Integrated molecular analysis of clear-cell renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06-24

AUTHORS

Yusuke Sato, Tetsuichi Yoshizato, Yuichi Shiraishi, Shigekatsu Maekawa, Yusuke Okuno, Takumi Kamura, Teppei Shimamura, Aiko Sato-Otsubo, Genta Nagae, Hiromichi Suzuki, Yasunobu Nagata, Kenichi Yoshida, Ayana Kon, Yutaka Suzuki, Kenichi Chiba, Hiroko Tanaka, Atsushi Niida, Akihiro Fujimoto, Tatsuhiko Tsunoda, Teppei Morikawa, Daichi Maeda, Haruki Kume, Sumio Sugano, Masashi Fukayama, Hiroyuki Aburatani, Masashi Sanada, Satoru Miyano, Yukio Homma, Seishi Ogawa

ABSTRACT

Seishi Ogawa and colleagues report an integrated genomics analysis of more than 100 clear-cell renal carcinoma samples. They analyze whole genomes or exomes, RNA sequences and DNA methylation in ∼100 paired specimens and perform SNP array-based copy number analysis for 240 specimens. They identify new recurrently mutated pathways and new associations between DNA methylation, mutations, gene expression and copy number profiles. More... »

PAGES

860-867

References to SciGraph publications

  • 2009-05-31. Acquired mutations in TET2 are common in myelodysplastic syndromes in NATURE GENETICS
  • 2012-05-27. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators in NATURE GENETICS
  • 2012-12-09. TET2 promotes histone O-GlcNAcylation during gene transcription in NATURE
  • 2012-06-10. BAP1 loss defines a new class of renal cell carcinoma in NATURE GENETICS
  • 2011-12-04. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma in NATURE GENETICS
  • 2008-12-18. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2011-09-11. Frequent pathway mutations of splicing machinery in myelodysplasia in NATURE
  • 2012-08-26. Exome sequencing of hepatitis B virus–associated hepatocellular carcinoma in NATURE GENETICS
  • 2012-05-27. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma in NATURE GENETICS
  • 1997-10-30. Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma in ONCOGENE
  • 1994-05. Mutations of the VHL tumour suppressor gene in renal carcinoma in NATURE GENETICS
  • 2011-01-19. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma in NATURE
  • 2009-03-15. Human mutation rate associated with DNA replication timing in NATURE GENETICS
  • 2012-07-18. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2013-05-05. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy in NATURE GENETICS
  • 2007-03. Patterns of somatic mutation in human cancer genomes in NATURE
  • 2000-06-01. Plat-E: an efficient and stable system for transient packaging of retroviruses in GENE THERAPY
  • 2010-01-06. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes in NATURE
  • 2012-05-06. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma in NATURE GENETICS
  • Journal

    TITLE

    Nature Genetics

    ISSUE

    8

    VOLUME

    45

    Related Patents

  • Systems And Methods For Identifying Responders And Non-Responders To Immune Checkpoint Blockade Therapy
  • Systems And Methods For Identifying Cancer Treatments From Normalized Biomarker Scores
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Methods And Tools For The Diagnosis And Prognosis Of Urogenital Cancers
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Using Subject Sequencing Data And A Database Of Therapy Biomarker Distributions To Determine Therapy Impact
  • Using Cancer Or Pre-Cancer Subject Sequencing Data And A Database Of Therapy Biomarker Distributions To Determine Normalized Biomarker Scores And Generate A Graphical User Interface
  • Using Subject Sequencing Data And A Database Of Therapy Biomarker Distributions To Determine Normalized Biomarker Scores And Therapy Scores
  • Systems And Methods For Identifying Cancer Treatments From Normalized Biomarker Scores
  • Method For Administering A Checkpoint Blockade Therapy To A Subject
  • Mit Biomarkers And Methods Using The Same
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Using Cancer Or Pre-Cancer Subject Sequencing Data And A Database Of Therapy Biomarker Distributions To Determine Normalized Biomarker Scores And Generate A Graphical User Interface
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Systems And Methods For Generating, Visualizing And Classifying Molecular Functional Profiles
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2699

    DOI

    http://dx.doi.org/10.1038/ng.2699

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023979397

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23797736


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Renal Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cluster Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Copy Number Variations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Elongin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "High-Throughput Nucleotide Sequencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypoxia-Inducible Factor 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
                "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sato", 
            "givenName": "Yusuke", 
            "id": "sg:person.0745671714.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745671714.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshizato", 
            "givenName": "Tetsuichi", 
            "id": "sg:person.0646225667.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646225667.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiraishi", 
            "givenName": "Yuichi", 
            "id": "sg:person.01015664064.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015664064.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
                "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maekawa", 
            "givenName": "Shigekatsu", 
            "id": "sg:person.01062246332.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062246332.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okuno", 
            "givenName": "Yusuke", 
            "id": "sg:person.0717455442.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717455442.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamura", 
            "givenName": "Takumi", 
            "id": "sg:person.01330302270.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330302270.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimamura", 
            "givenName": "Teppei", 
            "id": "sg:person.01004150325.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004150325.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sato-Otsubo", 
            "givenName": "Aiko", 
            "id": "sg:person.01050365066.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050365066.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagae", 
            "givenName": "Genta", 
            "id": "sg:person.0727714666.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727714666.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Hiromichi", 
            "id": "sg:person.0721722331.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721722331.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagata", 
            "givenName": "Yasunobu", 
            "id": "sg:person.0765570642.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765570642.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshida", 
            "givenName": "Kenichi", 
            "id": "sg:person.013055324062.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013055324062.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kon", 
            "givenName": "Ayana", 
            "id": "sg:person.01132112464.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132112464.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Yutaka", 
            "id": "sg:person.016245415444.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016245415444.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chiba", 
            "givenName": "Kenichi", 
            "id": "sg:person.01246341064.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246341064.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Hiroko", 
            "id": "sg:person.016066062624.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016066062624.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niida", 
            "givenName": "Atsushi", 
            "id": "sg:person.0601347253.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601347253.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Genomic Medicine, RIKEN, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.7597.c", 
              "name": [
                "Center for Genomic Medicine, RIKEN, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujimoto", 
            "givenName": "Akihiro", 
            "id": "sg:person.01107361662.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107361662.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Genomic Medicine, RIKEN, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.7597.c", 
              "name": [
                "Center for Genomic Medicine, RIKEN, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsunoda", 
            "givenName": "Tatsuhiko", 
            "id": "sg:person.013516116052.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013516116052.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morikawa", 
            "givenName": "Teppei", 
            "id": "sg:person.01164446451.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164446451.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maeda", 
            "givenName": "Daichi", 
            "id": "sg:person.0644521430.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644521430.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kume", 
            "givenName": "Haruki", 
            "id": "sg:person.0741253071.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741253071.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sugano", 
            "givenName": "Sumio", 
            "id": "sg:person.01364774350.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364774350.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukayama", 
            "givenName": "Masashi", 
            "id": "sg:person.01004770244.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004770244.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aburatani", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.0713466430.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713466430.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
                "Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sanada", 
            "givenName": "Masashi", 
            "id": "sg:person.0620134357.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620134357.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
                "Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyano", 
            "givenName": "Satoru", 
            "id": "sg:person.0701353106.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701353106.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Homma", 
            "givenName": "Yukio", 
            "id": "sg:person.0705167135.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705167135.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan", 
                "Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogawa", 
            "givenName": "Seishi", 
            "id": "sg:person.014513351602.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014513351602.44"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature09639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009539954", 
              "https://doi.org/10.1038/nature09639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042330799", 
              "https://doi.org/10.1038/ng.2295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.1014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031490994", 
              "https://doi.org/10.1038/ng.1014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0594-85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020232019", 
              "https://doi.org/10.1038/ng0594-85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028644962", 
              "https://doi.org/10.1038/ng.2256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050246665", 
              "https://doi.org/10.1038/ng.2391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033482125", 
              "https://doi.org/10.1038/nature05610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044829641", 
              "https://doi.org/10.1038/sj.onc.1201394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039987283", 
              "https://doi.org/10.1038/nprot.2008.211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011180194", 
              "https://doi.org/10.1038/ng.363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11742", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035853848", 
              "https://doi.org/10.1038/nature11742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032864882", 
              "https://doi.org/10.1038/sj.gt.3301206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002477386", 
              "https://doi.org/10.1038/ng.2291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043591147", 
              "https://doi.org/10.1038/ng.2323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048670152", 
              "https://doi.org/10.1038/ng.391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2628", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023030104", 
              "https://doi.org/10.1038/ng.2628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008245757", 
              "https://doi.org/10.1038/nature10496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032969139", 
              "https://doi.org/10.1038/nature08672"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-06-24", 
        "datePublishedReg": "2013-06-24", 
        "description": "Seishi Ogawa and colleagues report an integrated genomics analysis of more than 100 clear-cell renal carcinoma samples. They analyze whole genomes or exomes, RNA sequences and DNA methylation in \u223c100 paired specimens and perform SNP array-based copy number analysis for 240 specimens. They identify new recurrently mutated pathways and new associations between DNA methylation, mutations, gene expression and copy number profiles.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ng.2699", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6121525", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6103938", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6084776", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6131865", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6028873", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6129171", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6076650", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6032585", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6108938", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5793440", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "45"
          }
        ], 
        "keywords": [
          "DNA methylation", 
          "integrated molecular analysis", 
          "array-based copy number analysis", 
          "copy number profiles", 
          "copy number analysis", 
          "renal carcinoma samples", 
          "genomic analysis", 
          "whole genome", 
          "gene expression", 
          "RNA sequences", 
          "clear cell renal cell carcinoma", 
          "molecular analysis", 
          "number analysis", 
          "methylation", 
          "number profiles", 
          "new associations", 
          "genome", 
          "carcinoma samples", 
          "Seishi Ogawa", 
          "exome", 
          "mutations", 
          "pathway", 
          "renal cell carcinoma", 
          "sequence", 
          "expression", 
          "analysis", 
          "specimens", 
          "cell carcinoma", 
          "profile", 
          "association", 
          "carcinoma", 
          "samples", 
          "Ogawa", 
          "colleagues"
        ], 
        "name": "Integrated molecular analysis of clear-cell renal cell carcinoma", 
        "pagination": "860-867", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1023979397"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.2699"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23797736"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.2699", 
          "https://app.dimensions.ai/details/publication/pub.1023979397"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_599.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ng.2699"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2699'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2699'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2699'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2699'


     

    This table displays all metadata directly associated to this object as RDF triples.

    481 TRIPLES      21 PREDICATES      96 URIs      69 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.2699 schema:about N0f8e6cf089d640c98e891b5f283f6881
    2 N1819715beb54483f9f7585ae64b94875
    3 N1a54eff883124267b70aaf975056bf85
    4 N260434176e014cc394dca341179fe8bf
    5 N271ff66ca10a425db50be9499d48ecbc
    6 N27e432caee934ca781767222c94f08e9
    7 N4916c9186ec54872aa65d45c470a08f5
    8 N4a9c31b37b2a43328b55213266bb0f26
    9 N4e7161bec4284802800c89ec9d08c66a
    10 N50d79987c3c544c88df14fec05b8a619
    11 N57914b1d404b4c31bc55b2aec83b1ed4
    12 N5bd1cab8dcde457f8f4ee743124fc72a
    13 N6473ceca26c74b489435345b44b72428
    14 N6b869af300484e87b057fa1faa14ab95
    15 Nbc566c0f202e4ea39ccd584216461b0c
    16 Nc86c1d3da49e49aab7426a215cda8236
    17 Nf068acc07b764cec971953f4bb75679b
    18 Nf645e56730714309b7b8a95a41303eef
    19 anzsrc-for:06
    20 anzsrc-for:0604
    21 schema:author N1c898c3b5a2c4c72be7edb76b7645f8b
    22 schema:citation sg:pub.10.1038/nature05610
    23 sg:pub.10.1038/nature08672
    24 sg:pub.10.1038/nature09639
    25 sg:pub.10.1038/nature10496
    26 sg:pub.10.1038/nature11252
    27 sg:pub.10.1038/nature11742
    28 sg:pub.10.1038/ng.1014
    29 sg:pub.10.1038/ng.2256
    30 sg:pub.10.1038/ng.2291
    31 sg:pub.10.1038/ng.2295
    32 sg:pub.10.1038/ng.2323
    33 sg:pub.10.1038/ng.2391
    34 sg:pub.10.1038/ng.2628
    35 sg:pub.10.1038/ng.363
    36 sg:pub.10.1038/ng.391
    37 sg:pub.10.1038/ng0594-85
    38 sg:pub.10.1038/nprot.2008.211
    39 sg:pub.10.1038/sj.gt.3301206
    40 sg:pub.10.1038/sj.onc.1201394
    41 schema:datePublished 2013-06-24
    42 schema:datePublishedReg 2013-06-24
    43 schema:description Seishi Ogawa and colleagues report an integrated genomics analysis of more than 100 clear-cell renal carcinoma samples. They analyze whole genomes or exomes, RNA sequences and DNA methylation in ∼100 paired specimens and perform SNP array-based copy number analysis for 240 specimens. They identify new recurrently mutated pathways and new associations between DNA methylation, mutations, gene expression and copy number profiles.
    44 schema:genre article
    45 schema:isAccessibleForFree false
    46 schema:isPartOf N8a41573fb5814e7690bddad2d3bd02c5
    47 Nf86a5af9d87a4e888f9434a20413e4d1
    48 sg:journal.1103138
    49 schema:keywords DNA methylation
    50 Ogawa
    51 RNA sequences
    52 Seishi Ogawa
    53 analysis
    54 array-based copy number analysis
    55 association
    56 carcinoma
    57 carcinoma samples
    58 cell carcinoma
    59 clear cell renal cell carcinoma
    60 colleagues
    61 copy number analysis
    62 copy number profiles
    63 exome
    64 expression
    65 gene expression
    66 genome
    67 genomic analysis
    68 integrated molecular analysis
    69 methylation
    70 molecular analysis
    71 mutations
    72 new associations
    73 number analysis
    74 number profiles
    75 pathway
    76 profile
    77 renal carcinoma samples
    78 renal cell carcinoma
    79 samples
    80 sequence
    81 specimens
    82 whole genome
    83 schema:name Integrated molecular analysis of clear-cell renal cell carcinoma
    84 schema:pagination 860-867
    85 schema:productId N686e0a6fd2c54abc800044aecc15de39
    86 N7de99ed2a84c45b4b7b1e9d5fded536e
    87 Ne182af2499bb479b94e0529d8cbbc6a1
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023979397
    89 https://doi.org/10.1038/ng.2699
    90 schema:sdDatePublished 2022-12-01T06:30
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher N5e7fb5609644402e90cf8a70995b2f7e
    93 schema:url https://doi.org/10.1038/ng.2699
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N038d72e6cce340a4a117dace17c1d39f rdf:first sg:person.01004150325.07
    98 rdf:rest Nc27d60dca2914ce980b90b427c0776e2
    99 N04ed2a942aad42568fc4c53ab98f3f62 rdf:first sg:person.01015664064.91
    100 rdf:rest Nac09d8b25a3b4c67a8fae5f17eb8d097
    101 N07428bc3ab7f457385d4938b3dc62b77 rdf:first sg:person.0713466430.47
    102 rdf:rest N471e73e7725a448c9e9dc3972706d4c8
    103 N0f8e6cf089d640c98e891b5f283f6881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Mutation
    105 rdf:type schema:DefinedTerm
    106 N14474c96beda442fb5460195090873eb rdf:first sg:person.0741253071.83
    107 rdf:rest N7ea86b97c10044bf879e336a89767b3f
    108 N1819715beb54483f9f7585ae64b94875 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name High-Throughput Nucleotide Sequencing
    110 rdf:type schema:DefinedTerm
    111 N1a54eff883124267b70aaf975056bf85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name DNA Methylation
    113 rdf:type schema:DefinedTerm
    114 N1c898c3b5a2c4c72be7edb76b7645f8b rdf:first sg:person.0745671714.86
    115 rdf:rest N6945a464c59b437690bca501ae35de1a
    116 N248bccffb927412fa07821e46cb1f4ee rdf:first sg:person.014513351602.44
    117 rdf:rest rdf:nil
    118 N2597161eba2547268ec1a8e3b30b827b rdf:first sg:person.013516116052.47
    119 rdf:rest N900b4f7ed88a43e4abbbbe4dfa04ab01
    120 N260434176e014cc394dca341179fe8bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Cell Line
    122 rdf:type schema:DefinedTerm
    123 N271ff66ca10a425db50be9499d48ecbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Gene Expression Regulation, Neoplastic
    125 rdf:type schema:DefinedTerm
    126 N27e432caee934ca781767222c94f08e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Hypoxia-Inducible Factor 1
    128 rdf:type schema:DefinedTerm
    129 N2bbac4c4d7bd41ef867cc66f7e9dc972 rdf:first sg:person.01004770244.75
    130 rdf:rest N07428bc3ab7f457385d4938b3dc62b77
    131 N31779c1e8c144a0cb19f3b58ad4282c7 rdf:first sg:person.01330302270.71
    132 rdf:rest N038d72e6cce340a4a117dace17c1d39f
    133 N31bf186a96fb42c0a431140c39407377 rdf:first sg:person.0727714666.27
    134 rdf:rest Nd018208333b24428a64c24e688d143c0
    135 N34bc28c3efa84bbe9d189361e7db7683 rdf:first sg:person.0601347253.62
    136 rdf:rest Nd61d82795ab046b4885076e4a7a6f9bd
    137 N471e73e7725a448c9e9dc3972706d4c8 rdf:first sg:person.0620134357.25
    138 rdf:rest Ncf7673b21512495e9a9daebba2f524da
    139 N4916c9186ec54872aa65d45c470a08f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Genomics
    141 rdf:type schema:DefinedTerm
    142 N4a9c31b37b2a43328b55213266bb0f26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Signal Transduction
    144 rdf:type schema:DefinedTerm
    145 N4e7161bec4284802800c89ec9d08c66a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Elongin
    147 rdf:type schema:DefinedTerm
    148 N50d79987c3c544c88df14fec05b8a619 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Genome, Human
    150 rdf:type schema:DefinedTerm
    151 N57914b1d404b4c31bc55b2aec83b1ed4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Exome
    153 rdf:type schema:DefinedTerm
    154 N5bd1cab8dcde457f8f4ee743124fc72a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Transcription Factors
    156 rdf:type schema:DefinedTerm
    157 N5e7fb5609644402e90cf8a70995b2f7e schema:name Springer Nature - SN SciGraph project
    158 rdf:type schema:Organization
    159 N6473ceca26c74b489435345b44b72428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Carcinoma, Renal Cell
    161 rdf:type schema:DefinedTerm
    162 N686e0a6fd2c54abc800044aecc15de39 schema:name pubmed_id
    163 schema:value 23797736
    164 rdf:type schema:PropertyValue
    165 N6945a464c59b437690bca501ae35de1a rdf:first sg:person.0646225667.66
    166 rdf:rest N04ed2a942aad42568fc4c53ab98f3f62
    167 N6b869af300484e87b057fa1faa14ab95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Kidney Neoplasms
    169 rdf:type schema:DefinedTerm
    170 N720b2bc21f0e47859de70003358c4a5e rdf:first sg:person.013055324062.39
    171 rdf:rest N961f11c4a0284afd80ae256273e595d5
    172 N7cb68a67bab444898fb14f9f0e8a4365 rdf:first sg:person.0644521430.71
    173 rdf:rest N14474c96beda442fb5460195090873eb
    174 N7de99ed2a84c45b4b7b1e9d5fded536e schema:name doi
    175 schema:value 10.1038/ng.2699
    176 rdf:type schema:PropertyValue
    177 N7ea86b97c10044bf879e336a89767b3f rdf:first sg:person.01364774350.53
    178 rdf:rest N2bbac4c4d7bd41ef867cc66f7e9dc972
    179 N859181dc97c6466c9e7b7bd3ae684ea1 rdf:first sg:person.016066062624.57
    180 rdf:rest N34bc28c3efa84bbe9d189361e7db7683
    181 N8a41573fb5814e7690bddad2d3bd02c5 schema:issueNumber 8
    182 rdf:type schema:PublicationIssue
    183 N900b4f7ed88a43e4abbbbe4dfa04ab01 rdf:first sg:person.01164446451.02
    184 rdf:rest N7cb68a67bab444898fb14f9f0e8a4365
    185 N961f11c4a0284afd80ae256273e595d5 rdf:first sg:person.01132112464.26
    186 rdf:rest Nf2cd355caeb647148f6272ce113f8df2
    187 Nac09d8b25a3b4c67a8fae5f17eb8d097 rdf:first sg:person.01062246332.33
    188 rdf:rest Ncbafd1152b8c4603adb6140499cb0e22
    189 Nbc566c0f202e4ea39ccd584216461b0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name DNA Copy Number Variations
    191 rdf:type schema:DefinedTerm
    192 Nbcf3409ed27440dba09573d0795caf2c rdf:first sg:person.01246341064.50
    193 rdf:rest N859181dc97c6466c9e7b7bd3ae684ea1
    194 Nc27d60dca2914ce980b90b427c0776e2 rdf:first sg:person.01050365066.67
    195 rdf:rest N31bf186a96fb42c0a431140c39407377
    196 Nc86c1d3da49e49aab7426a215cda8236 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Cluster Analysis
    198 rdf:type schema:DefinedTerm
    199 Ncbafd1152b8c4603adb6140499cb0e22 rdf:first sg:person.0717455442.15
    200 rdf:rest N31779c1e8c144a0cb19f3b58ad4282c7
    201 Ncf7673b21512495e9a9daebba2f524da rdf:first sg:person.0701353106.90
    202 rdf:rest Nf44f19ff61e94db9956ec763419e4709
    203 Nd018208333b24428a64c24e688d143c0 rdf:first sg:person.0721722331.06
    204 rdf:rest Nddaa346d709f483ab19b4225029bb5b2
    205 Nd61d82795ab046b4885076e4a7a6f9bd rdf:first sg:person.01107361662.84
    206 rdf:rest N2597161eba2547268ec1a8e3b30b827b
    207 Nddaa346d709f483ab19b4225029bb5b2 rdf:first sg:person.0765570642.44
    208 rdf:rest N720b2bc21f0e47859de70003358c4a5e
    209 Ne182af2499bb479b94e0529d8cbbc6a1 schema:name dimensions_id
    210 schema:value pub.1023979397
    211 rdf:type schema:PropertyValue
    212 Nf068acc07b764cec971953f4bb75679b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Humans
    214 rdf:type schema:DefinedTerm
    215 Nf2cd355caeb647148f6272ce113f8df2 rdf:first sg:person.016245415444.19
    216 rdf:rest Nbcf3409ed27440dba09573d0795caf2c
    217 Nf44f19ff61e94db9956ec763419e4709 rdf:first sg:person.0705167135.01
    218 rdf:rest N248bccffb927412fa07821e46cb1f4ee
    219 Nf645e56730714309b7b8a95a41303eef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Gene Expression Profiling
    221 rdf:type schema:DefinedTerm
    222 Nf86a5af9d87a4e888f9434a20413e4d1 schema:volumeNumber 45
    223 rdf:type schema:PublicationVolume
    224 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    225 schema:name Biological Sciences
    226 rdf:type schema:DefinedTerm
    227 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    228 schema:name Genetics
    229 rdf:type schema:DefinedTerm
    230 sg:grant.5793440 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    231 rdf:type schema:MonetaryGrant
    232 sg:grant.6028873 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    233 rdf:type schema:MonetaryGrant
    234 sg:grant.6032585 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.6076650 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.6084776 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.6103938 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.6108938 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.6121525 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.6129171 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    247 rdf:type schema:MonetaryGrant
    248 sg:grant.6131865 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2699
    249 rdf:type schema:MonetaryGrant
    250 sg:journal.1103138 schema:issn 1061-4036
    251 1546-1718
    252 schema:name Nature Genetics
    253 schema:publisher Springer Nature
    254 rdf:type schema:Periodical
    255 sg:person.01004150325.07 schema:affiliation grid-institutes:grid.26999.3d
    256 schema:familyName Shimamura
    257 schema:givenName Teppei
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004150325.07
    259 rdf:type schema:Person
    260 sg:person.01004770244.75 schema:affiliation grid-institutes:grid.26999.3d
    261 schema:familyName Fukayama
    262 schema:givenName Masashi
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004770244.75
    264 rdf:type schema:Person
    265 sg:person.01015664064.91 schema:affiliation grid-institutes:grid.26999.3d
    266 schema:familyName Shiraishi
    267 schema:givenName Yuichi
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015664064.91
    269 rdf:type schema:Person
    270 sg:person.01050365066.67 schema:affiliation grid-institutes:grid.26999.3d
    271 schema:familyName Sato-Otsubo
    272 schema:givenName Aiko
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050365066.67
    274 rdf:type schema:Person
    275 sg:person.01062246332.33 schema:affiliation grid-institutes:grid.26999.3d
    276 schema:familyName Maekawa
    277 schema:givenName Shigekatsu
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062246332.33
    279 rdf:type schema:Person
    280 sg:person.01107361662.84 schema:affiliation grid-institutes:grid.7597.c
    281 schema:familyName Fujimoto
    282 schema:givenName Akihiro
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107361662.84
    284 rdf:type schema:Person
    285 sg:person.01132112464.26 schema:affiliation grid-institutes:grid.26999.3d
    286 schema:familyName Kon
    287 schema:givenName Ayana
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132112464.26
    289 rdf:type schema:Person
    290 sg:person.01164446451.02 schema:affiliation grid-institutes:grid.26999.3d
    291 schema:familyName Morikawa
    292 schema:givenName Teppei
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164446451.02
    294 rdf:type schema:Person
    295 sg:person.01246341064.50 schema:affiliation grid-institutes:grid.26999.3d
    296 schema:familyName Chiba
    297 schema:givenName Kenichi
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246341064.50
    299 rdf:type schema:Person
    300 sg:person.013055324062.39 schema:affiliation grid-institutes:grid.26999.3d
    301 schema:familyName Yoshida
    302 schema:givenName Kenichi
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013055324062.39
    304 rdf:type schema:Person
    305 sg:person.01330302270.71 schema:affiliation grid-institutes:grid.27476.30
    306 schema:familyName Kamura
    307 schema:givenName Takumi
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330302270.71
    309 rdf:type schema:Person
    310 sg:person.013516116052.47 schema:affiliation grid-institutes:grid.7597.c
    311 schema:familyName Tsunoda
    312 schema:givenName Tatsuhiko
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013516116052.47
    314 rdf:type schema:Person
    315 sg:person.01364774350.53 schema:affiliation grid-institutes:grid.26999.3d
    316 schema:familyName Sugano
    317 schema:givenName Sumio
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364774350.53
    319 rdf:type schema:Person
    320 sg:person.014513351602.44 schema:affiliation grid-institutes:grid.258799.8
    321 schema:familyName Ogawa
    322 schema:givenName Seishi
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014513351602.44
    324 rdf:type schema:Person
    325 sg:person.016066062624.57 schema:affiliation grid-institutes:grid.26999.3d
    326 schema:familyName Tanaka
    327 schema:givenName Hiroko
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016066062624.57
    329 rdf:type schema:Person
    330 sg:person.016245415444.19 schema:affiliation grid-institutes:grid.26999.3d
    331 schema:familyName Suzuki
    332 schema:givenName Yutaka
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016245415444.19
    334 rdf:type schema:Person
    335 sg:person.0601347253.62 schema:affiliation grid-institutes:grid.26999.3d
    336 schema:familyName Niida
    337 schema:givenName Atsushi
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601347253.62
    339 rdf:type schema:Person
    340 sg:person.0620134357.25 schema:affiliation grid-institutes:grid.258799.8
    341 schema:familyName Sanada
    342 schema:givenName Masashi
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620134357.25
    344 rdf:type schema:Person
    345 sg:person.0644521430.71 schema:affiliation grid-institutes:grid.26999.3d
    346 schema:familyName Maeda
    347 schema:givenName Daichi
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644521430.71
    349 rdf:type schema:Person
    350 sg:person.0646225667.66 schema:affiliation grid-institutes:grid.26999.3d
    351 schema:familyName Yoshizato
    352 schema:givenName Tetsuichi
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646225667.66
    354 rdf:type schema:Person
    355 sg:person.0701353106.90 schema:affiliation grid-institutes:grid.26999.3d
    356 schema:familyName Miyano
    357 schema:givenName Satoru
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701353106.90
    359 rdf:type schema:Person
    360 sg:person.0705167135.01 schema:affiliation grid-institutes:grid.26999.3d
    361 schema:familyName Homma
    362 schema:givenName Yukio
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705167135.01
    364 rdf:type schema:Person
    365 sg:person.0713466430.47 schema:affiliation grid-institutes:grid.26999.3d
    366 schema:familyName Aburatani
    367 schema:givenName Hiroyuki
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713466430.47
    369 rdf:type schema:Person
    370 sg:person.0717455442.15 schema:affiliation grid-institutes:grid.26999.3d
    371 schema:familyName Okuno
    372 schema:givenName Yusuke
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717455442.15
    374 rdf:type schema:Person
    375 sg:person.0721722331.06 schema:affiliation grid-institutes:grid.26999.3d
    376 schema:familyName Suzuki
    377 schema:givenName Hiromichi
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721722331.06
    379 rdf:type schema:Person
    380 sg:person.0727714666.27 schema:affiliation grid-institutes:grid.26999.3d
    381 schema:familyName Nagae
    382 schema:givenName Genta
    383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727714666.27
    384 rdf:type schema:Person
    385 sg:person.0741253071.83 schema:affiliation grid-institutes:grid.26999.3d
    386 schema:familyName Kume
    387 schema:givenName Haruki
    388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741253071.83
    389 rdf:type schema:Person
    390 sg:person.0745671714.86 schema:affiliation grid-institutes:grid.26999.3d
    391 schema:familyName Sato
    392 schema:givenName Yusuke
    393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745671714.86
    394 rdf:type schema:Person
    395 sg:person.0765570642.44 schema:affiliation grid-institutes:grid.26999.3d
    396 schema:familyName Nagata
    397 schema:givenName Yasunobu
    398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765570642.44
    399 rdf:type schema:Person
    400 sg:pub.10.1038/nature05610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033482125
    401 https://doi.org/10.1038/nature05610
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/nature08672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032969139
    404 https://doi.org/10.1038/nature08672
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/nature09639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009539954
    407 https://doi.org/10.1038/nature09639
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1038/nature10496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008245757
    410 https://doi.org/10.1038/nature10496
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    413 https://doi.org/10.1038/nature11252
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1038/nature11742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035853848
    416 https://doi.org/10.1038/nature11742
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/ng.1014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031490994
    419 https://doi.org/10.1038/ng.1014
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/ng.2256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028644962
    422 https://doi.org/10.1038/ng.2256
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/ng.2291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002477386
    425 https://doi.org/10.1038/ng.2291
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/ng.2295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042330799
    428 https://doi.org/10.1038/ng.2295
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1038/ng.2323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043591147
    431 https://doi.org/10.1038/ng.2323
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1038/ng.2391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050246665
    434 https://doi.org/10.1038/ng.2391
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1038/ng.2628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023030104
    437 https://doi.org/10.1038/ng.2628
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1038/ng.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011180194
    440 https://doi.org/10.1038/ng.363
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1038/ng.391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048670152
    443 https://doi.org/10.1038/ng.391
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1038/ng0594-85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020232019
    446 https://doi.org/10.1038/ng0594-85
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1038/nprot.2008.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039987283
    449 https://doi.org/10.1038/nprot.2008.211
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1038/sj.gt.3301206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032864882
    452 https://doi.org/10.1038/sj.gt.3301206
    453 rdf:type schema:CreativeWork
    454 sg:pub.10.1038/sj.onc.1201394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044829641
    455 https://doi.org/10.1038/sj.onc.1201394
    456 rdf:type schema:CreativeWork
    457 grid-institutes:grid.258799.8 schema:alternateName Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    458 schema:name Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    459 Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    460 rdf:type schema:Organization
    461 grid-institutes:grid.26999.3d schema:alternateName Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    462 Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
    463 Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    464 Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    465 Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
    466 Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    467 Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    468 schema:name Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    469 Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
    470 Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    471 Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    472 Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
    473 Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    474 Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    475 rdf:type schema:Organization
    476 grid-institutes:grid.27476.30 schema:alternateName Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan
    477 schema:name Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan
    478 rdf:type schema:Organization
    479 grid-institutes:grid.7597.c schema:alternateName Center for Genomic Medicine, RIKEN, Yokohama, Japan
    480 schema:name Center for Genomic Medicine, RIKEN, Yokohama, Japan
    481 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...