Whole-genome fingerprint of the DNA methylome during human B cell differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07

AUTHORS

Marta Kulis, Angelika Merkel, Simon Heath, Ana C Queirós, Ronald P Schuyler, Giancarlo Castellano, Renée Beekman, Emanuele Raineri, Anna Esteve, Guillem Clot, Néria Verdaguer-Dot, Martí Duran-Ferrer, Nuria Russiñol, Roser Vilarrasa-Blasi, Simone Ecker, Vera Pancaldi, Daniel Rico, Lidia Agueda, Julie Blanc, David Richardson, Laura Clarke, Avik Datta, Marien Pascual, Xabier Agirre, Felipe Prosper, Diego Alignani, Bruno Paiva, Gersende Caron, Thierry Fest, Marcus O Muench, Marina E Fomin, Seung-Tae Lee, Joseph L Wiemels, Alfonso Valencia, Marta Gut, Paul Flicek, Hendrik G Stunnenberg, Reiner Siebert, Ralf Küppers, Ivo G Gut, Elías Campo, José I Martín-Subero

ABSTRACT

We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation program by whole-genome bisulfite sequencing and high-density microarrays. We observed that non-CpG methylation disappeared upon B cell commitment, whereas CpG methylation changed extensively during B cell maturation, showing an accumulative pattern and affecting around 30% of all measured CpG sites. Early differentiation stages mainly displayed enhancer demethylation, which was associated with upregulation of key B cell transcription factors and affected multiple genes involved in B cell biology. Late differentiation stages, in contrast, showed extensive demethylation of heterochromatin and methylation gain at Polycomb-repressed areas, and genes with apparent functional impact in B cells were not affected. This signature, which has previously been linked to aging and cancer, was particularly widespread in mature cells with an extended lifespan. Comparing B cell neoplasms with their normal counterparts, we determined that they frequently acquire methylation changes in regions already undergoing dynamic methylation during normal B cell differentiation. More... »

PAGES

746-756

References to SciGraph publications

  • 1997-07. Lifetime of plasma cells in the bone marrow in NATURE
  • 2012-06. SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips in GENOME BIOLOGY
  • 2006-02. The Polycomb group protein EZH2 directly controls DNA methylation in NATURE
  • 2007-02. A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing in NATURE GENETICS
  • 2012-11. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia in NATURE GENETICS
  • 2014-02. Accounting for cellular heterogeneity is critical in epigenome-wide association studies in GENOME BIOLOGY
  • 2011-05-05. Mapping and analysis of chromatin state dynamics in nine human cell types in NATURE
  • 2013-03. DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes in GENOME BIOLOGY
  • 2013-12. Senescent cells harbour features of the cancer epigenome in NATURE CELL BIOLOGY
  • 2007-02. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer in NATURE GENETICS
  • 2015-02. Transcription factor binding dynamics during human ES cell differentiation in NATURE
  • 2005-06. Transcriptional networks in developing and mature B cells in NATURE REVIEWS IMMUNOLOGY
  • 2013-03. DNA methylation: roles in mammalian development in NATURE REVIEWS GENETICS
  • 2007-02. Epigenetic stem cell signature in cancer in NATURE GENETICS
  • 2013-10. Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues in NATURE GENETICS
  • 2012-10. Aging effects on DNA methylation modules in human brain and blood tissue in GENOME BIOLOGY
  • 2009-05. Linking DNA methylation and histone modification: patterns and paradigms in NATURE REVIEWS GENETICS
  • 2009-11. Human DNA methylomes at base resolution show widespread epigenomic differences in NATURE
  • 2013-03. DNA methylation dynamics in health and disease in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-01. Large conserved domains of low DNA methylation maintained by Dnmt3a in NATURE GENETICS
  • 2014-06. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing in NATURE
  • 2012-12. The GEM mapper: fast, accurate and versatile alignment by filtration in NATURE METHODS
  • 2013-08. Charting a dynamic DNA methylation landscape of the human genome in NATURE
  • 2011-08. Increased methylation variation in epigenetic domains across cancer types in NATURE GENETICS
  • 2011-12-14. DNA-binding factors shape the mouse methylome at distal regulatory regions in NATURE
  • 2012-01. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3291

    DOI

    http://dx.doi.org/10.1038/ng.3291

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030977436

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26053498


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