Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-19

AUTHORS

Sun-Gou Ji, Brian D Juran, Sören Mucha, Trine Folseraas, Luke Jostins, Espen Melum, Natsuhiko Kumasaka, Elizabeth J Atkinson, Erik M Schlicht, Jimmy Z Liu, Tejas Shah, Javier Gutierrez-Achury, Kirsten M Boberg, Annika Bergquist, Severine Vermeire, Bertus Eksteen, Peter R Durie, Martti Farkkila, Tobias Müller, Christoph Schramm, Martina Sterneck, Tobias J Weismüller, Daniel N Gotthardt, David Ellinghaus, Felix Braun, Andreas Teufel, Mattias Laudes, Wolfgang Lieb, Gunnar Jacobs, Ulrich Beuers, Rinse K Weersma, Cisca Wijmenga, Hanns-Ulrich Marschall, Piotr Milkiewicz, Albert Pares, Kimmo Kontula, Olivier Chazouillères, Pietro Invernizzi, Elizabeth Goode, Kelly Spiess, Carmel Moore, Jennifer Sambrook, Willem H Ouwehand, David J Roberts, John Danesh, Annarosa Floreani, Aliya F Gulamhusein, John E Eaton, Stefan Schreiber, Catalina Coltescu, Christopher L Bowlus, Velimir A Luketic, Joseph A Odin, Kapil B Chopra, Kris V Kowdley, Naga Chalasani, Michael P Manns, Brijesh Srivastava, George Mells, Richard N Sandford, Graeme Alexander, Daniel J Gaffney, Roger W Chapman, Gideon M Hirschfield, Mariza de Andrade, Simon M Rushbrook, Andre Franke, Tom H Karlsen, Konstantinos N Lazaridis, Carl A Anderson

ABSTRACT

Konstantinos Lazaridis, Carl Anderson and colleagues report results of a genome-wide association study of primary sclerosing cholangitis (PSC). They identify four new susceptibility loci for PSC and quantify the correlation of common genetic variation shared between PSC and inflammatory bowel diseases.

PAGES

269-273

References to SciGraph publications

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    2

    VOLUME

    49

    Author Affiliations

  • Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
  • Division of Gastroenterology and Hepatology, Center for Basic Research in Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
  • Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
  • Institute of Clinical Medicine, University of Oslo, Oslo, Norway
  • Christ Church, University of Oxford, St Aldates, Oxford, UK
  • Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
  • Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA
  • Department of Transplantation Medicine, Division of Cancer, Section of Gastroenterology, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway
  • Department of Gastroenterology and Hepatology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
  • Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium
  • Department of Medicine, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
  • Physiology and Experimental Medicine, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
  • Helsinki University and Helsinki University Hospital, Clinic of Gastroenterology, Helsinki, Finland
  • Department of Internal Medicine, Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, Germany
  • 1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Department of Hepatobiliary Surgery and Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Department of Internal Medicine 1, University Hospital of Bonn, Bonn, Germany
  • Department of Medicine, University Hospital of Heidelberg, Heidelberg, Germany
  • Department of General, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany
  • Department of Medicine I, University Medical Center, Regensburg, Germany
  • Clinic of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany
  • Institute of Epidemiology and Biobank PopGen, University Hospital Schleswig-Holstein, Kiel, Germany
  • Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
  • Department of Gastroenterology and Hepatology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands
  • Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands
  • Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  • Department of General, Liver and Internal Medicine Unit, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland
  • Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
  • Department of Medicine, University of Helsinki, Helsinki, Finland
  • Department of Hepatology, AP-HP Hôpital Saint Antoine, UPMC University Paris 6, Paris, France
  • Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
  • Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK
  • Department of Public Health and Primary Care, INTERVAL Coordinating Centre, University of Cambridge, Cambridge, UK
  • Department of Hematology, University of Cambridge, Cambridge, UK
  • NHS Blood and Transplant, Cambridge, UK
  • Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
  • Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy
  • Department for General Internal Medicine, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
  • Liver Centre, Toronto Western Hospital, Toronto, Ontario, Canada
  • Division of Gastroenterology and Hepatology, University of California at Davis, Davis, California, USA
  • Gastroenterology and Hepatology Section, Virginia Commonwealth University, Richmond, Virginia, USA
  • Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
  • Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  • Liver Care Network and Organ Care Research, Swedish Medical Center, Seattle, Washington, USA
  • Indiana University School of Medicine, Indianapolis, Indiana, USA
  • Integrated Research and Treatment Center–Transplantation (IFB-tx), Hannover Medical School, Hannover, Germany
  • Division of Gastroenterology and Hepatology, Addenbrooke's Hospital, Cambridge, UK
  • Department of Medicine, Division of Hepatology, University of Cambridge, Cambridge, UK
  • Department of Translational Gastroenterology, Oxford University Hospitals NHS Trust, Oxford, UK
  • University of Toronto and Liver Center, Toronto Western Hospital, Toronto, Ontario, Canada
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3745

    DOI

    http://dx.doi.org/10.1038/ng.3745

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001400355

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27992413


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