Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05

AUTHORS

James Dooley, Lei Tian, Susann Schonefeldt, Viviane Delghingaro-Augusto, Josselyn E Garcia-Perez, Emanuela Pasciuto, Daniele Di Marino, Edward J Carr, Nikolay Oskolkov, Valeriya Lyssenko, Dean Franckaert, Vasiliki Lagou, Lut Overbergh, Jonathan Vandenbussche, Joke Allemeersch, Genevieve Chabot-Roy, Jane E Dahlstrom, D Ross Laybutt, Nikolai Petrovsky, Luis Socha, Kris Gevaert, Anton M Jetten, Diether Lambrechts, Michelle A Linterman, Chris C Goodnow, Christopher J Nolan, Sylvie Lesage, Susan M Schlenner, Adrian Liston

ABSTRACT

Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes. More... »

PAGES

519-527

References to SciGraph publications

  • 2014-09-18. Emerging functions of the unfolded protein response in immunity in NATURE IMMUNOLOGY
  • 2000-08. EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome in NATURE GENETICS
  • 2004-01. A transgenic mouse model for monitoring endoplasmic reticulum stress in NATURE MEDICINE
  • 2015-07. Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls in NATURE GENETICS
  • 2009-11. A protocol for islet isolation from mouse pancreas in NATURE PROTOCOLS
  • 2012. Experimentally Induced Rodent Models of Type 2 Diabetes in ANIMAL MODELS IN DIABETES RESEARCH
  • 2005-10. Ubx2 links the Cdc48 complex to ER-associated protein degradation in NATURE CELL BIOLOGY
  • 2007-04. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes in DIABETOLOGIA
  • 2006-06. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism in NATURE GENETICS
  • 2001-01. Diabetes and gender in DIABETOLOGIA
  • 2010-03. A scaling normalization method for differential expression analysis of RNA-seq data in GENOME BIOLOGY
  • 2005-01. Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice in DIABETOLOGIA
  • 2014-05. A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining in ONCOGENE
  • 2014-03. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility in NATURE GENETICS
  • 2010-02. Thioredoxin-interacting protein links oxidative stress to inflammasome activation in NATURE IMMUNOLOGY
  • 2014-12. Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets in BMC MEDICINE
  • 2001-12-01. Crystal structure of an Xrcc4–DNA ligase IV complex in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-06-07. DNA repair is limiting for haematopoietic stem cells during ageing in NATURE
  • 2003-04. Aire regulates negative selection of organ-specific T cells in NATURE IMMUNOLOGY
  • 2004-10. Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo in NATURE MEDICINE
  • 2011-05. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3531

    DOI

    http://dx.doi.org/10.1038/ng.3531

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022552074

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26998692


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