Gene regulatory mechanisms underpinning prostate cancer susceptibility View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

Thomas Whitington, Ping Gao, Wei Song, Helen Ross-Adams, Alastair D Lamb, Yuehong Yang, Ilaria Svezia, Daniel Klevebring, Ian G Mills, Robert Karlsson, Silvia Halim, Mark J Dunning, Lars Egevad, Anne Y Warren, David E Neal, Henrik Grönberg, Johan Lindberg, Gong-Hong Wei, Fredrik Wiklund

ABSTRACT

Molecular characterization of genome-wide association study (GWAS) loci can uncover key genes and biological mechanisms underpinning complex traits and diseases. Here we present deep, high-throughput characterization of gene regulatory mechanisms underlying prostate cancer risk loci. Our methodology integrates data from 295 prostate cancer chromatin immunoprecipitation and sequencing experiments with genotype and gene expression data from 602 prostate tumor samples. The analysis identifies new gene regulatory mechanisms affected by risk locus SNPs, including widespread disruption of ternary androgen receptor (AR)-FOXA1 and AR-HOXB13 complexes and competitive binding mechanisms. We identify 57 expression quantitative trait loci at 35 risk loci, which we validate through analysis of allele-specific expression. We further validate predicted regulatory SNPs and target genes in prostate cancer cell line models. Finally, our integrated analysis can be accessed through an interactive visualization tool. This analysis elucidates how genome sequence variation affects disease predisposition via gene regulatory mechanisms and identifies relevant genes for downstream biomarker and drug development. More... »

PAGES

387-397

References to SciGraph publications

  • 2012-09. Transcription factors: from enhancer binding to developmental control in NATURE REVIEWS GENETICS
  • 2014-12. Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program in NATURE COMMUNICATIONS
  • 2010-04. Understanding mechanisms underlying human gene expression variation with RNA sequencing in NATURE
  • 2008-11. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2012-04-11. Topological domains in mammalian genomes identified by analysis of chromatin interactions in NATURE
  • 2015-07. Recurrent somatic mutations in regulatory regions of human cancer genomes in NATURE GENETICS
  • 2008-06. The human keratins: biology and pathology in HISTOCHEMISTRY AND CELL BIOLOGY
  • 2006-08. Principal components analysis corrects for stratification in genome-wide association studies in NATURE GENETICS
  • 2013-04. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array in NATURE GENETICS
  • 2014-03. Maintaining and reprogramming genomic androgen receptor activity in prostate cancer in NATURE REVIEWS CANCER
  • 2009-08. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling in NATURE GENETICS
  • 2014-10. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer in NATURE GENETICS
  • 2011-08. Cistrome: an integrative platform for transcriptional regulation studies in GENOME BIOLOGY
  • 2012-09. The accessible chromatin landscape of the human genome in NATURE
  • 2011-01. Integrative genomics viewer in NATURE BIOTECHNOLOGY
  • 2006-05. GenePattern 2.0 in NATURE GENETICS
  • 2014-12. Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads in BMC BIOINFORMATICS
  • 2014-02. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding in NATURE GENETICS
  • 2015-11. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis in NATURE GENETICS
  • 2014-04. Variants at IRX4 as prostate cancer expression quantitative trait loci in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2013-09. Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3523

    DOI

    http://dx.doi.org/10.1038/ng.3523

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019808950

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26950096


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