Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06

AUTHORS

Cigall Kadoch, Diana C Hargreaves, Courtney Hodges, Laura Elias, Lena Ho, Jeff Ranish, Gerald R Crabtree

ABSTRACT

Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been implicated as tumor suppressors in human malignancies. To understand the full extent of their involvement, we conducted a proteomic analysis of endogenous mSWI/SNF complexes, which identified several new dedicated, stable subunits not found in yeast SWI/SNF complexes, including BCL7A, BCL7B and BCL7C, BCL11A and BCL11B, BRD9 and SS18. Incorporating these new members, we determined mSWI/SNF subunit mutation frequency in exome and whole-genome sequencing studies of primary human tumors. Notably, mSWI/SNF subunits are mutated in 19.6% of all human tumors reported in 44 studies. Our analysis suggests that specific subunits protect against cancer in specific tissues. In addition, mutations affecting more than one subunit, defined here as compound heterozygosity, are prevalent in certain cancers. Our studies demonstrate that mSWI/SNF is the most frequently mutated chromatin-regulatory complex (CRC) in human cancer, exhibiting a broad mutation pattern, similar to that of TP53. Thus, proper functioning of polymorphic BAF complexes may constitute a major mechanism of tumor suppression. More... »

PAGES

592-601

References to SciGraph publications

  • 2010-11. The TLX1 oncogene drives aneuploidy in T cell transformation in NATURE MEDICINE
  • 2011-09. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma in NATURE GENETICS
  • 2011-04. EZH2 Y641 mutations in follicular lymphoma in LEUKEMIA
  • 2011-09. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder in NATURE GENETICS
  • 2012-08. Novel mutations target distinct subgroups of medulloblastoma in NATURE
  • 2003-06. Bcl11: sibling rivalry in lymphoid development in NATURE IMMUNOLOGY
  • 2012-07. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators in NATURE GENETICS
  • 2012-12. The genetic landscape of mutations in Burkitt lymphoma in NATURE GENETICS
  • 2009-07. MicroRNA-mediated switching of chromatin-remodelling complexes in neural development in NATURE
  • 2012-07. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2012-12. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing in NATURE GENETICS
  • 2011-12. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer in NATURE GENETICS
  • 2010-02. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin in NATURE GENETICS
  • 2011-06-29. Integrated genomic analyses of ovarian carcinoma in NATURE
  • 2012-06. The landscape of cancer genes and mutational processes in breast cancer in NATURE
  • 2011-08. MicroRNA-mediated conversion of human fibroblasts to neurons in NATURE
  • 2002-02. Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression in ONCOGENE
  • 2012-06. Sequence analysis of mutations and translocations across breast cancer subtypes in NATURE
  • 2012-08. Recurrent R-spondin fusions in colon cancer in NATURE
  • 2012-05. Melanoma genome sequencing reveals frequent PREX2 mutations in NATURE
  • 2012-06. Whole-genome analysis informs breast cancer response to aromatase inhibition in NATURE
  • 2012-01. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia in NATURE
  • 2012-07. BAP1 loss defines a new class of renal cell carcinoma in NATURE GENETICS
  • 2010-01. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes in NATURE
  • 2011-05. Exome sequencing identifies GRIN2A as frequently mutated in melanoma in NATURE GENETICS
  • 1998-07. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer in NATURE
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2011-08. esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function in NATURE CELL BIOLOGY
  • 2001-12. Selectivity of chromatin-remodelling cofactors for ligand-activated transcription in NATURE
  • 2012-06. The clonal and mutational evolution spectrum of primary triple-negative breast cancers in NATURE
  • 2011-09. Analysis of the coding genome of diffuse large B-cell lymphoma in NATURE GENETICS
  • 2011-08. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma in NATURE
  • 1993-11. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription in NATURE
  • 2011-03-13. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia in NATURE GENETICS
  • 1994-08. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma in NATURE GENETICS
  • 2012-05. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes in NATURE GENETICS
  • 2011-07. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia in NATURE
  • 2011-01-27. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma in NATURE
  • 2012-01. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia in NATURE GENETICS
  • 2008-10-23. Comprehensive genomic characterization defines human glioblastoma genes and core pathways in NATURE
  • 2011-03. Initial genome sequencing and analysis of multiple myeloma in NATURE
  • 2012-08. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations in NATURE
  • 2012-08. Dissecting the genomic complexity underlying medulloblastoma in NATURE
  • 2011-02. Initial impact of the sequencing of the human genome in NATURE
  • 2003-09. t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH) in LEUKEMIA
  • 2012-09. Comprehensive genomic characterization of squamous cell lung cancers in NATURE
  • 2012-06. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma in NATURE GENETICS
  • 2012-11. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes in NATURE
  • 2012-02. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2628

    DOI

    http://dx.doi.org/10.1038/ng.2628

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023030104

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23644491


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomal Proteins, Non-Histone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Frequency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Tumor Suppressor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oncogenes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Subunits", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.", 
                "Program in Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kadoch", 
            "givenName": "Cigall", 
            "id": "sg:person.01274472031.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274472031.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Program in Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hargreaves", 
            "givenName": "Diana C", 
            "id": "sg:person.01253672654.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253672654.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Program in Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hodges", 
            "givenName": "Courtney", 
            "id": "sg:person.01277756027.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277756027.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Program in Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Elias", 
            "givenName": "Laura", 
            "id": "sg:person.0645020414.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645020414.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Program in Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ho", 
            "givenName": "Lena", 
            "id": "sg:person.0767613145.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767613145.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Systems Biology", 
              "id": "https://www.grid.ac/institutes/grid.64212.33", 
              "name": [
                "Institute for Systems Biology, Seattle, Washington, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ranish", 
            "givenName": "Jeff", 
            "id": "sg:person.01370042670.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370042670.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.", 
                "Program in Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.", 
                "Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Crabtree", 
            "givenName": "Gerald R", 
            "id": "sg:person.012126676102.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012126676102.17"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.1200609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000382958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v98.12.3413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000387986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000736346", 
              "https://doi.org/10.1038/nature10166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000834660", 
              "https://doi.org/10.1038/nature11143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0603-512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001273572", 
              "https://doi.org/10.1038/ni0603-512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0603-512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001273572", 
              "https://doi.org/10.1038/ni0603-512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001723375", 
              "https://doi.org/10.1038/ng.518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001723375", 
              "https://doi.org/10.1038/ng.518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.992102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001935759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812889106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002066445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812889106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002066445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002477386", 
              "https://doi.org/10.1038/ng.2291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002983807", 
              "https://doi.org/10.1038/sj.onc.1205188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002983807", 
              "https://doi.org/10.1038/sj.onc.1205188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/302833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003062681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003167714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004805088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(69)90215-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004979396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006014163", 
              "https://doi.org/10.1038/nature11404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006014163", 
              "https://doi.org/10.1038/nature11404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1008433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006460072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006487337", 
              "https://doi.org/10.1038/nature10725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006710792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007161398", 
              "https://doi.org/10.1038/nature09837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008342832", 
              "https://doi.org/10.1038/ng.907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.10052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008695500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008698030", 
              "https://doi.org/10.1038/nature10113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.6.12.18492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008856871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009539954", 
              "https://doi.org/10.1038/nature09639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/embo-reports/kvd129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009789486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.02019-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010093923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(69)90214-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010617037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90405-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011719199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-11-318873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012278816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0894-502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014050184", 
              "https://doi.org/10.1038/ng0894-502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.06.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014079572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1121343109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014174095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015512980", 
              "https://doi.org/10.1038/nature11071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016716428", 
              "https://doi.org/10.1038/nm.2246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016745974", 
              "https://doi.org/10.1038/ng.982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018122872", 
              "https://doi.org/10.1038/nature09792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1165409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018203920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1165409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018203920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/humu.21415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018212814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81633-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018680819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018806881", 
              "https://doi.org/10.1038/ng.903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019649945", 
              "https://doi.org/10.1038/nature10351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366170a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019735918", 
              "https://doi.org/10.1038/366170a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020577076", 
              "https://doi.org/10.1038/ncb2285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020681837", 
              "https://doi.org/10.1038/ng.2468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021752665", 
              "https://doi.org/10.1038/ng.2469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e318212782a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022167705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e318212782a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022167705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023106003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.06.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024635810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024855438", 
              "https://doi.org/10.1038/nature11282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942368", 
              "https://doi.org/10.1038/nature11412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024945277", 
              "https://doi.org/10.1038/nature10323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024945277", 
              "https://doi.org/10.1038/nature10323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025587486", 
              "https://doi.org/10.1038/ng.788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025648471", 
              "https://doi.org/10.1038/leu.2010.311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2787(70)90707-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026374223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2787(70)90707-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026374223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2787(71)90014-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026424859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2787(71)90014-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026424859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0033834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027118907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027243747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027243747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027457561", 
              "https://doi.org/10.1038/nature10933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027806447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028644962", 
              "https://doi.org/10.1038/ng.2256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.leukres.2010.08.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028975061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029387548", 
              "https://doi.org/10.1038/nature11547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1198056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030704690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032031050", 
              "https://doi.org/10.1038/ng.810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m806061200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032755382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032969139", 
              "https://doi.org/10.1038/nature08672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032969139", 
              "https://doi.org/10.1038/nature08672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033749871", 
              "https://doi.org/10.1038/sj.leu.2403061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033749871", 
              "https://doi.org/10.1038/sj.leu.2403061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034041413", 
              "https://doi.org/10.1038/nature11017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81820-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036107686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/414924a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036174221", 
              "https://doi.org/10.1038/414924a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/414924a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036174221", 
              "https://doi.org/10.1038/414924a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1196333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036640408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036872856", 
              "https://doi.org/10.1038/nature11329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1208130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038068253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1208130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038068253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038367682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039302414", 
              "https://doi.org/10.1038/nature11284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039570773", 
              "https://doi.org/10.1038/nature07385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039575824", 
              "https://doi.org/10.1038/nature10833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.02.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039594071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1090701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040136786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040240428", 
              "https://doi.org/10.1038/nature11213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042121182", 
              "https://doi.org/10.1038/ng.892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.14.7748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042559882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043591147", 
              "https://doi.org/10.1038/ng.2323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043591147", 
              "https://doi.org/10.1038/ng.2323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.1032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046870423", 
              "https://doi.org/10.1038/ng.1032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.287755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047552839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047821839", 
              "https://doi.org/10.1038/ng.2246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047865255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048029720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.06.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048271589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049222218", 
              "https://doi.org/10.1038/nature11154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049280395", 
              "https://doi.org/10.1038/nature08139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049280395", 
              "https://doi.org/10.1038/nature08139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049280395", 
              "https://doi.org/10.1038/nature08139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0028585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051826038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/28212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052086874", 
              "https://doi.org/10.1038/28212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/28212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052086874", 
              "https://doi.org/10.1038/28212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2007.06.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052095309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.250492697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052416665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.10.17.2117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053027462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/302639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058610207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/4.6.1097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059645448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1206923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062464764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1206923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062464764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1186/1477-3163-4-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064133359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074730799", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.14670/hh-23.1069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077666840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1995.tb07228.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082404725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00921.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082990337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083376141", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-06", 
        "datePublishedReg": "2013-06-01", 
        "description": "Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been implicated as tumor suppressors in human malignancies. To understand the full extent of their involvement, we conducted a proteomic analysis of endogenous mSWI/SNF complexes, which identified several new dedicated, stable subunits not found in yeast SWI/SNF complexes, including BCL7A, BCL7B and BCL7C, BCL11A and BCL11B, BRD9 and SS18. Incorporating these new members, we determined mSWI/SNF subunit mutation frequency in exome and whole-genome sequencing studies of primary human tumors. Notably, mSWI/SNF subunits are mutated in 19.6% of all human tumors reported in 44 studies. Our analysis suggests that specific subunits protect against cancer in specific tissues. In addition, mutations affecting more than one subunit, defined here as compound heterozygosity, are prevalent in certain cancers. Our studies demonstrate that mSWI/SNF is the most frequently mutated chromatin-regulatory complex (CRC) in human cancer, exhibiting a broad mutation pattern, similar to that of TP53. Thus, proper functioning of polymorphic BAF complexes may constitute a major mechanism of tumor suppression.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ng.2628", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2682529", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2636192", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2560801", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2481721", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2384673", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "45"
          }
        ], 
        "name": "Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy", 
        "pagination": "592-601", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6db84e2b6e279af423f2c1cfb0b0666d4385fab8392c14118c7494a5e5c0453c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23644491"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.2628"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1023030104"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.2628", 
          "https://app.dimensions.ai/details/publication/pub.1023030104"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T18:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ng/journal/v45/n6/full/ng.2628.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2628'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2628'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2628'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2628'


     

    This table displays all metadata directly associated to this object as RDF triples.

    544 TRIPLES      21 PREDICATES      148 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.2628 schema:about N0ffd79276c3d439d9d26fdcda2e0412a
    2 N22c69b96565640fb80929a2803cd7dd6
    3 N3eb4425171a746a68cc20e3855bf305a
    4 N5c6ca1bfb15e4de2b294d9610fd7caa9
    5 N5cee74e1b8ad48569bbe336ec8f8134e
    6 N5ffbb76965fa4a3591f818407c7f575c
    7 N7d9f6c156c874492bd064e6189a6d51c
    8 N8e8776c85e9c4c1bb2cfadd8a1685c9d
    9 Nb638ffa0d23d4972a7ce7af296db131a
    10 Nb7df5da9174b4ec3b3d41c1e30007710
    11 Nc2e9dd3d983c41839fee0a4ecce99697
    12 Nc82908f3b4984b53852b584496346b6f
    13 Nfc80ede78c4944b4a728960c16dd874b
    14 anzsrc-for:06
    15 anzsrc-for:0601
    16 schema:author N4e80b3ab8a224393bfaead76c2a9222b
    17 schema:citation sg:pub.10.1038/28212
    18 sg:pub.10.1038/366170a0
    19 sg:pub.10.1038/414924a
    20 sg:pub.10.1038/leu.2010.311
    21 sg:pub.10.1038/nature07385
    22 sg:pub.10.1038/nature08139
    23 sg:pub.10.1038/nature08672
    24 sg:pub.10.1038/nature09639
    25 sg:pub.10.1038/nature09792
    26 sg:pub.10.1038/nature09837
    27 sg:pub.10.1038/nature10113
    28 sg:pub.10.1038/nature10166
    29 sg:pub.10.1038/nature10323
    30 sg:pub.10.1038/nature10351
    31 sg:pub.10.1038/nature10725
    32 sg:pub.10.1038/nature10833
    33 sg:pub.10.1038/nature10933
    34 sg:pub.10.1038/nature11017
    35 sg:pub.10.1038/nature11071
    36 sg:pub.10.1038/nature11143
    37 sg:pub.10.1038/nature11154
    38 sg:pub.10.1038/nature11213
    39 sg:pub.10.1038/nature11252
    40 sg:pub.10.1038/nature11282
    41 sg:pub.10.1038/nature11284
    42 sg:pub.10.1038/nature11329
    43 sg:pub.10.1038/nature11404
    44 sg:pub.10.1038/nature11412
    45 sg:pub.10.1038/nature11547
    46 sg:pub.10.1038/ncb2285
    47 sg:pub.10.1038/ng.1032
    48 sg:pub.10.1038/ng.2246
    49 sg:pub.10.1038/ng.2256
    50 sg:pub.10.1038/ng.2291
    51 sg:pub.10.1038/ng.2323
    52 sg:pub.10.1038/ng.2468
    53 sg:pub.10.1038/ng.2469
    54 sg:pub.10.1038/ng.518
    55 sg:pub.10.1038/ng.788
    56 sg:pub.10.1038/ng.810
    57 sg:pub.10.1038/ng.892
    58 sg:pub.10.1038/ng.903
    59 sg:pub.10.1038/ng.907
    60 sg:pub.10.1038/ng.982
    61 sg:pub.10.1038/ng0894-502
    62 sg:pub.10.1038/ni0603-512
    63 sg:pub.10.1038/nm.2246
    64 sg:pub.10.1038/sj.leu.2403061
    65 sg:pub.10.1038/sj.onc.1205188
    66 https://app.dimensions.ai/details/publication/pub.1074730799
    67 https://app.dimensions.ai/details/publication/pub.1083376141
    68 https://doi.org/10.1002/gcc.10052
    69 https://doi.org/10.1002/gcc.20021
    70 https://doi.org/10.1002/gcc.20459
    71 https://doi.org/10.1002/humu.21415
    72 https://doi.org/10.1002/j.1460-2075.1995.tb07228.x
    73 https://doi.org/10.1002/j.1460-2075.1996.tb00921.x
    74 https://doi.org/10.1016/0005-2787(70)90707-0
    75 https://doi.org/10.1016/0005-2787(71)90014-1
    76 https://doi.org/10.1016/0022-2836(69)90214-9
    77 https://doi.org/10.1016/0022-2836(69)90215-0
    78 https://doi.org/10.1016/0092-8674(94)90405-7
    79 https://doi.org/10.1016/j.cell.2012.06.013
    80 https://doi.org/10.1016/j.cell.2012.06.023
    81 https://doi.org/10.1016/j.cell.2012.06.024
    82 https://doi.org/10.1016/j.cell.2012.08.024
    83 https://doi.org/10.1016/j.cell.2012.08.029
    84 https://doi.org/10.1016/j.cell.2013.02.036
    85 https://doi.org/10.1016/j.leukres.2010.08.018
    86 https://doi.org/10.1016/j.neuron.2007.06.019
    87 https://doi.org/10.1016/s0092-8674(00)81633-5
    88 https://doi.org/10.1016/s0092-8674(00)81820-6
    89 https://doi.org/10.1056/nejmoa1008433
    90 https://doi.org/10.1073/pnas.0812889106
    91 https://doi.org/10.1073/pnas.1121343109
    92 https://doi.org/10.1073/pnas.250492697
    93 https://doi.org/10.1073/pnas.97.14.7748
    94 https://doi.org/10.1074/jbc.m111.287755
    95 https://doi.org/10.1074/jbc.m806061200
    96 https://doi.org/10.1086/302639
    97 https://doi.org/10.1086/302833
    98 https://doi.org/10.1093/embo-reports/kvd129
    99 https://doi.org/10.1093/hmg/4.6.1097
    100 https://doi.org/10.1097/pas.0b013e318212782a
    101 https://doi.org/10.1101/gad.10.17.2117
    102 https://doi.org/10.1101/gad.992102
    103 https://doi.org/10.1126/science.1090701
    104 https://doi.org/10.1126/science.1164368
    105 https://doi.org/10.1126/science.1164382
    106 https://doi.org/10.1126/science.1165409
    107 https://doi.org/10.1126/science.1196333
    108 https://doi.org/10.1126/science.1198056
    109 https://doi.org/10.1126/science.1200609
    110 https://doi.org/10.1126/science.1206923
    111 https://doi.org/10.1126/science.1208130
    112 https://doi.org/10.1128/mcb.02019-07
    113 https://doi.org/10.1158/0008-5472.can-09-2166
    114 https://doi.org/10.1158/2159-8290.cd-11-0028
    115 https://doi.org/10.1182/blood-2010-11-318873
    116 https://doi.org/10.1182/blood.v98.12.3413
    117 https://doi.org/10.1186/1477-3163-4-13
    118 https://doi.org/10.1371/journal.pone.0028585
    119 https://doi.org/10.1371/journal.pone.0033834
    120 https://doi.org/10.14670/hh-23.1069
    121 https://doi.org/10.18632/oncotarget.689
    122 https://doi.org/10.4161/epi.6.12.18492
    123 schema:datePublished 2013-06
    124 schema:datePublishedReg 2013-06-01
    125 schema:description Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been implicated as tumor suppressors in human malignancies. To understand the full extent of their involvement, we conducted a proteomic analysis of endogenous mSWI/SNF complexes, which identified several new dedicated, stable subunits not found in yeast SWI/SNF complexes, including BCL7A, BCL7B and BCL7C, BCL11A and BCL11B, BRD9 and SS18. Incorporating these new members, we determined mSWI/SNF subunit mutation frequency in exome and whole-genome sequencing studies of primary human tumors. Notably, mSWI/SNF subunits are mutated in 19.6% of all human tumors reported in 44 studies. Our analysis suggests that specific subunits protect against cancer in specific tissues. In addition, mutations affecting more than one subunit, defined here as compound heterozygosity, are prevalent in certain cancers. Our studies demonstrate that mSWI/SNF is the most frequently mutated chromatin-regulatory complex (CRC) in human cancer, exhibiting a broad mutation pattern, similar to that of TP53. Thus, proper functioning of polymorphic BAF complexes may constitute a major mechanism of tumor suppression.
    126 schema:genre research_article
    127 schema:inLanguage en
    128 schema:isAccessibleForFree true
    129 schema:isPartOf N06088c33ea8341208d724e3c5f9ee485
    130 Ndd47c304e6ce42bd9db03a6f0f4f95e9
    131 sg:journal.1103138
    132 schema:name Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
    133 schema:pagination 592-601
    134 schema:productId N2f48bf3593b245df84466b020151dfa2
    135 N3eeb00814fb94e80953c94afc0329770
    136 N59662ba5eefd4bc294e62c2fd8bf02cc
    137 N5dd10ae065144fb692a75a12df08a830
    138 Ne24823bbd50442b6a4a409a0e83c08eb
    139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023030104
    140 https://doi.org/10.1038/ng.2628
    141 schema:sdDatePublished 2019-04-10T18:56
    142 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    143 schema:sdPublisher N338e04dd173b43eb8ef7e624cdc9edce
    144 schema:url http://www.nature.com/ng/journal/v45/n6/full/ng.2628.html
    145 sgo:license sg:explorer/license/
    146 sgo:sdDataset articles
    147 rdf:type schema:ScholarlyArticle
    148 N00d2f963d66749d984cf7b4444cd7b79 rdf:first sg:person.01277756027.00
    149 rdf:rest Na255adb551d84a3891e0417a6417bad4
    150 N06088c33ea8341208d724e3c5f9ee485 schema:volumeNumber 45
    151 rdf:type schema:PublicationVolume
    152 N0ffd79276c3d439d9d26fdcda2e0412a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Neoplasms
    154 rdf:type schema:DefinedTerm
    155 N1a6fde8f8dda472fbeb8ae3db055dabc rdf:first sg:person.01370042670.98
    156 rdf:rest N1ba30d4d062c452e9dfdc009f55226ea
    157 N1ba30d4d062c452e9dfdc009f55226ea rdf:first sg:person.012126676102.17
    158 rdf:rest rdf:nil
    159 N22c69b96565640fb80929a2803cd7dd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Transcription Factors
    161 rdf:type schema:DefinedTerm
    162 N2f48bf3593b245df84466b020151dfa2 schema:name readcube_id
    163 schema:value 6db84e2b6e279af423f2c1cfb0b0666d4385fab8392c14118c7494a5e5c0453c
    164 rdf:type schema:PropertyValue
    165 N338e04dd173b43eb8ef7e624cdc9edce schema:name Springer Nature - SN SciGraph project
    166 rdf:type schema:Organization
    167 N3eb4425171a746a68cc20e3855bf305a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Cells, Cultured
    169 rdf:type schema:DefinedTerm
    170 N3eeb00814fb94e80953c94afc0329770 schema:name nlm_unique_id
    171 schema:value 9216904
    172 rdf:type schema:PropertyValue
    173 N47cfc9fad0ec4cfa8a836a8fe3a68014 rdf:first sg:person.0767613145.09
    174 rdf:rest N1a6fde8f8dda472fbeb8ae3db055dabc
    175 N4e80b3ab8a224393bfaead76c2a9222b rdf:first sg:person.01274472031.96
    176 rdf:rest Nce207ad94cca4793839c1d80b1d37a0c
    177 N59662ba5eefd4bc294e62c2fd8bf02cc schema:name doi
    178 schema:value 10.1038/ng.2628
    179 rdf:type schema:PropertyValue
    180 N5c6ca1bfb15e4de2b294d9610fd7caa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Animals
    182 rdf:type schema:DefinedTerm
    183 N5cee74e1b8ad48569bbe336ec8f8134e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Mice
    185 rdf:type schema:DefinedTerm
    186 N5dd10ae065144fb692a75a12df08a830 schema:name dimensions_id
    187 schema:value pub.1023030104
    188 rdf:type schema:PropertyValue
    189 N5ffbb76965fa4a3591f818407c7f575c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Protein Subunits
    191 rdf:type schema:DefinedTerm
    192 N7d9f6c156c874492bd064e6189a6d51c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Humans
    194 rdf:type schema:DefinedTerm
    195 N8e8776c85e9c4c1bb2cfadd8a1685c9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Genes, Tumor Suppressor
    197 rdf:type schema:DefinedTerm
    198 Na255adb551d84a3891e0417a6417bad4 rdf:first sg:person.0645020414.25
    199 rdf:rest N47cfc9fad0ec4cfa8a836a8fe3a68014
    200 Nb638ffa0d23d4972a7ce7af296db131a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Proteomics
    202 rdf:type schema:DefinedTerm
    203 Nb7df5da9174b4ec3b3d41c1e30007710 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Chromosomal Proteins, Non-Histone
    205 rdf:type schema:DefinedTerm
    206 Nc2e9dd3d983c41839fee0a4ecce99697 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Mutation
    208 rdf:type schema:DefinedTerm
    209 Nc82908f3b4984b53852b584496346b6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Gene Frequency
    211 rdf:type schema:DefinedTerm
    212 Nce207ad94cca4793839c1d80b1d37a0c rdf:first sg:person.01253672654.89
    213 rdf:rest N00d2f963d66749d984cf7b4444cd7b79
    214 Ndd47c304e6ce42bd9db03a6f0f4f95e9 schema:issueNumber 6
    215 rdf:type schema:PublicationIssue
    216 Ne24823bbd50442b6a4a409a0e83c08eb schema:name pubmed_id
    217 schema:value 23644491
    218 rdf:type schema:PropertyValue
    219 Nfc80ede78c4944b4a728960c16dd874b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Oncogenes
    221 rdf:type schema:DefinedTerm
    222 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Biological Sciences
    224 rdf:type schema:DefinedTerm
    225 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    226 schema:name Biochemistry and Cell Biology
    227 rdf:type schema:DefinedTerm
    228 sg:grant.2384673 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2628
    229 rdf:type schema:MonetaryGrant
    230 sg:grant.2481721 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2628
    231 rdf:type schema:MonetaryGrant
    232 sg:grant.2560801 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2628
    233 rdf:type schema:MonetaryGrant
    234 sg:grant.2636192 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2628
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.2682529 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2628
    237 rdf:type schema:MonetaryGrant
    238 sg:journal.1103138 schema:issn 1061-4036
    239 1546-1718
    240 schema:name Nature Genetics
    241 rdf:type schema:Periodical
    242 sg:person.012126676102.17 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    243 schema:familyName Crabtree
    244 schema:givenName Gerald R
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012126676102.17
    246 rdf:type schema:Person
    247 sg:person.01253672654.89 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    248 schema:familyName Hargreaves
    249 schema:givenName Diana C
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253672654.89
    251 rdf:type schema:Person
    252 sg:person.01274472031.96 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    253 schema:familyName Kadoch
    254 schema:givenName Cigall
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274472031.96
    256 rdf:type schema:Person
    257 sg:person.01277756027.00 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    258 schema:familyName Hodges
    259 schema:givenName Courtney
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277756027.00
    261 rdf:type schema:Person
    262 sg:person.01370042670.98 schema:affiliation https://www.grid.ac/institutes/grid.64212.33
    263 schema:familyName Ranish
    264 schema:givenName Jeff
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370042670.98
    266 rdf:type schema:Person
    267 sg:person.0645020414.25 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    268 schema:familyName Elias
    269 schema:givenName Laura
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645020414.25
    271 rdf:type schema:Person
    272 sg:person.0767613145.09 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    273 schema:familyName Ho
    274 schema:givenName Lena
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767613145.09
    276 rdf:type schema:Person
    277 sg:pub.10.1038/28212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052086874
    278 https://doi.org/10.1038/28212
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/366170a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019735918
    281 https://doi.org/10.1038/366170a0
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/414924a schema:sameAs https://app.dimensions.ai/details/publication/pub.1036174221
    284 https://doi.org/10.1038/414924a
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/leu.2010.311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025648471
    287 https://doi.org/10.1038/leu.2010.311
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/nature07385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039570773
    290 https://doi.org/10.1038/nature07385
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/nature08139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049280395
    293 https://doi.org/10.1038/nature08139
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/nature08672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032969139
    296 https://doi.org/10.1038/nature08672
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nature09639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009539954
    299 https://doi.org/10.1038/nature09639
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/nature09792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018122872
    302 https://doi.org/10.1038/nature09792
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/nature09837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007161398
    305 https://doi.org/10.1038/nature09837
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/nature10113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008698030
    308 https://doi.org/10.1038/nature10113
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
    311 https://doi.org/10.1038/nature10166
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/nature10323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024945277
    314 https://doi.org/10.1038/nature10323
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nature10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019649945
    317 https://doi.org/10.1038/nature10351
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nature10725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006487337
    320 https://doi.org/10.1038/nature10725
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/nature10833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039575824
    323 https://doi.org/10.1038/nature10833
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nature10933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457561
    326 https://doi.org/10.1038/nature10933
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nature11017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034041413
    329 https://doi.org/10.1038/nature11017
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nature11071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015512980
    332 https://doi.org/10.1038/nature11071
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/nature11143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000834660
    335 https://doi.org/10.1038/nature11143
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/nature11154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049222218
    338 https://doi.org/10.1038/nature11154
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nature11213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040240428
    341 https://doi.org/10.1038/nature11213
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    344 https://doi.org/10.1038/nature11252
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/nature11282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024855438
    347 https://doi.org/10.1038/nature11282
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/nature11284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039302414
    350 https://doi.org/10.1038/nature11284
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/nature11329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036872856
    353 https://doi.org/10.1038/nature11329
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/nature11404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006014163
    356 https://doi.org/10.1038/nature11404
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
    359 https://doi.org/10.1038/nature11412
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/nature11547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029387548
    362 https://doi.org/10.1038/nature11547
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/ncb2285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020577076
    365 https://doi.org/10.1038/ncb2285
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/ng.1032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046870423
    368 https://doi.org/10.1038/ng.1032
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/ng.2246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047821839
    371 https://doi.org/10.1038/ng.2246
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/ng.2256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028644962
    374 https://doi.org/10.1038/ng.2256
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/ng.2291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002477386
    377 https://doi.org/10.1038/ng.2291
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/ng.2323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043591147
    380 https://doi.org/10.1038/ng.2323
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/ng.2468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020681837
    383 https://doi.org/10.1038/ng.2468
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/ng.2469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021752665
    386 https://doi.org/10.1038/ng.2469
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/ng.518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001723375
    389 https://doi.org/10.1038/ng.518
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/ng.788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025587486
    392 https://doi.org/10.1038/ng.788
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/ng.810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032031050
    395 https://doi.org/10.1038/ng.810
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/ng.892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042121182
    398 https://doi.org/10.1038/ng.892
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/ng.903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018806881
    401 https://doi.org/10.1038/ng.903
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/ng.907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008342832
    404 https://doi.org/10.1038/ng.907
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/ng.982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016745974
    407 https://doi.org/10.1038/ng.982
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1038/ng0894-502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014050184
    410 https://doi.org/10.1038/ng0894-502
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1038/ni0603-512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001273572
    413 https://doi.org/10.1038/ni0603-512
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1038/nm.2246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016716428
    416 https://doi.org/10.1038/nm.2246
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/sj.leu.2403061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033749871
    419 https://doi.org/10.1038/sj.leu.2403061
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/sj.onc.1205188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002983807
    422 https://doi.org/10.1038/sj.onc.1205188
    423 rdf:type schema:CreativeWork
    424 https://app.dimensions.ai/details/publication/pub.1074730799 schema:CreativeWork
    425 https://app.dimensions.ai/details/publication/pub.1083376141 schema:CreativeWork
    426 https://doi.org/10.1002/gcc.10052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008695500
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1002/gcc.20021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004805088
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1002/gcc.20459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003167714
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1002/humu.21415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018212814
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1002/j.1460-2075.1995.tb07228.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082404725
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1002/j.1460-2075.1996.tb00921.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082990337
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1016/0005-2787(70)90707-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026374223
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1016/0005-2787(71)90014-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026424859
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1016/0022-2836(69)90214-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010617037
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1016/0022-2836(69)90215-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004979396
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1016/0092-8674(94)90405-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011719199
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1016/j.cell.2012.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048271589
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1016/j.cell.2012.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014079572
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1016/j.cell.2012.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024635810
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1016/j.cell.2012.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047865255
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1016/j.cell.2012.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027243747
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1016/j.cell.2013.02.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039594071
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1016/j.leukres.2010.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028975061
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1016/j.neuron.2007.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052095309
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1016/s0092-8674(00)81633-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018680819
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1016/s0092-8674(00)81820-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036107686
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1056/nejmoa1008433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006460072
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1073/pnas.0812889106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002066445
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1073/pnas.1121343109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014174095
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1073/pnas.250492697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052416665
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1073/pnas.97.14.7748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042559882
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1074/jbc.m111.287755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047552839
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1074/jbc.m806061200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032755382
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1086/302639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610207
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1086/302833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003062681
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1093/embo-reports/kvd129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009789486
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1093/hmg/4.6.1097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645448
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1097/pas.0b013e318212782a schema:sameAs https://app.dimensions.ai/details/publication/pub.1022167705
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1101/gad.10.17.2117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053027462
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1101/gad.992102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001935759
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1126/science.1090701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040136786
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1126/science.1164368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006710792
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1126/science.1164382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048029720
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1126/science.1165409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018203920
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1126/science.1196333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036640408
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1126/science.1198056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030704690
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1126/science.1200609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000382958
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1126/science.1206923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464764
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1126/science.1208130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038068253
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1128/mcb.02019-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010093923
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1158/0008-5472.can-09-2166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023106003
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1158/2159-8290.cd-11-0028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038367682
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1182/blood-2010-11-318873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012278816
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1182/blood.v98.12.3413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000387986
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1186/1477-3163-4-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064133359
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1371/journal.pone.0028585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051826038
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1371/journal.pone.0033834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027118907
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.14670/hh-23.1069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077666840
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.18632/oncotarget.689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027806447
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.4161/epi.6.12.18492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008856871
    535 rdf:type schema:CreativeWork
    536 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
    537 schema:name Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.
    538 Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
    539 Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
    540 Program in Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.
    541 rdf:type schema:Organization
    542 https://www.grid.ac/institutes/grid.64212.33 schema:alternateName Institute for Systems Biology
    543 schema:name Institute for Systems Biology, Seattle, Washington, USA.
    544 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...