The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04

AUTHORS

Anna K Andersson, Jing Ma, Jianmin Wang, Xiang Chen, Amanda Larson Gedman, Jinjun Dang, Joy Nakitandwe, Linda Holmfeldt, Matthew Parker, John Easton, Robert Huether, Richard Kriwacki, Michael Rusch, Gang Wu, Yongjin Li, Heather Mulder, Susana Raimondi, Stanley Pounds, Guolian Kang, Lei Shi, Jared Becksfort, Pankaj Gupta, Debbie Payne-Turner, Bhavin Vadodaria, Kristy Boggs, Donald Yergeau, Jayanthi Manne, Guangchun Song, Michael Edmonson, Panduka Nagahawatte, Lei Wei, Cheng Cheng, Deqing Pei, Rosemary Sutton, Nicola C Venn, Albert Chetcuti, Amanda Rush, Daniel Catchpoole, Jesper Heldrup, Thoas Fioretos, Charles Lu, Li Ding, Ching-Hon Pui, Sheila Shurtleff, Charles G Mullighan, Elaine R Mardis, Richard K Wilson, Tanja A Gruber, Jinghui Zhang, James R Downing, The St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project

ABSTRACT

Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis. To define its mutational landscape, we performed whole-genome, exome, RNA and targeted DNA sequencing on 65 infants (47 MLL-R and 18 non-MLL-R cases) and 20 older children (MLL-R cases) with leukemia. Our data show that infant MLL-R ALL has one of the lowest frequencies of somatic mutations of any sequenced cancer, with the predominant leukemic clone carrying a mean of 1.3 non-silent mutations. Despite this paucity of mutations, we detected activating mutations in kinase-PI3K-RAS signaling pathway components in 47% of cases. Surprisingly, these mutations were often subclonal and were frequently lost at relapse. In contrast to infant cases, MLL-R leukemia in older children had more somatic mutations (mean of 6.5 mutations/case versus 1.3 mutations/case, P = 7.15 × 10(-5)) and had frequent mutations (45%) in epigenetic regulators, a category of genes that, with the exception of MLL, was rarely mutated in infant MLL-R ALL. More... »

PAGES

330-337

References to SciGraph publications

  • 2010-04-15. Genome remodelling in a basal-like breast cancer metastasis and xenograft in NATURE
  • 2011-01. Implementation of array based whole-genome high-resolution technologies confirms the absence of secondary copy-number alterations in MLL-AF4-positive infant ALL patients in LEUKEMIA
  • 2013-06. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas in NATURE GENETICS
  • 2012-03. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas in NATURE GENETICS
  • 1993-05. In utero rearrangements in the trithorax-related oncogene in infant leukaemias in NATURE
  • 2013-06. Secondary mutations in t(4;11) leukemia patients in LEUKEMIA
  • 2007-11. MLL translocations, histone modifications and leukaemia stem-cell development in NATURE REVIEWS CANCER
  • 2007-04. Hyperactive Ras in developmental disorders and cancer in NATURE REVIEWS CANCER
  • 2012-01. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia in NATURE
  • 1998-12. Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation in ONCOGENE
  • 2014-12. The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes in NATURE COMMUNICATIONS
  • 2011-08. CREST maps somatic structural variation in cancer genomes with base-pair resolution in NATURE METHODS
  • 1999-08-26. Primer3 on the WWW for General Users and for Biologist Programmers in BIOINFORMATICS METHODS AND PROTOCOLS
  • 2012-06. The Pediatric Cancer Genome Project in NATURE GENETICS
  • 2014-02. Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements in LEUKEMIA
  • 1999-08. A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells in ONCOGENE
  • 2009-09. BreakDancer: an algorithm for high-resolution mapping of genomic structural variation in NATURE METHODS
  • 2013-12. Identification of somatic and germline mutations using whole exome sequencing of congenital acute lymphoblastic leukemia in BMC CANCER
  • 2007-04. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia in NATURE
  • 2013-11. The MLL recombinome of acute leukemias in 2013 in LEUKEMIA
  • 2013-01. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma in NATURE GENETICS
  • 2015-01. Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement in LEUKEMIA
  • 2010-05. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation in NATURE BIOTECHNOLOGY
  • 2010-02. Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine in BRITISH JOURNAL OF CANCER
  • 2011-05. Activated K-Ras protein accelerates human MLL/AF4-induced leukemo-lymphomogenicity in a transgenic mouse model in LEUKEMIA
  • 2012-01. A novel retinoblastoma therapy from genomic and epigenetic analyses in NATURE
  • 2013-07. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2014-05. Targeting bromodomains: epigenetic readers of lysine acetylation in NATURE REVIEWS DRUG DISCOVERY
  • 2013-01. Differential analysis of gene regulation at transcript resolution with RNA-seq in NATURE BIOTECHNOLOGY
  • 2009-12. Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation in LEUKEMIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3230

    DOI

    http://dx.doi.org/10.1038/ng.3230

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048699191

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25730765


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