Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-21

AUTHORS

Andrew Dunford, David M Weinstock, Virginia Savova, Steven E Schumacher, John P Cleary, Akinori Yoda, Timothy J Sullivan, Julian M Hess, Alexander A Gimelbrant, Rameen Beroukhim, Michael S Lawrence, Gad Getz, Andrew A Lane

ABSTRACT

Andrew Lane and colleagues analyze somatic alterations across 21 tumor types for evidence of sex bias. They find that an excess of genes on the non-pseudoautosomal region of the X chromosome harbor loss-of-function mutations more frequently in males, suggesting that biallelic expression of these genes in females contributes to reduced cancer incidence in females across a variety of tumor types. More... »

PAGES

10-16

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3726

    DOI

    http://dx.doi.org/10.1038/ng.3726

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050932941

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27869828


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