Multiple loci associated with indices of renal function and chronic kidney disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-06

AUTHORS

Anna Köttgen, Nicole L Glazer, Abbas Dehghan, Shih-Jen Hwang, Ronit Katz, Man Li, Qiong Yang, Vilmundur Gudnason, Lenore J Launer, Tamara B Harris, Albert V Smith, Dan E Arking, Brad C Astor, Eric Boerwinkle, Georg B Ehret, Ingo Ruczinski, Robert B Scharpf, Yii-Der Ida Chen, Ian H de Boer, Talin Haritunians, Thomas Lumley, Mark Sarnak, David Siscovick, Emelia J Benjamin, Daniel Levy, Ashish Upadhyay, Yurii S Aulchenko, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Cornelia M van Duijn, Daniel I Chasman, Guillaume Paré, Paul M Ridker, W H Linda Kao, Jacqueline C Witteman, Josef Coresh, Michael G Shlipak, Caroline S Fox

ABSTRACT

Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS) to identify susceptibility loci for glomerular filtration rate, estimated by serum creatinine (eGFRcrea) and cystatin C (eGFRcys), and CKD (eGFRcrea < 60 ml/min/1.73 m(2)) in European-ancestry participants of four population-based cohorts (ARIC, CHS, FHS, RS; n = 19,877; 2,388 CKD cases), and tested for replication in 21,466 participants (1,932 CKD cases). We identified significant SNP associations (P < 5 × 10(-8)) with CKD at the UMOD locus, with eGFRcrea at UMOD, SHROOM3 and GATM-SPATA5L1, and with eGFRcys at CST and STC1. UMOD encodes the most common protein in human urine, Tamm-Horsfall protein, and rare mutations in UMOD cause mendelian forms of kidney disease. Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease. More... »

PAGES

712-717

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.377

DOI

http://dx.doi.org/10.1038/ng.377

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029463141

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19430482


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerular Filtration Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Failure, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meta-Analysis as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mucoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Netherlands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uromodulin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "K\u00f6ttgen", 
        "givenName": "Anna", 
        "id": "sg:person.01372404626.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372404626.99"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Glazer", 
        "givenName": "Nicole L", 
        "type": "Person"
      }, 
      {
        "familyName": "Dehghan", 
        "givenName": "Abbas", 
        "id": "sg:person.01333534554.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333534554.85"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hwang", 
        "givenName": "Shih-Jen", 
        "type": "Person"
      }, 
      {
        "familyName": "Katz", 
        "givenName": "Ronit", 
        "type": "Person"
      }, 
      {
        "familyName": "Li", 
        "givenName": "Man", 
        "type": "Person"
      }, 
      {
        "familyName": "Yang", 
        "givenName": "Qiong", 
        "type": "Person"
      }, 
      {
        "familyName": "Gudnason", 
        "givenName": "Vilmundur", 
        "id": "sg:person.012745117217.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012745117217.03"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Launer", 
        "givenName": "Lenore J", 
        "type": "Person"
      }, 
      {
        "familyName": "Harris", 
        "givenName": "Tamara B", 
        "type": "Person"
      }, 
      {
        "familyName": "Smith", 
        "givenName": "Albert V", 
        "id": "sg:person.01112257404.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112257404.07"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Arking", 
        "givenName": "Dan E", 
        "type": "Person"
      }, 
      {
        "familyName": "Astor", 
        "givenName": "Brad C", 
        "type": "Person"
      }, 
      {
        "familyName": "Boerwinkle", 
        "givenName": "Eric", 
        "id": "sg:person.01104262534.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104262534.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ehret", 
        "givenName": "Georg B", 
        "type": "Person"
      }, 
      {
        "familyName": "Ruczinski", 
        "givenName": "Ingo", 
        "id": "sg:person.0604723045.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604723045.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Scharpf", 
        "givenName": "Robert B", 
        "type": "Person"
      }, 
      {
        "familyName": "Chen", 
        "givenName": "Yii-Der Ida", 
        "type": "Person"
      }, 
      {
        "familyName": "de Boer", 
        "givenName": "Ian H", 
        "type": "Person"
      }, 
      {
        "familyName": "Haritunians", 
        "givenName": "Talin", 
        "id": "sg:person.01304165677.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304165677.44"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Lumley", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "familyName": "Sarnak", 
        "givenName": "Mark", 
        "id": "sg:person.07702137257.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07702137257.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Siscovick", 
        "givenName": "David", 
        "type": "Person"
      }, 
      {
        "familyName": "Benjamin", 
        "givenName": "Emelia J", 
        "id": "sg:person.01153350506.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153350506.35"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Levy", 
        "givenName": "Daniel", 
        "type": "Person"
      }, 
      {
        "familyName": "Upadhyay", 
        "givenName": "Ashish", 
        "id": "sg:person.01130101423.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130101423.75"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Aulchenko", 
        "givenName": "Yurii S", 
        "id": "sg:person.01231510236.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231510236.78"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hofman", 
        "givenName": "Albert", 
        "type": "Person"
      }, 
      {
        "familyName": "Rivadeneira", 
        "givenName": "Fernando", 
        "id": "sg:person.01006410206.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006410206.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Uitterlinden", 
        "givenName": "Andr\u00e9 G", 
        "type": "Person"
      }, 
      {
        "familyName": "van Duijn", 
        "givenName": "Cornelia M", 
        "type": "Person"
      }, 
      {
        "familyName": "Chasman", 
        "givenName": "Daniel I", 
        "type": "Person"
      }, 
      {
        "familyName": "Par\u00e9", 
        "givenName": "Guillaume", 
        "id": "sg:person.01207753503.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207753503.50"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ridker", 
        "givenName": "Paul M", 
        "type": "Person"
      }, 
      {
        "familyName": "Kao", 
        "givenName": "W H Linda", 
        "id": "sg:person.010012617237.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010012617237.52"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Witteman", 
        "givenName": "Jacqueline C", 
        "type": "Person"
      }, 
      {
        "familyName": "Coresh", 
        "givenName": "Josef", 
        "type": "Person"
      }, 
      {
        "familyName": "Shlipak", 
        "givenName": "Michael G", 
        "id": "sg:person.013125514737.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013125514737.99"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fox", 
        "givenName": "Caroline S", 
        "id": "sg:person.0734736344.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734736344.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/gepi.20303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008645052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra054415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012143696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00143.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013106983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014364350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2350-8-s1-s10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016415940", 
          "https://doi.org/10.1186/1471-2350-8-s1-s10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ki.5002343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018157803", 
          "https://doi.org/10.1038/sj.ki.5002343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0272-6386(03)00829-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018704023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0272-6386(03)00829-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018704023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2008.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019209319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2003.12.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020441080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ajkd.2002.32765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021983972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.298.17.2038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022327258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2009.080476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023067640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.108.829747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023385733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.108.829747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023385733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.019646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029249931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2005.00055.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030572924", 
          "https://doi.org/10.1111/j.1523-1755.2005.00055.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.293.23.2892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033910173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.peptides.2004.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036343516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.27.12.729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037903131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000095676.90936.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038647312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ki.5001728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039304711", 
          "https://doi.org/10.1038/sj.ki.5001728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2458-8-117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040742438", 
          "https://doi.org/10.1186/1471-2458-8-117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1214/07-aoas102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041923648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.39.12.882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043396656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddg353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047003641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ajkd.2002.29865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047330717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2007.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051956308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041552-200005000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053229383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041552-200005000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053229383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000123691.46138.e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000123691.46138.e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000123691.46138.e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000135972.13396.6f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000135972.13396.6f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000135972.13396.6f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000135972.13396.6f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-130-6-199903160-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073703194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075017372", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-06", 
    "datePublishedReg": "2009-06-01", 
    "description": "Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS) to identify susceptibility loci for glomerular filtration rate, estimated by serum creatinine (eGFRcrea) and cystatin C (eGFRcys), and CKD (eGFRcrea < 60 ml/min/1.73 m(2)) in European-ancestry participants of four population-based cohorts (ARIC, CHS, FHS, RS; n = 19,877; 2,388 CKD cases), and tested for replication in 21,466 participants (1,932 CKD cases). We identified significant SNP associations (P < 5 \u00d7 10(-8)) with CKD at the UMOD locus, with eGFRcrea at UMOD, SHROOM3 and GATM-SPATA5L1, and with eGFRcys at CST and STC1. UMOD encodes the most common protein in human urine, Tamm-Horsfall protein, and rare mutations in UMOD cause mendelian forms of kidney disease. Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.377", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2423245", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2533515", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430172", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430171", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691245", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430092", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705143", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430025", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430170", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430169", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2429985", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430097", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2536122", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430033", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430099", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2725872", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2447964", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2404053", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430095", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2499161", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2537302", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439028", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691844", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2423980", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2541398", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705230", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2469915", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430175", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430173", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2541272", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430174", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430093", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430098", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430117", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430167", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2725949", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430176", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2424188", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2541401", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430096", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430005", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "name": "Multiple loci associated with indices of renal function and chronic kidney disease", 
    "pagination": "712-717", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8c5ba06d4500aefb73eca9d7765a55844eff1bd68a1d0643b05ae3ea134f84ba"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19430482"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.377"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029463141"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.377", 
      "https://app.dimensions.ai/details/publication/pub.1029463141"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ng/journal/v41/n6/full/ng.377.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.377'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.377'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.377'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.377'


 

This table displays all metadata directly associated to this object as RDF triples.

509 TRIPLES      21 PREDICATES      74 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.377 schema:about N3ed4148774e144b18178a7294748e99e
2 N4a7133ae43704dfb8dd85cf8d3b8d185
3 N61250bb1ac4c4d91bf68e66fcd105923
4 N7817d776b8d84f1ba6e4c0b42aed3b80
5 N7f90fa15489140988c281a8f996400a2
6 N9417f718a7be4015a60e29fb69671d96
7 Na9395ac686ae4fa09f3baa9d1e08c6c4
8 Nb254450da26f4227bf5183a134fd50d2
9 Nbcb793aeeecd456a96ad87055aa83c6a
10 Nc99eb14fe38c4eb68ee9762b00830981
11 Nccdf1739a18f40b4b42864b00bfc7bee
12 Ne0e9062fb6de414d98df6eb82162dcd6
13 Nf204195042434b61ba0b9ccca8a45b3a
14 Nfc56abb8f7184f799bda0b9f516a9571
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Neb8b0f140430404bb1e3fffdbd4cdff6
18 schema:citation sg:pub.10.1038/sj.ki.5001728
19 sg:pub.10.1038/sj.ki.5002343
20 sg:pub.10.1111/j.1523-1755.2005.00055.x
21 sg:pub.10.1186/1471-2350-8-s1-s10
22 sg:pub.10.1186/1471-2458-8-117
23 https://app.dimensions.ai/details/publication/pub.1075017372
24 https://doi.org/10.1001/jama.293.23.2892
25 https://doi.org/10.1001/jama.298.17.2038
26 https://doi.org/10.1002/gepi.20303
27 https://doi.org/10.1016/j.peptides.2004.04.015
28 https://doi.org/10.1016/s0272-6386(03)00829-1
29 https://doi.org/10.1053/ajkd.2002.29865
30 https://doi.org/10.1053/ajkd.2002.32765
31 https://doi.org/10.1053/j.ajkd.2003.12.043
32 https://doi.org/10.1053/j.ajkd.2007.11.018
33 https://doi.org/10.1053/j.ajkd.2008.08.020
34 https://doi.org/10.1056/nejmra054415
35 https://doi.org/10.1093/hmg/ddg353
36 https://doi.org/10.1097/00041552-200005000-00011
37 https://doi.org/10.1097/01.asn.0000123691.46138.e2
38 https://doi.org/10.1097/01.asn.0000135972.13396.6f
39 https://doi.org/10.1136/jmg.27.12.729
40 https://doi.org/10.1136/jmg.39.12.882
41 https://doi.org/10.1152/ajprenal.00143.2004
42 https://doi.org/10.1161/01.cir.0000095676.90936.80
43 https://doi.org/10.1161/circgenetics.108.829747
44 https://doi.org/10.1214/07-aoas102
45 https://doi.org/10.1242/dev.019646
46 https://doi.org/10.1371/journal.pgen.0030114
47 https://doi.org/10.2353/ajpath.2009.080476
48 https://doi.org/10.7326/0003-4819-130-6-199903160-00002
49 schema:datePublished 2009-06
50 schema:datePublishedReg 2009-06-01
51 schema:description Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS) to identify susceptibility loci for glomerular filtration rate, estimated by serum creatinine (eGFRcrea) and cystatin C (eGFRcys), and CKD (eGFRcrea < 60 ml/min/1.73 m(2)) in European-ancestry participants of four population-based cohorts (ARIC, CHS, FHS, RS; n = 19,877; 2,388 CKD cases), and tested for replication in 21,466 participants (1,932 CKD cases). We identified significant SNP associations (P < 5 × 10(-8)) with CKD at the UMOD locus, with eGFRcrea at UMOD, SHROOM3 and GATM-SPATA5L1, and with eGFRcys at CST and STC1. UMOD encodes the most common protein in human urine, Tamm-Horsfall protein, and rare mutations in UMOD cause mendelian forms of kidney disease. Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree true
55 schema:isPartOf N9e2a86dd98dd40bb8599ac31fc785578
56 Ndd5e37a31625469da300fe2323f9a747
57 sg:journal.1103138
58 schema:name Multiple loci associated with indices of renal function and chronic kidney disease
59 schema:pagination 712-717
60 schema:productId N3cc85e3829814c3f9b9c0ecb58b22b2c
61 N446ff99bc447466d80553191ea1ef8f6
62 N46a6775fca1b480ebe914775538fc492
63 Nda6ee11c98284669b9dbc332ddbcf278
64 Ne56b7be9321e4752a48f14f685f2ea45
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029463141
66 https://doi.org/10.1038/ng.377
67 schema:sdDatePublished 2019-04-10T16:29
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N850c7db0024c411d8dc8ca63a9a867c9
70 schema:url http://www.nature.com/ng/journal/v41/n6/full/ng.377.html
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N02b0dbefd2164227bb9722cff677ccff rdf:first Nb41be5773d8945eab64a9ddd57d37f95
75 rdf:rest N83b3d9d3d20644f281441dd1e578b73e
76 N02dfca1385ca41268b247c0cb5f141ca rdf:first sg:person.01112257404.07
77 rdf:rest Naffd46380e1e4111b217438d6d4cdfef
78 N067992ee7c45475f98806ee1d085a770 rdf:first sg:person.01333534554.85
79 rdf:rest N69861319bcb54fef9c4a2833b5bd97ff
80 N06e81111fd464baba4416fe038a67963 rdf:first sg:person.01104262534.26
81 rdf:rest Nc80361311be841d583b304915ea162c1
82 N0a01126c869a4cd789f83536fd55a012 schema:familyName Coresh
83 schema:givenName Josef
84 rdf:type schema:Person
85 N17ddf388d34b49f8a43e8b813c746d90 schema:familyName Harris
86 schema:givenName Tamara B
87 rdf:type schema:Person
88 N212aa94438604215aec482733df53d44 rdf:first N4795dd74eeb242deb4a2f36310b729a8
89 rdf:rest Na45d2dce568e4ff595c22ce6f324f9a0
90 N21e20f91712e4a74af9d92f1bde44d9e schema:familyName Levy
91 schema:givenName Daniel
92 rdf:type schema:Person
93 N284127c886234cf78a79a5e1b9b8cc43 schema:familyName Katz
94 schema:givenName Ronit
95 rdf:type schema:Person
96 N2a4cf7ed90a94dc29d6726e3a538e361 schema:familyName Hofman
97 schema:givenName Albert
98 rdf:type schema:Person
99 N31bdf9bb4aff46c58805ba1aaaca5e05 rdf:first N8c1cb919a7da44c486ba54c0e1e8b19b
100 rdf:rest N747cae56ff4a4a2f9fc9b19f78e4c4e1
101 N3cc85e3829814c3f9b9c0ecb58b22b2c schema:name nlm_unique_id
102 schema:value 9216904
103 rdf:type schema:PropertyValue
104 N3e1292c938b742e7ae0ccc69170d7334 schema:familyName Yang
105 schema:givenName Qiong
106 rdf:type schema:Person
107 N3ed4148774e144b18178a7294748e99e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Uromodulin
109 rdf:type schema:DefinedTerm
110 N446ff99bc447466d80553191ea1ef8f6 schema:name pubmed_id
111 schema:value 19430482
112 rdf:type schema:PropertyValue
113 N4477ceb37e794a05b48ee8b352d10ba1 rdf:first sg:person.0734736344.00
114 rdf:rest rdf:nil
115 N448d4ed915c446d792feed7a7d31d7ad schema:familyName Hwang
116 schema:givenName Shih-Jen
117 rdf:type schema:Person
118 N46a6775fca1b480ebe914775538fc492 schema:name doi
119 schema:value 10.1038/ng.377
120 rdf:type schema:PropertyValue
121 N4795dd74eeb242deb4a2f36310b729a8 schema:familyName Siscovick
122 schema:givenName David
123 rdf:type schema:Person
124 N4a7133ae43704dfb8dd85cf8d3b8d185 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Polymorphism, Single Nucleotide
126 rdf:type schema:DefinedTerm
127 N4d7cf61545b2428bb3b830fec6a3097b rdf:first sg:person.013125514737.99
128 rdf:rest N4477ceb37e794a05b48ee8b352d10ba1
129 N4ddf7ae0170e4847998b624dc524255b rdf:first N522e63ae4f0b42ad896f84ec4be283c5
130 rdf:rest N31bdf9bb4aff46c58805ba1aaaca5e05
131 N522e63ae4f0b42ad896f84ec4be283c5 schema:familyName Chen
132 schema:givenName Yii-Der Ida
133 rdf:type schema:Person
134 N5da6adf2292546aeb454c1ef7611d591 rdf:first Na1a5a08192574d37853548c19bc47f8d
135 rdf:rest N696458bbcac64b60bf5176287dc58593
136 N61250bb1ac4c4d91bf68e66fcd105923 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Genome-Wide Association Study
138 rdf:type schema:DefinedTerm
139 N63657e49cf89405f8893abcceb0bd8e9 rdf:first Ned1da93a82244fa2932a37facf9a341c
140 rdf:rest Nbdf15fce7beb41f09d4557af1dff8d9e
141 N696458bbcac64b60bf5176287dc58593 rdf:first N966bf1957d0f401b84e3e6d6547904d6
142 rdf:rest Nc6fa70b446dc441095a312da9a862488
143 N69861319bcb54fef9c4a2833b5bd97ff rdf:first N448d4ed915c446d792feed7a7d31d7ad
144 rdf:rest Nd0ec7ec871a04bfca3ee88c41bf85ebc
145 N6cf1bb91cbec426cba4d3ed8081906ca schema:familyName Ridker
146 schema:givenName Paul M
147 rdf:type schema:Person
148 N6de344112d424043a4db8dcd2892cc93 rdf:first Nc96b3ce9ee3c49148a3d2b0764b91910
149 rdf:rest N4ddf7ae0170e4847998b624dc524255b
150 N6ea42008ee144aa48d7b57f3b170eea5 rdf:first N21e20f91712e4a74af9d92f1bde44d9e
151 rdf:rest N91a459a118154028a77c78a884ace1ce
152 N71149a6032554296b0a4f26d7bf1b232 schema:familyName Glazer
153 schema:givenName Nicole L
154 rdf:type schema:Person
155 N747cae56ff4a4a2f9fc9b19f78e4c4e1 rdf:first sg:person.01304165677.44
156 rdf:rest Nfcf4d6cb06434b77b644e27a6e442933
157 N7679d8ae3b9b4ea9915136f8699f5f9d schema:familyName Arking
158 schema:givenName Dan E
159 rdf:type schema:Person
160 N7778400193af402c84aaeaf8a7bfac8a rdf:first N6cf1bb91cbec426cba4d3ed8081906ca
161 rdf:rest N837451966bae4f9486707ed67021bac3
162 N7817d776b8d84f1ba6e4c0b42aed3b80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 N78e717192af34b0b9a59eaa75a2cc9cc rdf:first sg:person.01006410206.09
166 rdf:rest Na4f65e991a724bbf9f56160bb88f348b
167 N7cfe55ca5fd44e9a81178753648a0bbf schema:familyName Uitterlinden
168 schema:givenName André G
169 rdf:type schema:Person
170 N7f90fa15489140988c281a8f996400a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cohort Studies
172 rdf:type schema:DefinedTerm
173 N837451966bae4f9486707ed67021bac3 rdf:first sg:person.010012617237.52
174 rdf:rest N63657e49cf89405f8893abcceb0bd8e9
175 N83b3d9d3d20644f281441dd1e578b73e rdf:first N17ddf388d34b49f8a43e8b813c746d90
176 rdf:rest N02dfca1385ca41268b247c0cb5f141ca
177 N850c7db0024c411d8dc8ca63a9a867c9 schema:name Springer Nature - SN SciGraph project
178 rdf:type schema:Organization
179 N8aac4d2e7401484b91f829d334ee9d44 schema:familyName Ehret
180 schema:givenName Georg B
181 rdf:type schema:Person
182 N8c1cb919a7da44c486ba54c0e1e8b19b schema:familyName de Boer
183 schema:givenName Ian H
184 rdf:type schema:Person
185 N91a459a118154028a77c78a884ace1ce rdf:first sg:person.01130101423.75
186 rdf:rest Ne6b96db6ceca48c286a1c0ced7b8bbb3
187 N9417f718a7be4015a60e29fb69671d96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Mucoproteins
189 rdf:type schema:DefinedTerm
190 N966bf1957d0f401b84e3e6d6547904d6 schema:familyName Chasman
191 schema:givenName Daniel I
192 rdf:type schema:Person
193 N9e2a86dd98dd40bb8599ac31fc785578 schema:volumeNumber 41
194 rdf:type schema:PublicationVolume
195 Na1a5a08192574d37853548c19bc47f8d schema:familyName van Duijn
196 schema:givenName Cornelia M
197 rdf:type schema:Person
198 Na45d2dce568e4ff595c22ce6f324f9a0 rdf:first sg:person.01153350506.35
199 rdf:rest N6ea42008ee144aa48d7b57f3b170eea5
200 Na4f65e991a724bbf9f56160bb88f348b rdf:first N7cfe55ca5fd44e9a81178753648a0bbf
201 rdf:rest N5da6adf2292546aeb454c1ef7611d591
202 Na708c34da79f442c80c2f5013bf906de schema:familyName Lumley
203 schema:givenName Thomas
204 rdf:type schema:Person
205 Na9395ac686ae4fa09f3baa9d1e08c6c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Netherlands
207 rdf:type schema:DefinedTerm
208 Naffd46380e1e4111b217438d6d4cdfef rdf:first N7679d8ae3b9b4ea9915136f8699f5f9d
209 rdf:rest Ne45469941dff4a94a92d8a984064f1c4
210 Nb254450da26f4227bf5183a134fd50d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Meta-Analysis as Topic
212 rdf:type schema:DefinedTerm
213 Nb41be5773d8945eab64a9ddd57d37f95 schema:familyName Launer
214 schema:givenName Lenore J
215 rdf:type schema:Person
216 Nb43d680c458a4347b86e021b11e929c8 rdf:first N3e1292c938b742e7ae0ccc69170d7334
217 rdf:rest Nec48d353460445fdb33b7795ae777da1
218 Nbcb793aeeecd456a96ad87055aa83c6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Chromosome Mapping
220 rdf:type schema:DefinedTerm
221 Nbdf15fce7beb41f09d4557af1dff8d9e rdf:first N0a01126c869a4cd789f83536fd55a012
222 rdf:rest N4d7cf61545b2428bb3b830fec6a3097b
223 Nc66946f0cd424980b7b28632cf9733f9 rdf:first Ne90ea14784cf4812a7c5ce38f4ed9469
224 rdf:rest Nb43d680c458a4347b86e021b11e929c8
225 Nc6fa70b446dc441095a312da9a862488 rdf:first sg:person.01207753503.50
226 rdf:rest N7778400193af402c84aaeaf8a7bfac8a
227 Nc80361311be841d583b304915ea162c1 rdf:first N8aac4d2e7401484b91f829d334ee9d44
228 rdf:rest Nf4a96bb08fbf471e8c37b81fb59eab2e
229 Nc96b3ce9ee3c49148a3d2b0764b91910 schema:familyName Scharpf
230 schema:givenName Robert B
231 rdf:type schema:Person
232 Nc99eb14fe38c4eb68ee9762b00830981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Prevalence
234 rdf:type schema:DefinedTerm
235 Nccdf1739a18f40b4b42864b00bfc7bee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Genetic Variation
237 rdf:type schema:DefinedTerm
238 Ncda5c28b5aa54eb0963bd27be9f2bde0 rdf:first N2a4cf7ed90a94dc29d6726e3a538e361
239 rdf:rest N78e717192af34b0b9a59eaa75a2cc9cc
240 Nd0ec7ec871a04bfca3ee88c41bf85ebc rdf:first N284127c886234cf78a79a5e1b9b8cc43
241 rdf:rest Nc66946f0cd424980b7b28632cf9733f9
242 Nda6ee11c98284669b9dbc332ddbcf278 schema:name dimensions_id
243 schema:value pub.1029463141
244 rdf:type schema:PropertyValue
245 Ndd5e37a31625469da300fe2323f9a747 schema:issueNumber 6
246 rdf:type schema:PublicationIssue
247 Nde290cd3fe6d4a84b1560386187eb57f rdf:first sg:person.07702137257.09
248 rdf:rest N212aa94438604215aec482733df53d44
249 Ne0e9062fb6de414d98df6eb82162dcd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Kidney
251 rdf:type schema:DefinedTerm
252 Ne45469941dff4a94a92d8a984064f1c4 rdf:first Nef1a228944a64f82856a0646a52c0b8e
253 rdf:rest N06e81111fd464baba4416fe038a67963
254 Ne56b7be9321e4752a48f14f685f2ea45 schema:name readcube_id
255 schema:value 8c5ba06d4500aefb73eca9d7765a55844eff1bd68a1d0643b05ae3ea134f84ba
256 rdf:type schema:PropertyValue
257 Ne6b96db6ceca48c286a1c0ced7b8bbb3 rdf:first sg:person.01231510236.78
258 rdf:rest Ncda5c28b5aa54eb0963bd27be9f2bde0
259 Ne7ed6aca88c343d59949203d69f662cc rdf:first N71149a6032554296b0a4f26d7bf1b232
260 rdf:rest N067992ee7c45475f98806ee1d085a770
261 Ne90ea14784cf4812a7c5ce38f4ed9469 schema:familyName Li
262 schema:givenName Man
263 rdf:type schema:Person
264 Neb8b0f140430404bb1e3fffdbd4cdff6 rdf:first sg:person.01372404626.99
265 rdf:rest Ne7ed6aca88c343d59949203d69f662cc
266 Nec48d353460445fdb33b7795ae777da1 rdf:first sg:person.012745117217.03
267 rdf:rest N02b0dbefd2164227bb9722cff677ccff
268 Ned1da93a82244fa2932a37facf9a341c schema:familyName Witteman
269 schema:givenName Jacqueline C
270 rdf:type schema:Person
271 Nef1a228944a64f82856a0646a52c0b8e schema:familyName Astor
272 schema:givenName Brad C
273 rdf:type schema:Person
274 Nf204195042434b61ba0b9ccca8a45b3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
275 schema:name Glomerular Filtration Rate
276 rdf:type schema:DefinedTerm
277 Nf4a96bb08fbf471e8c37b81fb59eab2e rdf:first sg:person.0604723045.12
278 rdf:rest N6de344112d424043a4db8dcd2892cc93
279 Nfc56abb8f7184f799bda0b9f516a9571 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
280 schema:name Kidney Failure, Chronic
281 rdf:type schema:DefinedTerm
282 Nfcf4d6cb06434b77b644e27a6e442933 rdf:first Na708c34da79f442c80c2f5013bf906de
283 rdf:rest Nde290cd3fe6d4a84b1560386187eb57f
284 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
285 schema:name Medical and Health Sciences
286 rdf:type schema:DefinedTerm
287 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
288 schema:name Clinical Sciences
289 rdf:type schema:DefinedTerm
290 sg:grant.2404053 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
291 rdf:type schema:MonetaryGrant
292 sg:grant.2423245 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
293 rdf:type schema:MonetaryGrant
294 sg:grant.2423980 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
295 rdf:type schema:MonetaryGrant
296 sg:grant.2424188 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
297 rdf:type schema:MonetaryGrant
298 sg:grant.2429985 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
299 rdf:type schema:MonetaryGrant
300 sg:grant.2430005 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
301 rdf:type schema:MonetaryGrant
302 sg:grant.2430025 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
303 rdf:type schema:MonetaryGrant
304 sg:grant.2430033 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
305 rdf:type schema:MonetaryGrant
306 sg:grant.2430092 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
307 rdf:type schema:MonetaryGrant
308 sg:grant.2430093 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
309 rdf:type schema:MonetaryGrant
310 sg:grant.2430095 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
311 rdf:type schema:MonetaryGrant
312 sg:grant.2430096 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
313 rdf:type schema:MonetaryGrant
314 sg:grant.2430097 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
315 rdf:type schema:MonetaryGrant
316 sg:grant.2430098 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
317 rdf:type schema:MonetaryGrant
318 sg:grant.2430099 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
319 rdf:type schema:MonetaryGrant
320 sg:grant.2430117 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
321 rdf:type schema:MonetaryGrant
322 sg:grant.2430167 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
323 rdf:type schema:MonetaryGrant
324 sg:grant.2430169 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
325 rdf:type schema:MonetaryGrant
326 sg:grant.2430170 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
327 rdf:type schema:MonetaryGrant
328 sg:grant.2430171 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
329 rdf:type schema:MonetaryGrant
330 sg:grant.2430172 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
331 rdf:type schema:MonetaryGrant
332 sg:grant.2430173 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
333 rdf:type schema:MonetaryGrant
334 sg:grant.2430174 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
335 rdf:type schema:MonetaryGrant
336 sg:grant.2430175 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
337 rdf:type schema:MonetaryGrant
338 sg:grant.2430176 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
339 rdf:type schema:MonetaryGrant
340 sg:grant.2439028 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
341 rdf:type schema:MonetaryGrant
342 sg:grant.2447964 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
343 rdf:type schema:MonetaryGrant
344 sg:grant.2469915 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
345 rdf:type schema:MonetaryGrant
346 sg:grant.2499161 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
347 rdf:type schema:MonetaryGrant
348 sg:grant.2533515 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
349 rdf:type schema:MonetaryGrant
350 sg:grant.2536122 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
351 rdf:type schema:MonetaryGrant
352 sg:grant.2537302 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
353 rdf:type schema:MonetaryGrant
354 sg:grant.2541272 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
355 rdf:type schema:MonetaryGrant
356 sg:grant.2541398 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
357 rdf:type schema:MonetaryGrant
358 sg:grant.2541401 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
359 rdf:type schema:MonetaryGrant
360 sg:grant.2691245 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
361 rdf:type schema:MonetaryGrant
362 sg:grant.2691844 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
363 rdf:type schema:MonetaryGrant
364 sg:grant.2705143 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
365 rdf:type schema:MonetaryGrant
366 sg:grant.2705230 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
367 rdf:type schema:MonetaryGrant
368 sg:grant.2725872 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
369 rdf:type schema:MonetaryGrant
370 sg:grant.2725949 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.377
371 rdf:type schema:MonetaryGrant
372 sg:journal.1103138 schema:issn 1061-4036
373 1546-1718
374 schema:name Nature Genetics
375 rdf:type schema:Periodical
376 sg:person.010012617237.52 schema:familyName Kao
377 schema:givenName W H Linda
378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010012617237.52
379 rdf:type schema:Person
380 sg:person.01006410206.09 schema:familyName Rivadeneira
381 schema:givenName Fernando
382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006410206.09
383 rdf:type schema:Person
384 sg:person.01104262534.26 schema:familyName Boerwinkle
385 schema:givenName Eric
386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104262534.26
387 rdf:type schema:Person
388 sg:person.01112257404.07 schema:familyName Smith
389 schema:givenName Albert V
390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112257404.07
391 rdf:type schema:Person
392 sg:person.01130101423.75 schema:familyName Upadhyay
393 schema:givenName Ashish
394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130101423.75
395 rdf:type schema:Person
396 sg:person.01153350506.35 schema:familyName Benjamin
397 schema:givenName Emelia J
398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153350506.35
399 rdf:type schema:Person
400 sg:person.01207753503.50 schema:familyName Paré
401 schema:givenName Guillaume
402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207753503.50
403 rdf:type schema:Person
404 sg:person.01231510236.78 schema:familyName Aulchenko
405 schema:givenName Yurii S
406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231510236.78
407 rdf:type schema:Person
408 sg:person.012745117217.03 schema:familyName Gudnason
409 schema:givenName Vilmundur
410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012745117217.03
411 rdf:type schema:Person
412 sg:person.01304165677.44 schema:familyName Haritunians
413 schema:givenName Talin
414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304165677.44
415 rdf:type schema:Person
416 sg:person.013125514737.99 schema:familyName Shlipak
417 schema:givenName Michael G
418 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013125514737.99
419 rdf:type schema:Person
420 sg:person.01333534554.85 schema:familyName Dehghan
421 schema:givenName Abbas
422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333534554.85
423 rdf:type schema:Person
424 sg:person.01372404626.99 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
425 schema:familyName Köttgen
426 schema:givenName Anna
427 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372404626.99
428 rdf:type schema:Person
429 sg:person.0604723045.12 schema:familyName Ruczinski
430 schema:givenName Ingo
431 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604723045.12
432 rdf:type schema:Person
433 sg:person.0734736344.00 schema:familyName Fox
434 schema:givenName Caroline S
435 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734736344.00
436 rdf:type schema:Person
437 sg:person.07702137257.09 schema:familyName Sarnak
438 schema:givenName Mark
439 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07702137257.09
440 rdf:type schema:Person
441 sg:pub.10.1038/sj.ki.5001728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039304711
442 https://doi.org/10.1038/sj.ki.5001728
443 rdf:type schema:CreativeWork
444 sg:pub.10.1038/sj.ki.5002343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018157803
445 https://doi.org/10.1038/sj.ki.5002343
446 rdf:type schema:CreativeWork
447 sg:pub.10.1111/j.1523-1755.2005.00055.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030572924
448 https://doi.org/10.1111/j.1523-1755.2005.00055.x
449 rdf:type schema:CreativeWork
450 sg:pub.10.1186/1471-2350-8-s1-s10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016415940
451 https://doi.org/10.1186/1471-2350-8-s1-s10
452 rdf:type schema:CreativeWork
453 sg:pub.10.1186/1471-2458-8-117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040742438
454 https://doi.org/10.1186/1471-2458-8-117
455 rdf:type schema:CreativeWork
456 https://app.dimensions.ai/details/publication/pub.1075017372 schema:CreativeWork
457 https://doi.org/10.1001/jama.293.23.2892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033910173
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1001/jama.298.17.2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022327258
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1002/gepi.20303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008645052
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1016/j.peptides.2004.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036343516
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1016/s0272-6386(03)00829-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018704023
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1053/ajkd.2002.29865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047330717
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1053/ajkd.2002.32765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021983972
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1053/j.ajkd.2003.12.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020441080
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1053/j.ajkd.2007.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051956308
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1053/j.ajkd.2008.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019209319
476 rdf:type schema:CreativeWork
477 https://doi.org/10.1056/nejmra054415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012143696
478 rdf:type schema:CreativeWork
479 https://doi.org/10.1093/hmg/ddg353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047003641
480 rdf:type schema:CreativeWork
481 https://doi.org/10.1097/00041552-200005000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053229383
482 rdf:type schema:CreativeWork
483 https://doi.org/10.1097/01.asn.0000123691.46138.e2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319572
484 rdf:type schema:CreativeWork
485 https://doi.org/10.1097/01.asn.0000135972.13396.6f schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319690
486 rdf:type schema:CreativeWork
487 https://doi.org/10.1136/jmg.27.12.729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037903131
488 rdf:type schema:CreativeWork
489 https://doi.org/10.1136/jmg.39.12.882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043396656
490 rdf:type schema:CreativeWork
491 https://doi.org/10.1152/ajprenal.00143.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013106983
492 rdf:type schema:CreativeWork
493 https://doi.org/10.1161/01.cir.0000095676.90936.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038647312
494 rdf:type schema:CreativeWork
495 https://doi.org/10.1161/circgenetics.108.829747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023385733
496 rdf:type schema:CreativeWork
497 https://doi.org/10.1214/07-aoas102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041923648
498 rdf:type schema:CreativeWork
499 https://doi.org/10.1242/dev.019646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029249931
500 rdf:type schema:CreativeWork
501 https://doi.org/10.1371/journal.pgen.0030114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014364350
502 rdf:type schema:CreativeWork
503 https://doi.org/10.2353/ajpath.2009.080476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023067640
504 rdf:type schema:CreativeWork
505 https://doi.org/10.7326/0003-4819-130-6-199903160-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073703194
506 rdf:type schema:CreativeWork
507 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
508 schema:name Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
509 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...