Pan-cancer patterns of somatic copy number alteration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09-26

AUTHORS

Travis I Zack, Steven E Schumacher, Scott L Carter, Andrew D Cherniack, Gordon Saksena, Barbara Tabak, Michael S Lawrence, Cheng-Zhong Zhang, Jeremiah Wala, Craig H Mermel, Carrie Sougnez, Stacey B Gabriel, Bryan Hernandez, Hui Shen, Peter W Laird, Gad Getz, Matthew Meyerson, Rameen Beroukhim

ABSTRACT

Rameen Beroukhim and colleagues analyzed somatic structural alterations in 12 tumor types. Whole-genome doubling was found in over a third of all cancers, associated with TP53 mutation. Fifteen new significantly mutated candidate driver genes were found associated with recurrently amplified or deleted regions.

PAGES

1134-1140

References to SciGraph publications

  • 2001-08-03. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application in GENOME BIOLOGY
  • 2012-07-18. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2001-03. DNA double-strand breaks: signaling, repair and the cancer connection in NATURE GENETICS
  • 2011-04-28. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers in GENOME BIOLOGY
  • 2012-12-20. DNA Ploidy is an Independent Predictor of Survival in Breast Invasive Ductal Carcinoma: A Long-term Multivariate Analysis of 393 Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2009-04. The cancer genome in NATURE
  • 2012-04-13. Epigenetic protein families: a new frontier for drug discovery in NATURE REVIEWS DRUG DISCOVERY
  • 2013-05-09. Long noncoding RNAs and the genetics of cancer in BRITISH JOURNAL OF CANCER
  • 2012-04-29. Absolute quantification of somatic DNA alterations in human cancer in NATURE BIOTECHNOLOGY
  • 2000-08. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice in NATURE
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2007-12-18. Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data in BMC CANCER
  • 1996-09. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein in NATURE GENETICS
  • 2008-09-07. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs in NATURE GENETICS
  • 2006-08-20. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers in NATURE GENETICS
  • 2010-02. The landscape of somatic copy-number alteration across human cancers in NATURE
  • 2011-01-19. Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells in NATURE
  • 2011-04-05. FOXC1, a target of polycomb, inhibits metastasis of breast cancer cells in BREAST CANCER RESEARCH AND TREATMENT
  • 1996-12. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation in NATURE GENETICS
  • 2007-03-07. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia in NATURE
  • 2009-08-23. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA in NATURE
  • 1985-01. Thermodynamical approach to the traveling salesman problem: An efficient simulation algorithm in JOURNAL OF OPTIMIZATION THEORY AND APPLICATIONS
  • 2009-12. Complex landscapes of somatic rearrangement in human breast cancer genomes in NATURE
  • 2011-04-25. Histone onco-modifications in ONCOGENE
  • 2010-02. Signatures of mutation and selection in the cancer genome in NATURE
  • 2011-11-20. High order chromatin architecture shapes the landscape of chromosomal alterations in cancer in NATURE BIOTECHNOLOGY
  • 2007-10-22. Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays in ONCOGENE
  • 2013-06-02. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-11-04. Characterizing the cancer genome in lung adenocarcinoma in NATURE
  • 2001-09-12. Arrays of DNA-binding sites in GENOME BIOLOGY
  • 2013-06-16. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2012-09-09. Comprehensive genomic characterization of squamous cell lung cancers in NATURE
  • 2011-11-27. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains in NATURE GENETICS
  • 2010-01-11. p53 suppresses structural chromosome instability after mitotic arrest in human cells in ONCOGENE
  • Journal

    TITLE

    Nature Genetics

    ISSUE

    10

    VOLUME

    45

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2760

    DOI

    http://dx.doi.org/10.1038/ng.2760

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042520483

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24071852


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Copy Number Variations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Regulatory Networks", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Association Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutagenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ploidies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Biophysics Program, Harvard University, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA", 
                "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA", 
                "Biophysics Program, Harvard University, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zack", 
            "givenName": "Travis I", 
            "id": "sg:person.0763225213.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763225213.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA", 
                "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schumacher", 
            "givenName": "Steven E", 
            "id": "sg:person.01055166050.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055166050.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carter", 
            "givenName": "Scott L", 
            "id": "sg:person.01300465737.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300465737.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cherniack", 
            "givenName": "Andrew D", 
            "id": "sg:person.01224262616.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224262616.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saksena", 
            "givenName": "Gordon", 
            "id": "sg:person.01027152075.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027152075.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tabak", 
            "givenName": "Barbara", 
            "id": "sg:person.01245317456.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245317456.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lawrence", 
            "givenName": "Michael S", 
            "id": "sg:person.01017523331.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017523331.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Cheng-Zhong", 
            "id": "sg:person.0753202054.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753202054.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA", 
                "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA", 
                "Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA", 
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wala", 
            "givenName": "Jeremiah", 
            "id": "sg:person.01303624731.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303624731.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mermel", 
            "givenName": "Craig H", 
            "id": "sg:person.01066471003.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066471003.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sougnez", 
            "givenName": "Carrie", 
            "id": "sg:person.0727475244.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727475244.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gabriel", 
            "givenName": "Stacey B", 
            "id": "sg:person.012151177437.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012151177437.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hernandez", 
            "givenName": "Bryan", 
            "id": "sg:person.0742562431.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742562431.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "USC Epigenome Center, University of Southern California, Los Angeles, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "USC Epigenome Center, University of Southern California, Los Angeles, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shen", 
            "givenName": "Hui", 
            "id": "sg:person.011125251607.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011125251607.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "USC Epigenome Center, University of Southern California, Los Angeles, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "USC Epigenome Center, University of Southern California, Los Angeles, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laird", 
            "givenName": "Peter W", 
            "id": "sg:person.01235401076.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235401076.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Getz", 
            "givenName": "Gad", 
            "id": "sg:person.01316313531.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA", 
                "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA", 
                "Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meyerson", 
            "givenName": "Matthew", 
            "id": "sg:person.016012142422.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012142422.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Broad Institute, Cambridge, Massachusetts, USA", 
                "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA", 
                "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA", 
                "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beroukhim", 
            "givenName": "Rameen", 
            "id": "sg:person.01310170137.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310170137.53"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/gb-2011-12-4-r41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036416165", 
              "https://doi.org/10.1186/gb-2011-12-4-r41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007920084", 
              "https://doi.org/10.1038/nrd3674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-7-226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000973888", 
              "https://doi.org/10.1186/1471-2407-7-226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-011-1396-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005922842", 
              "https://doi.org/10.1007/s10549-011-1396-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026717592", 
              "https://doi.org/10.1038/nature09733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045642945", 
              "https://doi.org/10.1038/nature08283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003051025", 
              "https://doi.org/10.1038/nbt.2049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1296-415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034201592", 
              "https://doi.org/10.1038/ng1296-415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025727035", 
              "https://doi.org/10.1038/onc.2011.121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35020592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017226982", 
              "https://doi.org/10.1038/35020592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0996-33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047351790", 
              "https://doi.org/10.1038/ng0996-33"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030444175", 
              "https://doi.org/10.1038/ng.237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002735811", 
              "https://doi.org/10.1038/nature08768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004829095", 
              "https://doi.org/10.1038/nature07943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534738", 
              "https://doi.org/10.1038/ng1861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018447895", 
              "https://doi.org/10.1038/ng.969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002215841", 
              "https://doi.org/10.1038/nsmb.2591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029749648", 
              "https://doi.org/10.1038/onc.2009.477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2001-2-10-reports0032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085169177", 
              "https://doi.org/10.1186/gb-2001-2-10-reports0032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036425682", 
              "https://doi.org/10.1038/85798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048499715", 
              "https://doi.org/10.1038/bjc.2013.233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2001-2-8-research0032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015228558", 
              "https://doi.org/10.1186/gb-2001-2-8-research0032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019681472", 
              "https://doi.org/10.1038/nature06358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942368", 
              "https://doi.org/10.1038/nature11412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050729897", 
              "https://doi.org/10.1038/nature08645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006014163", 
              "https://doi.org/10.1038/nature11404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041730631", 
              "https://doi.org/10.1038/sj.onc.1210832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014017146", 
              "https://doi.org/10.1038/nature05690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-012-2804-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028659167", 
              "https://doi.org/10.1245/s10434-012-2804-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010515132", 
              "https://doi.org/10.1038/nbt.2203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021761707", 
              "https://doi.org/10.1038/nature12213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00940812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051937309", 
              "https://doi.org/10.1007/bf00940812"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-09-26", 
        "datePublishedReg": "2013-09-26", 
        "description": "Rameen Beroukhim and colleagues analyzed somatic structural alterations in 12 tumor types. Whole-genome doubling was found in over a third of all cancers, associated with TP53 mutation. Fifteen new significantly mutated candidate driver genes were found associated with recurrently amplified or deleted regions.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ng.2760", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2683815", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2696334", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699070", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699326", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2696338", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2684537", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2696339", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "45"
          }
        ], 
        "keywords": [
          "whole-genome doubling", 
          "candidate driver genes", 
          "somatic copy number alterations", 
          "pan-cancer patterns", 
          "copy number alterations", 
          "driver genes", 
          "number alterations", 
          "structural alterations", 
          "genes", 
          "TP53 mutations", 
          "tumor types", 
          "mutations", 
          "alterations", 
          "region", 
          "doubling", 
          "patterns", 
          "cancer", 
          "types", 
          "third", 
          "colleagues"
        ], 
        "name": "Pan-cancer patterns of somatic copy number alteration", 
        "pagination": "1134-1140", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1042520483"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.2760"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24071852"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.2760", 
          "https://app.dimensions.ai/details/publication/pub.1042520483"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_614.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ng.2760"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2760'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2760'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2760'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2760'


     

    This table displays all metadata directly associated to this object as RDF triples.

    407 TRIPLES      21 PREDICATES      88 URIs      46 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.2760 schema:about N0064ee7b2d1e46d3a0a42289178ccf29
    2 N28648d5e1c384d11a4a22d410f831210
    3 N43972992dbb546b189ac04e804916ed0
    4 N6093ad9fc135411b8c70930e7315509a
    5 N67804c70b399424d8b46640ba2e222d9
    6 N99a8525dc5fd4959ba1b0009f1f3975d
    7 Na6c645b4d7e34199abff1a43b339571a
    8 Nb7b74be8fa464af5abb5b99762da5734
    9 Nd6489d5b1d934a488eddc9e1f71dae90
    10 anzsrc-for:11
    11 anzsrc-for:1112
    12 schema:author Nb41e61cd03784fc68a7d624734089558
    13 schema:citation sg:pub.10.1007/bf00940812
    14 sg:pub.10.1007/s10549-011-1396-3
    15 sg:pub.10.1038/35020592
    16 sg:pub.10.1038/85798
    17 sg:pub.10.1038/bjc.2013.233
    18 sg:pub.10.1038/nature05690
    19 sg:pub.10.1038/nature06358
    20 sg:pub.10.1038/nature07943
    21 sg:pub.10.1038/nature08283
    22 sg:pub.10.1038/nature08645
    23 sg:pub.10.1038/nature08768
    24 sg:pub.10.1038/nature08822
    25 sg:pub.10.1038/nature09733
    26 sg:pub.10.1038/nature11252
    27 sg:pub.10.1038/nature11404
    28 sg:pub.10.1038/nature11412
    29 sg:pub.10.1038/nature12213
    30 sg:pub.10.1038/nbt.2049
    31 sg:pub.10.1038/nbt.2203
    32 sg:pub.10.1038/ng.237
    33 sg:pub.10.1038/ng.969
    34 sg:pub.10.1038/ng0996-33
    35 sg:pub.10.1038/ng1296-415
    36 sg:pub.10.1038/ng1861
    37 sg:pub.10.1038/nrd3674
    38 sg:pub.10.1038/nsmb.2591
    39 sg:pub.10.1038/onc.2009.477
    40 sg:pub.10.1038/onc.2011.121
    41 sg:pub.10.1038/sj.onc.1210832
    42 sg:pub.10.1186/1471-2407-7-226
    43 sg:pub.10.1186/gb-2001-2-10-reports0032
    44 sg:pub.10.1186/gb-2001-2-8-research0032
    45 sg:pub.10.1186/gb-2011-12-4-r41
    46 sg:pub.10.1245/s10434-012-2804-6
    47 schema:datePublished 2013-09-26
    48 schema:datePublishedReg 2013-09-26
    49 schema:description Rameen Beroukhim and colleagues analyzed somatic structural alterations in 12 tumor types. Whole-genome doubling was found in over a third of all cancers, associated with TP53 mutation. Fifteen new significantly mutated candidate driver genes were found associated with recurrently amplified or deleted regions.
    50 schema:genre article
    51 schema:isAccessibleForFree true
    52 schema:isPartOf N3d0101758d594478af61ed11f471d4d4
    53 N66d5d2e8f57a463db99aad9ceef1f949
    54 sg:journal.1103138
    55 schema:keywords TP53 mutations
    56 alterations
    57 cancer
    58 candidate driver genes
    59 colleagues
    60 copy number alterations
    61 doubling
    62 driver genes
    63 genes
    64 mutations
    65 number alterations
    66 pan-cancer patterns
    67 patterns
    68 region
    69 somatic copy number alterations
    70 structural alterations
    71 third
    72 tumor types
    73 types
    74 whole-genome doubling
    75 schema:name Pan-cancer patterns of somatic copy number alteration
    76 schema:pagination 1134-1140
    77 schema:productId Nbb16ea83062e42308d7921e227e2c0a8
    78 Nf782f4c6ec5a4d8896eb5bc7a2b1053c
    79 Nf8d069143d314c498f40ea42caffa66a
    80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042520483
    81 https://doi.org/10.1038/ng.2760
    82 schema:sdDatePublished 2022-10-01T06:39
    83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    84 schema:sdPublisher N791cab4e526e4a09a5b43841d94c52de
    85 schema:url https://doi.org/10.1038/ng.2760
    86 sgo:license sg:explorer/license/
    87 sgo:sdDataset articles
    88 rdf:type schema:ScholarlyArticle
    89 N0064ee7b2d1e46d3a0a42289178ccf29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name DNA Copy Number Variations
    91 rdf:type schema:DefinedTerm
    92 N0326a7ba86894ad7b46fc1a0ee807992 rdf:first sg:person.012151177437.05
    93 rdf:rest Naa35a2255f6c4179b8567b10095d2671
    94 N07c8b6051c4c45a4b1c184a1df659fa3 rdf:first sg:person.01316313531.32
    95 rdf:rest Nc802e29039814ef684228e58c6a3b321
    96 N28648d5e1c384d11a4a22d410f831210 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Ploidies
    98 rdf:type schema:DefinedTerm
    99 N36b1939d304343fd9d78aff0fc5f13a2 rdf:first sg:person.01055166050.55
    100 rdf:rest Na6a542c4460f49b6918747e6c6a296b8
    101 N3d0101758d594478af61ed11f471d4d4 schema:issueNumber 10
    102 rdf:type schema:PublicationIssue
    103 N43972992dbb546b189ac04e804916ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Neoplasms
    105 rdf:type schema:DefinedTerm
    106 N49af8b1cbf2e4299a36804a603435bd3 rdf:first sg:person.011125251607.50
    107 rdf:rest Nfafa59ddc6dc4571a227773dc4d0bf1f
    108 N505e238a0f634fe6aa93f5641ff7c2d9 rdf:first sg:person.01066471003.08
    109 rdf:rest Nff382f22cf9444beaaf31db27e46b882
    110 N6093ad9fc135411b8c70930e7315509a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Epigenesis, Genetic
    112 rdf:type schema:DefinedTerm
    113 N66d5d2e8f57a463db99aad9ceef1f949 schema:volumeNumber 45
    114 rdf:type schema:PublicationVolume
    115 N67804c70b399424d8b46640ba2e222d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Genetic Predisposition to Disease
    117 rdf:type schema:DefinedTerm
    118 N69c4eba05e60410f85543a99b5a7b291 rdf:first sg:person.01245317456.38
    119 rdf:rest Nd5bbc98567bb46dbad87125636213b54
    120 N6e8e38da97cd406cac7c60a65cd8b1d4 rdf:first sg:person.01303624731.38
    121 rdf:rest N505e238a0f634fe6aa93f5641ff7c2d9
    122 N70a13fdabb0749f3babcdbe3781d4017 rdf:first sg:person.01310170137.53
    123 rdf:rest rdf:nil
    124 N746058154d954fdc9ff5d2ccdbf6b36a rdf:first sg:person.01027152075.90
    125 rdf:rest N69c4eba05e60410f85543a99b5a7b291
    126 N791cab4e526e4a09a5b43841d94c52de schema:name Springer Nature - SN SciGraph project
    127 rdf:type schema:Organization
    128 N99a8525dc5fd4959ba1b0009f1f3975d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Genetic Association Studies
    130 rdf:type schema:DefinedTerm
    131 Na6a542c4460f49b6918747e6c6a296b8 rdf:first sg:person.01300465737.85
    132 rdf:rest Ne0ebc253b4b14d38bbf1ff1dcf898968
    133 Na6c645b4d7e34199abff1a43b339571a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Mutagenesis
    135 rdf:type schema:DefinedTerm
    136 Naa35a2255f6c4179b8567b10095d2671 rdf:first sg:person.0742562431.07
    137 rdf:rest N49af8b1cbf2e4299a36804a603435bd3
    138 Nb41e61cd03784fc68a7d624734089558 rdf:first sg:person.0763225213.89
    139 rdf:rest N36b1939d304343fd9d78aff0fc5f13a2
    140 Nb7b74be8fa464af5abb5b99762da5734 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Gene Regulatory Networks
    142 rdf:type schema:DefinedTerm
    143 Nba9591e77e934363a8e580c26654ef7e rdf:first sg:person.0753202054.57
    144 rdf:rest N6e8e38da97cd406cac7c60a65cd8b1d4
    145 Nbb16ea83062e42308d7921e227e2c0a8 schema:name doi
    146 schema:value 10.1038/ng.2760
    147 rdf:type schema:PropertyValue
    148 Nc802e29039814ef684228e58c6a3b321 rdf:first sg:person.016012142422.14
    149 rdf:rest N70a13fdabb0749f3babcdbe3781d4017
    150 Nd5bbc98567bb46dbad87125636213b54 rdf:first sg:person.01017523331.47
    151 rdf:rest Nba9591e77e934363a8e580c26654ef7e
    152 Nd6489d5b1d934a488eddc9e1f71dae90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Humans
    154 rdf:type schema:DefinedTerm
    155 Ne0ebc253b4b14d38bbf1ff1dcf898968 rdf:first sg:person.01224262616.31
    156 rdf:rest N746058154d954fdc9ff5d2ccdbf6b36a
    157 Nf782f4c6ec5a4d8896eb5bc7a2b1053c schema:name pubmed_id
    158 schema:value 24071852
    159 rdf:type schema:PropertyValue
    160 Nf8d069143d314c498f40ea42caffa66a schema:name dimensions_id
    161 schema:value pub.1042520483
    162 rdf:type schema:PropertyValue
    163 Nfafa59ddc6dc4571a227773dc4d0bf1f rdf:first sg:person.01235401076.98
    164 rdf:rest N07c8b6051c4c45a4b1c184a1df659fa3
    165 Nff382f22cf9444beaaf31db27e46b882 rdf:first sg:person.0727475244.45
    166 rdf:rest N0326a7ba86894ad7b46fc1a0ee807992
    167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Medical and Health Sciences
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Oncology and Carcinogenesis
    172 rdf:type schema:DefinedTerm
    173 sg:grant.2683815 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2760
    174 rdf:type schema:MonetaryGrant
    175 sg:grant.2684537 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2760
    176 rdf:type schema:MonetaryGrant
    177 sg:grant.2696334 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2760
    178 rdf:type schema:MonetaryGrant
    179 sg:grant.2696338 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2760
    180 rdf:type schema:MonetaryGrant
    181 sg:grant.2696339 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2760
    182 rdf:type schema:MonetaryGrant
    183 sg:grant.2699070 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2760
    184 rdf:type schema:MonetaryGrant
    185 sg:grant.2699326 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2760
    186 rdf:type schema:MonetaryGrant
    187 sg:journal.1103138 schema:issn 1061-4036
    188 1546-1718
    189 schema:name Nature Genetics
    190 schema:publisher Springer Nature
    191 rdf:type schema:Periodical
    192 sg:person.01017523331.47 schema:affiliation grid-institutes:grid.66859.34
    193 schema:familyName Lawrence
    194 schema:givenName Michael S
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017523331.47
    196 rdf:type schema:Person
    197 sg:person.01027152075.90 schema:affiliation grid-institutes:grid.66859.34
    198 schema:familyName Saksena
    199 schema:givenName Gordon
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027152075.90
    201 rdf:type schema:Person
    202 sg:person.01055166050.55 schema:affiliation grid-institutes:grid.65499.37
    203 schema:familyName Schumacher
    204 schema:givenName Steven E
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055166050.55
    206 rdf:type schema:Person
    207 sg:person.01066471003.08 schema:affiliation grid-institutes:grid.66859.34
    208 schema:familyName Mermel
    209 schema:givenName Craig H
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066471003.08
    211 rdf:type schema:Person
    212 sg:person.011125251607.50 schema:affiliation grid-institutes:grid.42505.36
    213 schema:familyName Shen
    214 schema:givenName Hui
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011125251607.50
    216 rdf:type schema:Person
    217 sg:person.012151177437.05 schema:affiliation grid-institutes:grid.66859.34
    218 schema:familyName Gabriel
    219 schema:givenName Stacey B
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012151177437.05
    221 rdf:type schema:Person
    222 sg:person.01224262616.31 schema:affiliation grid-institutes:grid.66859.34
    223 schema:familyName Cherniack
    224 schema:givenName Andrew D
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224262616.31
    226 rdf:type schema:Person
    227 sg:person.01235401076.98 schema:affiliation grid-institutes:grid.42505.36
    228 schema:familyName Laird
    229 schema:givenName Peter W
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235401076.98
    231 rdf:type schema:Person
    232 sg:person.01245317456.38 schema:affiliation grid-institutes:grid.66859.34
    233 schema:familyName Tabak
    234 schema:givenName Barbara
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245317456.38
    236 rdf:type schema:Person
    237 sg:person.01300465737.85 schema:affiliation grid-institutes:grid.66859.34
    238 schema:familyName Carter
    239 schema:givenName Scott L
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300465737.85
    241 rdf:type schema:Person
    242 sg:person.01303624731.38 schema:affiliation grid-institutes:grid.38142.3c
    243 schema:familyName Wala
    244 schema:givenName Jeremiah
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303624731.38
    246 rdf:type schema:Person
    247 sg:person.01310170137.53 schema:affiliation grid-institutes:grid.38142.3c
    248 schema:familyName Beroukhim
    249 schema:givenName Rameen
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310170137.53
    251 rdf:type schema:Person
    252 sg:person.01316313531.32 schema:affiliation grid-institutes:grid.66859.34
    253 schema:familyName Getz
    254 schema:givenName Gad
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32
    256 rdf:type schema:Person
    257 sg:person.016012142422.14 schema:affiliation grid-institutes:grid.38142.3c
    258 schema:familyName Meyerson
    259 schema:givenName Matthew
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012142422.14
    261 rdf:type schema:Person
    262 sg:person.0727475244.45 schema:affiliation grid-institutes:grid.66859.34
    263 schema:familyName Sougnez
    264 schema:givenName Carrie
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727475244.45
    266 rdf:type schema:Person
    267 sg:person.0742562431.07 schema:affiliation grid-institutes:grid.66859.34
    268 schema:familyName Hernandez
    269 schema:givenName Bryan
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742562431.07
    271 rdf:type schema:Person
    272 sg:person.0753202054.57 schema:affiliation grid-institutes:grid.66859.34
    273 schema:familyName Zhang
    274 schema:givenName Cheng-Zhong
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753202054.57
    276 rdf:type schema:Person
    277 sg:person.0763225213.89 schema:affiliation grid-institutes:grid.38142.3c
    278 schema:familyName Zack
    279 schema:givenName Travis I
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763225213.89
    281 rdf:type schema:Person
    282 sg:pub.10.1007/bf00940812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051937309
    283 https://doi.org/10.1007/bf00940812
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1007/s10549-011-1396-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005922842
    286 https://doi.org/10.1007/s10549-011-1396-3
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/35020592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017226982
    289 https://doi.org/10.1038/35020592
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/85798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036425682
    292 https://doi.org/10.1038/85798
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/bjc.2013.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048499715
    295 https://doi.org/10.1038/bjc.2013.233
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nature05690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014017146
    298 https://doi.org/10.1038/nature05690
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/nature06358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019681472
    301 https://doi.org/10.1038/nature06358
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nature07943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004829095
    304 https://doi.org/10.1038/nature07943
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/nature08283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045642945
    307 https://doi.org/10.1038/nature08283
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/nature08645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050729897
    310 https://doi.org/10.1038/nature08645
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/nature08768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002735811
    313 https://doi.org/10.1038/nature08768
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
    316 https://doi.org/10.1038/nature08822
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/nature09733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026717592
    319 https://doi.org/10.1038/nature09733
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    322 https://doi.org/10.1038/nature11252
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nature11404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006014163
    325 https://doi.org/10.1038/nature11404
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
    328 https://doi.org/10.1038/nature11412
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nature12213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021761707
    331 https://doi.org/10.1038/nature12213
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nbt.2049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003051025
    334 https://doi.org/10.1038/nbt.2049
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nbt.2203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010515132
    337 https://doi.org/10.1038/nbt.2203
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/ng.237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030444175
    340 https://doi.org/10.1038/ng.237
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/ng.969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018447895
    343 https://doi.org/10.1038/ng.969
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/ng0996-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047351790
    346 https://doi.org/10.1038/ng0996-33
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/ng1296-415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034201592
    349 https://doi.org/10.1038/ng1296-415
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/ng1861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534738
    352 https://doi.org/10.1038/ng1861
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nrd3674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007920084
    355 https://doi.org/10.1038/nrd3674
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nsmb.2591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002215841
    358 https://doi.org/10.1038/nsmb.2591
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/onc.2009.477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029749648
    361 https://doi.org/10.1038/onc.2009.477
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/onc.2011.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025727035
    364 https://doi.org/10.1038/onc.2011.121
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/sj.onc.1210832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041730631
    367 https://doi.org/10.1038/sj.onc.1210832
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1186/1471-2407-7-226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000973888
    370 https://doi.org/10.1186/1471-2407-7-226
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1186/gb-2001-2-10-reports0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085169177
    373 https://doi.org/10.1186/gb-2001-2-10-reports0032
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1186/gb-2001-2-8-research0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015228558
    376 https://doi.org/10.1186/gb-2001-2-8-research0032
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1186/gb-2011-12-4-r41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036416165
    379 https://doi.org/10.1186/gb-2011-12-4-r41
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1245/s10434-012-2804-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028659167
    382 https://doi.org/10.1245/s10434-012-2804-6
    383 rdf:type schema:CreativeWork
    384 grid-institutes:grid.38142.3c schema:alternateName Biophysics Program, Harvard University, Boston, Massachusetts, USA
    385 Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
    386 Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    387 Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    388 schema:name Biophysics Program, Harvard University, Boston, Massachusetts, USA
    389 Broad Institute, Cambridge, Massachusetts, USA
    390 Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
    391 Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
    392 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
    393 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
    394 Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    395 Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    396 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    397 rdf:type schema:Organization
    398 grid-institutes:grid.42505.36 schema:alternateName USC Epigenome Center, University of Southern California, Los Angeles, California, USA
    399 schema:name USC Epigenome Center, University of Southern California, Los Angeles, California, USA
    400 rdf:type schema:Organization
    401 grid-institutes:grid.65499.37 schema:alternateName Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
    402 schema:name Broad Institute, Cambridge, Massachusetts, USA
    403 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
    404 rdf:type schema:Organization
    405 grid-institutes:grid.66859.34 schema:alternateName Broad Institute, Cambridge, Massachusetts, USA
    406 schema:name Broad Institute, Cambridge, Massachusetts, USA
    407 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...