Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07-27

AUTHORS

Michael Krauthammer, Yong Kong, Antonella Bacchiocchi, Perry Evans, Natapol Pornputtapong, Cen Wu, Jamie P McCusker, Shuangge Ma, Elaine Cheng, Robert Straub, Merdan Serin, Marcus Bosenberg, Stephan Ariyan, Deepak Narayan, Mario Sznol, Harriet M Kluger, Shrikant Mane, Joseph Schlessinger, Richard P Lifton, Ruth Halaban

ABSTRACT

Ruth Halaban, Michael Krauthammer and colleagues report exome sequencing of 213 melanomas and identify a distinct co-mutation pattern of NF1 with known RASopathy genes. They identify novel melanoma mutations in several RASopathy genes and suggest that mutations in these genes may enhance the pathogenicity of NF1 mutation.

PAGES

996-1002

References to SciGraph publications

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    9

    VOLUME

    47

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3361

    DOI

    http://dx.doi.org/10.1038/ng.3361

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040467727

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26214590


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