Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

Jimmy Z Liu, Suzanne van Sommeren, Hailiang Huang, Siew C Ng, Rudi Alberts, Atsushi Takahashi, Stephan Ripke, James C Lee, Luke Jostins, Tejas Shah, Shifteh Abedian, Jae Hee Cheon, Judy Cho, Naser E Daryani, Lude Franke, Yuta Fuyuno, Ailsa Hart, Ramesh C Juyal, Garima Juyal, Won Ho Kim, Andrew P Morris, Hossein Poustchi, William G Newman, Vandana Midha, Timothy R Orchard, Homayon Vahedi, Ajit Sood, Joseph J Y Sung, Reza Malekzadeh, Harm-Jan Westra, Keiko Yamazaki, Suk-Kyun Yang, International Multiple Sclerosis Genetics Consortium, International IBD Genetics Consortium, Jeffrey C Barrett, Andre Franke, Behrooz Z Alizadeh, Miles Parkes, B K Thelma, Mark J Daly, Michiaki Kubo, Carl A Anderson, Rinse K Weersma

ABSTRACT

Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the majority of the IBD risk loci, the direction and magnitude of effect are consistent in European and non-European cohorts. Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM). Our results provide biological insights into the pathogenesis of IBD and demonstrate the usefulness of trans-ancestry association studies for mapping loci associated with complex diseases and understanding genetic architecture across diverse populations. More... »

PAGES

979-986

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3359

    DOI

    http://dx.doi.org/10.1038/ng.3359

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019843926

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26192919


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