Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03

AUTHORS

Alvin P Makohon-Moore, Ming Zhang, Johannes G Reiter, Ivana Bozic, Benjamin Allen, Deepanjan Kundu, Krishnendu Chatterjee, Fay Wong, Yuchen Jiao, Zachary A Kohutek, Jungeui Hong, Marc Attiyeh, Breanna Javier, Laura D Wood, Ralph H Hruban, Martin A Nowak, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Christine A Iacobuzio-Donahue

ABSTRACT

The extent of heterogeneity among driver gene mutations present in naturally occurring metastases-that is, treatment-naive metastatic disease-is largely unknown. To address this issue, we carried out 60× whole-genome sequencing of 26 metastases from four patients with pancreatic cancer. We found that identical mutations in known driver genes were present in every metastatic lesion for each patient studied. Passenger gene mutations, which do not have known or predicted functional consequences, accounted for all intratumoral heterogeneity. Even with respect to these passenger mutations, our analysis suggests that the genetic similarity among the founding cells of metastases was higher than that expected for any two cells randomly taken from a normal tissue. The uniformity of known driver gene mutations among metastases in the same patient has critical and encouraging implications for the success of future targeted therapies in advanced-stage disease. More... »

PAGES

358-366

References to SciGraph publications

  • 2015-12. Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets in NATURE COMMUNICATIONS
  • 2015-12. Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer in NATURE COMMUNICATIONS
  • 2006-04. Genetic clonal diversity predicts progression to esophageal adenocarcinoma in NATURE GENETICS
  • 2015-07. The European Genome-phenome Archive of human data consented for biomedical research in NATURE GENETICS
  • 2015-03. A Big Bang model of human colorectal tumor growth in NATURE GENETICS
  • 2016-08. The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis in NATURE GENETICS
  • 2016-04. Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer in NATURE MEDICINE
  • 2010-10-28. The patterns and dynamics of genomic instability in metastatic pancreatic cancer in NATURE
  • 2009-04. Metastasis: from dissemination to organ-specific colonization in NATURE REVIEWS CANCER
  • 2016-03. Identification of neutral tumor evolution across cancer types in NATURE GENETICS
  • 2016-10. Tissue-specific mutation accumulation in human adult stem cells during life in NATURE
  • 2015-09. A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity in NATURE
  • 2016-01. Somatic mosaicism: on the road to cancer in NATURE REVIEWS CANCER
  • 2012-06. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer in NATURE
  • 2012-06. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers in NATURE
  • 2015-04. The evolutionary history of lethal metastatic prostate cancer in NATURE
  • 2016-09. Pancreatic cancer biology and genetics from an evolutionary perspective in NATURE REVIEWS CANCER
  • 2011-04. Tumour evolution inferred by single-cell sequencing in NATURE
  • 2016-03. Genomic analyses identify molecular subtypes of pancreatic cancer in NATURE
  • 2015-08. Toward understanding and exploiting tumor heterogeneity in NATURE MEDICINE
  • 2014-03. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing in NATURE GENETICS
  • 2015-02. Whole genomes redefine the mutational landscape of pancreatic cancer in NATURE
  • 2015-07. Subclonal diversification of primary breast cancer revealed by multiregion sequencing in NATURE MEDICINE
  • 2010-10-28. Distant metastasis occurs late during the genetic evolution of pancreatic cancer in NATURE
  • 2017-01-31. Reconstructing metastatic seeding patterns of human cancers in NATURE COMMUNICATIONS
  • 2015-12. Fast and scalable inference of multi-sample cancer lineages in GENOME BIOLOGY
  • 2012-01. Clonal evolution in cancer in NATURE
  • 2013-12. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas in NATURE GENETICS
  • 2012-11. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes in NATURE
  • 2010-01. A census of amplified and overexpressed human cancer genes in NATURE REVIEWS CANCER
  • 2016-02. Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3764

    DOI

    http://dx.doi.org/10.1038/ng.3764

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051450199

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28092682


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