Whole-genome sequence-based analysis of high-density lipoprotein cholesterol View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08

AUTHORS

Alanna C. Morrison, Arend Voorman, Andrew D. Johnson, Xiaoming Liu, Jin Yu, Alexander Li, Donna Muzny, Fuli Yu, Kenneth Rice, Chengsong Zhu, Joshua Bis, Gerardo Heiss, Christopher J. O’Donnell, Bruce M. Psaty, L. Adrienne Cupples, Richard Gibbs, Eric Boerwinkle,

ABSTRACT

We describe initial steps for interrogating whole-genome sequence data to characterize the genetic architecture of a complex trait, levels of high-density lipoprotein cholesterol (HDL-C). We report whole-genome sequencing and analysis of 962 individuals from the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) studies. From this analysis, we estimate that common variation contributes more to heritability of HDL-C levels than rare variation, and screening for mendelian variants for dyslipidemia identified individuals with extreme HDL-C levels. Whole-genome sequencing analyses highlight the value of regulatory and non-protein-coding regions of the genome in addition to protein-coding regions. More... »

PAGES

899-901

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.2671

DOI

http://dx.doi.org/10.1038/ng.2671

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036646012

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23770607


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