Ontology type: schema:ScholarlyArticle Open Access: True
2013-08
AUTHORSAlanna C. Morrison, Arend Voorman, Andrew D. Johnson, Xiaoming Liu, Jin Yu, Alexander Li, Donna Muzny, Fuli Yu, Kenneth Rice, Chengsong Zhu, Joshua Bis, Gerardo Heiss, Christopher J. O’Donnell, Bruce M. Psaty, L. Adrienne Cupples, Richard Gibbs, Eric Boerwinkle,
ABSTRACTWe describe initial steps for interrogating whole-genome sequence data to characterize the genetic architecture of a complex trait, levels of high-density lipoprotein cholesterol (HDL-C). We report whole-genome sequencing and analysis of 962 individuals from the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) studies. From this analysis, we estimate that common variation contributes more to heritability of HDL-C levels than rare variation, and screening for mendelian variants for dyslipidemia identified individuals with extreme HDL-C levels. Whole-genome sequencing analyses highlight the value of regulatory and non-protein-coding regions of the genome in addition to protein-coding regions. More... »
PAGES899-901
http://scigraph.springernature.com/pub.10.1038/ng.2671
DOIhttp://dx.doi.org/10.1038/ng.2671
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23770607
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{
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"sameAs": [
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"sdDataset": "articles",
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Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2671'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2671'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2671'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2671'
This table displays all metadata directly associated to this object as RDF triples.
408 TRIPLES
21 PREDICATES
64 URIs
31 LITERALS
19 BLANK NODES