Common variants at 30 loci contribute to polygenic dyslipidemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12-07

AUTHORS

Sekar Kathiresan, Cristen J Willer, Gina M Peloso, Serkalem Demissie, Kiran Musunuru, Eric E Schadt, Lee Kaplan, Derrick Bennett, Yun Li, Toshiko Tanaka, Benjamin F Voight, Lori L Bonnycastle, Anne U Jackson, Gabriel Crawford, Aarti Surti, Candace Guiducci, Noel P Burtt, Sarah Parish, Robert Clarke, Diana Zelenika, Kari A Kubalanza, Mario A Morken, Laura J Scott, Heather M Stringham, Pilar Galan, Amy J Swift, Johanna Kuusisto, Richard N Bergman, Jouko Sundvall, Markku Laakso, Luigi Ferrucci, Paul Scheet, Serena Sanna, Manuela Uda, Qiong Yang, Kathryn L Lunetta, Josée Dupuis, Paul I W de Bakker, Christopher J O'Donnell, John C Chambers, Jaspal S Kooner, Serge Hercberg, Pierre Meneton, Edward G Lakatta, Angelo Scuteri, David Schlessinger, Jaakko Tuomilehto, Francis S Collins, Leif Groop, David Altshuler, Rory Collins, G Mark Lathrop, Olle Melander, Veikko Salomaa, Leena Peltonen, Marju Orho-Melander, Jose M Ordovas, Michael Boehnke, Gonçalo R Abecasis, Karen L Mohlke, L Adrienne Cupples

ABSTRACT

Sekar Kathiresan et al. report genome-wide association studies for polygenic dyslipidemia. From a meta-analysis of seven genome-wide association studies and follow-up in five replication studies, they identify 11 new genetic associations for LDL cholesterol, HDL cholesterol and triglycerides.

PAGES

56-65

Journal

TITLE

Nature Genetics

ISSUE

1

VOLUME

41

Author Affiliations

  • Department of Medicine, Harvard Medical School, 02115, Boston, Massachusetts, USA
  • Department of Biostatistics, Center for Statistical Genetics, University of Michigan, 48109, Ann Arbor, Michigan, USA
  • Department of Biostatistics, Boston University School of Public Health, 02118, Boston, Massachusetts, USA
  • Center for Human Genetic Research, Massachusetts General Hospital, 02114, Boston, Massachusetts, USA
  • Rosetta Inpharmatics LLC, Merck & Co., Inc., 98109, Seattle, Washington, USA
  • Massachusetts General Hospital Weight Center, 02114, Boston, Massachusetts, USA
  • Clinical Trial Service Unit, University of Oxford, OX3 7LF, Oxford, UK
  • Clinical Research Branch, National Institute on Aging, National Institutes of Health, 21225, Baltimore, Maryland, USA
  • Department of Molecular Biology, Massachusetts General Hospital, 02114, Boston, Massachusetts, USA
  • National Human Genome Research Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA
  • Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA
  • Centre Nationale de Genotypage, Institut Genomique, Commissariat a l'Energie Atomique, 91057, Evry Cedex, France
  • INSERM U557, INRA U1125, CNAM, Paris 13 SMBH, Bobigny, France
  • Department of Medicine, University of Kuopio, 70210, Kuopio, Finland
  • Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, 90033, Los Angeles, California, USA
  • Department of Health Promotion and Chronic Disease Prevention, Diabetes Unit, National Public Health Institute, 00300, Helsinki, Finland
  • Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, 08045, Cagliari, Italy
  • Division of Genetics, Bringham and Women's Hospital, 02115, Boston, Massachusetts, USA
  • National, Lung, and Blood Institute, National Institutes of Health, 01702, Framingham, Massachusetts, USA
  • Department of Epidemiology and Public Health, Imperial College London, W2 1PG, London, UK
  • Hammersmith Hospital, National Heart and Lung Institute, Imperial College London, W12 0NN, London, UK
  • INSERM U872, Centre de Recherche des Cordeliers, 75270, Paris, Cedex 06, France
  • Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, 21224, Baltimore, Maryland, USA
  • Unità Operativa Geriatria, Istituto Nazionale Ricovero e Cura per Anziani, 00189, Rome, Italy
  • Laboratory of Genetics, Gerontology Research Center, National Institute on Aging, 21224, Baltimore, Maryland, USA
  • Department of Medicine, Helsinki University Hospital, 00029, Helsinki, Finland
  • Department of Genetics, Harvard Medical School, 02115, Boston, Massachusetts, USA
  • Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, 20502, Malmö, Sweden
  • Department of Health Promotion and Chronic Disease Prevention, Chronic Disease Epidemiology Unit, National Public Health Institute, 00300, Helsinki, Finland
  • Wellcome Trust Sanger Institute, CB10 1SA, Cambridge, UK
  • Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, 20502, Malmö, Sweden
  • Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Nutrition and Genomics Laboratory, 02111, Boston, Massachusetts, USA
  • Department of Genetics, University of North Carolina, 27599, Chapel Hill, North Carolina, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.291

    DOI

    http://dx.doi.org/10.1038/ng.291

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044117587

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19060906


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