Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Richard S Houlston, Emily Webb, Peter Broderick, Alan M Pittman, Maria Chiara Di Bernardo, Steven Lubbe, Ian Chandler, Jayaram Vijayakrishnan, Kate Sullivan, Steven Penegar, Luis Carvajal-Carmona, Kimberley Howarth, Emma Jaeger, Sarah L Spain, Axel Walther, Ella Barclay, Lynn Martin, Maggie Gorman, Enric Domingo, Ana S Teixeira, David Kerr, Jean-Baptiste Cazier, Iina Niittymäki, Sari Tuupanen, Auli Karhu, Lauri A Aaltonen, Ian P M Tomlinson, Susan M Farrington, Albert Tenesa, James G D Prendergast, Rebecca A Barnetson, Roseanne Cetnarskyj, Mary E Porteous, Paul D P Pharoah, Thibaud Koessler, Jochen Hampe, Stephan Buch, Clemens Schafmayer, Jurgen Tepel, Stefan Schreiber, Henry Völzke, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Brent W Zanke, Alexandre Montpetit, Thomas J Hudson, Steven Gallinger, Harry Campbell, Malcolm G Dunlop

ABSTRACT

Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC. More... »

PAGES

1426-1435

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.262

DOI

http://dx.doi.org/10.1038/ng.262

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025725602

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19011631


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK. richard.houlston@icr.ac.uk"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houlston", 
        "givenName": "Richard S", 
        "id": "sg:person.010115766245.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010115766245.30"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Webb", 
        "givenName": "Emily", 
        "id": "sg:person.01303235220.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303235220.85"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Broderick", 
        "givenName": "Peter", 
        "id": "sg:person.01146370076.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146370076.54"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pittman", 
        "givenName": "Alan M", 
        "id": "sg:person.01000634420.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000634420.06"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Di Bernardo", 
        "givenName": "Maria Chiara", 
        "type": "Person"
      }, 
      {
        "familyName": "Lubbe", 
        "givenName": "Steven", 
        "type": "Person"
      }, 
      {
        "familyName": "Chandler", 
        "givenName": "Ian", 
        "type": "Person"
      }, 
      {
        "familyName": "Vijayakrishnan", 
        "givenName": "Jayaram", 
        "id": "sg:person.0611721341.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611721341.72"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Sullivan", 
        "givenName": "Kate", 
        "type": "Person"
      }, 
      {
        "familyName": "Penegar", 
        "givenName": "Steven", 
        "id": "sg:person.0641657135.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641657135.92"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Carvajal-Carmona", 
        "givenName": "Luis", 
        "type": "Person"
      }, 
      {
        "familyName": "Howarth", 
        "givenName": "Kimberley", 
        "type": "Person"
      }, 
      {
        "familyName": "Jaeger", 
        "givenName": "Emma", 
        "type": "Person"
      }, 
      {
        "familyName": "Spain", 
        "givenName": "Sarah L", 
        "id": "sg:person.01356351034.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356351034.79"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Walther", 
        "givenName": "Axel", 
        "type": "Person"
      }, 
      {
        "familyName": "Barclay", 
        "givenName": "Ella", 
        "type": "Person"
      }, 
      {
        "familyName": "Martin", 
        "givenName": "Lynn", 
        "type": "Person"
      }, 
      {
        "familyName": "Gorman", 
        "givenName": "Maggie", 
        "type": "Person"
      }, 
      {
        "familyName": "Domingo", 
        "givenName": "Enric", 
        "id": "sg:person.0753633043.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753633043.29"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Teixeira", 
        "givenName": "Ana S", 
        "type": "Person"
      }, 
      {
        "familyName": "Kerr", 
        "givenName": "David", 
        "type": "Person"
      }, 
      {
        "familyName": "Cazier", 
        "givenName": "Jean-Baptiste", 
        "type": "Person"
      }, 
      {
        "familyName": "Niittym\u00e4ki", 
        "givenName": "Iina", 
        "id": "sg:person.01252574746.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252574746.84"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tuupanen", 
        "givenName": "Sari", 
        "id": "sg:person.01021200765.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021200765.59"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Karhu", 
        "givenName": "Auli", 
        "id": "sg:person.01140416457.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140416457.07"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Aaltonen", 
        "givenName": "Lauri A", 
        "id": "sg:person.014335002177.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014335002177.17"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tomlinson", 
        "givenName": "Ian P M", 
        "id": "sg:person.01177572330.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177572330.00"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Farrington", 
        "givenName": "Susan M", 
        "id": "sg:person.012142217732.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012142217732.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tenesa", 
        "givenName": "Albert", 
        "id": "sg:person.01210572206.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210572206.68"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Prendergast", 
        "givenName": "James G D", 
        "id": "sg:person.01202112735.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202112735.10"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Barnetson", 
        "givenName": "Rebecca A", 
        "type": "Person"
      }, 
      {
        "familyName": "Cetnarskyj", 
        "givenName": "Roseanne", 
        "id": "sg:person.01216730540.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216730540.28"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Porteous", 
        "givenName": "Mary E", 
        "type": "Person"
      }, 
      {
        "familyName": "Pharoah", 
        "givenName": "Paul D P", 
        "id": "sg:person.01034602463.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034602463.88"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Koessler", 
        "givenName": "Thibaud", 
        "id": "sg:person.0723612320.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723612320.08"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hampe", 
        "givenName": "Jochen", 
        "id": "sg:person.0770420375.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770420375.31"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Buch", 
        "givenName": "Stephan", 
        "type": "Person"
      }, 
      {
        "familyName": "Schafmayer", 
        "givenName": "Clemens", 
        "id": "sg:person.0613704750.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613704750.91"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tepel", 
        "givenName": "Jurgen", 
        "type": "Person"
      }, 
      {
        "familyName": "Schreiber", 
        "givenName": "Stefan", 
        "type": "Person"
      }, 
      {
        "familyName": "V\u00f6lzke", 
        "givenName": "Henry", 
        "type": "Person"
      }, 
      {
        "familyName": "Chang-Claude", 
        "givenName": "Jenny", 
        "id": "sg:person.01266747622.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266747622.46"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hoffmeister", 
        "givenName": "Michael", 
        "id": "sg:person.01132005235.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132005235.58"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Brenner", 
        "givenName": "Hermann", 
        "id": "sg:person.01055762674.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055762674.33"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Zanke", 
        "givenName": "Brent W", 
        "id": "sg:person.01354551016.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354551016.07"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Montpetit", 
        "givenName": "Alexandre", 
        "type": "Person"
      }, 
      {
        "familyName": "Hudson", 
        "givenName": "Thomas J", 
        "type": "Person"
      }, 
      {
        "familyName": "Gallinger", 
        "givenName": "Steven", 
        "id": "sg:person.014617747257.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014617747257.97"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Campbell", 
        "givenName": "Harry", 
        "type": "Person"
      }, 
      {
        "familyName": "Dunlop", 
        "givenName": "Malcolm G", 
        "id": "sg:person.015240220737.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015240220737.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000093208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.48.3.367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000382104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002420498", 
          "https://doi.org/10.1038/ng.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003791570", 
          "https://doi.org/10.1038/ng2022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003791570", 
          "https://doi.org/10.1038/ng2022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.10261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004067474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2007.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006234981", 
          "https://doi.org/10.1038/ng.2007.18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200007133430201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007171562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008452967", 
          "https://doi.org/10.1038/ng1981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008586672", 
          "https://doi.org/10.1038/ng1430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008586672", 
          "https://doi.org/10.1038/ng1430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009205998", 
          "https://doi.org/10.1038/ng1706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009205998", 
          "https://doi.org/10.1038/ng1706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014607564", 
          "https://doi.org/10.1038/ng.219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020895882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199802)21:2<101::aid-gcc4>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021064988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/88919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022573828", 
          "https://doi.org/10.1038/88919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/88919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022573828", 
          "https://doi.org/10.1038/88919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/qjmed/89.10.737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022953180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0010078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023546182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0010078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023546182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2001.04677.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023595240", 
          "https://doi.org/10.1111/j.1572-0241.2001.04677.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.4780040112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025831554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029921641", 
          "https://doi.org/10.1038/sj.onc.1209682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029921641", 
          "https://doi.org/10.1038/sj.onc.1209682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2350-7-74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030074679", 
          "https://doi.org/10.1186/1471-2350-7-74"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1136678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031480762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2007.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032668790", 
          "https://doi.org/10.1038/ng.2007.41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-8-244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035692813", 
          "https://doi.org/10.1186/1471-2407-8-244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/98.4.464a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035855628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m203569200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036484741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037524163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037612918", 
          "https://doi.org/10.1038/sj.bjc.6603997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/dyi183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041266836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/dyi183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041266836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/8.4.607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043302149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a009876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043743953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044276531", 
          "https://doi.org/10.1038/ng2089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044664817", 
          "https://doi.org/10.1038/32918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044664817", 
          "https://doi.org/10.1038/32918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045441389", 
          "https://doi.org/10.1038/ng.133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.1186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047418980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048660016", 
          "https://doi.org/10.1038/ng2085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049957008", 
          "https://doi.org/10.1038/ng2098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0330672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052000942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0330672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052000942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/323703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058624247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.8.4.439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071509390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074601037", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075055332", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a115530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078626937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083350376", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/acprof:oso/9780195133646.001.0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1098759728"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-12", 
    "datePublishedReg": "2008-12-01", 
    "description": "Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.262", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2417393", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5148599", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5147685", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2779928", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2688799", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5141454", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5141849", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2781420", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696269", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5135017", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5144511", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2773833", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2786745", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer", 
    "pagination": "1426-1435", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7a8f0b250ef4e21284d3806242732551b876de0e2ae14d68dd27666e8e356d4b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19011631"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.262"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025725602"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.262", 
      "https://app.dimensions.ai/details/publication/pub.1025725602"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ng/journal/v40/n12/full/ng.262.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.262'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.262'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.262'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.262'


 

This table displays all metadata directly associated to this object as RDF triples.

554 TRIPLES      21 PREDICATES      83 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.262 schema:about N1180f673030940f0a6ebad5f2ea0d01e
2 N397e2e2bce8548ff94ed5095cd875d73
3 N6ee01291a8004a12a47bc62857b2052b
4 N6fafcd79cb454fdeb8885e0c5bc846a1
5 N8805ddb41f984885a3d76ded0ed52ab8
6 N91d3a8f041344687bc33edc8bcd930fa
7 N9a5300e85f1c48559963598f129d670b
8 Nb3bbf86d47654e80a5875e8b0ffa86f9
9 Nd2e9f599ce2242f59394c77663842ce6
10 Nf72e458780e84a8b9e351befd6231f2d
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author N001c5984922644bca0e5cfae2d9a07ff
14 schema:citation sg:pub.10.1038/32918
15 sg:pub.10.1038/88919
16 sg:pub.10.1038/ng.111
17 sg:pub.10.1038/ng.133
18 sg:pub.10.1038/ng.2007.18
19 sg:pub.10.1038/ng.2007.41
20 sg:pub.10.1038/ng.219
21 sg:pub.10.1038/ng1430
22 sg:pub.10.1038/ng1706
23 sg:pub.10.1038/ng1981
24 sg:pub.10.1038/ng2022
25 sg:pub.10.1038/ng2085
26 sg:pub.10.1038/ng2089
27 sg:pub.10.1038/ng2098
28 sg:pub.10.1038/sj.bjc.6603997
29 sg:pub.10.1038/sj.onc.1209682
30 sg:pub.10.1111/j.1572-0241.2001.04677.x
31 sg:pub.10.1186/1471-2350-7-74
32 sg:pub.10.1186/1471-2407-8-244
33 https://app.dimensions.ai/details/publication/pub.1074601037
34 https://app.dimensions.ai/details/publication/pub.1075055332
35 https://app.dimensions.ai/details/publication/pub.1083350376
36 https://doi.org/10.1002/(sici)1098-2264(199802)21:2<101::aid-gcc4>3.0.co;2-4
37 https://doi.org/10.1002/gepi.10261
38 https://doi.org/10.1002/sim.1186
39 https://doi.org/10.1002/sim.4780040112
40 https://doi.org/10.1042/bst0330672
41 https://doi.org/10.1056/nejm200007133430201
42 https://doi.org/10.1074/jbc.m203569200
43 https://doi.org/10.1086/323703
44 https://doi.org/10.1093/acprof:oso/9780195133646.001.0001
45 https://doi.org/10.1093/ajcp/98.4.464a
46 https://doi.org/10.1093/hmg/8.4.607
47 https://doi.org/10.1093/ije/dyi183
48 https://doi.org/10.1093/jnci/djn190
49 https://doi.org/10.1093/oxfordjournals.aje.a009876
50 https://doi.org/10.1093/oxfordjournals.aje.a115530
51 https://doi.org/10.1093/qjmed/89.10.737
52 https://doi.org/10.1126/science.1136678
53 https://doi.org/10.1136/gut.48.3.367
54 https://doi.org/10.1158/0008-5472.can-06-1818
55 https://doi.org/10.1158/1078-0432.ccr-06-1256
56 https://doi.org/10.1371/journal.pgen.0010078
57 https://doi.org/10.3892/ijmm.8.4.439
58 schema:datePublished 2008-12
59 schema:datePublishedReg 2008-12-01
60 schema:description Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N783a585960004e24a9faa82a17e97090
65 Ncea3987feb484f2da92b32208c26a684
66 sg:journal.1103138
67 schema:name Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
68 schema:pagination 1426-1435
69 schema:productId N53008871afa54f11b92438ff10a2d0bd
70 N6cd4150cb8f34f6499b04fa69470c341
71 N9f034175ca4044b59bc168473062af3e
72 Na606e1f8ae0f4617b72c9f978c49af09
73 Nb222ecd18d2d4cba9daecbf5db1fe7a6
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025725602
75 https://doi.org/10.1038/ng.262
76 schema:sdDatePublished 2019-04-10T15:38
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nbd3d5939667e42f3bfafb094d96d6dac
79 schema:url http://www.nature.com/ng/journal/v40/n12/full/ng.262.html
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N001c5984922644bca0e5cfae2d9a07ff rdf:first sg:person.010115766245.30
84 rdf:rest N8a63977fb6814bb3914c3b021fbc8247
85 N01765497c57d41209070bfc98be10faf rdf:first Nb65e0b3cfba142eb95bff623b58f4d28
86 rdf:rest N490ffe375e6549d486f6e9fad7ee4ef8
87 N0786ec67ff8f4193877397a1051140c4 schema:familyName Barnetson
88 schema:givenName Rebecca A
89 rdf:type schema:Person
90 N0d1ea1b0cb26418582a34cebb257aa40 rdf:first sg:person.01132005235.58
91 rdf:rest Nb0416705b11a4b489b388761be09f388
92 N0d77acd69cd24c4eb1f45b0f55979bd3 schema:familyName Porteous
93 schema:givenName Mary E
94 rdf:type schema:Person
95 N0d93c5ac08e44948a4e2f0d7b38c7cea rdf:first N86f648aff5024f548ab9fd69930f893a
96 rdf:rest N9026e38fe0fa4903b0eb2fe2845e393e
97 N1180f673030940f0a6ebad5f2ea0d01e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Genome, Human
99 rdf:type schema:DefinedTerm
100 N170df52c068d498bb34a5929c381f029 schema:familyName Buch
101 schema:givenName Stephan
102 rdf:type schema:Person
103 N1809658a45f94ff2909a7e4ab8ae317b rdf:first N4f312e77caf847d18bc059e8a2de5d36
104 rdf:rest N5e38331845b44799a240235997c6e7a2
105 N19ed5166695243e3967140fd84f3e0ed rdf:first N7bdaeedc76fc457daef1b278454b11d7
106 rdf:rest N1809658a45f94ff2909a7e4ab8ae317b
107 N2e9a4d566223420b880bff6ae8f9eb29 rdf:first sg:person.01034602463.88
108 rdf:rest N5dc2cfc69e344c97bcf1126e4154fdff
109 N30649d3d3d2a4e3f9924ee0117b57ff9 rdf:first sg:person.0770420375.31
110 rdf:rest Nb74ab5eebd6f4fc1abead4dbdca0921d
111 N30e5182883cb4880bc23dfe0c6c3a4c5 rdf:first N93790d8c06264c0f9e83895d1e42201e
112 rdf:rest Ndab4ff7f5d6843adbc363a4700d434cc
113 N329eae61c216494ea2d6722db8536d46 schema:familyName Campbell
114 schema:givenName Harry
115 rdf:type schema:Person
116 N370180a961fd4b99b26c151b89d45b41 rdf:first sg:person.01356351034.79
117 rdf:rest N19ed5166695243e3967140fd84f3e0ed
118 N397e2e2bce8548ff94ed5095cd875d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 N42f3689acf2a44beb3511d8b07af35a8 rdf:first Nd777ed0c23b541e9aa4ad5144f1b3f45
122 rdf:rest Nab05423200cb41898fcf2680abef3082
123 N43f8f9139c9642e6abf754b44eb1d1e4 rdf:first sg:person.014335002177.17
124 rdf:rest Nd04b4649eed0432b8ba74c208e02a66a
125 N450ff93036e54dd9aceeccb666f6f470 rdf:first sg:person.01354551016.07
126 rdf:rest N7272b9eae4ea4954aa91a9bd2b5cf8f7
127 N490ffe375e6549d486f6e9fad7ee4ef8 rdf:first N91a55103fb474dffafae85eb562d603f
128 rdf:rest N370180a961fd4b99b26c151b89d45b41
129 N4f312e77caf847d18bc059e8a2de5d36 schema:familyName Barclay
130 schema:givenName Ella
131 rdf:type schema:Person
132 N51879cf128d4479cba1163f27b509706 rdf:first sg:person.01266747622.46
133 rdf:rest N0d1ea1b0cb26418582a34cebb257aa40
134 N53008871afa54f11b92438ff10a2d0bd schema:name doi
135 schema:value 10.1038/ng.262
136 rdf:type schema:PropertyValue
137 N54a0a603ccb247e79271243f92ed6bb1 rdf:first sg:person.0613704750.91
138 rdf:rest N61ceaf0050cb46a0b6993c53d05c6eba
139 N55d5efccd18b473e84e16d3c9f07b448 rdf:first sg:person.01021200765.59
140 rdf:rest Nef07d3a91b4a469ab5daa52bfc6b4941
141 N57ce175f06e442eeb4e913a6e9411c4d schema:familyName Tepel
142 schema:givenName Jurgen
143 rdf:type schema:Person
144 N594d2c9ab71843c5a25d9f90f3fed529 rdf:first Nfd44ed1c20134cef833e26cb8a404e63
145 rdf:rest N0d93c5ac08e44948a4e2f0d7b38c7cea
146 N5d64fa6946de4c5f8e61e6623b83e272 rdf:first sg:person.01216730540.28
147 rdf:rest N6f29bfd66a5b45db960ef83e967bd06d
148 N5dc2cfc69e344c97bcf1126e4154fdff rdf:first sg:person.0723612320.08
149 rdf:rest N30649d3d3d2a4e3f9924ee0117b57ff9
150 N5e38331845b44799a240235997c6e7a2 rdf:first Nc61d6bd77963459d88901d22b09c0fbb
151 rdf:rest N7bdb617cce944fe593fb40a7b0d624df
152 N61ceaf0050cb46a0b6993c53d05c6eba rdf:first N57ce175f06e442eeb4e913a6e9411c4d
153 rdf:rest N42f3689acf2a44beb3511d8b07af35a8
154 N62cb81f3b9144f9890e8302ebc426358 rdf:first Nc477b343a90f45d696dc3b06991e1b36
155 rdf:rest Nd584f6754ba942478b6f22e3024ddd5e
156 N677ce24323104071be983ecbbf0229c2 schema:familyName Cazier
157 schema:givenName Jean-Baptiste
158 rdf:type schema:Person
159 N6cd4150cb8f34f6499b04fa69470c341 schema:name pubmed_id
160 schema:value 19011631
161 rdf:type schema:PropertyValue
162 N6ee01291a8004a12a47bc62857b2052b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Colorectal Neoplasms
164 rdf:type schema:DefinedTerm
165 N6f29bfd66a5b45db960ef83e967bd06d rdf:first N0d77acd69cd24c4eb1f45b0f55979bd3
166 rdf:rest N2e9a4d566223420b880bff6ae8f9eb29
167 N6fafcd79cb454fdeb8885e0c5bc846a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Male
169 rdf:type schema:DefinedTerm
170 N7272b9eae4ea4954aa91a9bd2b5cf8f7 rdf:first N86d27cf6d27c4d34960925d0aaae60fe
171 rdf:rest Nc6e10e7856e74f1bac8bdb5e41e6f11b
172 N737c2eadb38d4f9a9fa3770b0debdf31 rdf:first Nf90641335f4f45db9d3d3907bcde8ba9
173 rdf:rest Nb46308b1065e4ef397f88d9a0b634112
174 N75b6d14a71164e4eba9d54fa9675a2d7 rdf:first sg:person.015240220737.44
175 rdf:rest rdf:nil
176 N783a585960004e24a9faa82a17e97090 schema:issueNumber 12
177 rdf:type schema:PublicationIssue
178 N7bdaeedc76fc457daef1b278454b11d7 schema:familyName Walther
179 schema:givenName Axel
180 rdf:type schema:Person
181 N7bdb617cce944fe593fb40a7b0d624df rdf:first Nb03628f6d7f141129147c614917d77c1
182 rdf:rest N9d2ff4662d084bccbcac2962f413b281
183 N7edcd78887134c22908062e97f26cef6 rdf:first N0786ec67ff8f4193877397a1051140c4
184 rdf:rest N5d64fa6946de4c5f8e61e6623b83e272
185 N8115fb37eb504deb913558b3d6b2b5cb schema:familyName Völzke
186 schema:givenName Henry
187 rdf:type schema:Person
188 N86d27cf6d27c4d34960925d0aaae60fe schema:familyName Montpetit
189 schema:givenName Alexandre
190 rdf:type schema:Person
191 N86f648aff5024f548ab9fd69930f893a schema:familyName Kerr
192 schema:givenName David
193 rdf:type schema:Person
194 N8805ddb41f984885a3d76ded0ed52ab8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Aged
196 rdf:type schema:DefinedTerm
197 N8877ae7c4d074b63920fdd819ab5aac6 rdf:first sg:person.01210572206.68
198 rdf:rest Na722555bb4e64e11bfb0901dcd473c40
199 N8a63977fb6814bb3914c3b021fbc8247 rdf:first sg:person.01303235220.85
200 rdf:rest Na0014a6b495d487c81f5a5a247542c94
201 N9026e38fe0fa4903b0eb2fe2845e393e rdf:first N677ce24323104071be983ecbbf0229c2
202 rdf:rest Nace0ad145184417d978f218d74340d2e
203 N91a55103fb474dffafae85eb562d603f schema:familyName Jaeger
204 schema:givenName Emma
205 rdf:type schema:Person
206 N91d3a8f041344687bc33edc8bcd930fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Genetic Predisposition to Disease
208 rdf:type schema:DefinedTerm
209 N93790d8c06264c0f9e83895d1e42201e schema:familyName Chandler
210 schema:givenName Ian
211 rdf:type schema:Person
212 N96cbc5e2a5b94be192ec0bb695a107d2 schema:familyName Hudson
213 schema:givenName Thomas J
214 rdf:type schema:Person
215 N9a5300e85f1c48559963598f129d670b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Humans
217 rdf:type schema:DefinedTerm
218 N9b03e1f6db89465eb7ac8298be10c3b2 rdf:first Nfccecc5c590846dfadf28e0a9c71f653
219 rdf:rest N01765497c57d41209070bfc98be10faf
220 N9d2ff4662d084bccbcac2962f413b281 rdf:first sg:person.0753633043.29
221 rdf:rest N594d2c9ab71843c5a25d9f90f3fed529
222 N9f034175ca4044b59bc168473062af3e schema:name readcube_id
223 schema:value 7a8f0b250ef4e21284d3806242732551b876de0e2ae14d68dd27666e8e356d4b
224 rdf:type schema:PropertyValue
225 Na0014a6b495d487c81f5a5a247542c94 rdf:first sg:person.01146370076.54
226 rdf:rest Nf5e1e1ce93e745cfabccef1cff68f1c0
227 Na0be58c3a19f4236a0b1cbab637393ca rdf:first sg:person.014617747257.97
228 rdf:rest Nc5688d278f654afd8e285438914365c9
229 Na533776dff20423da914c1783556b494 rdf:first sg:person.012142217732.11
230 rdf:rest N8877ae7c4d074b63920fdd819ab5aac6
231 Na606e1f8ae0f4617b72c9f978c49af09 schema:name dimensions_id
232 schema:value pub.1025725602
233 rdf:type schema:PropertyValue
234 Na722555bb4e64e11bfb0901dcd473c40 rdf:first sg:person.01202112735.10
235 rdf:rest N7edcd78887134c22908062e97f26cef6
236 Nab05423200cb41898fcf2680abef3082 rdf:first N8115fb37eb504deb913558b3d6b2b5cb
237 rdf:rest N51879cf128d4479cba1163f27b509706
238 Nace0ad145184417d978f218d74340d2e rdf:first sg:person.01252574746.84
239 rdf:rest N55d5efccd18b473e84e16d3c9f07b448
240 Nb03628f6d7f141129147c614917d77c1 schema:familyName Gorman
241 schema:givenName Maggie
242 rdf:type schema:Person
243 Nb0416705b11a4b489b388761be09f388 rdf:first sg:person.01055762674.33
244 rdf:rest N450ff93036e54dd9aceeccb666f6f470
245 Nb222ecd18d2d4cba9daecbf5db1fe7a6 schema:name nlm_unique_id
246 schema:value 9216904
247 rdf:type schema:PropertyValue
248 Nb3bbf86d47654e80a5875e8b0ffa86f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
249 schema:name Middle Aged
250 rdf:type schema:DefinedTerm
251 Nb46308b1065e4ef397f88d9a0b634112 rdf:first Nf0985858ac63447e9742d57e9c6facc6
252 rdf:rest N30e5182883cb4880bc23dfe0c6c3a4c5
253 Nb65e0b3cfba142eb95bff623b58f4d28 schema:familyName Howarth
254 schema:givenName Kimberley
255 rdf:type schema:Person
256 Nb74ab5eebd6f4fc1abead4dbdca0921d rdf:first N170df52c068d498bb34a5929c381f029
257 rdf:rest N54a0a603ccb247e79271243f92ed6bb1
258 Nbd3d5939667e42f3bfafb094d96d6dac schema:name Springer Nature - SN SciGraph project
259 rdf:type schema:Organization
260 Nc477b343a90f45d696dc3b06991e1b36 schema:familyName Sullivan
261 schema:givenName Kate
262 rdf:type schema:Person
263 Nc5688d278f654afd8e285438914365c9 rdf:first N329eae61c216494ea2d6722db8536d46
264 rdf:rest N75b6d14a71164e4eba9d54fa9675a2d7
265 Nc61d6bd77963459d88901d22b09c0fbb schema:familyName Martin
266 schema:givenName Lynn
267 rdf:type schema:Person
268 Nc6e10e7856e74f1bac8bdb5e41e6f11b rdf:first N96cbc5e2a5b94be192ec0bb695a107d2
269 rdf:rest Na0be58c3a19f4236a0b1cbab637393ca
270 Ncea3987feb484f2da92b32208c26a684 schema:volumeNumber 40
271 rdf:type schema:PublicationVolume
272 Nd04b4649eed0432b8ba74c208e02a66a rdf:first sg:person.01177572330.00
273 rdf:rest Na533776dff20423da914c1783556b494
274 Nd2e9f599ce2242f59394c77663842ce6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
275 schema:name Case-Control Studies
276 rdf:type schema:DefinedTerm
277 Nd584f6754ba942478b6f22e3024ddd5e rdf:first sg:person.0641657135.92
278 rdf:rest N9b03e1f6db89465eb7ac8298be10c3b2
279 Nd777ed0c23b541e9aa4ad5144f1b3f45 schema:familyName Schreiber
280 schema:givenName Stefan
281 rdf:type schema:Person
282 Ndab4ff7f5d6843adbc363a4700d434cc rdf:first sg:person.0611721341.72
283 rdf:rest N62cb81f3b9144f9890e8302ebc426358
284 Nef07d3a91b4a469ab5daa52bfc6b4941 rdf:first sg:person.01140416457.07
285 rdf:rest N43f8f9139c9642e6abf754b44eb1d1e4
286 Nf0985858ac63447e9742d57e9c6facc6 schema:familyName Lubbe
287 schema:givenName Steven
288 rdf:type schema:Person
289 Nf5e1e1ce93e745cfabccef1cff68f1c0 rdf:first sg:person.01000634420.06
290 rdf:rest N737c2eadb38d4f9a9fa3770b0debdf31
291 Nf72e458780e84a8b9e351befd6231f2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
292 schema:name Genome-Wide Association Study
293 rdf:type schema:DefinedTerm
294 Nf90641335f4f45db9d3d3907bcde8ba9 schema:familyName Di Bernardo
295 schema:givenName Maria Chiara
296 rdf:type schema:Person
297 Nfccecc5c590846dfadf28e0a9c71f653 schema:familyName Carvajal-Carmona
298 schema:givenName Luis
299 rdf:type schema:Person
300 Nfd44ed1c20134cef833e26cb8a404e63 schema:familyName Teixeira
301 schema:givenName Ana S
302 rdf:type schema:Person
303 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
304 schema:name Biological Sciences
305 rdf:type schema:DefinedTerm
306 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
307 schema:name Genetics
308 rdf:type schema:DefinedTerm
309 sg:grant.2417393 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
310 rdf:type schema:MonetaryGrant
311 sg:grant.2688799 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
312 rdf:type schema:MonetaryGrant
313 sg:grant.2696269 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
314 rdf:type schema:MonetaryGrant
315 sg:grant.2773833 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
316 rdf:type schema:MonetaryGrant
317 sg:grant.2779928 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
318 rdf:type schema:MonetaryGrant
319 sg:grant.2781420 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
320 rdf:type schema:MonetaryGrant
321 sg:grant.2786745 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
322 rdf:type schema:MonetaryGrant
323 sg:grant.5135017 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
324 rdf:type schema:MonetaryGrant
325 sg:grant.5141454 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
326 rdf:type schema:MonetaryGrant
327 sg:grant.5141849 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
328 rdf:type schema:MonetaryGrant
329 sg:grant.5144511 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
330 rdf:type schema:MonetaryGrant
331 sg:grant.5147685 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
332 rdf:type schema:MonetaryGrant
333 sg:grant.5148599 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.262
334 rdf:type schema:MonetaryGrant
335 sg:journal.1103138 schema:issn 1061-4036
336 1546-1718
337 schema:name Nature Genetics
338 rdf:type schema:Periodical
339 sg:person.01000634420.06 schema:familyName Pittman
340 schema:givenName Alan M
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000634420.06
342 rdf:type schema:Person
343 sg:person.010115766245.30 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
344 schema:familyName Houlston
345 schema:givenName Richard S
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010115766245.30
347 rdf:type schema:Person
348 sg:person.01021200765.59 schema:familyName Tuupanen
349 schema:givenName Sari
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021200765.59
351 rdf:type schema:Person
352 sg:person.01034602463.88 schema:familyName Pharoah
353 schema:givenName Paul D P
354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034602463.88
355 rdf:type schema:Person
356 sg:person.01055762674.33 schema:familyName Brenner
357 schema:givenName Hermann
358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055762674.33
359 rdf:type schema:Person
360 sg:person.01132005235.58 schema:familyName Hoffmeister
361 schema:givenName Michael
362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132005235.58
363 rdf:type schema:Person
364 sg:person.01140416457.07 schema:familyName Karhu
365 schema:givenName Auli
366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140416457.07
367 rdf:type schema:Person
368 sg:person.01146370076.54 schema:familyName Broderick
369 schema:givenName Peter
370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146370076.54
371 rdf:type schema:Person
372 sg:person.01177572330.00 schema:familyName Tomlinson
373 schema:givenName Ian P M
374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177572330.00
375 rdf:type schema:Person
376 sg:person.01202112735.10 schema:familyName Prendergast
377 schema:givenName James G D
378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202112735.10
379 rdf:type schema:Person
380 sg:person.01210572206.68 schema:familyName Tenesa
381 schema:givenName Albert
382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210572206.68
383 rdf:type schema:Person
384 sg:person.012142217732.11 schema:familyName Farrington
385 schema:givenName Susan M
386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012142217732.11
387 rdf:type schema:Person
388 sg:person.01216730540.28 schema:familyName Cetnarskyj
389 schema:givenName Roseanne
390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216730540.28
391 rdf:type schema:Person
392 sg:person.01252574746.84 schema:familyName Niittymäki
393 schema:givenName Iina
394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252574746.84
395 rdf:type schema:Person
396 sg:person.01266747622.46 schema:familyName Chang-Claude
397 schema:givenName Jenny
398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266747622.46
399 rdf:type schema:Person
400 sg:person.01303235220.85 schema:familyName Webb
401 schema:givenName Emily
402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303235220.85
403 rdf:type schema:Person
404 sg:person.01354551016.07 schema:familyName Zanke
405 schema:givenName Brent W
406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354551016.07
407 rdf:type schema:Person
408 sg:person.01356351034.79 schema:familyName Spain
409 schema:givenName Sarah L
410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356351034.79
411 rdf:type schema:Person
412 sg:person.014335002177.17 schema:familyName Aaltonen
413 schema:givenName Lauri A
414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014335002177.17
415 rdf:type schema:Person
416 sg:person.014617747257.97 schema:familyName Gallinger
417 schema:givenName Steven
418 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014617747257.97
419 rdf:type schema:Person
420 sg:person.015240220737.44 schema:familyName Dunlop
421 schema:givenName Malcolm G
422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015240220737.44
423 rdf:type schema:Person
424 sg:person.0611721341.72 schema:familyName Vijayakrishnan
425 schema:givenName Jayaram
426 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611721341.72
427 rdf:type schema:Person
428 sg:person.0613704750.91 schema:familyName Schafmayer
429 schema:givenName Clemens
430 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613704750.91
431 rdf:type schema:Person
432 sg:person.0641657135.92 schema:familyName Penegar
433 schema:givenName Steven
434 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641657135.92
435 rdf:type schema:Person
436 sg:person.0723612320.08 schema:familyName Koessler
437 schema:givenName Thibaud
438 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723612320.08
439 rdf:type schema:Person
440 sg:person.0753633043.29 schema:familyName Domingo
441 schema:givenName Enric
442 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753633043.29
443 rdf:type schema:Person
444 sg:person.0770420375.31 schema:familyName Hampe
445 schema:givenName Jochen
446 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770420375.31
447 rdf:type schema:Person
448 sg:pub.10.1038/32918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044664817
449 https://doi.org/10.1038/32918
450 rdf:type schema:CreativeWork
451 sg:pub.10.1038/88919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022573828
452 https://doi.org/10.1038/88919
453 rdf:type schema:CreativeWork
454 sg:pub.10.1038/ng.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002420498
455 https://doi.org/10.1038/ng.111
456 rdf:type schema:CreativeWork
457 sg:pub.10.1038/ng.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045441389
458 https://doi.org/10.1038/ng.133
459 rdf:type schema:CreativeWork
460 sg:pub.10.1038/ng.2007.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006234981
461 https://doi.org/10.1038/ng.2007.18
462 rdf:type schema:CreativeWork
463 sg:pub.10.1038/ng.2007.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032668790
464 https://doi.org/10.1038/ng.2007.41
465 rdf:type schema:CreativeWork
466 sg:pub.10.1038/ng.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607564
467 https://doi.org/10.1038/ng.219
468 rdf:type schema:CreativeWork
469 sg:pub.10.1038/ng1430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008586672
470 https://doi.org/10.1038/ng1430
471 rdf:type schema:CreativeWork
472 sg:pub.10.1038/ng1706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009205998
473 https://doi.org/10.1038/ng1706
474 rdf:type schema:CreativeWork
475 sg:pub.10.1038/ng1981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008452967
476 https://doi.org/10.1038/ng1981
477 rdf:type schema:CreativeWork
478 sg:pub.10.1038/ng2022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003791570
479 https://doi.org/10.1038/ng2022
480 rdf:type schema:CreativeWork
481 sg:pub.10.1038/ng2085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048660016
482 https://doi.org/10.1038/ng2085
483 rdf:type schema:CreativeWork
484 sg:pub.10.1038/ng2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044276531
485 https://doi.org/10.1038/ng2089
486 rdf:type schema:CreativeWork
487 sg:pub.10.1038/ng2098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049957008
488 https://doi.org/10.1038/ng2098
489 rdf:type schema:CreativeWork
490 sg:pub.10.1038/sj.bjc.6603997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037612918
491 https://doi.org/10.1038/sj.bjc.6603997
492 rdf:type schema:CreativeWork
493 sg:pub.10.1038/sj.onc.1209682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029921641
494 https://doi.org/10.1038/sj.onc.1209682
495 rdf:type schema:CreativeWork
496 sg:pub.10.1111/j.1572-0241.2001.04677.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023595240
497 https://doi.org/10.1111/j.1572-0241.2001.04677.x
498 rdf:type schema:CreativeWork
499 sg:pub.10.1186/1471-2350-7-74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030074679
500 https://doi.org/10.1186/1471-2350-7-74
501 rdf:type schema:CreativeWork
502 sg:pub.10.1186/1471-2407-8-244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035692813
503 https://doi.org/10.1186/1471-2407-8-244
504 rdf:type schema:CreativeWork
505 https://app.dimensions.ai/details/publication/pub.1074601037 schema:CreativeWork
506 https://app.dimensions.ai/details/publication/pub.1075055332 schema:CreativeWork
507 https://app.dimensions.ai/details/publication/pub.1083350376 schema:CreativeWork
508 https://doi.org/10.1002/(sici)1098-2264(199802)21:2<101::aid-gcc4>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021064988
509 rdf:type schema:CreativeWork
510 https://doi.org/10.1002/gepi.10261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004067474
511 rdf:type schema:CreativeWork
512 https://doi.org/10.1002/sim.1186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047418980
513 rdf:type schema:CreativeWork
514 https://doi.org/10.1002/sim.4780040112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025831554
515 rdf:type schema:CreativeWork
516 https://doi.org/10.1042/bst0330672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052000942
517 rdf:type schema:CreativeWork
518 https://doi.org/10.1056/nejm200007133430201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007171562
519 rdf:type schema:CreativeWork
520 https://doi.org/10.1074/jbc.m203569200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036484741
521 rdf:type schema:CreativeWork
522 https://doi.org/10.1086/323703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058624247
523 rdf:type schema:CreativeWork
524 https://doi.org/10.1093/acprof:oso/9780195133646.001.0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098759728
525 rdf:type schema:CreativeWork
526 https://doi.org/10.1093/ajcp/98.4.464a schema:sameAs https://app.dimensions.ai/details/publication/pub.1035855628
527 rdf:type schema:CreativeWork
528 https://doi.org/10.1093/hmg/8.4.607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043302149
529 rdf:type schema:CreativeWork
530 https://doi.org/10.1093/ije/dyi183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041266836
531 rdf:type schema:CreativeWork
532 https://doi.org/10.1093/jnci/djn190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020895882
533 rdf:type schema:CreativeWork
534 https://doi.org/10.1093/oxfordjournals.aje.a009876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043743953
535 rdf:type schema:CreativeWork
536 https://doi.org/10.1093/oxfordjournals.aje.a115530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078626937
537 rdf:type schema:CreativeWork
538 https://doi.org/10.1093/qjmed/89.10.737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022953180
539 rdf:type schema:CreativeWork
540 https://doi.org/10.1126/science.1136678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031480762
541 rdf:type schema:CreativeWork
542 https://doi.org/10.1136/gut.48.3.367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000382104
543 rdf:type schema:CreativeWork
544 https://doi.org/10.1158/0008-5472.can-06-1818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000093208
545 rdf:type schema:CreativeWork
546 https://doi.org/10.1158/1078-0432.ccr-06-1256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037524163
547 rdf:type schema:CreativeWork
548 https://doi.org/10.1371/journal.pgen.0010078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023546182
549 rdf:type schema:CreativeWork
550 https://doi.org/10.3892/ijmm.8.4.439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071509390
551 rdf:type schema:CreativeWork
552 https://www.grid.ac/institutes/grid.18886.3f schema:alternateName Institute of Cancer Research
553 schema:name Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK. richard.houlston@icr.ac.uk
554 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...