An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09

AUTHORS

Steven A Roberts, Michael S Lawrence, Leszek J Klimczak, Sara A Grimm, David Fargo, Petar Stojanov, Adam Kiezun, Gregory V Kryukov, Scott L Carter, Gordon Saksena, Shawn Harris, Ruchir R Shah, Michael A Resnick, Gad Getz, Dmitry A Gordenin

ABSTRACT

Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may induce mutation clusters in human tumors. We show here that throughout cancer genomes APOBEC-mediated mutagenesis is pervasive and correlates with APOBEC mRNA levels. Mutation clusters in whole-genome and exome data sets conformed to the stringent criteria indicative of an APOBEC mutation pattern. Applying these criteria to 954,247 mutations in 2,680 exomes from 14 cancer types, mostly from The Cancer Genome Atlas (TCGA), showed a significant presence of the APOBEC mutation pattern in bladder, cervical, breast, head and neck, and lung cancers, reaching 68% of all mutations in some samples. Within breast cancer, the HER2-enriched subtype was clearly enriched for tumors with the APOBEC mutation pattern, suggesting that this type of mutagenesis is functionally linked with cancer development. The APOBEC mutation pattern also extended to cancer-associated genes, implying that ubiquitous APOBEC-mediated mutagenesis is carcinogenic. More... »

PAGES

970-976

References to SciGraph publications

  • 2012-12. APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells in SCIENTIFIC REPORTS
  • 2005-02. Nature and nurture – lessons from chemical carcinogenesis in NATURE REVIEWS CANCER
  • 2012-06. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer in NATURE GENETICS
  • 2005-09. Gene expression analysis reveals a strong signature of an interferon-induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer in ONCOGENE
  • 2013-02. APOBEC3B is an enzymatic source of mutation in breast cancer in NATURE
  • 2003-08. S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex in NATURE
  • 2005-06. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer in NATURE GENETICS
  • 2011-03. Initial genome sequencing and analysis of multiple myeloma in NATURE
  • 2004-03. A census of human cancer genes in NATURE REVIEWS CANCER
  • 2010-06. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-02. The genomic complexity of primary human prostate cancer in NATURE
  • 2012-11. Evolution of the cancer genome in NATURE REVIEWS GENETICS
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2009-05. Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-10. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2702

    DOI

    http://dx.doi.org/10.1038/ng.2702

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020175364

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23852170


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