Somatic mutation of CDKN1B in small intestine neuroendocrine tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Joshua M Francis, Adam Kiezun, Alex H Ramos, Stefano Serra, Chandra Sekhar Pedamallu, Zhi Rong Qian, Michaela S Banck, Rahul Kanwar, Amit A Kulkarni, Anna Karpathakis, Veronica Manzo, Tanupriya Contractor, Juliet Philips, Elizabeth Nickerson, Nam Pho, Susanne M Hooshmand, Lauren K Brais, Michael S Lawrence, Trevor Pugh, Aaron McKenna, Andrey Sivachenko, Kristian Cibulskis, Scott L Carter, Akinyemi I Ojesina, Samuel Freeman, Robert T Jones, Douglas Voet, Gordon Saksena, Daniel Auclair, Robert Onofrio, Erica Shefler, Carrie Sougnez, Jonna Grimsby, Lisa Green, Niall Lennon, Tim Meyer, Martyn Caplin, Daniel C Chung, Andreas S Beutler, Shuji Ogino, Christina Thirlwell, Ramesh Shivdasani, Sylvia L Asa, Chris R Harris, Gad Getz, Matthew Kulke, Matthew Meyerson

ABSTRACT

The diagnosed incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, and the underlying genomic mechanisms have not yet been defined. Using exome- and genome-sequence analysis of SI-NETs, we identified recurrent somatic mutations and deletions in CDKN1B, the cyclin-dependent kinase inhibitor gene, which encodes p27. We observed frameshift mutations of CDKN1B in 14 of 180 SI-NETs, and we detected hemizygous deletions encompassing CDKN1B in 7 out of 50 SI-NETs, nominating p27 as a tumor suppressor and implicating cell cycle dysregulation in the etiology of SI-NETs. More... »

PAGES

1483-1486

References to SciGraph publications

  • 2012-06. The landscape of cancer genes and mutational processes in breast cancer in NATURE
  • 2013-03. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples in NATURE BIOTECHNOLOGY
  • 2013-10. Outcome of surgery for ileojejunal neuroendocrine tumors in SURGERY TODAY
  • 2011-01. A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries in GENOME BIOLOGY
  • 2012-06. Sequence analysis of mutations and translocations across breast cancer subtypes in NATURE
  • 2012-06. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer in NATURE GENETICS
  • 2000. Recurrent molecular deletion of the 12p13 region, centromeric to ETV6/TEL, in T-cell prolymphocytic leukemia. in HAEMATOLOGICA
  • 2012-10. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer in NATURE GENETICS
  • 2012-07. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2012-08. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations in NATURE
  • 2004-03. A census of human cancer genes in NATURE REVIEWS CANCER
  • 2012-10. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer in NATURE GENETICS
  • 1997-05. Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes in BRITISH JOURNAL OF CANCER
  • 2009-01. High-resolution mapping of copy-number alterations with massively parallel sequencing in NATURE METHODS
  • 2013-07. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2011-04. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers in GENOME BIOLOGY
  • 1998-11. The murine gene p27Kip1 is haplo-insufficient for tumour suppression in NATURE
  • 2011-05. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2821

    DOI

    http://dx.doi.org/10.1038/ng.2821

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031454446

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24185511


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin-Dependent Kinase Inhibitor p27", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Tumor Suppressor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestinal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestine, Small", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuroendocrine Tumors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, DNA", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA.", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Francis", 
            "givenName": "Joshua M", 
            "id": "sg:person.0744302314.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744302314.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kiezun", 
            "givenName": "Adam", 
            "id": "sg:person.01274672135.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274672135.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA.", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramos", 
            "givenName": "Alex H", 
            "id": "sg:person.01260766452.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260766452.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "Department of Pathology, University Health Network, Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serra", 
            "givenName": "Stefano", 
            "id": "sg:person.01356517305.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356517305.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA.", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pedamallu", 
            "givenName": "Chandra Sekhar", 
            "id": "sg:person.01311124344.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311124344.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qian", 
            "givenName": "Zhi Rong", 
            "id": "sg:person.01074021634.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074021634.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.", 
                "Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Banck", 
            "givenName": "Michaela S", 
            "id": "sg:person.01217155410.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217155410.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanwar", 
            "givenName": "Rahul", 
            "id": "sg:person.0730470361.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730470361.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kulkarni", 
            "givenName": "Amit A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Royal Free Hospital", 
              "id": "https://www.grid.ac/institutes/grid.426108.9", 
              "name": [
                "University College London Cancer Institute, London, UK.", 
                "Royal Free Hospital NET Unit, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karpathakis", 
            "givenName": "Anna", 
            "id": "sg:person.01101161465.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101161465.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manzo", 
            "givenName": "Veronica", 
            "id": "sg:person.01243442767.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243442767.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Raymond and Beverly Sackler Foundation, New Brunswick, New Jersey, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Contractor", 
            "givenName": "Tanupriya", 
            "id": "sg:person.0656705057.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656705057.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Philips", 
            "givenName": "Juliet", 
            "id": "sg:person.01050567544.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050567544.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nickerson", 
            "givenName": "Elizabeth", 
            "id": "sg:person.01132741370.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132741370.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pho", 
            "givenName": "Nam", 
            "id": "sg:person.0736306067.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736306067.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hooshmand", 
            "givenName": "Susanne M", 
            "id": "sg:person.010647675207.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010647675207.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brais", 
            "givenName": "Lauren K", 
            "id": "sg:person.0770064244.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770064244.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lawrence", 
            "givenName": "Michael S", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pugh", 
            "givenName": "Trevor", 
            "id": "sg:person.011314310445.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314310445.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "McKenna", 
            "givenName": "Aaron", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sivachenko", 
            "givenName": "Andrey", 
            "id": "sg:person.0715340031.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715340031.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cibulskis", 
            "givenName": "Kristian", 
            "id": "sg:person.01217611000.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217611000.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carter", 
            "givenName": "Scott L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA.", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ojesina", 
            "givenName": "Akinyemi I", 
            "id": "sg:person.0774567405.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774567405.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Freeman", 
            "givenName": "Samuel", 
            "id": "sg:person.0575461106.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575461106.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jones", 
            "givenName": "Robert T", 
            "id": "sg:person.01333163466.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333163466.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Voet", 
            "givenName": "Douglas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saksena", 
            "givenName": "Gordon", 
            "id": "sg:person.01027152075.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027152075.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Auclair", 
            "givenName": "Daniel", 
            "id": "sg:person.01237362200.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237362200.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onofrio", 
            "givenName": "Robert", 
            "id": "sg:person.01234470615.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234470615.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shefler", 
            "givenName": "Erica", 
            "id": "sg:person.01075022055.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075022055.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sougnez", 
            "givenName": "Carrie", 
            "id": "sg:person.0727475244.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727475244.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grimsby", 
            "givenName": "Jonna", 
            "id": "sg:person.01112545240.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112545240.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Green", 
            "givenName": "Lisa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lennon", 
            "givenName": "Niall", 
            "id": "sg:person.01150562060.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150562060.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Royal Free Hospital", 
              "id": "https://www.grid.ac/institutes/grid.426108.9", 
              "name": [
                "University College London Cancer Institute, London, UK.", 
                "Royal Free Hospital NET Unit, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meyer", 
            "givenName": "Tim", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Royal Free Hospital", 
              "id": "https://www.grid.ac/institutes/grid.426108.9", 
              "name": [
                "Royal Free Hospital NET Unit, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caplin", 
            "givenName": "Martyn", 
            "id": "sg:person.01257175430.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257175430.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.", 
                "Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chung", 
            "givenName": "Daniel C", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.", 
                "Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beutler", 
            "givenName": "Andreas S", 
            "id": "sg:person.01343507161.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343507161.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.", 
                "Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.", 
                "Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogino", 
            "givenName": "Shuji", 
            "id": "sg:person.01006336021.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006336021.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Royal Free Hospital", 
              "id": "https://www.grid.ac/institutes/grid.426108.9", 
              "name": [
                "University College London Cancer Institute, London, UK.", 
                "Royal Free Hospital NET Unit, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thirlwell", 
            "givenName": "Christina", 
            "id": "sg:person.01263550671.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263550671.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shivdasani", 
            "givenName": "Ramesh", 
            "id": "sg:person.0666246216.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666246216.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Department of Pathology, University Health Network, Toronto, Ontario, Canada.", 
                "Ontario Cancer Institute, University of Toronto, Ontario, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Asa", 
            "givenName": "Sylvia L", 
            "id": "sg:person.016052605457.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016052605457.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rutgers University", 
              "id": "https://www.grid.ac/institutes/grid.430387.b", 
              "name": [
                "Raymond and Beverly Sackler Foundation, New Brunswick, New Jersey, USA.", 
                "Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.", 
                "Department of Pediatrics, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harris", 
            "givenName": "Chris R", 
            "id": "sg:person.0773133457.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773133457.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Getz", 
            "givenName": "Gad", 
            "id": "sg:person.01316313531.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kulke", 
            "givenName": "Matthew", 
            "id": "sg:person.012555161017.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012555161017.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA.", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.", 
                "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meyerson", 
            "givenName": "Matthew", 
            "id": "sg:person.016012142422.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012142422.14"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.1200609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000382958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000477771", 
              "https://doi.org/10.1038/nbt.2514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90572-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004129838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0503484102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006413454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0408836102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006707059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-09-307942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009256840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010244476", 
              "https://doi.org/10.1038/ng.806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci67963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010674005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.05.078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010850948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/jto.0b013e3181a94af4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011894909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012031985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1997.214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012142499", 
              "https://doi.org/10.1038/bjc.1997.214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1997.214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012142499", 
              "https://doi.org/10.1038/bjc.1997.214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90573-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015252677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2012-0350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018406239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0603877103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019106210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1219580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020078844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1219580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020078844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020829840", 
              "https://doi.org/10.1038/ng.2279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021761707", 
              "https://doi.org/10.1038/nature12213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022731034", 
              "https://doi.org/10.1038/nrc1299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022731034", 
              "https://doi.org/10.1038/nrc1299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81239-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024367811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942368", 
              "https://doi.org/10.1038/nature11412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1848209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00595-012-0408-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025002050", 
              "https://doi.org/10.1007/s00595-012-0408-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025333243", 
              "https://doi.org/10.1038/nmeth.1276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2264(199907)25:3<270::aid-gcc9>3.0.co;2-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025387063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027243747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027243747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029691008", 
              "https://doi.org/10.1038/ng.2396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/24179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030795983", 
              "https://doi.org/10.1038/24179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/24179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030795983", 
              "https://doi.org/10.1038/24179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1113205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031166230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032375178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034041413", 
              "https://doi.org/10.1038/nature11017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034586473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034586473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0407693101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035767870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-4-r41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036416165", 
              "https://doi.org/10.1186/gb-2011-12-4-r41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-06-095570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036742835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036846543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036872856", 
              "https://doi.org/10.1038/nature11329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.22.7.2204-2219.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037695908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043035086", 
              "https://doi.org/10.1038/ng.2405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043144872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81237-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045077598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-1-r1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045286538", 
              "https://doi.org/10.1186/gb-2011-12-1-r1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81238-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049084210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049222218", 
              "https://doi.org/10.1038/nature11154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e3181ebaffd", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050617799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e3181ebaffd", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050617799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.thj.6200008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056649283", 
              "https://doi.org/10.1038/sj.thj.6200008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1138764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062455244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.6004/jnccn.2011.0118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078486554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.6004/jnccn.2011.0118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078486554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082549091", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082886167", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-12", 
        "datePublishedReg": "2013-12-01", 
        "description": "The diagnosed incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, and the underlying genomic mechanisms have not yet been defined. Using exome- and genome-sequence analysis of SI-NETs, we identified recurrent somatic mutations and deletions in CDKN1B, the cyclin-dependent kinase inhibitor gene, which encodes p27. We observed frameshift mutations of CDKN1B in 14 of 180 SI-NETs, and we detected hemizygous deletions encompassing CDKN1B in 7 out of 50 SI-NETs, nominating p27 as a tumor suppressor and implicating cell cycle dysregulation in the etiology of SI-NETs. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ng.2821", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5137704", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438813", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440224", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "45"
          }
        ], 
        "name": "Somatic mutation of CDKN1B in small intestine neuroendocrine tumors", 
        "pagination": "1483-1486", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "95d79dc420c9f0288fc3dba80c1444180293b733f9019e0dc9ed9e97778bff2c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24185511"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.2821"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031454446"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.2821", 
          "https://app.dimensions.ai/details/publication/pub.1031454446"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/ng.2821"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2821'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2821'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2821'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2821'


     

    This table displays all metadata directly associated to this object as RDF triples.

    639 TRIPLES      21 PREDICATES      91 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.2821 schema:about N0cf6e881dd9340fd85e389f7e3b5e22a
    2 N171eabb3618f404a9b35ca02b9ef076c
    3 N304d5386f4a144649ea05cef4ea53f70
    4 N33ab8ee6031643dd87488eb2f14cf834
    5 N464c2999c7e34ca98bc558e603114433
    6 N49081c992c2a44319eccd782a0878f77
    7 N54118dfb63ad4522b245f47616a0a6ce
    8 N6c4fe97c210e41cd8db39ecd27729b99
    9 N9d4778cff92c49c98edcffab22002627
    10 Ndaca2178b5bd44d39d5cce29011c5f85
    11 Ne5487bab233341eea25f82df5970201a
    12 anzsrc-for:06
    13 anzsrc-for:0604
    14 schema:author Ne02dcb9ab62e4ad0ad8fc872160b6b05
    15 schema:citation sg:pub.10.1007/s00595-012-0408-1
    16 sg:pub.10.1038/24179
    17 sg:pub.10.1038/bjc.1997.214
    18 sg:pub.10.1038/nature11017
    19 sg:pub.10.1038/nature11154
    20 sg:pub.10.1038/nature11252
    21 sg:pub.10.1038/nature11329
    22 sg:pub.10.1038/nature11412
    23 sg:pub.10.1038/nature12213
    24 sg:pub.10.1038/nbt.2514
    25 sg:pub.10.1038/ng.2279
    26 sg:pub.10.1038/ng.2396
    27 sg:pub.10.1038/ng.2405
    28 sg:pub.10.1038/ng.806
    29 sg:pub.10.1038/nmeth.1276
    30 sg:pub.10.1038/nrc1299
    31 sg:pub.10.1038/sj.thj.6200008
    32 sg:pub.10.1186/gb-2011-12-1-r1
    33 sg:pub.10.1186/gb-2011-12-4-r41
    34 https://app.dimensions.ai/details/publication/pub.1082549091
    35 https://app.dimensions.ai/details/publication/pub.1082886167
    36 https://doi.org/10.1002/(sici)1098-2264(199907)25:3<270::aid-gcc9>3.0.co;2-z
    37 https://doi.org/10.1002/gcc.20561
    38 https://doi.org/10.1002/gcc.20834
    39 https://doi.org/10.1016/0092-8674(94)90572-x
    40 https://doi.org/10.1016/0092-8674(94)90573-8
    41 https://doi.org/10.1016/j.cell.2012.08.029
    42 https://doi.org/10.1016/s0092-8674(00)81237-4
    43 https://doi.org/10.1016/s0092-8674(00)81238-6
    44 https://doi.org/10.1016/s0092-8674(00)81239-8
    45 https://doi.org/10.1053/j.gastro.2010.05.078
    46 https://doi.org/10.1056/nejmoa1113205
    47 https://doi.org/10.1073/pnas.0407693101
    48 https://doi.org/10.1073/pnas.0408836102
    49 https://doi.org/10.1073/pnas.0503484102
    50 https://doi.org/10.1073/pnas.0603877103
    51 https://doi.org/10.1093/bioinformatics/btp698
    52 https://doi.org/10.1093/bioinformatics/bts271
    53 https://doi.org/10.1097/jto.0b013e3181a94af4
    54 https://doi.org/10.1097/mpa.0b013e3181ebaffd
    55 https://doi.org/10.1101/gad.1848209
    56 https://doi.org/10.1126/science.1138764
    57 https://doi.org/10.1126/science.1200609
    58 https://doi.org/10.1126/science.1219580
    59 https://doi.org/10.1128/mcb.22.7.2204-2219.2002
    60 https://doi.org/10.1158/2159-8290.cd-11-0031
    61 https://doi.org/10.1172/jci67963
    62 https://doi.org/10.1182/blood-2007-06-095570
    63 https://doi.org/10.1182/blood-2010-09-307942
    64 https://doi.org/10.1634/theoncologist.2012-0350
    65 https://doi.org/10.6004/jnccn.2011.0118
    66 schema:datePublished 2013-12
    67 schema:datePublishedReg 2013-12-01
    68 schema:description The diagnosed incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, and the underlying genomic mechanisms have not yet been defined. Using exome- and genome-sequence analysis of SI-NETs, we identified recurrent somatic mutations and deletions in CDKN1B, the cyclin-dependent kinase inhibitor gene, which encodes p27. We observed frameshift mutations of CDKN1B in 14 of 180 SI-NETs, and we detected hemizygous deletions encompassing CDKN1B in 7 out of 50 SI-NETs, nominating p27 as a tumor suppressor and implicating cell cycle dysregulation in the etiology of SI-NETs.
    69 schema:genre research_article
    70 schema:inLanguage en
    71 schema:isAccessibleForFree true
    72 schema:isPartOf N3f8a257a803e4f7a88f731ea5d70f829
    73 N68858491e247430cb195304ba2064adb
    74 sg:journal.1103138
    75 schema:name Somatic mutation of CDKN1B in small intestine neuroendocrine tumors
    76 schema:pagination 1483-1486
    77 schema:productId N2d974e0df0114c69995b0a9b2dc4df04
    78 N40a37aac48d6454e8d5f0756a6594de1
    79 N5233689d48294663ae31e992b03cbc03
    80 N9b033ca4610c481d8508ae9b1da9058e
    81 Ne41e7c15f3864c6d8af68f9b82fe9ada
    82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031454446
    83 https://doi.org/10.1038/ng.2821
    84 schema:sdDatePublished 2019-04-10T16:29
    85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    86 schema:sdPublisher Nc0b187d998464d4dbc830df56f208a38
    87 schema:url http://www.nature.com/articles/ng.2821
    88 sgo:license sg:explorer/license/
    89 sgo:sdDataset articles
    90 rdf:type schema:ScholarlyArticle
    91 N094a6bcc9217454aaf90885fcf681d72 rdf:first sg:person.01260766452.93
    92 rdf:rest N8522eba03eb541949b340625c38bb6dc
    93 N0cf6e881dd9340fd85e389f7e3b5e22a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Cyclin-Dependent Kinase Inhibitor p27
    95 rdf:type schema:DefinedTerm
    96 N0eb06a44c971409c87f8601c28d9afa6 rdf:first sg:person.01217611000.46
    97 rdf:rest N5458b9055ccf4318b42a9fb9322315e0
    98 N0f8cf1e46213402dbe57db77646e5cbc rdf:first N595c4b420bc84fe4b0489def91942102
    99 rdf:rest N54652853550b48708d3f16ff8d845f8d
    100 N1069f81154ef4c2e989385f5a0c181e1 rdf:first sg:person.01050567544.20
    101 rdf:rest Nf2acef155d804b10a010ebe92e1d8afe
    102 N154c2c0041f0423a94f4715350fe486e rdf:first sg:person.01006336021.57
    103 rdf:rest Nc99e07b3d0a24661811723e7efdc2f24
    104 N171eabb3618f404a9b35ca02b9ef076c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Neuroendocrine Tumors
    106 rdf:type schema:DefinedTerm
    107 N224b1cc9914d465daa1e82dd25295c72 rdf:first sg:person.0715340031.86
    108 rdf:rest N0eb06a44c971409c87f8601c28d9afa6
    109 N2916d5d9f2bf4f728d66efa84f889065 rdf:first sg:person.0656705057.22
    110 rdf:rest N1069f81154ef4c2e989385f5a0c181e1
    111 N2bc9e99294bd4ec484a3e57984588ff1 rdf:first sg:person.01101161465.51
    112 rdf:rest Ne143714ceae04c0e995655ec3d82d56f
    113 N2d974e0df0114c69995b0a9b2dc4df04 schema:name nlm_unique_id
    114 schema:value 9216904
    115 rdf:type schema:PropertyValue
    116 N2f77c62767be405c975ded433f7ca873 rdf:first sg:person.01075022055.19
    117 rdf:rest Ncd09bdb915ae4d5ea558ea335241df56
    118 N304d5386f4a144649ea05cef4ea53f70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Genetic Predisposition to Disease
    120 rdf:type schema:DefinedTerm
    121 N30e80146cfd04125b6d45952b141b581 rdf:first sg:person.0770064244.43
    122 rdf:rest N46f8103d3a114f7b9a412d0d9738c393
    123 N310992803a4e4060b500d9a8b7c25deb rdf:first sg:person.01112545240.63
    124 rdf:rest N0f8cf1e46213402dbe57db77646e5cbc
    125 N33ab8ee6031643dd87488eb2f14cf834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Cell Cycle
    127 rdf:type schema:DefinedTerm
    128 N36f67712480b47518cfcae1358a73625 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    129 schema:familyName Kulkarni
    130 schema:givenName Amit A
    131 rdf:type schema:Person
    132 N3ba17aa03fd043e6a19e1fc2dac1b9db schema:affiliation https://www.grid.ac/institutes/grid.426108.9
    133 schema:familyName Meyer
    134 schema:givenName Tim
    135 rdf:type schema:Person
    136 N3f8a257a803e4f7a88f731ea5d70f829 schema:volumeNumber 45
    137 rdf:type schema:PublicationVolume
    138 N40a37aac48d6454e8d5f0756a6594de1 schema:name readcube_id
    139 schema:value 95d79dc420c9f0288fc3dba80c1444180293b733f9019e0dc9ed9e97778bff2c
    140 rdf:type schema:PropertyValue
    141 N41840f6d95404afeb79419159eb703bf schema:name Raymond and Beverly Sackler Foundation, New Brunswick, New Jersey, USA.
    142 rdf:type schema:Organization
    143 N434d0086fcce44eabf8db6a1b2951ab3 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    144 schema:familyName Carter
    145 schema:givenName Scott L
    146 rdf:type schema:Person
    147 N4556fa1670f8471f81d31ae7207755ac rdf:first sg:person.016012142422.14
    148 rdf:rest rdf:nil
    149 N464c2999c7e34ca98bc558e603114433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Sequence Analysis, DNA
    151 rdf:type schema:DefinedTerm
    152 N46f3fc84f2a44264a8848b45ae1c3ef3 rdf:first sg:person.0730470361.05
    153 rdf:rest N6abe77a6c0b348a98738c46d752d7ff1
    154 N46f8103d3a114f7b9a412d0d9738c393 rdf:first N85a398e2d89d470b9aaff03f47aaa1d4
    155 rdf:rest N6059c95a71a54896b22eee79691aeda6
    156 N475ae32e3437410097745ff23d63137a rdf:first sg:person.0736306067.78
    157 rdf:rest N8016317daec04d7e937aeda478bb3ca6
    158 N49081c992c2a44319eccd782a0878f77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Genes, Tumor Suppressor
    160 rdf:type schema:DefinedTerm
    161 N5233689d48294663ae31e992b03cbc03 schema:name dimensions_id
    162 schema:value pub.1031454446
    163 rdf:type schema:PropertyValue
    164 N54118dfb63ad4522b245f47616a0a6ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Humans
    166 rdf:type schema:DefinedTerm
    167 N5458b9055ccf4318b42a9fb9322315e0 rdf:first N434d0086fcce44eabf8db6a1b2951ab3
    168 rdf:rest Nfdcc43cb1a19405898ddaa36088a1537
    169 N54652853550b48708d3f16ff8d845f8d rdf:first sg:person.01150562060.69
    170 rdf:rest Nf0c1419c33454b5cb81321de591c2fa9
    171 N595c4b420bc84fe4b0489def91942102 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    172 schema:familyName Green
    173 schema:givenName Lisa
    174 rdf:type schema:Person
    175 N6059c95a71a54896b22eee79691aeda6 rdf:first sg:person.011314310445.23
    176 rdf:rest N8135c7f8cce04920b2275f2a8d67730f
    177 N6773ed9353f94ce69f5452b0ae49bea3 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    178 schema:familyName McKenna
    179 schema:givenName Aaron
    180 rdf:type schema:Person
    181 N68858491e247430cb195304ba2064adb schema:issueNumber 12
    182 rdf:type schema:PublicationIssue
    183 N6abe77a6c0b348a98738c46d752d7ff1 rdf:first N36f67712480b47518cfcae1358a73625
    184 rdf:rest N2bc9e99294bd4ec484a3e57984588ff1
    185 N6c4fe97c210e41cd8db39ecd27729b99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Mutation
    187 rdf:type schema:DefinedTerm
    188 N6e423f111eae4cd19b83566730900ac7 rdf:first sg:person.01074021634.28
    189 rdf:rest Nd1d8f9464a1149579728c9d169919db8
    190 N77ed0de5785d472f85946c60e46336be rdf:first sg:person.01333163466.04
    191 rdf:rest Na02ee68701ee40d58b4f19f28d2c42c4
    192 N8016317daec04d7e937aeda478bb3ca6 rdf:first sg:person.010647675207.42
    193 rdf:rest N30e80146cfd04125b6d45952b141b581
    194 N8135c7f8cce04920b2275f2a8d67730f rdf:first N6773ed9353f94ce69f5452b0ae49bea3
    195 rdf:rest N224b1cc9914d465daa1e82dd25295c72
    196 N817c392767764beda001931ae0f802e1 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
    197 schema:familyName Chung
    198 schema:givenName Daniel C
    199 rdf:type schema:Person
    200 N82ef4d9491834385a45806388b9adadc schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    201 schema:familyName Voet
    202 schema:givenName Douglas
    203 rdf:type schema:Person
    204 N8522eba03eb541949b340625c38bb6dc rdf:first sg:person.01356517305.97
    205 rdf:rest Ne940e6c24f60495593fc4b24dd2b4b89
    206 N85a398e2d89d470b9aaff03f47aaa1d4 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    207 schema:familyName Lawrence
    208 schema:givenName Michael S
    209 rdf:type schema:Person
    210 N95403d134e58426fa8cdd6b6411b7223 rdf:first sg:person.01257175430.09
    211 rdf:rest Nfbc239076fb4429b88519a39459ddc70
    212 N9ab5f182c6cd44a5b29578fdc48b4b72 rdf:first sg:person.01316313531.32
    213 rdf:rest Ne2fdeecac90c49758022d20288035cae
    214 N9b033ca4610c481d8508ae9b1da9058e schema:name doi
    215 schema:value 10.1038/ng.2821
    216 rdf:type schema:PropertyValue
    217 N9d4778cff92c49c98edcffab22002627 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Cohort Studies
    219 rdf:type schema:DefinedTerm
    220 Na02ee68701ee40d58b4f19f28d2c42c4 rdf:first N82ef4d9491834385a45806388b9adadc
    221 rdf:rest Nada8354c6de84779a398017d15a96cc8
    222 Na651bd4a0b554d9da991e9fcceb7e26b rdf:first sg:person.0666246216.28
    223 rdf:rest Nd63562dd424949a3956d1dee5f7664ee
    224 Nada8354c6de84779a398017d15a96cc8 rdf:first sg:person.01027152075.90
    225 rdf:rest Nd796e7f4ba704824ae43f38d915f5329
    226 Nbb2ec5eadf8a4356a3f60451dba4a1e8 rdf:first sg:person.01274672135.88
    227 rdf:rest N094a6bcc9217454aaf90885fcf681d72
    228 Nc0b187d998464d4dbc830df56f208a38 schema:name Springer Nature - SN SciGraph project
    229 rdf:type schema:Organization
    230 Nc99e07b3d0a24661811723e7efdc2f24 rdf:first sg:person.01263550671.67
    231 rdf:rest Na651bd4a0b554d9da991e9fcceb7e26b
    232 Ncd09bdb915ae4d5ea558ea335241df56 rdf:first sg:person.0727475244.45
    233 rdf:rest N310992803a4e4060b500d9a8b7c25deb
    234 Nd1d8f9464a1149579728c9d169919db8 rdf:first sg:person.01217155410.27
    235 rdf:rest N46f3fc84f2a44264a8848b45ae1c3ef3
    236 Nd35d1d508772425d8bd2f71a6dee39db rdf:first sg:person.01343507161.52
    237 rdf:rest N154c2c0041f0423a94f4715350fe486e
    238 Nd63562dd424949a3956d1dee5f7664ee rdf:first sg:person.016052605457.32
    239 rdf:rest Nf4365f0ec2424b3fa33e6fe7bafb0a44
    240 Nd796e7f4ba704824ae43f38d915f5329 rdf:first sg:person.01237362200.80
    241 rdf:rest Nf377d452768d446495df251cc34e249a
    242 Ndaca2178b5bd44d39d5cce29011c5f85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Intestinal Neoplasms
    244 rdf:type schema:DefinedTerm
    245 Ne02dcb9ab62e4ad0ad8fc872160b6b05 rdf:first sg:person.0744302314.40
    246 rdf:rest Nbb2ec5eadf8a4356a3f60451dba4a1e8
    247 Ne06c81ab6df84f5c884ca74122eacad3 rdf:first sg:person.0575461106.51
    248 rdf:rest N77ed0de5785d472f85946c60e46336be
    249 Ne143714ceae04c0e995655ec3d82d56f rdf:first sg:person.01243442767.09
    250 rdf:rest N2916d5d9f2bf4f728d66efa84f889065
    251 Ne2fdeecac90c49758022d20288035cae rdf:first sg:person.012555161017.38
    252 rdf:rest N4556fa1670f8471f81d31ae7207755ac
    253 Ne41e7c15f3864c6d8af68f9b82fe9ada schema:name pubmed_id
    254 schema:value 24185511
    255 rdf:type schema:PropertyValue
    256 Ne5487bab233341eea25f82df5970201a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Intestine, Small
    258 rdf:type schema:DefinedTerm
    259 Ne940e6c24f60495593fc4b24dd2b4b89 rdf:first sg:person.01311124344.08
    260 rdf:rest N6e423f111eae4cd19b83566730900ac7
    261 Nf0c1419c33454b5cb81321de591c2fa9 rdf:first N3ba17aa03fd043e6a19e1fc2dac1b9db
    262 rdf:rest N95403d134e58426fa8cdd6b6411b7223
    263 Nf2acef155d804b10a010ebe92e1d8afe rdf:first sg:person.01132741370.54
    264 rdf:rest N475ae32e3437410097745ff23d63137a
    265 Nf377d452768d446495df251cc34e249a rdf:first sg:person.01234470615.07
    266 rdf:rest N2f77c62767be405c975ded433f7ca873
    267 Nf4365f0ec2424b3fa33e6fe7bafb0a44 rdf:first sg:person.0773133457.04
    268 rdf:rest N9ab5f182c6cd44a5b29578fdc48b4b72
    269 Nfbc239076fb4429b88519a39459ddc70 rdf:first N817c392767764beda001931ae0f802e1
    270 rdf:rest Nd35d1d508772425d8bd2f71a6dee39db
    271 Nfdcc43cb1a19405898ddaa36088a1537 rdf:first sg:person.0774567405.84
    272 rdf:rest Ne06c81ab6df84f5c884ca74122eacad3
    273 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    274 schema:name Biological Sciences
    275 rdf:type schema:DefinedTerm
    276 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    277 schema:name Genetics
    278 rdf:type schema:DefinedTerm
    279 sg:grant.2438813 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2821
    280 rdf:type schema:MonetaryGrant
    281 sg:grant.2440224 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2821
    282 rdf:type schema:MonetaryGrant
    283 sg:grant.5137704 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2821
    284 rdf:type schema:MonetaryGrant
    285 sg:journal.1103138 schema:issn 1061-4036
    286 1546-1718
    287 schema:name Nature Genetics
    288 rdf:type schema:Periodical
    289 sg:person.01006336021.57 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    290 schema:familyName Ogino
    291 schema:givenName Shuji
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006336021.57
    293 rdf:type schema:Person
    294 sg:person.01027152075.90 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    295 schema:familyName Saksena
    296 schema:givenName Gordon
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027152075.90
    298 rdf:type schema:Person
    299 sg:person.01050567544.20 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    300 schema:familyName Philips
    301 schema:givenName Juliet
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050567544.20
    303 rdf:type schema:Person
    304 sg:person.010647675207.42 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    305 schema:familyName Hooshmand
    306 schema:givenName Susanne M
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010647675207.42
    308 rdf:type schema:Person
    309 sg:person.01074021634.28 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    310 schema:familyName Qian
    311 schema:givenName Zhi Rong
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074021634.28
    313 rdf:type schema:Person
    314 sg:person.01075022055.19 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    315 schema:familyName Shefler
    316 schema:givenName Erica
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075022055.19
    318 rdf:type schema:Person
    319 sg:person.01101161465.51 schema:affiliation https://www.grid.ac/institutes/grid.426108.9
    320 schema:familyName Karpathakis
    321 schema:givenName Anna
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101161465.51
    323 rdf:type schema:Person
    324 sg:person.01112545240.63 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    325 schema:familyName Grimsby
    326 schema:givenName Jonna
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112545240.63
    328 rdf:type schema:Person
    329 sg:person.011314310445.23 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    330 schema:familyName Pugh
    331 schema:givenName Trevor
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314310445.23
    333 rdf:type schema:Person
    334 sg:person.01132741370.54 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    335 schema:familyName Nickerson
    336 schema:givenName Elizabeth
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132741370.54
    338 rdf:type schema:Person
    339 sg:person.01150562060.69 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    340 schema:familyName Lennon
    341 schema:givenName Niall
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150562060.69
    343 rdf:type schema:Person
    344 sg:person.01217155410.27 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    345 schema:familyName Banck
    346 schema:givenName Michaela S
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217155410.27
    348 rdf:type schema:Person
    349 sg:person.01217611000.46 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    350 schema:familyName Cibulskis
    351 schema:givenName Kristian
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217611000.46
    353 rdf:type schema:Person
    354 sg:person.01234470615.07 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    355 schema:familyName Onofrio
    356 schema:givenName Robert
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234470615.07
    358 rdf:type schema:Person
    359 sg:person.01237362200.80 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    360 schema:familyName Auclair
    361 schema:givenName Daniel
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237362200.80
    363 rdf:type schema:Person
    364 sg:person.01243442767.09 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    365 schema:familyName Manzo
    366 schema:givenName Veronica
    367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243442767.09
    368 rdf:type schema:Person
    369 sg:person.012555161017.38 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    370 schema:familyName Kulke
    371 schema:givenName Matthew
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012555161017.38
    373 rdf:type schema:Person
    374 sg:person.01257175430.09 schema:affiliation https://www.grid.ac/institutes/grid.426108.9
    375 schema:familyName Caplin
    376 schema:givenName Martyn
    377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257175430.09
    378 rdf:type schema:Person
    379 sg:person.01260766452.93 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    380 schema:familyName Ramos
    381 schema:givenName Alex H
    382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260766452.93
    383 rdf:type schema:Person
    384 sg:person.01263550671.67 schema:affiliation https://www.grid.ac/institutes/grid.426108.9
    385 schema:familyName Thirlwell
    386 schema:givenName Christina
    387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263550671.67
    388 rdf:type schema:Person
    389 sg:person.01274672135.88 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    390 schema:familyName Kiezun
    391 schema:givenName Adam
    392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274672135.88
    393 rdf:type schema:Person
    394 sg:person.01311124344.08 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    395 schema:familyName Pedamallu
    396 schema:givenName Chandra Sekhar
    397 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311124344.08
    398 rdf:type schema:Person
    399 sg:person.01316313531.32 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    400 schema:familyName Getz
    401 schema:givenName Gad
    402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32
    403 rdf:type schema:Person
    404 sg:person.01333163466.04 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    405 schema:familyName Jones
    406 schema:givenName Robert T
    407 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333163466.04
    408 rdf:type schema:Person
    409 sg:person.01343507161.52 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    410 schema:familyName Beutler
    411 schema:givenName Andreas S
    412 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343507161.52
    413 rdf:type schema:Person
    414 sg:person.01356517305.97 schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    415 schema:familyName Serra
    416 schema:givenName Stefano
    417 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356517305.97
    418 rdf:type schema:Person
    419 sg:person.016012142422.14 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    420 schema:familyName Meyerson
    421 schema:givenName Matthew
    422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012142422.14
    423 rdf:type schema:Person
    424 sg:person.016052605457.32 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    425 schema:familyName Asa
    426 schema:givenName Sylvia L
    427 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016052605457.32
    428 rdf:type schema:Person
    429 sg:person.0575461106.51 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    430 schema:familyName Freeman
    431 schema:givenName Samuel
    432 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575461106.51
    433 rdf:type schema:Person
    434 sg:person.0656705057.22 schema:affiliation N41840f6d95404afeb79419159eb703bf
    435 schema:familyName Contractor
    436 schema:givenName Tanupriya
    437 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656705057.22
    438 rdf:type schema:Person
    439 sg:person.0666246216.28 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    440 schema:familyName Shivdasani
    441 schema:givenName Ramesh
    442 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666246216.28
    443 rdf:type schema:Person
    444 sg:person.0715340031.86 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    445 schema:familyName Sivachenko
    446 schema:givenName Andrey
    447 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715340031.86
    448 rdf:type schema:Person
    449 sg:person.0727475244.45 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    450 schema:familyName Sougnez
    451 schema:givenName Carrie
    452 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727475244.45
    453 rdf:type schema:Person
    454 sg:person.0730470361.05 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    455 schema:familyName Kanwar
    456 schema:givenName Rahul
    457 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730470361.05
    458 rdf:type schema:Person
    459 sg:person.0736306067.78 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    460 schema:familyName Pho
    461 schema:givenName Nam
    462 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736306067.78
    463 rdf:type schema:Person
    464 sg:person.0744302314.40 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    465 schema:familyName Francis
    466 schema:givenName Joshua M
    467 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744302314.40
    468 rdf:type schema:Person
    469 sg:person.0770064244.43 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    470 schema:familyName Brais
    471 schema:givenName Lauren K
    472 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770064244.43
    473 rdf:type schema:Person
    474 sg:person.0773133457.04 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
    475 schema:familyName Harris
    476 schema:givenName Chris R
    477 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773133457.04
    478 rdf:type schema:Person
    479 sg:person.0774567405.84 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    480 schema:familyName Ojesina
    481 schema:givenName Akinyemi I
    482 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774567405.84
    483 rdf:type schema:Person
    484 sg:pub.10.1007/s00595-012-0408-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025002050
    485 https://doi.org/10.1007/s00595-012-0408-1
    486 rdf:type schema:CreativeWork
    487 sg:pub.10.1038/24179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030795983
    488 https://doi.org/10.1038/24179
    489 rdf:type schema:CreativeWork
    490 sg:pub.10.1038/bjc.1997.214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012142499
    491 https://doi.org/10.1038/bjc.1997.214
    492 rdf:type schema:CreativeWork
    493 sg:pub.10.1038/nature11017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034041413
    494 https://doi.org/10.1038/nature11017
    495 rdf:type schema:CreativeWork
    496 sg:pub.10.1038/nature11154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049222218
    497 https://doi.org/10.1038/nature11154
    498 rdf:type schema:CreativeWork
    499 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    500 https://doi.org/10.1038/nature11252
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1038/nature11329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036872856
    503 https://doi.org/10.1038/nature11329
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
    506 https://doi.org/10.1038/nature11412
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1038/nature12213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021761707
    509 https://doi.org/10.1038/nature12213
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1038/nbt.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477771
    512 https://doi.org/10.1038/nbt.2514
    513 rdf:type schema:CreativeWork
    514 sg:pub.10.1038/ng.2279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020829840
    515 https://doi.org/10.1038/ng.2279
    516 rdf:type schema:CreativeWork
    517 sg:pub.10.1038/ng.2396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029691008
    518 https://doi.org/10.1038/ng.2396
    519 rdf:type schema:CreativeWork
    520 sg:pub.10.1038/ng.2405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043035086
    521 https://doi.org/10.1038/ng.2405
    522 rdf:type schema:CreativeWork
    523 sg:pub.10.1038/ng.806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010244476
    524 https://doi.org/10.1038/ng.806
    525 rdf:type schema:CreativeWork
    526 sg:pub.10.1038/nmeth.1276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025333243
    527 https://doi.org/10.1038/nmeth.1276
    528 rdf:type schema:CreativeWork
    529 sg:pub.10.1038/nrc1299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022731034
    530 https://doi.org/10.1038/nrc1299
    531 rdf:type schema:CreativeWork
    532 sg:pub.10.1038/sj.thj.6200008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056649283
    533 https://doi.org/10.1038/sj.thj.6200008
    534 rdf:type schema:CreativeWork
    535 sg:pub.10.1186/gb-2011-12-1-r1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045286538
    536 https://doi.org/10.1186/gb-2011-12-1-r1
    537 rdf:type schema:CreativeWork
    538 sg:pub.10.1186/gb-2011-12-4-r41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036416165
    539 https://doi.org/10.1186/gb-2011-12-4-r41
    540 rdf:type schema:CreativeWork
    541 https://app.dimensions.ai/details/publication/pub.1082549091 schema:CreativeWork
    542 https://app.dimensions.ai/details/publication/pub.1082886167 schema:CreativeWork
    543 https://doi.org/10.1002/(sici)1098-2264(199907)25:3<270::aid-gcc9>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1025387063
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1002/gcc.20561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032375178
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1002/gcc.20834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034586473
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1016/0092-8674(94)90572-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004129838
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1016/0092-8674(94)90573-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015252677
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1016/j.cell.2012.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027243747
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1016/s0092-8674(00)81237-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045077598
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1016/s0092-8674(00)81238-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049084210
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1016/s0092-8674(00)81239-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024367811
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1053/j.gastro.2010.05.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010850948
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1056/nejmoa1113205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031166230
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1073/pnas.0407693101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035767870
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1073/pnas.0408836102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006707059
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1073/pnas.0503484102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006413454
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1073/pnas.0603877103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019106210
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1093/bioinformatics/btp698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012031985
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1093/bioinformatics/bts271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036846543
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1097/jto.0b013e3181a94af4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011894909
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1097/mpa.0b013e3181ebaffd schema:sameAs https://app.dimensions.ai/details/publication/pub.1050617799
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1101/gad.1848209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942648
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1126/science.1138764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455244
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1126/science.1200609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000382958
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1126/science.1219580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020078844
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1128/mcb.22.7.2204-2219.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037695908
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1158/2159-8290.cd-11-0031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043144872
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1172/jci67963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010674005
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1182/blood-2007-06-095570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036742835
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1182/blood-2010-09-307942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009256840
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1634/theoncologist.2012-0350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018406239
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.6004/jnccn.2011.0118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078486554
    602 rdf:type schema:CreativeWork
    603 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
    604 schema:name Department of Pathology, University Health Network, Toronto, Ontario, Canada.
    605 Ontario Cancer Institute, University of Toronto, Ontario, Canada.
    606 rdf:type schema:Organization
    607 https://www.grid.ac/institutes/grid.231844.8 schema:alternateName University Health Network
    608 schema:name Department of Pathology, University Health Network, Toronto, Ontario, Canada.
    609 rdf:type schema:Organization
    610 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
    611 schema:name Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
    612 Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
    613 rdf:type schema:Organization
    614 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    615 schema:name Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
    616 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    617 Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    618 rdf:type schema:Organization
    619 https://www.grid.ac/institutes/grid.426108.9 schema:alternateName Royal Free Hospital
    620 schema:name Royal Free Hospital NET Unit, London, UK.
    621 University College London Cancer Institute, London, UK.
    622 rdf:type schema:Organization
    623 https://www.grid.ac/institutes/grid.430387.b schema:alternateName Rutgers University
    624 schema:name Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.
    625 Department of Pediatrics, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.
    626 Raymond and Beverly Sackler Foundation, New Brunswick, New Jersey, USA.
    627 rdf:type schema:Organization
    628 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
    629 schema:name Broad Institute, Cambridge, Massachusetts, USA.
    630 Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    631 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    632 rdf:type schema:Organization
    633 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
    634 schema:name Broad Institute, Cambridge, Massachusetts, USA.
    635 rdf:type schema:Organization
    636 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
    637 schema:name Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
    638 Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, USA.
    639 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...