DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07

AUTHORS

Mingchao Xie, Chibo Hong, Bo Zhang, Rebecca F Lowdon, Xiaoyun Xing, Daofeng Li, Xin Zhou, Hyung Joo Lee, Cecile L Maire, Keith L Ligon, Philippe Gascard, Mahvash Sigaroudinia, Thea D Tlsty, Theresa Kadlecek, Arthur Weiss, Henriette O'Geen, Peggy J Farnham, Pamela A F Madden, Andrew J Mungall, Angela Tam, Baljit Kamoh, Stephanie Cho, Richard Moore, Martin Hirst, Marco A Marra, Joseph F Costello, Ting Wang

ABSTRACT

Transposable element (TE)-derived sequences comprise half of the human genome and DNA methylome and are presumed to be densely methylated and inactive. Examination of genome-wide DNA methylation status within 928 TE subfamilies in human embryonic and adult tissues identified unexpected tissue-specific and subfamily-specific hypomethylation signatures. Genes proximal to tissue-specific hypomethylated TE sequences were enriched for functions important for the relevant tissue type, and their expression correlated strongly with hypomethylation within the TEs. When hypomethylated, these TE sequences gained tissue-specific enhancer marks, including monomethylation of histone H3 at lysine 4 (H3K4me1) and occupancy by p300, and a majority exhibited enhancer activity in reporter gene assays. Many such TEs also harbored binding sites for transcription factors that are important for tissue-specific functions and showed evidence of evolutionary selection. These data suggest that sequences derived from TEs may be responsible for wiring tissue type-specific regulatory networks and may have acquired tissue-specific epigenetic regulation. More... »

PAGES

836-841

References to SciGraph publications

  • 2001-02. Initial sequencing and analysis of the human genome in NATURE
  • 2007-04. Transposable elements and the epigenetic regulation of the genome in NATURE REVIEWS GENETICS
  • 2001-02. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes in NATURE
  • 1999-11. Epigenetic inheritance at the agouti locus in the mouse in NATURE GENETICS
  • 2003-11. De novo insertion of an Alu sequence in the coding region of the CLCN5 gene results in Dent's disease in HUMAN GENETICS
  • 2010-07. Conserved role of intragenic DNA methylation in regulating alternative promoters in NATURE
  • 2008-12. Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA in BMC GENOMICS
  • 2004-06. Epigenomics: beyond CpG islands in NATURE REVIEWS GENETICS
  • 1980-04. Selfish genes, the phenotype paradigm and genome evolution in NATURE
  • 2010-12. BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences in BMC BIOINFORMATICS
  • 2010-05. GREAT improves functional interpretation of cis-regulatory regions in NATURE BIOTECHNOLOGY
  • 2008-05. Transposable elements and the evolution of regulatory networks in NATURE REVIEWS GENETICS
  • 2010-10. The NIH Roadmap Epigenomics Mapping Consortium in NATURE BIOTECHNOLOGY
  • 2011-11. Transposon-mediated rewiring of gene regulatory networks contributed to the evolution of pregnancy in mammals in NATURE GENETICS
  • 2013-03. Endogenous retroviruses function as species-specific enhancer elements in the placenta in NATURE GENETICS
  • 1980-04. Selfish DNA: the ultimate parasite in NATURE
  • 2010-10. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications in NATURE BIOTECHNOLOGY
  • 2007-07. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project in NATURE
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 1999-12. Molecular domestication – more than a sporadic episode in evolution in GENETICA
  • 2011-08-18. Using ChIP-Seq Technology to Generate High-Resolution Profiles of Histone Modifications in EPIGENETICS PROTOCOLS
  • 2010-01. Correcting the record in NATURE BIOTECHNOLOGY
  • 2010-07. Transposable elements have rewired the core regulatory network of human embryonic stem cells in NATURE GENETICS
  • 2010-06. Estimating enrichment of repetitive elements from high-throughput sequence data in GENOME BIOLOGY
  • 2006-05. A distal enhancer and an ultraconserved exon are derived from a novel retroposon in NATURE
  • 2009. TGF-β in Dopamine Neuron Development, Maintenance and Neuroprotection in DEVELOPMENT AND ENGINEERING OF DOPAMINE NEURONS
  • 2002-05. Alu repeats and human genomic diversity in NATURE REVIEWS GENETICS
  • 2011-10. A high-resolution map of human evolutionary constraint using 29 mammals in NATURE
  • 2011-12-14. DNA-binding factors shape the mouse methylome at distal regulatory regions in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2649

    DOI

    http://dx.doi.org/10.1038/ng.2649

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021764403

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23708189


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Binding Sites", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Mapping", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Transposable Elements", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Embryo, Mammalian", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enhancer Elements, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multigene Family", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organ Specificity", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xie", 
            "givenName": "Mingchao", 
            "id": "sg:person.01122142106.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122142106.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hong", 
            "givenName": "Chibo", 
            "id": "sg:person.01322771707.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322771707.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Bo", 
            "id": "sg:person.0653601341.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653601341.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lowdon", 
            "givenName": "Rebecca F", 
            "id": "sg:person.01366343306.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366343306.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xing", 
            "givenName": "Xiaoyun", 
            "id": "sg:person.01222453356.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222453356.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Daofeng", 
            "id": "sg:person.01170255306.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170255306.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Xin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Hyung Joo", 
            "id": "sg:person.0646251033.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646251033.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maire", 
            "givenName": "Cecile L", 
            "id": "sg:person.0726756260.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726756260.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.", 
                "Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ligon", 
            "givenName": "Keith L", 
            "id": "sg:person.01152270445.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152270445.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gascard", 
            "givenName": "Philippe", 
            "id": "sg:person.0735014054.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735014054.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sigaroudinia", 
            "givenName": "Mahvash", 
            "id": "sg:person.0660324777.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660324777.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tlsty", 
            "givenName": "Thea D", 
            "id": "sg:person.0662010442.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662010442.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kadlecek", 
            "givenName": "Theresa", 
            "id": "sg:person.07713125404.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07713125404.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA.", 
                "Division of Rheumatology, University of California, San Francisco, San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weiss", 
            "givenName": "Arthur", 
            "id": "sg:person.01353000412.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353000412.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Davis", 
              "id": "https://www.grid.ac/institutes/grid.27860.3b", 
              "name": [
                "Genome Center, University of California\u2013Davis, Davis, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "O'Geen", 
            "givenName": "Henriette", 
            "id": "sg:person.01252463635.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252463635.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Southern California", 
              "id": "https://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Department of Biochemistry & Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Farnham", 
            "givenName": "Peggy J", 
            "id": "sg:person.01357726511.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357726511.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Madden", 
            "givenName": "Pamela A F", 
            "id": "sg:person.010656516214.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010656516214.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mungall", 
            "givenName": "Andrew J", 
            "id": "sg:person.0627357425.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627357425.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tam", 
            "givenName": "Angela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamoh", 
            "givenName": "Baljit", 
            "id": "sg:person.0664562404.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664562404.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cho", 
            "givenName": "Stephanie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moore", 
            "givenName": "Richard", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.", 
                "Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirst", 
            "givenName": "Martin", 
            "id": "sg:person.0601713543.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601713543.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marra", 
            "givenName": "Marco A", 
            "id": "sg:person.01150455763.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Costello", 
            "givenName": "Joseph F", 
            "id": "sg:person.013474410037.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013474410037.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Ting", 
            "id": "sg:person.0727137372.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727137372.57"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature05874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005913886", 
              "https://doi.org/10.1038/nature05874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-11-230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005918999", 
              "https://doi.org/10.1186/1471-2105-11-230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.100594.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006628641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.100594.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006628641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.11.058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007206139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2010-11-6-r69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008026977", 
              "https://doi.org/10.1186/gb-2010-11-6-r69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr1012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008353709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m006557200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011142212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.022630299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011464582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/284601a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013133318", 
              "https://doi.org/10.1038/284601a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013402885", 
              "https://doi.org/10.1038/nature10530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1399-0004.2003.00166.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015540429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016430364", 
              "https://doi.org/10.1038/nrg2072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017918736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0110-22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018405220", 
              "https://doi.org/10.1038/nbt0110-22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0110-22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018405220", 
              "https://doi.org/10.1038/nbt0110-22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019242813", 
              "https://doi.org/10.1038/nature09165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019242813", 
              "https://doi.org/10.1038/nature09165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.36.6.344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019329581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019643731", 
              "https://doi.org/10.1038/ng.600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019643731", 
              "https://doi.org/10.1038/ng.600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1004070603792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020960364", 
              "https://doi.org/10.1023/a:1004070603792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35054579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021199009", 
              "https://doi.org/10.1038/35054579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35054579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021199009", 
              "https://doi.org/10.1038/35054579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/29.13.e65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022346000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023421025", 
              "https://doi.org/10.1038/nbt.1630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-9-226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023496135", 
              "https://doi.org/10.1186/1471-2164-9-226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.11.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023753839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025444771", 
              "https://doi.org/10.1038/nrg798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025444771", 
              "https://doi.org/10.1038/nrg798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.186601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026030725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026180143", 
              "https://doi.org/10.1038/nature10716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027944303", 
              "https://doi.org/10.1038/nature04696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027944303", 
              "https://doi.org/10.1038/nature04696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027944303", 
              "https://doi.org/10.1038/nature04696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0611223104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028702517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029065430", 
              "https://doi.org/10.1038/nature11247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0011425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030321502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.947102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030570608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031224351", 
              "https://doi.org/10.1038/nbt.1682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031224351", 
              "https://doi.org/10.1038/nbt.1682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-003-0991-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031495081", 
              "https://doi.org/10.1007/s00439-003-0991-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-003-0991-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031495081", 
              "https://doi.org/10.1007/s00439-003-0991-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.05.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033093395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.15.7704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033349869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033825316", 
              "https://doi.org/10.1038/ng.917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(02)00006-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034569785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(02)00006-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034569785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0709398105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034620660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036005113", 
              "https://doi.org/10.1038/nrg2337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4419-0322-8_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036317953", 
              "https://doi.org/10.1007/978-1-4419-0322-8_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4419-0322-8_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036317953", 
              "https://doi.org/10.1007/978-1-4419-0322-8_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.080663.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036971575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2009.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036985358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-316-5_20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037428771", 
              "https://doi.org/10.1007/978-1-61779-316-5_20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-316-5_20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037428771", 
              "https://doi.org/10.1007/978-1-61779-316-5_20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mpev.1996.0003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038399237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.genet.35.102401.091032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038407568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0703637104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039620426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35057062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042854081", 
              "https://doi.org/10.1038/35057062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35057062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042854081", 
              "https://doi.org/10.1038/35057062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2005.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045218625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.10.6.2513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045325968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.05.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046632705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047349707", 
              "https://doi.org/10.1038/nrg1349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047349707", 
              "https://doi.org/10.1038/nrg1349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2003.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047593060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2003.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047593060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1002111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048281760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1010-1045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048301228", 
              "https://doi.org/10.1038/nbt1010-1045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/15490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048828813", 
              "https://doi.org/10.1038/15490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/15490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048828813", 
              "https://doi.org/10.1038/15490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050701683", 
              "https://doi.org/10.1038/ng.2553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2134464100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051479675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/284604a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052905388", 
              "https://doi.org/10.1038/284604a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi902022n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055210507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi902022n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055210507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.1956.021.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060403222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1990437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062516645"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-07", 
        "datePublishedReg": "2013-07-01", 
        "description": "Transposable element (TE)-derived sequences comprise half of the human genome and DNA methylome and are presumed to be densely methylated and inactive. Examination of genome-wide DNA methylation status within 928 TE subfamilies in human embryonic and adult tissues identified unexpected tissue-specific and subfamily-specific hypomethylation signatures. Genes proximal to tissue-specific hypomethylated TE sequences were enriched for functions important for the relevant tissue type, and their expression correlated strongly with hypomethylation within the TEs. When hypomethylated, these TE sequences gained tissue-specific enhancer marks, including monomethylation of histone H3 at lysine 4 (H3K4me1) and occupancy by p300, and a majority exhibited enhancer activity in reporter gene assays. Many such TEs also harbored binding sites for transcription factors that are important for tissue-specific functions and showed evidence of evolutionary selection. These data suggest that sequences derived from TEs may be responsible for wiring tissue type-specific regulatory networks and may have acquired tissue-specific epigenetic regulation. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ng.2649", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2435779", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2690499", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2529495", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440232", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2622811", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2435862", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2684137", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "45"
          }
        ], 
        "name": "DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape", 
        "pagination": "836-841", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "67b1b9a2e25ff73afa1936ccf97e30dba761a1ab94aae37e0c6c1a98fbf03858"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23708189"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.2649"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1021764403"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.2649", 
          "https://app.dimensions.ai/details/publication/pub.1021764403"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/ng.2649"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2649'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2649'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2649'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2649'


     

    This table displays all metadata directly associated to this object as RDF triples.

    556 TRIPLES      21 PREDICATES      104 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.2649 schema:about N0c751d97df754c28a8bcfd2cc066ad45
    2 N12863901d1bf475f968c31a53e523978
    3 N2c12072113a246c8adcc92939ace95cb
    4 N36309d7955fb4540a1cea58d8dee3459
    5 N5354e4764702458c8f1486bd07e8ac0f
    6 N539f1eb7d71d417b9be29d8c202218d7
    7 N7c566b3af7024ee7b709e957b600c15e
    8 N89a32dcd77a44a17a55d52a27e06c5d5
    9 Nae09639d8e7e4ac1a0cf3cb96d52a49c
    10 Nbe2f87957a1f4cfeae4c8eb1cf02cb34
    11 Ncac8e16275764a328e0883301d62ae9a
    12 Nf031bda5f8e4452aadd1c46c63e89c3e
    13 Nf91213678480477d907229528468b5cd
    14 Nf985432b9d984f139a69144736474449
    15 anzsrc-for:06
    16 anzsrc-for:0604
    17 schema:author N8014488fb4d245e28b77ba8dcd646b48
    18 schema:citation sg:pub.10.1007/978-1-4419-0322-8_8
    19 sg:pub.10.1007/978-1-61779-316-5_20
    20 sg:pub.10.1007/s00439-003-0991-8
    21 sg:pub.10.1023/a:1004070603792
    22 sg:pub.10.1038/15490
    23 sg:pub.10.1038/284601a0
    24 sg:pub.10.1038/284604a0
    25 sg:pub.10.1038/35054579
    26 sg:pub.10.1038/35057062
    27 sg:pub.10.1038/nature04696
    28 sg:pub.10.1038/nature05874
    29 sg:pub.10.1038/nature09165
    30 sg:pub.10.1038/nature10530
    31 sg:pub.10.1038/nature10716
    32 sg:pub.10.1038/nature11247
    33 sg:pub.10.1038/nbt.1630
    34 sg:pub.10.1038/nbt.1682
    35 sg:pub.10.1038/nbt0110-22
    36 sg:pub.10.1038/nbt1010-1045
    37 sg:pub.10.1038/ng.2553
    38 sg:pub.10.1038/ng.600
    39 sg:pub.10.1038/ng.917
    40 sg:pub.10.1038/nrg1349
    41 sg:pub.10.1038/nrg2072
    42 sg:pub.10.1038/nrg2337
    43 sg:pub.10.1038/nrg798
    44 sg:pub.10.1186/1471-2105-11-230
    45 sg:pub.10.1186/1471-2164-9-226
    46 sg:pub.10.1186/gb-2010-11-6-r69
    47 https://doi.org/10.1006/mpev.1996.0003
    48 https://doi.org/10.1016/j.cell.2010.05.020
    49 https://doi.org/10.1016/j.cell.2010.05.021
    50 https://doi.org/10.1016/j.cell.2011.11.058
    51 https://doi.org/10.1016/j.gene.2009.06.020
    52 https://doi.org/10.1016/j.molcel.2012.11.013
    53 https://doi.org/10.1016/j.tig.2003.08.004
    54 https://doi.org/10.1016/j.tins.2005.08.008
    55 https://doi.org/10.1016/s0168-9525(02)00006-9
    56 https://doi.org/10.1021/bi902022n
    57 https://doi.org/10.1046/j.1399-0004.2003.00166.x
    58 https://doi.org/10.1073/pnas.022630299
    59 https://doi.org/10.1073/pnas.0611223104
    60 https://doi.org/10.1073/pnas.0703637104
    61 https://doi.org/10.1073/pnas.0709398105
    62 https://doi.org/10.1073/pnas.2134464100
    63 https://doi.org/10.1073/pnas.36.6.344
    64 https://doi.org/10.1073/pnas.94.15.7704
    65 https://doi.org/10.1074/jbc.m006557200
    66 https://doi.org/10.1093/bioinformatics/btq460
    67 https://doi.org/10.1093/nar/29.13.e65
    68 https://doi.org/10.1093/nar/gkr1012
    69 https://doi.org/10.1101/gad.186601
    70 https://doi.org/10.1101/gad.947102
    71 https://doi.org/10.1101/gr.080663.108
    72 https://doi.org/10.1101/gr.100594.109
    73 https://doi.org/10.1101/sqb.1956.021.01.017
    74 https://doi.org/10.1126/science.1990437
    75 https://doi.org/10.1128/mcb.10.6.2513
    76 https://doi.org/10.1146/annurev.genet.35.102401.091032
    77 https://doi.org/10.1371/journal.pcbi.1002111
    78 https://doi.org/10.1371/journal.pone.0011425
    79 schema:datePublished 2013-07
    80 schema:datePublishedReg 2013-07-01
    81 schema:description Transposable element (TE)-derived sequences comprise half of the human genome and DNA methylome and are presumed to be densely methylated and inactive. Examination of genome-wide DNA methylation status within 928 TE subfamilies in human embryonic and adult tissues identified unexpected tissue-specific and subfamily-specific hypomethylation signatures. Genes proximal to tissue-specific hypomethylated TE sequences were enriched for functions important for the relevant tissue type, and their expression correlated strongly with hypomethylation within the TEs. When hypomethylated, these TE sequences gained tissue-specific enhancer marks, including monomethylation of histone H3 at lysine 4 (H3K4me1) and occupancy by p300, and a majority exhibited enhancer activity in reporter gene assays. Many such TEs also harbored binding sites for transcription factors that are important for tissue-specific functions and showed evidence of evolutionary selection. These data suggest that sequences derived from TEs may be responsible for wiring tissue type-specific regulatory networks and may have acquired tissue-specific epigenetic regulation.
    82 schema:genre research_article
    83 schema:inLanguage en
    84 schema:isAccessibleForFree true
    85 schema:isPartOf N3ef1e0e7643940d8a0e118d5f9b85d09
    86 N6d615d310b224e6f89311dd3360080c7
    87 sg:journal.1103138
    88 schema:name DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape
    89 schema:pagination 836-841
    90 schema:productId N4d6bf0019d4a408dab2648ee06f572a6
    91 N519aaff983104860a5aede5f3cce1f1a
    92 N652efeced059472fbd8f617b57e83a2b
    93 Nc0c42fe6be674cf19bd9520ff029ef64
    94 Nde22e715f2f94aaf9ad580e6fcc018be
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021764403
    96 https://doi.org/10.1038/ng.2649
    97 schema:sdDatePublished 2019-04-11T00:55
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher N776c4332967044e0befc52c18a3fdca2
    100 schema:url http://www.nature.com/articles/ng.2649
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N0c751d97df754c28a8bcfd2cc066ad45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Multigene Family
    106 rdf:type schema:DefinedTerm
    107 N12863901d1bf475f968c31a53e523978 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Genome, Human
    109 rdf:type schema:DefinedTerm
    110 N19eb791abf7c42c99dc8428ac7bc3894 rdf:first sg:person.010656516214.83
    111 rdf:rest N9441acb496dc4c2099bacfcde7ce27b9
    112 N1a176fa189804b4180bbf8f9085db07c rdf:first sg:person.0646251033.56
    113 rdf:rest Na533a07c853a4384998136e9f4a25375
    114 N1b42998832e14e70a56aa0672dfe44b7 rdf:first sg:person.01353000412.04
    115 rdf:rest N868d2063cde64dce83791bef2cc6c6df
    116 N1d1e57ccd0104d0cb3b900e08947889c rdf:first sg:person.0727137372.57
    117 rdf:rest rdf:nil
    118 N208de2f956564a16b7ec9c345e8c4216 rdf:first sg:person.0664562404.83
    119 rdf:rest N9ae1615dbc564ba99d9b4ba677819639
    120 N2c12072113a246c8adcc92939ace95cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Adult
    122 rdf:type schema:DefinedTerm
    123 N36309d7955fb4540a1cea58d8dee3459 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Enhancer Elements, Genetic
    125 rdf:type schema:DefinedTerm
    126 N3b86e5f5194640109fafa64cc9de21a0 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    127 schema:familyName Cho
    128 schema:givenName Stephanie
    129 rdf:type schema:Person
    130 N3eabf37922df4f0d9fb72799bae108fd rdf:first sg:person.07713125404.19
    131 rdf:rest N1b42998832e14e70a56aa0672dfe44b7
    132 N3ef1e0e7643940d8a0e118d5f9b85d09 schema:volumeNumber 45
    133 rdf:type schema:PublicationVolume
    134 N474ac52020824fe691d4380c35ede677 rdf:first sg:person.01366343306.80
    135 rdf:rest Ne9fc8e3a827c4c28abb49ba80a6aef85
    136 N4d6bf0019d4a408dab2648ee06f572a6 schema:name pubmed_id
    137 schema:value 23708189
    138 rdf:type schema:PropertyValue
    139 N519aaff983104860a5aede5f3cce1f1a schema:name readcube_id
    140 schema:value 67b1b9a2e25ff73afa1936ccf97e30dba761a1ab94aae37e0c6c1a98fbf03858
    141 rdf:type schema:PropertyValue
    142 N5354e4764702458c8f1486bd07e8ac0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Humans
    144 rdf:type schema:DefinedTerm
    145 N539f1eb7d71d417b9be29d8c202218d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Epigenesis, Genetic
    147 rdf:type schema:DefinedTerm
    148 N5647ad17bb894d84a1737bf7f79bde6b rdf:first sg:person.0662010442.25
    149 rdf:rest N3eabf37922df4f0d9fb72799bae108fd
    150 N5b74ddffc0824cb984ca5647f939386a rdf:first sg:person.013474410037.15
    151 rdf:rest N1d1e57ccd0104d0cb3b900e08947889c
    152 N652efeced059472fbd8f617b57e83a2b schema:name dimensions_id
    153 schema:value pub.1021764403
    154 rdf:type schema:PropertyValue
    155 N6ab9de167afd4f6281384e7baa9b4a69 rdf:first sg:person.0653601341.15
    156 rdf:rest N474ac52020824fe691d4380c35ede677
    157 N6d615d310b224e6f89311dd3360080c7 schema:issueNumber 7
    158 rdf:type schema:PublicationIssue
    159 N776c4332967044e0befc52c18a3fdca2 schema:name Springer Nature - SN SciGraph project
    160 rdf:type schema:Organization
    161 N7c566b3af7024ee7b709e957b600c15e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Embryo, Mammalian
    163 rdf:type schema:DefinedTerm
    164 N8014488fb4d245e28b77ba8dcd646b48 rdf:first sg:person.01122142106.87
    165 rdf:rest Nbe514830678948b9bb36479d5329ba21
    166 N82219966e50a4adb84a2ceda58fb4efb rdf:first sg:person.01170255306.08
    167 rdf:rest Ndea493821151406b85ec2d4bf4df31d8
    168 N868d2063cde64dce83791bef2cc6c6df rdf:first sg:person.01252463635.40
    169 rdf:rest Nb09f00d8c793498e9dbe52c27c811374
    170 N885c2edd72cb4e14820d6cff39a180f5 rdf:first sg:person.0601713543.66
    171 rdf:rest Nf89f21a86b3c4244aa6b405d70458689
    172 N89a32dcd77a44a17a55d52a27e06c5d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Cells, Cultured
    174 rdf:type schema:DefinedTerm
    175 N9009241487134abf9e174c57a6158bf9 rdf:first Ndd0207b759fd4e63aa0f1b3a6b27f6c0
    176 rdf:rest N208de2f956564a16b7ec9c345e8c4216
    177 N9441acb496dc4c2099bacfcde7ce27b9 rdf:first sg:person.0627357425.48
    178 rdf:rest N9009241487134abf9e174c57a6158bf9
    179 N9ae1615dbc564ba99d9b4ba677819639 rdf:first N3b86e5f5194640109fafa64cc9de21a0
    180 rdf:rest Nfcc7c1c2a8f8412dbb75ab2cc1be4994
    181 Na533a07c853a4384998136e9f4a25375 rdf:first sg:person.0726756260.45
    182 rdf:rest Ncde199749848463795eac4c8c6ae913b
    183 Nac62a620b48543ebb66f13ccd0b65588 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    184 schema:familyName Moore
    185 schema:givenName Richard
    186 rdf:type schema:Person
    187 Nae09639d8e7e4ac1a0cf3cb96d52a49c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name DNA Transposable Elements
    189 rdf:type schema:DefinedTerm
    190 Nb09f00d8c793498e9dbe52c27c811374 rdf:first sg:person.01357726511.86
    191 rdf:rest N19eb791abf7c42c99dc8428ac7bc3894
    192 Nbe2f87957a1f4cfeae4c8eb1cf02cb34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Chromosome Mapping
    194 rdf:type schema:DefinedTerm
    195 Nbe514830678948b9bb36479d5329ba21 rdf:first sg:person.01322771707.06
    196 rdf:rest N6ab9de167afd4f6281384e7baa9b4a69
    197 Nc0c42fe6be674cf19bd9520ff029ef64 schema:name nlm_unique_id
    198 schema:value 9216904
    199 rdf:type schema:PropertyValue
    200 Ncac8e16275764a328e0883301d62ae9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name DNA Methylation
    202 rdf:type schema:DefinedTerm
    203 Ncde199749848463795eac4c8c6ae913b rdf:first sg:person.01152270445.99
    204 rdf:rest Ne04e54b285c14b80bad885929dd7818e
    205 Nd348cfac86574ccda5b006dc4b805459 rdf:first sg:person.0660324777.47
    206 rdf:rest N5647ad17bb894d84a1737bf7f79bde6b
    207 Ndd0207b759fd4e63aa0f1b3a6b27f6c0 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    208 schema:familyName Tam
    209 schema:givenName Angela
    210 rdf:type schema:Person
    211 Nde22e715f2f94aaf9ad580e6fcc018be schema:name doi
    212 schema:value 10.1038/ng.2649
    213 rdf:type schema:PropertyValue
    214 Ndea493821151406b85ec2d4bf4df31d8 rdf:first Ndedca9edc39a402181f7201c54a87969
    215 rdf:rest N1a176fa189804b4180bbf8f9085db07c
    216 Ndedca9edc39a402181f7201c54a87969 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    217 schema:familyName Zhou
    218 schema:givenName Xin
    219 rdf:type schema:Person
    220 Ne04e54b285c14b80bad885929dd7818e rdf:first sg:person.0735014054.21
    221 rdf:rest Nd348cfac86574ccda5b006dc4b805459
    222 Ne9fc8e3a827c4c28abb49ba80a6aef85 rdf:first sg:person.01222453356.45
    223 rdf:rest N82219966e50a4adb84a2ceda58fb4efb
    224 Nf031bda5f8e4452aadd1c46c63e89c3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Histones
    226 rdf:type schema:DefinedTerm
    227 Nf89f21a86b3c4244aa6b405d70458689 rdf:first sg:person.01150455763.02
    228 rdf:rest N5b74ddffc0824cb984ca5647f939386a
    229 Nf91213678480477d907229528468b5cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Organ Specificity
    231 rdf:type schema:DefinedTerm
    232 Nf985432b9d984f139a69144736474449 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    233 schema:name Binding Sites
    234 rdf:type schema:DefinedTerm
    235 Nfcc7c1c2a8f8412dbb75ab2cc1be4994 rdf:first Nac62a620b48543ebb66f13ccd0b65588
    236 rdf:rest N885c2edd72cb4e14820d6cff39a180f5
    237 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    238 schema:name Biological Sciences
    239 rdf:type schema:DefinedTerm
    240 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    241 schema:name Genetics
    242 rdf:type schema:DefinedTerm
    243 sg:grant.2435779 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2649
    244 rdf:type schema:MonetaryGrant
    245 sg:grant.2435862 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2649
    246 rdf:type schema:MonetaryGrant
    247 sg:grant.2440232 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2649
    248 rdf:type schema:MonetaryGrant
    249 sg:grant.2529495 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2649
    250 rdf:type schema:MonetaryGrant
    251 sg:grant.2622811 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2649
    252 rdf:type schema:MonetaryGrant
    253 sg:grant.2684137 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2649
    254 rdf:type schema:MonetaryGrant
    255 sg:grant.2690499 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2649
    256 rdf:type schema:MonetaryGrant
    257 sg:journal.1103138 schema:issn 1061-4036
    258 1546-1718
    259 schema:name Nature Genetics
    260 rdf:type schema:Periodical
    261 sg:person.010656516214.83 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    262 schema:familyName Madden
    263 schema:givenName Pamela A F
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010656516214.83
    265 rdf:type schema:Person
    266 sg:person.01122142106.87 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    267 schema:familyName Xie
    268 schema:givenName Mingchao
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122142106.87
    270 rdf:type schema:Person
    271 sg:person.01150455763.02 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    272 schema:familyName Marra
    273 schema:givenName Marco A
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02
    275 rdf:type schema:Person
    276 sg:person.01152270445.99 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    277 schema:familyName Ligon
    278 schema:givenName Keith L
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152270445.99
    280 rdf:type schema:Person
    281 sg:person.01170255306.08 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    282 schema:familyName Li
    283 schema:givenName Daofeng
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170255306.08
    285 rdf:type schema:Person
    286 sg:person.01222453356.45 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    287 schema:familyName Xing
    288 schema:givenName Xiaoyun
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222453356.45
    290 rdf:type schema:Person
    291 sg:person.01252463635.40 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
    292 schema:familyName O'Geen
    293 schema:givenName Henriette
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252463635.40
    295 rdf:type schema:Person
    296 sg:person.01322771707.06 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    297 schema:familyName Hong
    298 schema:givenName Chibo
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322771707.06
    300 rdf:type schema:Person
    301 sg:person.013474410037.15 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    302 schema:familyName Costello
    303 schema:givenName Joseph F
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013474410037.15
    305 rdf:type schema:Person
    306 sg:person.01353000412.04 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    307 schema:familyName Weiss
    308 schema:givenName Arthur
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353000412.04
    310 rdf:type schema:Person
    311 sg:person.01357726511.86 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
    312 schema:familyName Farnham
    313 schema:givenName Peggy J
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357726511.86
    315 rdf:type schema:Person
    316 sg:person.01366343306.80 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    317 schema:familyName Lowdon
    318 schema:givenName Rebecca F
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366343306.80
    320 rdf:type schema:Person
    321 sg:person.0601713543.66 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    322 schema:familyName Hirst
    323 schema:givenName Martin
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601713543.66
    325 rdf:type schema:Person
    326 sg:person.0627357425.48 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    327 schema:familyName Mungall
    328 schema:givenName Andrew J
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627357425.48
    330 rdf:type schema:Person
    331 sg:person.0646251033.56 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    332 schema:familyName Lee
    333 schema:givenName Hyung Joo
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646251033.56
    335 rdf:type schema:Person
    336 sg:person.0653601341.15 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    337 schema:familyName Zhang
    338 schema:givenName Bo
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653601341.15
    340 rdf:type schema:Person
    341 sg:person.0660324777.47 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    342 schema:familyName Sigaroudinia
    343 schema:givenName Mahvash
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660324777.47
    345 rdf:type schema:Person
    346 sg:person.0662010442.25 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    347 schema:familyName Tlsty
    348 schema:givenName Thea D
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662010442.25
    350 rdf:type schema:Person
    351 sg:person.0664562404.83 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    352 schema:familyName Kamoh
    353 schema:givenName Baljit
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664562404.83
    355 rdf:type schema:Person
    356 sg:person.0726756260.45 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    357 schema:familyName Maire
    358 schema:givenName Cecile L
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726756260.45
    360 rdf:type schema:Person
    361 sg:person.0727137372.57 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    362 schema:familyName Wang
    363 schema:givenName Ting
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727137372.57
    365 rdf:type schema:Person
    366 sg:person.0735014054.21 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    367 schema:familyName Gascard
    368 schema:givenName Philippe
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735014054.21
    370 rdf:type schema:Person
    371 sg:person.07713125404.19 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    372 schema:familyName Kadlecek
    373 schema:givenName Theresa
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07713125404.19
    375 rdf:type schema:Person
    376 sg:pub.10.1007/978-1-4419-0322-8_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036317953
    377 https://doi.org/10.1007/978-1-4419-0322-8_8
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1007/978-1-61779-316-5_20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037428771
    380 https://doi.org/10.1007/978-1-61779-316-5_20
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1007/s00439-003-0991-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031495081
    383 https://doi.org/10.1007/s00439-003-0991-8
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1023/a:1004070603792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020960364
    386 https://doi.org/10.1023/a:1004070603792
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/15490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048828813
    389 https://doi.org/10.1038/15490
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/284601a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013133318
    392 https://doi.org/10.1038/284601a0
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/284604a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052905388
    395 https://doi.org/10.1038/284604a0
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/35054579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021199009
    398 https://doi.org/10.1038/35054579
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/35057062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042854081
    401 https://doi.org/10.1038/35057062
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/nature04696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027944303
    404 https://doi.org/10.1038/nature04696
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/nature05874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005913886
    407 https://doi.org/10.1038/nature05874
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1038/nature09165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019242813
    410 https://doi.org/10.1038/nature09165
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1038/nature10530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013402885
    413 https://doi.org/10.1038/nature10530
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1038/nature10716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026180143
    416 https://doi.org/10.1038/nature10716
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
    419 https://doi.org/10.1038/nature11247
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/nbt.1630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023421025
    422 https://doi.org/10.1038/nbt.1630
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/nbt.1682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031224351
    425 https://doi.org/10.1038/nbt.1682
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/nbt0110-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018405220
    428 https://doi.org/10.1038/nbt0110-22
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1038/nbt1010-1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048301228
    431 https://doi.org/10.1038/nbt1010-1045
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1038/ng.2553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050701683
    434 https://doi.org/10.1038/ng.2553
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1038/ng.600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019643731
    437 https://doi.org/10.1038/ng.600
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1038/ng.917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033825316
    440 https://doi.org/10.1038/ng.917
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1038/nrg1349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047349707
    443 https://doi.org/10.1038/nrg1349
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1038/nrg2072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016430364
    446 https://doi.org/10.1038/nrg2072
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1038/nrg2337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036005113
    449 https://doi.org/10.1038/nrg2337
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1038/nrg798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025444771
    452 https://doi.org/10.1038/nrg798
    453 rdf:type schema:CreativeWork
    454 sg:pub.10.1186/1471-2105-11-230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005918999
    455 https://doi.org/10.1186/1471-2105-11-230
    456 rdf:type schema:CreativeWork
    457 sg:pub.10.1186/1471-2164-9-226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023496135
    458 https://doi.org/10.1186/1471-2164-9-226
    459 rdf:type schema:CreativeWork
    460 sg:pub.10.1186/gb-2010-11-6-r69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008026977
    461 https://doi.org/10.1186/gb-2010-11-6-r69
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1006/mpev.1996.0003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038399237
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.cell.2010.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033093395
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/j.cell.2010.05.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046632705
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/j.cell.2011.11.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007206139
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/j.gene.2009.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036985358
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/j.molcel.2012.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023753839
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/j.tig.2003.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047593060
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/j.tins.2005.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045218625
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1016/s0168-9525(02)00006-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034569785
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1021/bi902022n schema:sameAs https://app.dimensions.ai/details/publication/pub.1055210507
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1046/j.1399-0004.2003.00166.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015540429
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1073/pnas.022630299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011464582
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1073/pnas.0611223104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028702517
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1073/pnas.0703637104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039620426
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1073/pnas.0709398105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034620660
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1073/pnas.2134464100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051479675
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1073/pnas.36.6.344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019329581
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1073/pnas.94.15.7704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033349869
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1074/jbc.m006557200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011142212
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1093/bioinformatics/btq460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017918736
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1093/nar/29.13.e65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022346000
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1093/nar/gkr1012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008353709
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1101/gad.186601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026030725
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1101/gad.947102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030570608
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1101/gr.080663.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036971575
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1101/gr.100594.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006628641
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1101/sqb.1956.021.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060403222
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1126/science.1990437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062516645
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1128/mcb.10.6.2513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045325968
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1146/annurev.genet.35.102401.091032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038407568
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1371/journal.pcbi.1002111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048281760
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1371/journal.pone.0011425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030321502
    526 rdf:type schema:CreativeWork
    527 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
    528 schema:name BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
    529 Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
    530 rdf:type schema:Organization
    531 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
    532 schema:name BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.
    533 rdf:type schema:Organization
    534 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
    535 schema:name Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.
    536 Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.
    537 Division of Rheumatology, University of California, San Francisco, San Francisco, California, USA.
    538 Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA.
    539 rdf:type schema:Organization
    540 https://www.grid.ac/institutes/grid.27860.3b schema:alternateName University of California, Davis
    541 schema:name Genome Center, University of California–Davis, Davis, California, USA.
    542 rdf:type schema:Organization
    543 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    544 schema:name Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    545 Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
    546 rdf:type schema:Organization
    547 https://www.grid.ac/institutes/grid.42505.36 schema:alternateName University of Southern California
    548 schema:name Department of Biochemistry & Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
    549 rdf:type schema:Organization
    550 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
    551 schema:name Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
    552 Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
    553 rdf:type schema:Organization
    554 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
    555 schema:name Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    556 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...