The Genotype-Tissue Expression (GTEx) project View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-05-29

AUTHORS

John Lonsdale, Jeffrey Thomas, Mike Salvatore, Rebecca Phillips, Edmund Lo, Saboor Shad, Richard Hasz, Gary Walters, Fernando Garcia, Nancy Young, Barbara Foster, Mike Moser, Ellen Karasik, Bryan Gillard, Kimberley Ramsey, Susan Sullivan, Jason Bridge, Harold Magazine, John Syron, Johnelle Fleming, Laura Siminoff, Heather Traino, Maghboeba Mosavel, Laura Barker, Scott Jewell, Dan Rohrer, Dan Maxim, Dana Filkins, Philip Harbach, Eddie Cortadillo, Bree Berghuis, Lisa Turner, Eric Hudson, Kristin Feenstra, Leslie Sobin, James Robb, Phillip Branton, Greg Korzeniewski, Charles Shive, David Tabor, Liqun Qi, Kevin Groch, Sreenath Nampally, Steve Buia, Angela Zimmerman, Anna Smith, Robin Burges, Karna Robinson, Kim Valentino, Deborah Bradbury, Mark Cosentino, Norma Diaz-Mayoral, Mary Kennedy, Theresa Engel, Penelope Williams, Kenyon Erickson, Kristin Ardlie, Wendy Winckler, Gad Getz, David DeLuca, Daniel MacArthur, Manolis Kellis, Alexander Thomson, Taylor Young, Ellen Gelfand, Molly Donovan, Yan Meng, George Grant, Deborah Mash, Yvonne Marcus, Margaret Basile, Jun Liu, Jun Zhu, Zhidong Tu, Nancy J Cox, Dan L Nicolae, Eric R Gamazon, Hae Kyung Im, Anuar Konkashbaev, Jonathan Pritchard, Matthew Stevens, Timothèe Flutre, Xiaoquan Wen, Emmanouil T Dermitzakis, Tuuli Lappalainen, Roderic Guigo, Jean Monlong, Michael Sammeth, Daphne Koller, Alexis Battle, Sara Mostafavi, Mark McCarthy, Manual Rivas, Julian Maller, Ivan Rusyn, Andrew Nobel, Fred Wright, Andrey Shabalin, Mike Feolo, Nataliya Sharopova, Anne Sturcke, Justin Paschal, James M Anderson, Elizabeth L Wilder, Leslie K Derr, Eric D Green, Jeffery P Struewing, Gary Temple, Simona Volpi, Joy T Boyer, Elizabeth J Thomson, Mark S Guyer, Cathy Ng, Assya Abdallah, Deborah Colantuoni, Thomas R Insel, Susan E Koester, A Roger Little, Patrick K Bender, Thomas Lehner, Yin Yao, Carolyn C Compton, Jimmie B Vaught, Sherilyn Sawyer, Nicole C Lockhart, Joanne Demchok, Helen F Moore

ABSTRACT

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues. More... »

PAGES

580-585

Journal

TITLE

Nature Genetics

ISSUE

6

VOLUME

45

Author Affiliations

  • National Disease Research Interchange, Philadelphia, Pennsylvania, USA
  • Gift of Life Donor Program, Philadelphia, Pennsylvania, USA
  • LifeNet Health, Virginia Beach, Virginia, USA
  • Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
  • Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA
  • Roswell Park Cancer Institute, Buffalo, New York, USA
  • Upstate New York Transplant Service, Buffalo, New York, USA
  • Science Care, Inc., Phoenix, Arizona, USA
  • Virginia Commonwealth University, Richmond, Virginia, USA
  • Van Andel Institute, Grand Rapids, Michigan, USA
  • SAIC-Frederick, Inc., Frederick, Maryland, USA
  • Sapient Government Services, Arlington, Virginia, USA
  • The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
  • Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA
  • Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
  • University of Miami School of Medicine, Miami, Florida, USA
  • Harvard University, Boston, Massachusetts, USA
  • Mount Sinai School of Medicine, New York, New York, USA
  • University of Chicago, Chicago, Illinois, USA
  • Howard Hughes Medical Institute, Chicago, Illinois, USA
  • University of Geneva, Geneva, Switzerland
  • Center for Genomic Regulation, Barcelona, Spain
  • Stanford University, Palo Alto, California, USA
  • Oxford University, Oxford, UK
  • University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
  • National Center for Biotechnology Information, National Library of Medicine, US National Institutes of Health, Bethesda, Maryland, USA
  • Division of Program Coordination, Planning and Strategic Initiatives, Office of Strategic Coordination (Common Fund), Office of the Director, US National Institutes of Health, Bethesda, Maryland, USA
  • National Human Genome Research Institute, Bethesda, Maryland, USA
  • National Institute of Mental Health, Bethesda, Maryland, USA
  • US National Cancer Institute, Bethesda, Maryland, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2653

    DOI

    http://dx.doi.org/10.1038/ng.2653

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032444369

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23715323


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