Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02-15

AUTHORS

Christopher Newton-Cheh, Martin G Larson, Ramachandran S Vasan, Daniel Levy, Kenneth D Bloch, Aarti Surti, Candace Guiducci, Sekar Kathiresan, Emelia J Benjamin, Joachim Struck, Nils G Morgenthaler, Andreas Bergmann, Stefan Blankenberg, Frank Kee, Peter Nilsson, Xiaoyan Yin, Leena Peltonen, Erkki Vartiainen, Veikko Salomaa, Joel N Hirschhorn, Olle Melander, Thomas J Wang

ABSTRACT

Christopher Newton-Cheh and colleagues report the identification of common variants at the NPPA-NPPB locus associated with plasma atrial natriuretic peptide concentration, as well as with lower systolic and diastolic blood pressure, and reduced risk of hypertension.

PAGES

348-353

Journal

TITLE

Nature Genetics

ISSUE

3

VOLUME

41

Author Affiliations

  • National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Avenue #2, 01702, Framingham, Massachusetts, USA
  • Department of Mathematics, Boston University School of Medicine, 111 Cummington Street, 02215, Boston, Massachusetts, USA
  • Preventive Medicine and Cardiology Sections, Boston University School of Medicine, 715 Albany Street, 02118, Boston, Massachusetts, USA
  • National Heart, Lung, and Blood Institute, 20892, Bethesda, Maryland, USA
  • Department of Anesthesia, Massachusetts General Hospital, 32 Fruit Street, 02114, Boston, Massachuestts, USA
  • Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA
  • Research Department, BRAHMS AG, Neuendorfstrasse 25, D-16761, Hennigsdorf, Germany
  • Department of Medicine II, Building 605, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany
  • A UKCRC, Centre of Excellence for Public Health (NI), Mulhouse, Royal Victoria Hospital, Grosvenor Road, BT12 6BJ, Belfast, Northern Ireland, UK
  • Clinical Research Center (CRC), Entrance 72, Bldg. 91, Floor 12, Malmö University Hospital, SE 205 02, Malmö, Sweden
  • Institute of Molecular Medicine Finland FIMM, Biomedicum Helsinki, 2U, Tukholmankatu 8, FI-00290, Helsinki, Finland
  • Department of Health Promotion and Chronic Disease Prevention, KTL National Public Health Institute, Mannerheimintie 166, FI-00300, Helsinki, Finland
  • Department of Genetics, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.328

    DOI

    http://dx.doi.org/10.1038/ng.328

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035621233

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19219041


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