Dense genomic sampling identifies highways of pneumococcal recombination View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03

AUTHORS

Claire Chewapreecha, Simon R Harris, Nicholas J Croucher, Claudia Turner, Pekka Marttinen, Lu Cheng, Alberto Pessia, David M Aanensen, Alison E Mather, Andrew J Page, Susannah J Salter, David Harris, Francois Nosten, David Goldblatt, Jukka Corander, Julian Parkhill, Paul Turner, Stephen D Bentley

ABSTRACT

Evasion of clinical interventions by Streptococcus pneumoniae occurs through selection of non-susceptible genomic variants. We report whole-genome sequencing of 3,085 pneumococcal carriage isolates from a 2.4-km(2) refugee camp. This sequencing provides unprecedented resolution of the process of recombination and its impact on population evolution. Genomic recombination hotspots show remarkable consistency between lineages, indicating common selective pressures acting at certain loci, particularly those associated with antibiotic resistance. Temporal changes in antibiotic consumption are reflected in changes in recombination trends, demonstrating rapid spread of resistance when selective pressure is high. The highest frequencies of receipt and donation of recombined DNA fragments were observed in non-encapsulated lineages, implying that this largely overlooked pneumococcal group, which is beyond the reach of current vaccines, may have a major role in genetic exchange and the adaptation of the species as a whole. These findings advance understanding of pneumococcal population dynamics and provide information for the design of future intervention strategies. More... »

PAGES

305-309

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.2895

DOI

http://dx.doi.org/10.1038/ng.2895

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037018769

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24509479


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