Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06

AUTHORS

Jaegil Kim, Kent W Mouw, Paz Polak, Lior Z Braunstein, Atanas Kamburov, Grace Tiao, David J Kwiatkowski, Jonathan E Rosenberg, Eliezer M Van Allen, Alan D D'Andrea, Gad Getz

ABSTRACT

Alterations in DNA repair pathways are common in tumors and can result in characteristic mutational signatures; however, a specific mutational signature associated with somatic alterations in the nucleotide- excision repair (NER) pathway has not yet been identified. Here we examine the mutational processes operating in urothelial cancer, a tumor type in which the core NER gene ERCC2 is significantly mutated. Analysis of three independent urothelial tumor cohorts demonstrates a strong association between somatic ERCC2 mutations and the activity of a mutational signature characterized by a broad spectrum of base changes. In addition, we note an association between the activity of this signature and smoking that is independent of ERCC2 mutation status, providing genomic evidence of tobacco-related mutagenesis in urothelial cancer. Together, these analyses identify an NER-related mutational signature and highlight the related roles of DNA damage and subsequent DNA repair in shaping tumor mutational landscape. More... »

PAGES

600-606

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.3557

DOI

http://dx.doi.org/10.1038/ng.3557

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013914776

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27111033


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tobacco", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urinary Bladder Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xeroderma Pigmentosum Group D Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jaegil", 
        "id": "sg:person.01162505670.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162505670.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.", 
            "Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mouw", 
        "givenName": "Kent W", 
        "id": "sg:person.01331645101.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331645101.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.", 
            "Harvard Medical School, Boston, Massachusetts, USA.", 
            "Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.", 
            "Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Polak", 
        "givenName": "Paz", 
        "id": "sg:person.0624257534.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624257534.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.", 
            "Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braunstein", 
        "givenName": "Lior Z", 
        "id": "sg:person.01167142554.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167142554.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.", 
            "Harvard Medical School, Boston, Massachusetts, USA.", 
            "Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.", 
            "Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamburov", 
        "givenName": "Atanas", 
        "id": "sg:person.01072333377.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072333377.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiao", 
        "givenName": "Grace", 
        "id": "sg:person.01022613307.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022613307.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Harvard Medical School, Boston, Massachusetts, USA.", 
            "Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwiatkowski", 
        "givenName": "David J", 
        "id": "sg:person.01045437517.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045437517.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenberg", 
        "givenName": "Jonathan E", 
        "id": "sg:person.01042672613.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042672613.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.", 
            "Harvard Medical School, Boston, Massachusetts, USA.", 
            "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Allen", 
        "givenName": "Eliezer M", 
        "id": "sg:person.01274137244.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274137244.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.", 
            "Harvard Medical School, Boston, Massachusetts, USA.", 
            "Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "D'Andrea", 
        "givenName": "Alan D", 
        "id": "sg:person.012727024557.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012727024557.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.", 
            "Harvard Medical School, Boston, Massachusetts, USA.", 
            "Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.", 
            "Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Getz", 
        "givenName": "Gad", 
        "id": "sg:person.01316313531.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature10166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000736346", 
          "https://doi.org/10.1038/nature10166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2014.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001475723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-14-0257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002011211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002579839", 
          "https://doi.org/10.1038/ng.2955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms5114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003529882", 
          "https://doi.org/10.1038/ncomms5114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004200719", 
          "https://doi.org/10.1038/sj.onc.1205803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004200719", 
          "https://doi.org/10.1038/sj.onc.1205803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1516373112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004550658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.12.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006000358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0383-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008652471", 
          "https://doi.org/10.1007/s00345-009-0383-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0383-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008652471", 
          "https://doi.org/10.1007/s00345-009-0383-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010515132", 
          "https://doi.org/10.1038/nbt.2203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011007538", 
          "https://doi.org/10.1038/ng.3441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.01.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012051399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015642657", 
          "https://doi.org/10.1038/nprot.2009.86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016942136", 
          "https://doi.org/10.1038/ng.2798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdl435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019050680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020175364", 
          "https://doi.org/10.1038/ng.2702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021761707", 
          "https://doi.org/10.1038/nature12213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms9866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022964729", 
          "https://doi.org/10.1038/ncomms9866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2015.02.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023876667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.12.5350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024139489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025644773", 
          "https://doi.org/10.1038/nrm3289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027089455", 
          "https://doi.org/10.1038/ng1103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027089455", 
          "https://doi.org/10.1038/ng1103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2015.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027190961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028207374", 
          "https://doi.org/10.1038/nrm3822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029095355", 
          "https://doi.org/10.1038/nrm3350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13073-015-0161-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029134559", 
          "https://doi.org/10.1186/s13073-015-0161-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13073-015-0161-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029134559", 
          "https://doi.org/10.1186/s13073-015-0161-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2011.1142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032167881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032218108", 
          "https://doi.org/10.1038/nature12965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3006086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034080411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-1091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034304631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.076570.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035175729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-14-0623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041311821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/mutage/geg020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042254212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.1954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044856974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045403173", 
          "https://doi.org/10.1038/nrg3729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045709558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.13.5806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045877435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046316043", 
          "https://doi.org/10.1038/ng.3292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047212289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2015.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048120504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050004918", 
          "https://doi.org/10.1038/nature12477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2011.04.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050514578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/44565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052721759", 
          "https://doi.org/10.1038/44565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/44565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052721759", 
          "https://doi.org/10.1038/44565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2015.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053080522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/9.2.297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059454173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/tpami.2012.240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061744334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3006200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062687952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or_00000854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071537638"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-06", 
    "datePublishedReg": "2016-06-01", 
    "description": "Alterations in DNA repair pathways are common in tumors and can result in characteristic mutational signatures; however, a specific mutational signature associated with somatic alterations in the nucleotide- excision repair (NER) pathway has not yet been identified. Here we examine the mutational processes operating in urothelial cancer, a tumor type in which the core NER gene ERCC2 is significantly mutated. Analysis of three independent urothelial tumor cohorts demonstrates a strong association between somatic ERCC2 mutations and the activity of a mutational signature characterized by a broad spectrum of base changes. In addition, we note an association between the activity of this signature and smoking that is independent of ERCC2 mutation status, providing genomic evidence of tobacco-related mutagenesis in urothelial cancer. Together, these analyses identify an NER-related mutational signature and highlight the related roles of DNA damage and subsequent DNA repair in shaping tumor mutational landscape.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.3557", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2696334", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438793", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "48"
      }
    ], 
    "name": "Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors", 
    "pagination": "600-606", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4249311d00a443f9f45d19cf18933ab73cbc77e59de775d04c3cf72b23884e26"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27111033"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.3557"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013914776"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.3557", 
      "https://app.dimensions.ai/details/publication/pub.1013914776"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ng/journal/v48/n6/full/ng.3557.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.3557'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.3557'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.3557'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.3557'


 

This table displays all metadata directly associated to this object as RDF triples.

369 TRIPLES      21 PREDICATES      86 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.3557 schema:about N0a1f03fd267041608dbf65253712a93b
2 N574f89b84511455e9bbabd4240933af7
3 N5da6d939319c43e18da8932b9cff7286
4 N8b3ce873aedc42d2bbdfbd8fa63b78e0
5 N8d13c91539c54522a5783eafe1abae33
6 N92ccff631c5f4975ba1b8374500bf1f1
7 N9cde0ae2353c45498791c21b20cc1648
8 N9fd26a47942b44be924fc4c8bfae53a8
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author Nf342c45ce3f34b67976da75fb1fd56cb
12 schema:citation sg:pub.10.1007/s00345-009-0383-3
13 sg:pub.10.1038/44565
14 sg:pub.10.1038/nature10166
15 sg:pub.10.1038/nature12213
16 sg:pub.10.1038/nature12477
17 sg:pub.10.1038/nature12965
18 sg:pub.10.1038/nbt.2203
19 sg:pub.10.1038/ncomms5114
20 sg:pub.10.1038/ncomms9866
21 sg:pub.10.1038/ng.2702
22 sg:pub.10.1038/ng.2798
23 sg:pub.10.1038/ng.2955
24 sg:pub.10.1038/ng.3292
25 sg:pub.10.1038/ng.3441
26 sg:pub.10.1038/ng1103
27 sg:pub.10.1038/nprot.2009.86
28 sg:pub.10.1038/nrg3729
29 sg:pub.10.1038/nrm3289
30 sg:pub.10.1038/nrm3350
31 sg:pub.10.1038/nrm3822
32 sg:pub.10.1038/sj.onc.1205803
33 sg:pub.10.1186/s13073-015-0161-3
34 https://doi.org/10.1001/jama.2011.1142
35 https://doi.org/10.1016/j.cell.2012.04.024
36 https://doi.org/10.1016/j.cell.2013.01.019
37 https://doi.org/10.1016/j.cell.2013.03.002
38 https://doi.org/10.1016/j.cell.2015.12.050
39 https://doi.org/10.1016/j.dnarep.2011.04.028
40 https://doi.org/10.1016/j.dnarep.2015.01.001
41 https://doi.org/10.1016/j.eururo.2015.01.014
42 https://doi.org/10.1016/j.eururo.2015.02.043
43 https://doi.org/10.1016/j.eururo.2015.07.009
44 https://doi.org/10.1016/j.tig.2014.06.003
45 https://doi.org/10.1073/pnas.0506580102
46 https://doi.org/10.1073/pnas.1516373112
47 https://doi.org/10.1073/pnas.88.12.5350
48 https://doi.org/10.1093/annonc/mdl435
49 https://doi.org/10.1093/carcin/9.2.297
50 https://doi.org/10.1093/mutage/geg020
51 https://doi.org/10.1101/gr.076570.108
52 https://doi.org/10.1109/tpami.2012.240
53 https://doi.org/10.1126/scitranslmed.3006086
54 https://doi.org/10.1126/scitranslmed.3006200
55 https://doi.org/10.1158/0008-5472.can-09-1091
56 https://doi.org/10.1158/1078-0432.ccr-14-0257
57 https://doi.org/10.1158/2159-8290.cd-14-0623
58 https://doi.org/10.1200/jco.2007.13.5806
59 https://doi.org/10.18632/oncotarget.1954
60 https://doi.org/10.3892/or_00000854
61 schema:datePublished 2016-06
62 schema:datePublishedReg 2016-06-01
63 schema:description Alterations in DNA repair pathways are common in tumors and can result in characteristic mutational signatures; however, a specific mutational signature associated with somatic alterations in the nucleotide- excision repair (NER) pathway has not yet been identified. Here we examine the mutational processes operating in urothelial cancer, a tumor type in which the core NER gene ERCC2 is significantly mutated. Analysis of three independent urothelial tumor cohorts demonstrates a strong association between somatic ERCC2 mutations and the activity of a mutational signature characterized by a broad spectrum of base changes. In addition, we note an association between the activity of this signature and smoking that is independent of ERCC2 mutation status, providing genomic evidence of tobacco-related mutagenesis in urothelial cancer. Together, these analyses identify an NER-related mutational signature and highlight the related roles of DNA damage and subsequent DNA repair in shaping tumor mutational landscape.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N8dc8c4f606134518a4167cf3bc35be03
68 Nd334da403ff740deaa7a28035d4029a9
69 sg:journal.1103138
70 schema:name Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors
71 schema:pagination 600-606
72 schema:productId N10c5f141ef92466a86968eae3d75a560
73 N50f2004778b746b9ae5b9b05fce8185b
74 N64bff6f866cf42e0acd27ffa45ab29dd
75 N87f137aa8e0d47ea99ed85b5744a7116
76 Nd67a63ba024b4211ac873d684d3eb313
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013914776
78 https://doi.org/10.1038/ng.3557
79 schema:sdDatePublished 2019-04-10T14:47
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N05a0c021fb984ac8a29cc01135d62437
82 schema:url http://www.nature.com/ng/journal/v48/n6/full/ng.3557.html
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N05a0c021fb984ac8a29cc01135d62437 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N0a1f03fd267041608dbf65253712a93b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Xeroderma Pigmentosum Group D Protein
90 rdf:type schema:DefinedTerm
91 N10c5f141ef92466a86968eae3d75a560 schema:name dimensions_id
92 schema:value pub.1013914776
93 rdf:type schema:PropertyValue
94 N36547e6abcce44f7b8f34cd52933515b rdf:first sg:person.012727024557.25
95 rdf:rest Nd2db87bc13f84ffaac82a1c979c83eda
96 N38552d1377fd48a2aec9f75216d80eb1 rdf:first sg:person.01072333377.90
97 rdf:rest Nfdb01104bd5b4d60b0b3353d7603f25e
98 N4b6a72167e4d41b689a87415468d0778 rdf:first sg:person.01274137244.17
99 rdf:rest N36547e6abcce44f7b8f34cd52933515b
100 N50f2004778b746b9ae5b9b05fce8185b schema:name doi
101 schema:value 10.1038/ng.3557
102 rdf:type schema:PropertyValue
103 N574f89b84511455e9bbabd4240933af7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Urinary Bladder Neoplasms
105 rdf:type schema:DefinedTerm
106 N5da6d939319c43e18da8932b9cff7286 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Tobacco
108 rdf:type schema:DefinedTerm
109 N64bff6f866cf42e0acd27ffa45ab29dd schema:name pubmed_id
110 schema:value 27111033
111 rdf:type schema:PropertyValue
112 N87f137aa8e0d47ea99ed85b5744a7116 schema:name readcube_id
113 schema:value 4249311d00a443f9f45d19cf18933ab73cbc77e59de775d04c3cf72b23884e26
114 rdf:type schema:PropertyValue
115 N8b3ce873aedc42d2bbdfbd8fa63b78e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Mutation
117 rdf:type schema:DefinedTerm
118 N8c68070854234e639929338c45c508af rdf:first sg:person.01042672613.79
119 rdf:rest N4b6a72167e4d41b689a87415468d0778
120 N8d13c91539c54522a5783eafe1abae33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name DNA Damage
122 rdf:type schema:DefinedTerm
123 N8dc8c4f606134518a4167cf3bc35be03 schema:volumeNumber 48
124 rdf:type schema:PublicationVolume
125 N92ccff631c5f4975ba1b8374500bf1f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N9cde0ae2353c45498791c21b20cc1648 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name DNA Repair
130 rdf:type schema:DefinedTerm
131 N9fd26a47942b44be924fc4c8bfae53a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cohort Studies
133 rdf:type schema:DefinedTerm
134 Nb44d358b9b954d24a87e5a4e60050b2a rdf:first sg:person.01331645101.36
135 rdf:rest Nf32bd9b8986046dcbfcb9fff300d894d
136 Nd2db87bc13f84ffaac82a1c979c83eda rdf:first sg:person.01316313531.32
137 rdf:rest rdf:nil
138 Nd334da403ff740deaa7a28035d4029a9 schema:issueNumber 6
139 rdf:type schema:PublicationIssue
140 Nd67a63ba024b4211ac873d684d3eb313 schema:name nlm_unique_id
141 schema:value 9216904
142 rdf:type schema:PropertyValue
143 Nde7834ed37764c9d96bcaabcc2ea9630 rdf:first sg:person.01167142554.18
144 rdf:rest N38552d1377fd48a2aec9f75216d80eb1
145 Nf22ebc799a0f434dbba51705b2e8951f rdf:first sg:person.01045437517.59
146 rdf:rest N8c68070854234e639929338c45c508af
147 Nf32bd9b8986046dcbfcb9fff300d894d rdf:first sg:person.0624257534.57
148 rdf:rest Nde7834ed37764c9d96bcaabcc2ea9630
149 Nf342c45ce3f34b67976da75fb1fd56cb rdf:first sg:person.01162505670.16
150 rdf:rest Nb44d358b9b954d24a87e5a4e60050b2a
151 Nfdb01104bd5b4d60b0b3353d7603f25e rdf:first sg:person.01022613307.72
152 rdf:rest Nf22ebc799a0f434dbba51705b2e8951f
153 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
154 schema:name Biological Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
157 schema:name Genetics
158 rdf:type schema:DefinedTerm
159 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3557
160 rdf:type schema:MonetaryGrant
161 sg:grant.2696334 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3557
162 rdf:type schema:MonetaryGrant
163 sg:journal.1103138 schema:issn 1061-4036
164 1546-1718
165 schema:name Nature Genetics
166 rdf:type schema:Periodical
167 sg:person.01022613307.72 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
168 schema:familyName Tiao
169 schema:givenName Grace
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022613307.72
171 rdf:type schema:Person
172 sg:person.01042672613.79 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
173 schema:familyName Rosenberg
174 schema:givenName Jonathan E
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042672613.79
176 rdf:type schema:Person
177 sg:person.01045437517.59 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
178 schema:familyName Kwiatkowski
179 schema:givenName David J
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045437517.59
181 rdf:type schema:Person
182 sg:person.01072333377.90 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
183 schema:familyName Kamburov
184 schema:givenName Atanas
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072333377.90
186 rdf:type schema:Person
187 sg:person.01162505670.16 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
188 schema:familyName Kim
189 schema:givenName Jaegil
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162505670.16
191 rdf:type schema:Person
192 sg:person.01167142554.18 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
193 schema:familyName Braunstein
194 schema:givenName Lior Z
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167142554.18
196 rdf:type schema:Person
197 sg:person.012727024557.25 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
198 schema:familyName D'Andrea
199 schema:givenName Alan D
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012727024557.25
201 rdf:type schema:Person
202 sg:person.01274137244.17 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
203 schema:familyName Van Allen
204 schema:givenName Eliezer M
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274137244.17
206 rdf:type schema:Person
207 sg:person.01316313531.32 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
208 schema:familyName Getz
209 schema:givenName Gad
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32
211 rdf:type schema:Person
212 sg:person.01331645101.36 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
213 schema:familyName Mouw
214 schema:givenName Kent W
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331645101.36
216 rdf:type schema:Person
217 sg:person.0624257534.57 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
218 schema:familyName Polak
219 schema:givenName Paz
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624257534.57
221 rdf:type schema:Person
222 sg:pub.10.1007/s00345-009-0383-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008652471
223 https://doi.org/10.1007/s00345-009-0383-3
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/44565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052721759
226 https://doi.org/10.1038/44565
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
229 https://doi.org/10.1038/nature10166
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nature12213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021761707
232 https://doi.org/10.1038/nature12213
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
235 https://doi.org/10.1038/nature12477
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nature12965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032218108
238 https://doi.org/10.1038/nature12965
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nbt.2203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010515132
241 https://doi.org/10.1038/nbt.2203
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/ncomms5114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003529882
244 https://doi.org/10.1038/ncomms5114
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/ncomms9866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022964729
247 https://doi.org/10.1038/ncomms9866
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/ng.2702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020175364
250 https://doi.org/10.1038/ng.2702
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/ng.2798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016942136
253 https://doi.org/10.1038/ng.2798
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/ng.2955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002579839
256 https://doi.org/10.1038/ng.2955
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/ng.3292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046316043
259 https://doi.org/10.1038/ng.3292
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/ng.3441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011007538
262 https://doi.org/10.1038/ng.3441
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/ng1103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027089455
265 https://doi.org/10.1038/ng1103
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/nprot.2009.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015642657
268 https://doi.org/10.1038/nprot.2009.86
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nrg3729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045403173
271 https://doi.org/10.1038/nrg3729
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nrm3289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025644773
274 https://doi.org/10.1038/nrm3289
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nrm3350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029095355
277 https://doi.org/10.1038/nrm3350
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nrm3822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028207374
280 https://doi.org/10.1038/nrm3822
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/sj.onc.1205803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004200719
283 https://doi.org/10.1038/sj.onc.1205803
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/s13073-015-0161-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029134559
286 https://doi.org/10.1186/s13073-015-0161-3
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1001/jama.2011.1142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032167881
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.cell.2012.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045709558
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.cell.2013.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012051399
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.cell.2013.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047212289
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.cell.2015.12.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006000358
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.dnarep.2011.04.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050514578
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.dnarep.2015.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048120504
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.eururo.2015.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053080522
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.eururo.2015.02.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023876667
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.eururo.2015.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027190961
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.tig.2014.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001475723
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1073/pnas.1516373112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004550658
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1073/pnas.88.12.5350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024139489
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1093/annonc/mdl435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019050680
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1093/carcin/9.2.297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059454173
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1093/mutage/geg020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042254212
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1101/gr.076570.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035175729
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1109/tpami.2012.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061744334
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1126/scitranslmed.3006086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034080411
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1126/scitranslmed.3006200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687952
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1158/0008-5472.can-09-1091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034304631
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1158/1078-0432.ccr-14-0257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002011211
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1158/2159-8290.cd-14-0623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041311821
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1200/jco.2007.13.5806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045877435
337 rdf:type schema:CreativeWork
338 https://doi.org/10.18632/oncotarget.1954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044856974
339 rdf:type schema:CreativeWork
340 https://doi.org/10.3892/or_00000854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071537638
341 rdf:type schema:CreativeWork
342 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
343 schema:name Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
344 Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
345 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
346 Harvard Medical School, Boston, Massachusetts, USA.
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
349 schema:name Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
350 Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
351 Harvard Medical School, Boston, Massachusetts, USA.
352 rdf:type schema:Organization
353 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
354 schema:name Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
355 rdf:type schema:Organization
356 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
357 schema:name Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
358 Harvard Medical School, Boston, Massachusetts, USA.
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
361 schema:name Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
362 Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
363 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
364 Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
365 Harvard Medical School, Boston, Massachusetts, USA.
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
368 schema:name Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
369 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...