505 schema:familyName Almdahl
    506 schema:givenName Ina S
    507 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620626735.30
    508 rdf:type schema:Person
    509 sg:person.0637651205.48 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    510 schema:familyName Gudbjartsson
    511 schema:givenName Daniel
    512 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637651205.48
    513 rdf:type schema:Person
    514 sg:person.0641377366.34 schema:affiliation https://www.grid.ac/institutes/grid.436559.8
    515 schema:familyName Christiansen
    516 schema:givenName Claus
    517 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641377366.34
    518 rdf:type schema:Person
    519 sg:person.0647426411.14 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
    520 schema:familyName Reynard
    521 schema:givenName Louise N
    522 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647426411.14
    523 rdf:type schema:Person
    524 sg:person.0651363747.00 schema:affiliation N015cffd98df04dd697c0e90b7e5a842e
    525 schema:familyName Rafnar
    526 schema:givenName Thorunn
    527 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651363747.00
    528 rdf:type schema:Person
    529 sg:person.0700374216.54 schema:affiliation N81a3d6e6b2d04496b0c10fca04986d20
    530 schema:familyName Sveinbjornsson
    531 schema:givenName Gardar
    532 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700374216.54
    533 rdf:type schema:Person
    534 sg:person.0712764112.84 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
    535 schema:familyName Koh
    536 schema:givenName Jung Min
    537 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712764112.84
    538 rdf:type schema:Person
    539 sg:person.0723426172.10 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    540 schema:familyName Stefansson
    541 schema:givenName Kari
    542 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723426172.10
    543 rdf:type schema:Person
    544 sg:person.0724300310.21 schema:affiliation Ne7aae2abc32b475fb0f6112893448a79
    545 schema:familyName Magnusdottir
    546 schema:givenName Audur
    547 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724300310.21
    548 rdf:type schema:Person
    549 sg:person.0726475763.17 schema:affiliation N8cd425db7c4a4b7fb5058d2a36727cdb
    550 schema:familyName Jonasdottir
    551 schema:givenName Aslaug
    552 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726475763.17
    553 rdf:type schema:Person
    554 sg:person.0734152634.26 schema:affiliation https://www.grid.ac/institutes/grid.411600.2
    555 schema:familyName Azizi
    556 schema:givenName Fereidoun
    557 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734152634.26
    558 rdf:type schema:Person
    559 sg:person.0736713725.41 schema:affiliation N8d4eaa73d2cc4361b2ee194cd102bb12
    560 schema:familyName Oddson
    561 schema:givenName Asmundur
    562 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736713725.41
    563 rdf:type schema:Person
    564 sg:person.0743534613.73 schema:affiliation Nda428a80529040afb07e194e791f0322
    565 schema:familyName Magnusson
    566 schema:givenName Olafur
    567 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743534613.73
    568 rdf:type schema:Person
    569 sg:person.0757733351.08 schema:affiliation https://www.grid.ac/institutes/grid.10784.3a
    570 schema:familyName Tang
    571 schema:givenName Nelson L S
    572 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757733351.08
    573 rdf:type schema:Person
    574 sg:person.0771421022.72 schema:affiliation Nabbf5963c3964c7b99d618fbfcd1d95b
    575 schema:familyName Norddahl
    576 schema:givenName Gudmundur L
    577 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771421022.72
    578 rdf:type schema:Person
    579 sg:person.0773127601.34 schema:affiliation N54d0ce2c998b4e8cb95b1166af400421
    580 schema:familyName Sulem
    581 schema:givenName Patrick
    582 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773127601.34
    583 rdf:type schema:Person
    584 sg:pub.10.1007/s00198-006-0255-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005968105
    585 https://doi.org/10.1007/s00198-006-0255-2
    586 rdf:type schema:CreativeWork
    587 sg:pub.10.1038/2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031965116
    588 https://doi.org/10.1038/2005
    589 rdf:type schema:CreativeWork
    590 sg:pub.10.1038/ejhg.2014.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035165019
    591 https://doi.org/10.1038/ejhg.2014.30
    592 rdf:type schema:CreativeWork
    593 sg:pub.10.1038/nature08625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017956321
    594 https://doi.org/10.1038/nature08625
    595 rdf:type schema:CreativeWork
    596 sg:pub.10.1038/nature19057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022281897
    597 https://doi.org/10.1038/nature19057
    598 rdf:type schema:CreativeWork
    599 sg:pub.10.1038/ng.216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045032711
    600 https://doi.org/10.1038/ng.216
    601 rdf:type schema:CreativeWork
    602 sg:pub.10.1038/ng.2957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000294613
    603 https://doi.org/10.1038/ng.2957
    604 rdf:type schema:CreativeWork
    605 sg:pub.10.1038/ng.296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010958400
    606 https://doi.org/10.1038/ng.296
    607 rdf:type schema:CreativeWork
    608 sg:pub.10.1038/ng.3246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045287472
    609 https://doi.org/10.1038/ng.3246
    610 rdf:type schema:CreativeWork
    611 sg:pub.10.1038/ng.3247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020692466
    612 https://doi.org/10.1038/ng.3247
    613 rdf:type schema:CreativeWork
    614 sg:pub.10.1038/ng.3507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043168111
    615 https://doi.org/10.1038/ng.3507
    616 rdf:type schema:CreativeWork
    617 sg:pub.10.1038/ng1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050287806
    618 https://doi.org/10.1038/ng1311
    619 rdf:type schema:CreativeWork
    620 sg:pub.10.1038/nm.3620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032746554
    621 https://doi.org/10.1038/nm.3620
    622 rdf:type schema:CreativeWork
    623 sg:pub.10.1038/sj.ki.5002374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020065676
    624 https://doi.org/10.1038/sj.ki.5002374
    625 rdf:type schema:CreativeWork
    626 sg:pub.10.1038/srep07729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024324417
    627 https://doi.org/10.1038/srep07729
    628 rdf:type schema:CreativeWork
    629 sg:pub.10.1186/ar3033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007003574
    630 https://doi.org/10.1186/ar3033
    631 rdf:type schema:CreativeWork
    632 sg:pub.10.1186/gb-2010-11-3-r25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050509557
    633 https://doi.org/10.1186/gb-2010-11-3-r25
    634 rdf:type schema:CreativeWork
    635 sg:pub.10.1186/s12881-015-0215-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020791919
    636 https://doi.org/10.1186/s12881-015-0215-9
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1002/1529-0131(200111)44:11<2548::aid-art435>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1020058171
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1002/art.34453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052578912
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1016/j.ajhg.2011.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038661579
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1016/j.bone.2009.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031268204
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1016/j.joca.2012.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045289277
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1016/j.matbio.2014.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034205816
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1016/j.maturitas.2015.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009103185
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1016/s0140-6736(12)60681-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051411617
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.1074/jbc.m114.593541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020070261
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1093/bioinformatics/btu638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053282140
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.1093/nar/gkl679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008829533
    659 rdf:type schema:CreativeWork
    660 https://doi.org/10.1101/gad.1968411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034829410
    661 rdf:type schema:CreativeWork
    662 https://doi.org/10.1101/gr.107524.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032096953
    663 rdf:type schema:CreativeWork
    664 https://doi.org/10.1111/j.0006-341x.1999.00997.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021081768
    665 rdf:type schema:CreativeWork
    666 https://doi.org/10.1136/annrheumdis-2012-203114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053235870
    667 rdf:type schema:CreativeWork
    668 https://doi.org/10.1136/annrheumdis-2012-203182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017383505
    669 rdf:type schema:CreativeWork
    670 https://doi.org/10.1136/jmedgenet-2013-101754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007837655
    671 rdf:type schema:CreativeWork
    672 https://doi.org/10.1210/jc.2006-1191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289385
    673 rdf:type schema:CreativeWork
    674 https://doi.org/10.1359/jbmr.050320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031556622
    675 rdf:type schema:CreativeWork
    676 https://doi.org/10.2196/resprot.6050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083861911
    677 rdf:type schema:CreativeWork
    678 https://doi.org/10.3109/17453679908997798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036446703
    679 rdf:type schema:CreativeWork
    680 https://doi.org/10.5435/jaaos-d-13-00173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072860349
    681 rdf:type schema:CreativeWork
    682 https://www.grid.ac/institutes/grid.1006.7 schema:alternateName Newcastle University
    683 schema:name Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
    684 rdf:type schema:Organization
    685 https://www.grid.ac/institutes/grid.10417.33 schema:alternateName Radboud University Nijmegen Medical Centre
    686 schema:name Radboud University Medical Center, Radboud Institute for Health Science, Nijmegen, the Netherlands.
    687 rdf:type schema:Organization
    688 https://www.grid.ac/institutes/grid.10784.3a schema:alternateName Chinese University of Hong Kong
    689 schema:name Department of Chemical Pathology and Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
    690 rdf:type schema:Organization
    691 https://www.grid.ac/institutes/grid.14013.37 schema:alternateName University of Iceland
    692 schema:name Department of Anthropology, University of Iceland, Reykjavik, Iceland.
    693 Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
    694 School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
    695 deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    696 rdf:type schema:Organization
    697 https://www.grid.ac/institutes/grid.16977.3e schema:alternateName University of Akureyri
    698 schema:name Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland.
    699 Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
    700 Institution of Health Science, University of Akureyri, Akureyri, Iceland.
    701 rdf:type schema:Organization
    702 https://www.grid.ac/institutes/grid.223827.e schema:alternateName University of Utah
    703 schema:name Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, USA.
    704 rdf:type schema:Organization
    705 https://www.grid.ac/institutes/grid.410540.4 schema:alternateName National University Hospital of Iceland
    706 schema:name Department of Immunology, Landspitali–The National University Hospital of Iceland, Reykjavik, Iceland.
    707 Department of Medicine, Landspitali–The National University Hospital of Iceland, Reykjavik, Iceland.
    708 Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
    709 deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    710 rdf:type schema:Organization
    711 https://www.grid.ac/institutes/grid.411279.8 schema:alternateName Akershus University Hospital
    712 schema:name Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
    713 rdf:type schema:Organization
    714 https://www.grid.ac/institutes/grid.411600.2 schema:alternateName Shahid Beheshti University of Medical Sciences
    715 schema:name Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    716 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    717 Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    718 rdf:type schema:Organization
    719 https://www.grid.ac/institutes/grid.412925.9 schema:alternateName Glenfield Hospital
    720 schema:name Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
    721 NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
    722 rdf:type schema:Organization
    723 https://www.grid.ac/institutes/grid.412929.5 schema:alternateName Innlandet Hospital Trust
    724 schema:name Centre for Old Age Psychiatry Research, Innlandet Hospital Trust, Ottestad, Norway.
    725 Faculty of Medicine, University of Oslo, Oslo, Norway.
    726 Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
    727 rdf:type schema:Organization
    728 https://www.grid.ac/institutes/grid.413967.e schema:alternateName Asan Medical Center
    729 schema:name Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    730 rdf:type schema:Organization
    731 https://www.grid.ac/institutes/grid.436559.8 schema:alternateName Nordic Bioscience (Denmark)
    732 schema:name Nordic Bioscience, Herlev, Denmark.
    733 rdf:type schema:Organization
    734 https://www.grid.ac/institutes/grid.4514.4 schema:alternateName Lund University
    735 schema:name Orthopaedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
    736 rdf:type schema:Organization
    737 https://www.grid.ac/institutes/grid.5510.1 schema:alternateName University of Oslo
    738 schema:name Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
    739 Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    740 rdf:type schema:Organization
    741 https://www.grid.ac/institutes/grid.55325.34 schema:alternateName Oslo University Hospital
    742 schema:name Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
    743 Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
    744 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...