The deleterious mutation load is insensitive to recent population history View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03

AUTHORS

Yuval B Simons, Michael C Turchin, Jonathan K Pritchard, Guy Sella

ABSTRACT

Human populations have undergone major changes in population size in the past 100,000 years, including recent rapid growth. How these demographic events have affected the burden of deleterious mutations in individuals and the frequencies of disease mutations in populations remains unclear. We use population genetic models to show that recent human demography has probably had little impact on the average burden of deleterious mutations. This prediction is supported by two exome sequence data sets showing that individuals of west African and European ancestry carry very similar burdens of damaging mutations. We further show that for many diseases, rare alleles are unlikely to contribute a large fraction of the heritable variation, and therefore the impact of recent growth is likely to be modest. However, for those diseases that have a direct impact on fitness, strongly deleterious rare mutations probably do have an important role, and recent growth will have increased their impact. More... »

PAGES

220-224

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.2896

DOI

http://dx.doi.org/10.1038/ng.2896

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033426202

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24509481


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "African Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "European Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Load", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetics, Population", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Population Dynamics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hebrew University of Jerusalem", 
          "id": "https://www.grid.ac/institutes/grid.9619.7", 
          "name": [
            "Department of Ecology, Evolution and Behavior, Hebrew University of Jerusalem, Jerusalem, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simons", 
        "givenName": "Yuval B", 
        "id": "sg:person.01052014720.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052014720.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago", 
          "id": "https://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Human Genetics, University of Chicago, Chicago, Illinois, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turchin", 
        "givenName": "Michael C", 
        "id": "sg:person.0677603740.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677603740.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.", 
            "Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.", 
            "Department of Biology, Stanford University, Stanford, California, USA.", 
            "Department of Genetics, Stanford University, Stanford, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pritchard", 
        "givenName": "Jonathan K", 
        "id": "sg:person.01104516710.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104516710.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA.", 
            "Present address: Department of Biological Sciences, Columbia University, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sella", 
        "givenName": "Guy", 
        "id": "sg:person.01052611255.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052611255.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrg3118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001779725", 
          "https://doi.org/10.1038/nrg3118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005147626", 
          "https://doi.org/10.1038/nature08494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005147626", 
          "https://doi.org/10.1038/nature08494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007191962", 
          "https://doi.org/10.1038/nature06611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth0410-248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007489634", 
          "https://doi.org/10.1038/nmeth0410-248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth0410-248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007489634", 
          "https://doi.org/10.1038/nmeth0410-248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008701542", 
          "https://doi.org/10.1038/nature11690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2005.1667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009076345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010608717", 
          "https://doi.org/10.1038/nature09534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010608717", 
          "https://doi.org/10.1038/nature09534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2011-12-9-r84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012643182", 
          "https://doi.org/10.1186/gb-2011-12-9-r84"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0507325102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013454322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015642657", 
          "https://doi.org/10.1038/nprot.2009.86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms1130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015907369", 
          "https://doi.org/10.1038/ncomms1130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms1130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015907369", 
          "https://doi.org/10.1038/ncomms1130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020792304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022599147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0906182107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022731697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth0810-575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028459136", 
          "https://doi.org/10.1038/nmeth0810-575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msm167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029524071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1219240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037292390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1219240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037292390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.092619.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040216656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.3709305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043284437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046660436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047350146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/321272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050711688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053487198", 
          "https://doi.org/10.1038/ng2116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1217283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062465881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1217876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062465921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1217876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062465921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1224528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062466836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1224528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062466836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2410432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069919282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074678904", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1558-5646.1995.tb04434.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085736569"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-03", 
    "datePublishedReg": "2014-03-01", 
    "description": "Human populations have undergone major changes in population size in the past 100,000 years, including recent rapid growth. How these demographic events have affected the burden of deleterious mutations in individuals and the frequencies of disease mutations in populations remains unclear. We use population genetic models to show that recent human demography has probably had little impact on the average burden of deleterious mutations. This prediction is supported by two exome sequence data sets showing that individuals of west African and European ancestry carry very similar burdens of damaging mutations. We further show that for many diseases, rare alleles are unlikely to contribute a large fraction of the heritable variation, and therefore the impact of recent growth is likely to be modest. However, for those diseases that have a direct impact on fitness, strongly deleterious rare mutations probably do have an important role, and recent growth will have increased their impact. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.2896", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2683697", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2551835", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2519865", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "46"
      }
    ], 
    "name": "The deleterious mutation load is insensitive to recent population history", 
    "pagination": "220-224", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9f3c15b139decbc92f85c2df52c2767c8eff91b2a2a10e9483afb89d11bc7d40"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24509481"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.2896"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033426202"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.2896", 
      "https://app.dimensions.ai/details/publication/pub.1033426202"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ng/journal/v46/n3/full/ng.2896.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2896'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2896'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2896'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2896'


 

This table displays all metadata directly associated to this object as RDF triples.

246 TRIPLES      21 PREDICATES      68 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.2896 schema:about N066bb40fdd244de4b76029b01a89209c
2 N56a2c1d0e1ed4e78a0ebe27bb2cfda07
3 N5ecc211741e14a479c5ad9f17c15f48c
4 N6ba7b8be052e4529bd4602a5aa80d466
5 N89636375875f487f86660f1e9d602812
6 N9a9f634aada34157917c8ec86dec491f
7 Na9ba2061330844e3b592db80f45b821f
8 Nadb4a3903fee4d889a94e79e9c2ad462
9 Nbbbccd76af0a4aa082341efc0a5777eb
10 Nbddf9e564c4040dd9b9a9431813cdd52
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author N1c1bd569b9524816a2d3b45760069fc1
14 schema:citation sg:pub.10.1038/nature06611
15 sg:pub.10.1038/nature08494
16 sg:pub.10.1038/nature09534
17 sg:pub.10.1038/nature11690
18 sg:pub.10.1038/ncomms1130
19 sg:pub.10.1038/ng2116
20 sg:pub.10.1038/nmeth0410-248
21 sg:pub.10.1038/nmeth0810-575
22 sg:pub.10.1038/nprot.2009.86
23 sg:pub.10.1038/nrg3118
24 sg:pub.10.1186/gb-2011-12-9-r84
25 https://app.dimensions.ai/details/publication/pub.1074678904
26 https://doi.org/10.1073/pnas.0507325102
27 https://doi.org/10.1073/pnas.0906182107
28 https://doi.org/10.1086/321272
29 https://doi.org/10.1093/molbev/msm167
30 https://doi.org/10.1093/nar/gkq603
31 https://doi.org/10.1098/rstb.2005.1667
32 https://doi.org/10.1101/gr.092619.109
33 https://doi.org/10.1101/gr.3709305
34 https://doi.org/10.1111/j.1558-5646.1995.tb04434.x
35 https://doi.org/10.1126/science.1217283
36 https://doi.org/10.1126/science.1217876
37 https://doi.org/10.1126/science.1219240
38 https://doi.org/10.1126/science.1224528
39 https://doi.org/10.1371/journal.pgen.1000471
40 https://doi.org/10.1371/journal.pgen.1000695
41 https://doi.org/10.1371/journal.pgen.1003258
42 https://doi.org/10.2307/2410432
43 schema:datePublished 2014-03
44 schema:datePublishedReg 2014-03-01
45 schema:description Human populations have undergone major changes in population size in the past 100,000 years, including recent rapid growth. How these demographic events have affected the burden of deleterious mutations in individuals and the frequencies of disease mutations in populations remains unclear. We use population genetic models to show that recent human demography has probably had little impact on the average burden of deleterious mutations. This prediction is supported by two exome sequence data sets showing that individuals of west African and European ancestry carry very similar burdens of damaging mutations. We further show that for many diseases, rare alleles are unlikely to contribute a large fraction of the heritable variation, and therefore the impact of recent growth is likely to be modest. However, for those diseases that have a direct impact on fitness, strongly deleterious rare mutations probably do have an important role, and recent growth will have increased their impact.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf N1d7d8de6ec9840329284d97a2b8c274f
50 N4b17fe294b154469a240cd1e1a1f2990
51 sg:journal.1103138
52 schema:name The deleterious mutation load is insensitive to recent population history
53 schema:pagination 220-224
54 schema:productId N0250ea7d324a4412a3c3b25ddc1b46ed
55 N45a077f1ae3e40f0b7ae1985ee41be6d
56 N511329a442ea42b9a7d3e3d2ab26be88
57 Ndb90a015ccdd439ea8a58a82a6899e67
58 Nf29e2a0067da41ec8642017e860e2854
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033426202
60 https://doi.org/10.1038/ng.2896
61 schema:sdDatePublished 2019-04-10T21:44
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nd880b840e30f4ce8929d8b422dacfc5b
64 schema:url http://www.nature.com/ng/journal/v46/n3/full/ng.2896.html
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N00c6a7844b384e0f905e9da4a9b99dfb rdf:first sg:person.01052611255.12
69 rdf:rest rdf:nil
70 N0250ea7d324a4412a3c3b25ddc1b46ed schema:name doi
71 schema:value 10.1038/ng.2896
72 rdf:type schema:PropertyValue
73 N04cb2f20971f48e6a012f7ed99d3cfca rdf:first sg:person.0677603740.99
74 rdf:rest N4246263aa47c42199eeabef980e0f33d
75 N066bb40fdd244de4b76029b01a89209c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Mutation
77 rdf:type schema:DefinedTerm
78 N1c1bd569b9524816a2d3b45760069fc1 rdf:first sg:person.01052014720.28
79 rdf:rest N04cb2f20971f48e6a012f7ed99d3cfca
80 N1d7d8de6ec9840329284d97a2b8c274f schema:issueNumber 3
81 rdf:type schema:PublicationIssue
82 N4246263aa47c42199eeabef980e0f33d rdf:first sg:person.01104516710.33
83 rdf:rest N00c6a7844b384e0f905e9da4a9b99dfb
84 N45a077f1ae3e40f0b7ae1985ee41be6d schema:name nlm_unique_id
85 schema:value 9216904
86 rdf:type schema:PropertyValue
87 N4b17fe294b154469a240cd1e1a1f2990 schema:volumeNumber 46
88 rdf:type schema:PublicationVolume
89 N511329a442ea42b9a7d3e3d2ab26be88 schema:name readcube_id
90 schema:value 9f3c15b139decbc92f85c2df52c2767c8eff91b2a2a10e9483afb89d11bc7d40
91 rdf:type schema:PropertyValue
92 N56a2c1d0e1ed4e78a0ebe27bb2cfda07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Population Dynamics
94 rdf:type schema:DefinedTerm
95 N5ecc211741e14a479c5ad9f17c15f48c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N6ba7b8be052e4529bd4602a5aa80d466 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Exome
100 rdf:type schema:DefinedTerm
101 N89636375875f487f86660f1e9d602812 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Genetic Load
103 rdf:type schema:DefinedTerm
104 N9a9f634aada34157917c8ec86dec491f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Genetics, Population
106 rdf:type schema:DefinedTerm
107 Na9ba2061330844e3b592db80f45b821f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Polymorphism, Single Nucleotide
109 rdf:type schema:DefinedTerm
110 Nadb4a3903fee4d889a94e79e9c2ad462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name African Continental Ancestry Group
112 rdf:type schema:DefinedTerm
113 Nbbbccd76af0a4aa082341efc0a5777eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name European Continental Ancestry Group
115 rdf:type schema:DefinedTerm
116 Nbddf9e564c4040dd9b9a9431813cdd52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Models, Genetic
118 rdf:type schema:DefinedTerm
119 Nd880b840e30f4ce8929d8b422dacfc5b schema:name Springer Nature - SN SciGraph project
120 rdf:type schema:Organization
121 Ndb90a015ccdd439ea8a58a82a6899e67 schema:name pubmed_id
122 schema:value 24509481
123 rdf:type schema:PropertyValue
124 Nf29e2a0067da41ec8642017e860e2854 schema:name dimensions_id
125 schema:value pub.1033426202
126 rdf:type schema:PropertyValue
127 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
128 schema:name Biological Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
131 schema:name Genetics
132 rdf:type schema:DefinedTerm
133 sg:grant.2519865 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2896
134 rdf:type schema:MonetaryGrant
135 sg:grant.2551835 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2896
136 rdf:type schema:MonetaryGrant
137 sg:grant.2683697 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2896
138 rdf:type schema:MonetaryGrant
139 sg:journal.1103138 schema:issn 1061-4036
140 1546-1718
141 schema:name Nature Genetics
142 rdf:type schema:Periodical
143 sg:person.01052014720.28 schema:affiliation https://www.grid.ac/institutes/grid.9619.7
144 schema:familyName Simons
145 schema:givenName Yuval B
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052014720.28
147 rdf:type schema:Person
148 sg:person.01052611255.12 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
149 schema:familyName Sella
150 schema:givenName Guy
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052611255.12
152 rdf:type schema:Person
153 sg:person.01104516710.33 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
154 schema:familyName Pritchard
155 schema:givenName Jonathan K
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104516710.33
157 rdf:type schema:Person
158 sg:person.0677603740.99 schema:affiliation https://www.grid.ac/institutes/grid.170205.1
159 schema:familyName Turchin
160 schema:givenName Michael C
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677603740.99
162 rdf:type schema:Person
163 sg:pub.10.1038/nature06611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007191962
164 https://doi.org/10.1038/nature06611
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/nature08494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005147626
167 https://doi.org/10.1038/nature08494
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nature09534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010608717
170 https://doi.org/10.1038/nature09534
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/nature11690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008701542
173 https://doi.org/10.1038/nature11690
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/ncomms1130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015907369
176 https://doi.org/10.1038/ncomms1130
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/ng2116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487198
179 https://doi.org/10.1038/ng2116
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nmeth0410-248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007489634
182 https://doi.org/10.1038/nmeth0410-248
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nmeth0810-575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028459136
185 https://doi.org/10.1038/nmeth0810-575
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nprot.2009.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015642657
188 https://doi.org/10.1038/nprot.2009.86
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nrg3118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001779725
191 https://doi.org/10.1038/nrg3118
192 rdf:type schema:CreativeWork
193 sg:pub.10.1186/gb-2011-12-9-r84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012643182
194 https://doi.org/10.1186/gb-2011-12-9-r84
195 rdf:type schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1074678904 schema:CreativeWork
197 https://doi.org/10.1073/pnas.0507325102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013454322
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1073/pnas.0906182107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022731697
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1086/321272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050711688
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1093/molbev/msm167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029524071
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1093/nar/gkq603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020792304
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1098/rstb.2005.1667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009076345
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1101/gr.092619.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040216656
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1101/gr.3709305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043284437
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1111/j.1558-5646.1995.tb04434.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1085736569
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1126/science.1217283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062465881
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1126/science.1217876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062465921
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1126/science.1219240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037292390
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1126/science.1224528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062466836
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1371/journal.pgen.1000471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022599147
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1371/journal.pgen.1000695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046660436
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1371/journal.pgen.1003258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047350146
228 rdf:type schema:CreativeWork
229 https://doi.org/10.2307/2410432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069919282
230 rdf:type schema:CreativeWork
231 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
232 schema:name Department of Biology, Stanford University, Stanford, California, USA.
233 Department of Genetics, Stanford University, Stanford, California, USA.
234 Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.
235 Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.170205.1 schema:alternateName University of Chicago
238 schema:name Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.
239 rdf:type schema:Organization
240 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
241 schema:name Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA.
242 Present address: Department of Biological Sciences, Columbia University, New York, New York, USA.
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.9619.7 schema:alternateName Hebrew University of Jerusalem
245 schema:name Department of Ecology, Evolution and Behavior, Hebrew University of Jerusalem, Jerusalem, Israel.
246 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...