Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11

AUTHORS

Ming Zhang, Yuxuan Wang, Sian Jones, Mark Sausen, Kevin McMahon, Rajni Sharma, Qing Wang, Allan J Belzberg, Kaisorn Chaichana, Gary L Gallia, Ziya L Gokaslan, Greg J Riggins, Jean-Paul Wolinksy, Laura D Wood, Elizabeth A Montgomery, Ralph H Hruban, Kenneth W Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Chetan Bettegowda

ABSTRACT

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation. More... »

PAGES

1170-1172

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.3116

DOI

http://dx.doi.org/10.1038/ng.3116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028147277

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25305755


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.3116'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.3116'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.3116'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.3116'


 

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