Ontology type: schema:ScholarlyArticle Open Access: True
2015-07-27
AUTHORSThomas G P Grünewald, Virginie Bernard, Pascale Gilardi-Hebenstreit, Virginie Raynal, Didier Surdez, Marie-Ming Aynaud, Olivier Mirabeau, Florencia Cidre-Aranaz, Franck Tirode, Sakina Zaidi, Gaëlle Perot, Anneliene H Jonker, Carlo Lucchesi, Marie-Cécile Le Deley, Odile Oberlin, Perrine Marec-Bérard, Amélie S Véron, Stephanie Reynaud, Eve Lapouble, Valentina Boeva, Thomas Rio Frio, Javier Alonso, Smita Bhatia, Gaëlle Pierron, Geraldine Cancel-Tassin, Olivier Cussenot, David G Cox, Lindsay M Morton, Mitchell J Machiela, Stephen J Chanock, Patrick Charnay, Olivier Delattre
ABSTRACTOlivier Delattre and colleagues show that a Ewing sarcoma susceptibility variant at 10q21.3 influences EGR2 expression by altering the activity of an enhancer bound by EWSR1-FLI1. They further show that EGR2 knockdown inhibits growth of Ewing sarcoma cells in vitro and induces complete regression of xenografts in vivo, establishing a critical role for EGR2 in Ewing sarcomagenesis. More... »
PAGES1073-1078
http://scigraph.springernature.com/pub.10.1038/ng.3363
DOIhttp://dx.doi.org/10.1038/ng.3363
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26214589
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