Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-05-04

AUTHORS

Yongxing Gong, Travis Ian Zack, Luc G T Morris, Kan Lin, Ellen Hukkelhoven, Radhika Raheja, I-Li Tan, Sevin Turcan, Selvaraju Veeriah, Shasha Meng, Agnes Viale, Steven E Schumacher, Perry Palmedo, Rameen Beroukhim, Timothy A Chan

ABSTRACT

Timothy Chan and colleagues show that the PARK2 tumor suppressor is a master regulator of G1 and S phase cyclins and is critical for proper cell cycle regulation. PARK2 genetic alterations are common across many human cancers as well as in hereditary Parkinson's disease.

PAGES

588-594

References to SciGraph publications

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    6

    VOLUME

    46

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2981

    DOI

    http://dx.doi.org/10.1038/ng.2981

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013606458

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24793136


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