An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07-14

AUTHORS

Steven A Roberts, Michael S Lawrence, Leszek J Klimczak, Sara A Grimm, David Fargo, Petar Stojanov, Adam Kiezun, Gregory V Kryukov, Scott L Carter, Gordon Saksena, Shawn Harris, Ruchir R Shah, Michael A Resnick, Gad Getz, Dmitry A Gordenin

ABSTRACT

Dmitry Gordenin, Gad Getz and colleagues report an analysis of mutation patterns in cancer genomes and find evidence of mutagenesis induced by APOBEC cytidine deaminase enzymes. They find an APOBEC mutagenesis pattern in bladder, cervical, breast, head and neck, and lung cancers, representing 68% of all mutations in some samples.

PAGES

970-976

References to SciGraph publications

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  • <error retrieving object. in <ERROR RETRIEVING OBJECT
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2702

    DOI

    http://dx.doi.org/10.1038/ng.2702

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020175364

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23852170


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