Intron retention is a widespread mechanism of tumor-suppressor inactivation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-11

AUTHORS

Hyunchul Jung, Donghoon Lee, Jongkeun Lee, Donghyun Park, Yeon Jeong Kim, Woong-Yang Park, Dongwan Hong, Peter J Park, Eunjung Lee

ABSTRACT

A substantial fraction of disease-causing mutations are pathogenic through aberrant splicing. Although genome profiling studies have identified somatic single-nucleotide variants (SNVs) in cancer, the extent to which these variants trigger abnormal splicing has not been systematically examined. Here we analyzed RNA sequencing and exome data from 1,812 patients with cancer and identified ∼900 somatic exonic SNVs that disrupt splicing. At least 163 SNVs, including 31 synonymous ones, were shown to cause intron retention or exon skipping in an allele-specific manner, with ∼70% of the SNVs occurring on the last base of exons. Notably, SNVs causing intron retention were enriched in tumor suppressors, and 97% of these SNVs generated a premature termination codon, leading to loss of function through nonsense-mediated decay or truncated protein. We also characterized the genomic features predictive of such splicing defects. Overall, this work demonstrates that intron retention is a common mechanism of tumor-suppressor inactivation. More... »

PAGES

1242-1248

References to SciGraph publications

  • 2011-12. Non-coding RNAs in human disease in NATURE REVIEWS GENETICS
  • 2011-12. pROC: an open-source package for R and S+ to analyze and compare ROC curves in BMC BIOINFORMATICS
  • 2012-07. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2014-07-09. Comprehensive molecular profiling of lung adenocarcinoma in NATURE
  • 2010-01. Activation of the hedgehog-signaling pathway in human cancer and the clinical implications in ONCOGENE
  • 2013-10. Pan-cancer patterns of somatic copy number alteration in NATURE GENETICS
  • 2010-05. Alternative splicing and evolution: diversification, exon definition and function in NATURE REVIEWS GENETICS
  • 2002-04. Listening to silence and understanding nonsense: exonic mutations that affect splicing in NATURE REVIEWS GENETICS
  • 2013-07. Comprehensive molecular characterization of clear cell renal cell carcinoma in NATURE
  • 2013-05-01. Integrated genomic characterization of endometrial carcinoma in NATURE
  • 2011-08. A continuum model for tumour suppression in NATURE
  • 2013-10. Mutational landscape and significance across 12 major cancer types in NATURE
  • 2013-09. Transcriptome and genome sequencing uncovers functional variation in humans in NATURE
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2004-10. How did alternative splicing evolve? in NATURE REVIEWS GENETICS
  • 2012-09. Comprehensive genomic characterization of squamous cell lung cancers in NATURE
  • 2014-01. Discovery and saturation analysis of cancer genes across 21 tumour types in NATURE
  • 2011-06-29. Integrated genomic analyses of ovarian carcinoma in NATURE
  • 2004-03. A census of human cancer genes in NATURE REVIEWS CANCER
  • 2012-12. Genomic signatures for predicting survival and adjuvant chemotherapy benefit in patients with non-small-cell lung cancer in BMC MEDICAL GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3414

    DOI

    http://dx.doi.org/10.1038/ng.3414

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015421317

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26437032


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alternative Splicing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Codon, Nonsense", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Introns", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, RNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Research Institute, National Cancer Center, Gyeonggi-do, South Korea.", 
                "Samsung Genome Institute, Samsung Medical Center, Seoul, South Korea.", 
                "Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jung", 
            "givenName": "Hyunchul", 
            "id": "sg:person.01171053140.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171053140.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yale University", 
              "id": "https://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Research Institute, National Cancer Center, Gyeonggi-do, South Korea.", 
                "Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Donghoon", 
            "id": "sg:person.01067043023.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067043023.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.410914.9", 
              "name": [
                "Research Institute, National Cancer Center, Gyeonggi-do, South Korea.", 
                "Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Gyeonggi-do, South Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Jongkeun", 
            "id": "sg:person.01165025100.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165025100.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Samsung (South Korea)", 
              "id": "https://www.grid.ac/institutes/grid.419666.a", 
              "name": [
                "Samsung Genome Institute, Samsung Medical Center, Seoul, South Korea.", 
                "Samsung Biomedical Research Institute, Samsung Advanced Institute of Technology, Samsung Electronics Company, Ltd., Seoul, South Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Donghyun", 
            "id": "sg:person.0665066166.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665066166.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Samsung (South Korea)", 
              "id": "https://www.grid.ac/institutes/grid.419666.a", 
              "name": [
                "Samsung Genome Institute, Samsung Medical Center, Seoul, South Korea.", 
                "Samsung Biomedical Research Institute, Samsung Advanced Institute of Technology, Samsung Electronics Company, Ltd., Seoul, South Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Yeon Jeong", 
            "id": "sg:person.0774532135.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774532135.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sungkyunkwan University", 
              "id": "https://www.grid.ac/institutes/grid.264381.a", 
              "name": [
                "Samsung Genome Institute, Samsung Medical Center, Seoul, South Korea.", 
                "Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Woong-Yang", 
            "id": "sg:person.01263651523.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263651523.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.410914.9", 
              "name": [
                "Research Institute, National Cancer Center, Gyeonggi-do, South Korea.", 
                "Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Gyeonggi-do, South Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hong", 
            "givenName": "Dongwan", 
            "id": "sg:person.01006511340.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006511340.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.", 
                "Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Peter J", 
            "id": "sg:person.01024612701.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024612701.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Brigham and Women's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Eunjung", 
            "id": "sg:person.015712733137.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015712733137.85"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1136/jmg.2004.029538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000226519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000364966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000736346", 
              "https://doi.org/10.1038/nature10166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001644479", 
              "https://doi.org/10.1038/nature12634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2012.03.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004507407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004984574", 
              "https://doi.org/10.1038/nature12113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005486377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006014163", 
              "https://doi.org/10.1038/nature11404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006014163", 
              "https://doi.org/10.1038/nature11404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/wrna.1222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006345225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2005.07.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007194936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2005.07.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007194936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1048803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009235689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1755-8794-5-30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009884395", 
              "https://doi.org/10.1186/1755-8794-5-30"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009915786", 
              "https://doi.org/10.1038/nrg2776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009915786", 
              "https://doi.org/10.1038/nrg2776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010854443", 
              "https://doi.org/10.1038/nrg3074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)00747-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011141829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011644042", 
              "https://doi.org/10.1038/nrg775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011644042", 
              "https://doi.org/10.1038/nrg775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2012.04.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013722517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014582441", 
              "https://doi.org/10.1186/1471-2105-12-77"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014582441", 
              "https://doi.org/10.1186/1471-2105-12-77"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015580011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016264399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.849004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016890117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/1066527041410418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017185537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m413897200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017186585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.876308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019603451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1219580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020078844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1219580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020078844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.01.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020420424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.01.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020420424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022731034", 
              "https://doi.org/10.1038/nrc1299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022731034", 
              "https://doi.org/10.1038/nrc1299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt1168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023238985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.03.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023914793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942368", 
              "https://doi.org/10.1038/nature11412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt1114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024961899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025810765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027111677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029047931", 
              "https://doi.org/10.1038/nrg1451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029047931", 
              "https://doi.org/10.1038/nrg1451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029269750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)01075-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029609912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/wrna.1137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030443324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031573444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.140988.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032357161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mgg3.23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033735302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1101135108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034714759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2008.09.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035377793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035638856", 
              "https://doi.org/10.1038/nature10275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036061051", 
              "https://doi.org/10.1038/onc.2009.392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036061051", 
              "https://doi.org/10.1038/onc.2009.392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036892131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.11.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037549848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038266369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038580641", 
              "https://doi.org/10.1038/nature13385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038580641", 
              "https://doi.org/10.1038/nature13385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.209759.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038612495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039506255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neubiorev.2013.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042173133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042520483", 
              "https://doi.org/10.1038/ng.2760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043554069", 
              "https://doi.org/10.1038/nature12912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1073774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049709064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050842404", 
              "https://doi.org/10.1038/nature12222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2005.02.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051771849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052616209", 
              "https://doi.org/10.1038/nature12531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1254806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052757843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8211139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062653653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18637/jss.v033.i01", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068672496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18637/jss.v033.i01", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068672496"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-11", 
        "datePublishedReg": "2015-11-01", 
        "description": "A substantial fraction of disease-causing mutations are pathogenic through aberrant splicing. Although genome profiling studies have identified somatic single-nucleotide variants (SNVs) in cancer, the extent to which these variants trigger abnormal splicing has not been systematically examined. Here we analyzed RNA sequencing and exome data from 1,812 patients with cancer and identified \u223c900 somatic exonic SNVs that disrupt splicing. At least 163 SNVs, including 31 synonymous ones, were shown to cause intron retention or exon skipping in an allele-specific manner, with \u223c70% of the SNVs occurring on the last base of exons. Notably, SNVs causing intron retention were enriched in tumor suppressors, and 97% of these SNVs generated a premature termination codon, leading to loss of function through nonsense-mediated decay or truncated protein. We also characterized the genomic features predictive of such splicing defects. Overall, this work demonstrates that intron retention is a common mechanism of tumor-suppressor inactivation. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ng.3414", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5504631", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "47"
          }
        ], 
        "name": "Intron retention is a widespread mechanism of tumor-suppressor inactivation", 
        "pagination": "1242-1248", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "497a17b749cd70af6661a4b455d9b77a0324d045c02ad430553fd551dc7e9fd8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26437032"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.3414"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1015421317"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.3414", 
          "https://app.dimensions.ai/details/publication/pub.1015421317"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000422.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/ng.3414"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.3414'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.3414'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.3414'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.3414'


     

    This table displays all metadata directly associated to this object as RDF triples.

    406 TRIPLES      21 PREDICATES      103 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.3414 schema:about N06da8a61c89c401db1f3887dea0c0c38
    2 N082209ea59fe4e9ba15ebd1945a5a68f
    3 N1f6b287013554de9a9ab8ff3fb6c8e77
    4 N42e37ce07ed546dab0289ee95d38bb07
    5 N485ea65b1a294186942c1f5494584bff
    6 N48b152c76c134fa092184cdbf759e45f
    7 N77e80aacfede439aa00e617789f9b8aa
    8 N8c3081dddb8e424888e396e7e55a50ef
    9 N937107c4839240cbb8a5747f6d9712bd
    10 Ndb51d6e11f234cba8f5275c3a2e9d204
    11 Ndbf3cd188fba4f4ba581404ca8685170
    12 Nef455d0e01b24d3ea2e9a9a7bf1f5813
    13 anzsrc-for:06
    14 anzsrc-for:0604
    15 schema:author N28a85a79a29643e987a037d83dcf3dbc
    16 schema:citation sg:pub.10.1038/nature10166
    17 sg:pub.10.1038/nature10275
    18 sg:pub.10.1038/nature11252
    19 sg:pub.10.1038/nature11404
    20 sg:pub.10.1038/nature11412
    21 sg:pub.10.1038/nature12113
    22 sg:pub.10.1038/nature12222
    23 sg:pub.10.1038/nature12531
    24 sg:pub.10.1038/nature12634
    25 sg:pub.10.1038/nature12912
    26 sg:pub.10.1038/nature13385
    27 sg:pub.10.1038/ng.2760
    28 sg:pub.10.1038/nrc1299
    29 sg:pub.10.1038/nrg1451
    30 sg:pub.10.1038/nrg2776
    31 sg:pub.10.1038/nrg3074
    32 sg:pub.10.1038/nrg775
    33 sg:pub.10.1038/onc.2009.392
    34 sg:pub.10.1186/1471-2105-12-77
    35 sg:pub.10.1186/1755-8794-5-30
    36 https://doi.org/10.1002/gcc.20156
    37 https://doi.org/10.1002/mgg3.23
    38 https://doi.org/10.1002/wrna.1137
    39 https://doi.org/10.1002/wrna.1222
    40 https://doi.org/10.1016/j.bbadis.2008.09.017
    41 https://doi.org/10.1016/j.cell.2004.11.010
    42 https://doi.org/10.1016/j.cell.2011.02.013
    43 https://doi.org/10.1016/j.cell.2013.03.008
    44 https://doi.org/10.1016/j.cell.2014.01.051
    45 https://doi.org/10.1016/j.celrep.2012.03.013
    46 https://doi.org/10.1016/j.febslet.2005.02.047
    47 https://doi.org/10.1016/j.febslet.2012.04.032
    48 https://doi.org/10.1016/j.neubiorev.2013.10.016
    49 https://doi.org/10.1016/j.ymeth.2005.07.015
    50 https://doi.org/10.1016/s0092-8674(03)01075-4
    51 https://doi.org/10.1016/s0960-9822(02)00747-9
    52 https://doi.org/10.1073/pnas.1101135108
    53 https://doi.org/10.1074/jbc.m413897200
    54 https://doi.org/10.1089/1066527041410418
    55 https://doi.org/10.1093/bioinformatics/bti310
    56 https://doi.org/10.1093/bioinformatics/btp324
    57 https://doi.org/10.1093/bioinformatics/btq033
    58 https://doi.org/10.1093/nar/gkg786
    59 https://doi.org/10.1093/nar/gkg901
    60 https://doi.org/10.1093/nar/gkq929
    61 https://doi.org/10.1093/nar/gks937
    62 https://doi.org/10.1093/nar/gkt1114
    63 https://doi.org/10.1093/nar/gkt1168
    64 https://doi.org/10.1093/nar/gkv210
    65 https://doi.org/10.1101/gad.1048803
    66 https://doi.org/10.1101/gad.209759.112
    67 https://doi.org/10.1101/gr.140988.112
    68 https://doi.org/10.1101/gr.849004
    69 https://doi.org/10.1126/science.1073774
    70 https://doi.org/10.1126/science.1219580
    71 https://doi.org/10.1126/science.1254806
    72 https://doi.org/10.1126/science.8211139
    73 https://doi.org/10.1136/jmg.2004.029538
    74 https://doi.org/10.1158/0008-5472.can-04-1910
    75 https://doi.org/10.1158/2159-8290.cd-12-0361
    76 https://doi.org/10.1261/rna.876308
    77 https://doi.org/10.18637/jss.v033.i01
    78 schema:datePublished 2015-11
    79 schema:datePublishedReg 2015-11-01
    80 schema:description A substantial fraction of disease-causing mutations are pathogenic through aberrant splicing. Although genome profiling studies have identified somatic single-nucleotide variants (SNVs) in cancer, the extent to which these variants trigger abnormal splicing has not been systematically examined. Here we analyzed RNA sequencing and exome data from 1,812 patients with cancer and identified ∼900 somatic exonic SNVs that disrupt splicing. At least 163 SNVs, including 31 synonymous ones, were shown to cause intron retention or exon skipping in an allele-specific manner, with ∼70% of the SNVs occurring on the last base of exons. Notably, SNVs causing intron retention were enriched in tumor suppressors, and 97% of these SNVs generated a premature termination codon, leading to loss of function through nonsense-mediated decay or truncated protein. We also characterized the genomic features predictive of such splicing defects. Overall, this work demonstrates that intron retention is a common mechanism of tumor-suppressor inactivation.
    81 schema:genre research_article
    82 schema:inLanguage en
    83 schema:isAccessibleForFree false
    84 schema:isPartOf N39a48eb74484441787a12317c93e8799
    85 N62a1171037fd477d8c56cbb7d88ad4a0
    86 sg:journal.1103138
    87 schema:name Intron retention is a widespread mechanism of tumor-suppressor inactivation
    88 schema:pagination 1242-1248
    89 schema:productId N3c374ad632b24812842c5fb350edbed1
    90 N4e430529bc1343e68ea38a793eb9e3e2
    91 Nae929b6439dc4dee85ec3b5db142c6df
    92 Nd01f0c49a8014f3ca4b909c02738b02c
    93 Ndb9584ce9b4a4f8280b12207755ff2f4
    94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015421317
    95 https://doi.org/10.1038/ng.3414
    96 schema:sdDatePublished 2019-04-10T23:11
    97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    98 schema:sdPublisher Nb544dd43343c41d9b253a11feff58a59
    99 schema:url http://www.nature.com/articles/ng.3414
    100 sgo:license sg:explorer/license/
    101 sgo:sdDataset articles
    102 rdf:type schema:ScholarlyArticle
    103 N06da8a61c89c401db1f3887dea0c0c38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Sequence Analysis, RNA
    105 rdf:type schema:DefinedTerm
    106 N082209ea59fe4e9ba15ebd1945a5a68f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Neoplasms
    108 rdf:type schema:DefinedTerm
    109 N10dad6dfe71f4d0bbb233cc307ae5b0f rdf:first sg:person.0774532135.47
    110 rdf:rest N71fd4e8497a446449a9a92e53475957e
    111 N1f6b287013554de9a9ab8ff3fb6c8e77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Codon, Nonsense
    113 rdf:type schema:DefinedTerm
    114 N28a85a79a29643e987a037d83dcf3dbc rdf:first sg:person.01171053140.33
    115 rdf:rest Nadfd08a0607a4bcfb8918d973b03be59
    116 N39a48eb74484441787a12317c93e8799 schema:volumeNumber 47
    117 rdf:type schema:PublicationVolume
    118 N3c374ad632b24812842c5fb350edbed1 schema:name dimensions_id
    119 schema:value pub.1015421317
    120 rdf:type schema:PropertyValue
    121 N42e37ce07ed546dab0289ee95d38bb07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Exome
    123 rdf:type schema:DefinedTerm
    124 N485ea65b1a294186942c1f5494584bff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Gene Expression Regulation, Neoplastic
    126 rdf:type schema:DefinedTerm
    127 N48b152c76c134fa092184cdbf759e45f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Tumor Suppressor Proteins
    129 rdf:type schema:DefinedTerm
    130 N4e430529bc1343e68ea38a793eb9e3e2 schema:name nlm_unique_id
    131 schema:value 9216904
    132 rdf:type schema:PropertyValue
    133 N62a1171037fd477d8c56cbb7d88ad4a0 schema:issueNumber 11
    134 rdf:type schema:PublicationIssue
    135 N71fd4e8497a446449a9a92e53475957e rdf:first sg:person.01263651523.67
    136 rdf:rest Nf56273c064904d7593c76d794c40571d
    137 N77e80aacfede439aa00e617789f9b8aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Humans
    139 rdf:type schema:DefinedTerm
    140 N8c3081dddb8e424888e396e7e55a50ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Exons
    142 rdf:type schema:DefinedTerm
    143 N937107c4839240cbb8a5747f6d9712bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Alternative Splicing
    145 rdf:type schema:DefinedTerm
    146 N9fa824d70eeb4464bb1536e940cc7e36 rdf:first sg:person.0665066166.14
    147 rdf:rest N10dad6dfe71f4d0bbb233cc307ae5b0f
    148 Nadfd08a0607a4bcfb8918d973b03be59 rdf:first sg:person.01067043023.03
    149 rdf:rest Nbf4b91d91d7040bc8b93d8d5cb45f5c1
    150 Nae929b6439dc4dee85ec3b5db142c6df schema:name pubmed_id
    151 schema:value 26437032
    152 rdf:type schema:PropertyValue
    153 Nb544dd43343c41d9b253a11feff58a59 schema:name Springer Nature - SN SciGraph project
    154 rdf:type schema:Organization
    155 Nbd1703f06bfe4f5dad680d7353d3e18b rdf:first sg:person.01024612701.33
    156 rdf:rest Nd65c3bcd409e402fbac650ba2106d9d7
    157 Nbf4b91d91d7040bc8b93d8d5cb45f5c1 rdf:first sg:person.01165025100.35
    158 rdf:rest N9fa824d70eeb4464bb1536e940cc7e36
    159 Nd01f0c49a8014f3ca4b909c02738b02c schema:name readcube_id
    160 schema:value 497a17b749cd70af6661a4b455d9b77a0324d045c02ad430553fd551dc7e9fd8
    161 rdf:type schema:PropertyValue
    162 Nd65c3bcd409e402fbac650ba2106d9d7 rdf:first sg:person.015712733137.85
    163 rdf:rest rdf:nil
    164 Ndb51d6e11f234cba8f5275c3a2e9d204 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Introns
    166 rdf:type schema:DefinedTerm
    167 Ndb9584ce9b4a4f8280b12207755ff2f4 schema:name doi
    168 schema:value 10.1038/ng.3414
    169 rdf:type schema:PropertyValue
    170 Ndbf3cd188fba4f4ba581404ca8685170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Polymorphism, Single Nucleotide
    172 rdf:type schema:DefinedTerm
    173 Nef455d0e01b24d3ea2e9a9a7bf1f5813 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Models, Genetic
    175 rdf:type schema:DefinedTerm
    176 Nf56273c064904d7593c76d794c40571d rdf:first sg:person.01006511340.55
    177 rdf:rest Nbd1703f06bfe4f5dad680d7353d3e18b
    178 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Biological Sciences
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Genetics
    183 rdf:type schema:DefinedTerm
    184 sg:grant.5504631 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.3414
    185 rdf:type schema:MonetaryGrant
    186 sg:journal.1103138 schema:issn 1061-4036
    187 1546-1718
    188 schema:name Nature Genetics
    189 rdf:type schema:Periodical
    190 sg:person.01006511340.55 schema:affiliation https://www.grid.ac/institutes/grid.410914.9
    191 schema:familyName Hong
    192 schema:givenName Dongwan
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006511340.55
    194 rdf:type schema:Person
    195 sg:person.01024612701.33 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    196 schema:familyName Park
    197 schema:givenName Peter J
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024612701.33
    199 rdf:type schema:Person
    200 sg:person.01067043023.03 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
    201 schema:familyName Lee
    202 schema:givenName Donghoon
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067043023.03
    204 rdf:type schema:Person
    205 sg:person.01165025100.35 schema:affiliation https://www.grid.ac/institutes/grid.410914.9
    206 schema:familyName Lee
    207 schema:givenName Jongkeun
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165025100.35
    209 rdf:type schema:Person
    210 sg:person.01171053140.33 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    211 schema:familyName Jung
    212 schema:givenName Hyunchul
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171053140.33
    214 rdf:type schema:Person
    215 sg:person.01263651523.67 schema:affiliation https://www.grid.ac/institutes/grid.264381.a
    216 schema:familyName Park
    217 schema:givenName Woong-Yang
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263651523.67
    219 rdf:type schema:Person
    220 sg:person.015712733137.85 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
    221 schema:familyName Lee
    222 schema:givenName Eunjung
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015712733137.85
    224 rdf:type schema:Person
    225 sg:person.0665066166.14 schema:affiliation https://www.grid.ac/institutes/grid.419666.a
    226 schema:familyName Park
    227 schema:givenName Donghyun
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665066166.14
    229 rdf:type schema:Person
    230 sg:person.0774532135.47 schema:affiliation https://www.grid.ac/institutes/grid.419666.a
    231 schema:familyName Kim
    232 schema:givenName Yeon Jeong
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774532135.47
    234 rdf:type schema:Person
    235 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
    236 https://doi.org/10.1038/nature10166
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/nature10275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035638856
    239 https://doi.org/10.1038/nature10275
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    242 https://doi.org/10.1038/nature11252
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/nature11404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006014163
    245 https://doi.org/10.1038/nature11404
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
    248 https://doi.org/10.1038/nature11412
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nature12113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004984574
    251 https://doi.org/10.1038/nature12113
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nature12222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050842404
    254 https://doi.org/10.1038/nature12222
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nature12531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052616209
    257 https://doi.org/10.1038/nature12531
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nature12634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001644479
    260 https://doi.org/10.1038/nature12634
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nature12912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043554069
    263 https://doi.org/10.1038/nature12912
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nature13385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038580641
    266 https://doi.org/10.1038/nature13385
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/ng.2760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042520483
    269 https://doi.org/10.1038/ng.2760
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nrc1299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022731034
    272 https://doi.org/10.1038/nrc1299
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nrg1451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029047931
    275 https://doi.org/10.1038/nrg1451
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nrg2776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009915786
    278 https://doi.org/10.1038/nrg2776
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nrg3074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010854443
    281 https://doi.org/10.1038/nrg3074
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nrg775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011644042
    284 https://doi.org/10.1038/nrg775
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/onc.2009.392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036061051
    287 https://doi.org/10.1038/onc.2009.392
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1186/1471-2105-12-77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014582441
    290 https://doi.org/10.1186/1471-2105-12-77
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1186/1755-8794-5-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009884395
    293 https://doi.org/10.1186/1755-8794-5-30
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1002/gcc.20156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027111677
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1002/mgg3.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033735302
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1002/wrna.1137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443324
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1002/wrna.1222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006345225
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.bbadis.2008.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035377793
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.cell.2004.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037549848
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.cell.2013.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023914793
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.cell.2014.01.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020420424
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.celrep.2012.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004507407
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.febslet.2005.02.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051771849
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.febslet.2012.04.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013722517
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.neubiorev.2013.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042173133
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.ymeth.2005.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007194936
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0092-8674(03)01075-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029609912
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s0960-9822(02)00747-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011141829
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1073/pnas.1101135108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034714759
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1074/jbc.m413897200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017186585
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1089/1066527041410418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017185537
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1093/bioinformatics/bti310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015580011
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1093/bioinformatics/btq033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036892131
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1093/nar/gkg786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000364966
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1093/nar/gkg901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031573444
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1093/nar/gkq929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005486377
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1093/nar/gks937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039506255
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1093/nar/gkt1114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024961899
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1093/nar/gkt1168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023238985
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1093/nar/gkv210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016264399
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1101/gad.1048803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009235689
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1101/gad.209759.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038612495
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1101/gr.140988.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032357161
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1101/gr.849004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016890117
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1126/science.1073774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049709064
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1126/science.1219580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020078844
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1126/science.1254806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052757843
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1126/science.8211139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653653
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1136/jmg.2004.029538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000226519
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1158/0008-5472.can-04-1910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029269750
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1158/2159-8290.cd-12-0361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025810765
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1261/rna.876308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019603451
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.18637/jss.v033.i01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068672496
    378 rdf:type schema:CreativeWork
    379 https://www.grid.ac/institutes/grid.264381.a schema:alternateName Sungkyunkwan University
    380 schema:name Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea.
    381 Samsung Genome Institute, Samsung Medical Center, Seoul, South Korea.
    382 rdf:type schema:Organization
    383 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
    384 schema:name Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, USA.
    385 Research Institute, National Cancer Center, Gyeonggi-do, South Korea.
    386 Samsung Genome Institute, Samsung Medical Center, Seoul, South Korea.
    387 rdf:type schema:Organization
    388 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    389 schema:name Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
    390 Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
    391 rdf:type schema:Organization
    392 https://www.grid.ac/institutes/grid.410914.9 schema:alternateName National Cancer Center
    393 schema:name Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Gyeonggi-do, South Korea.
    394 Research Institute, National Cancer Center, Gyeonggi-do, South Korea.
    395 rdf:type schema:Organization
    396 https://www.grid.ac/institutes/grid.419666.a schema:alternateName Samsung (South Korea)
    397 schema:name Samsung Biomedical Research Institute, Samsung Advanced Institute of Technology, Samsung Electronics Company, Ltd., Seoul, South Korea.
    398 Samsung Genome Institute, Samsung Medical Center, Seoul, South Korea.
    399 rdf:type schema:Organization
    400 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
    401 schema:name Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA.
    402 Research Institute, National Cancer Center, Gyeonggi-do, South Korea.
    403 rdf:type schema:Organization
    404 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
    405 schema:name Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
    406 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...