Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

Thomas G P Grünewald, Virginie Bernard, Pascale Gilardi-Hebenstreit, Virginie Raynal, Didier Surdez, Marie-Ming Aynaud, Olivier Mirabeau, Florencia Cidre-Aranaz, Franck Tirode, Sakina Zaidi, Gaëlle Perot, Anneliene H Jonker, Carlo Lucchesi, Marie-Cécile Le Deley, Odile Oberlin, Perrine Marec-Bérard, Amélie S Véron, Stephanie Reynaud, Eve Lapouble, Valentina Boeva, Thomas Rio Frio, Javier Alonso, Smita Bhatia, Gaëlle Pierron, Geraldine Cancel-Tassin, Olivier Cussenot, David G Cox, Lindsay M Morton, Mitchell J Machiela, Stephen J Chanock, Patrick Charnay, Olivier Delattre

ABSTRACT

Deciphering the ways in which somatic mutations and germline susceptibility variants cooperate to promote cancer is challenging. Ewing sarcoma is characterized by fusions between EWSR1 and members of the ETS gene family, usually EWSR1-FLI1, leading to the generation of oncogenic transcription factors that bind DNA at GGAA motifs. A recent genome-wide association study identified susceptibility variants near EGR2. Here we found that EGR2 knockdown inhibited proliferation, clonogenicity and spheroidal growth in vitro and induced regression of Ewing sarcoma xenografts. Targeted germline deep sequencing of the EGR2 locus in affected subjects and controls identified 291 Ewing-associated SNPs. At rs79965208, the A risk allele connected adjacent GGAA repeats by converting an interspaced GGAT motif into a GGAA motif, thereby increasing the number of consecutive GGAA motifs and thus the EWSR1-FLI1-dependent enhancer activity of this sequence, with epigenetic characteristics of an active regulatory element. EWSR1-FLI1 preferentially bound to the A risk allele, which increased global and allele-specific EGR2 expression. Collectively, our findings establish cooperation between a dominant oncogene and a susceptibility variant that regulates a major driver of Ewing sarcomagenesis. More... »

PAGES

1073-1078

References to SciGraph publications

  • 2007-05. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 in NATURE GENETICS
  • 2008-11. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2010-09. Integrating common and rare genetic variation in diverse human populations in NATURE
  • 2011-01-13. Integrative genomics identifies LMO1 as a neuroblastoma oncogene in NATURE
  • 2011-01. Integrative genomics viewer in NATURE BIOTECHNOLOGY
  • 2012-11. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2012-03. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma in NATURE GENETICS
  • 2006-12. Clonogenic assay of cells in vitro in NATURE PROTOCOLS
  • 2011-05-05. Mapping and analysis of chromatin state dynamics in nine human cell types in NATURE
  • 2011-07. Current status of genome-wide association studies in cancer in HUMAN GENETICS
  • 2007-07. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma in NATURE
  • 2013-06. The Genotype-Tissue Expression (GTEx) project in NATURE GENETICS
  • 2012-01. Improved imputation of common and uncommon SNPs with a new reference set in NATURE GENETICS
  • 1994-10. Krox-20 controls myelination in the peripheral nervous system in NATURE
  • 1992-09. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours in NATURE
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2012-08. Subgroup-specific structural variation across 1,000 medulloblastoma genomes in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3363

    DOI

    http://dx.doi.org/10.1038/ng.3363

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033290656

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26214589


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