LD Score regression distinguishes confounding from polygenicity in genome-wide association studies View Full Text


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Article Info

DATE

2015-02-02

AUTHORS

Brendan K Bulik-Sullivan, Po-Ru Loh, Hilary K Finucane, Stephan Ripke, Jian Yang, Nick Patterson, Mark J Daly, Alkes L Price, Benjamin M Neale

ABSTRACT

Benjamin Neale and colleagues report the LD Score regression method, used to distinguish the relative contributions of confounding bias and polygenicity to inflated test statistics in GWAS. They apply their method to summary statistics from GWAS for over 30 phenotypes, confirm that polygenicity accounts for the majority of inflation in test statistics and demonstrate use of this method as a correction factor. More... »

PAGES

291-295

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    DOI

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    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25642630


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