The support of human genetic evidence for approved drug indications View Full Text


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Article Info

DATE

2015-06-29

AUTHORS

Matthew R Nelson, Hannah Tipney, Jeffery L Painter, Judong Shen, Paola Nicoletti, Yufeng Shen, Aris Floratos, Pak Chung Sham, Mulin Jun Li, Junwen Wang, Lon R Cardon, John C Whittaker, Philippe Sanseau

ABSTRACT

Matthew Nelson and colleagues investigate how well genetic evidence for disease susceptibility predicts drug mechanisms. They find a correlation between gene products that are successful drug targets and genetic loci associated with the disease treated by the drug and predict that selecting genetically supported targets could increase the success rate of drugs in clinical development. More... »

PAGES

856-860

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3314

    DOI

    http://dx.doi.org/10.1038/ng.3314

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26121088


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