Physical and neurobehavioral determinants of reproductive onset and success View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06

AUTHORS

Felix R Day, Hannes Helgason, Daniel I Chasman, Lynda M Rose, Po-Ru Loh, Robert A Scott, Agnar Helgason, Augustine Kong, Gisli Masson, Olafur Th Magnusson, Daniel Gudbjartsson, Unnur Thorsteinsdottir, Julie E Buring, Paul M Ridker, Patrick Sulem, Kari Stefansson, Ken K Ong, John R B Perry

ABSTRACT

The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated (P < 5 × 10(-8)) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations (P < 5 × 10(-8)) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6-SEMA3F), number of children (CADM2 and ESR1), irritable temperament (MSRA) and risk-taking propensity (CADM2). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes. More... »

PAGES

617-623

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3551

    DOI

    http://dx.doi.org/10.1038/ng.3551

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035482808

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27089180


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