Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03-24

AUTHORS

Austin M Dulak, Petar Stojanov, Shouyong Peng, Michael S Lawrence, Cameron Fox, Chip Stewart, Santhoshi Bandla, Yu Imamura, Steven E Schumacher, Erica Shefler, Aaron McKenna, Scott L Carter, Kristian Cibulskis, Andrey Sivachenko, Gordon Saksena, Douglas Voet, Alex H Ramos, Daniel Auclair, Kristin Thompson, Carrie Sougnez, Robert C Onofrio, Candace Guiducci, Rameen Beroukhim, Zhongren Zhou, Lin Lin, Jules Lin, Rishindra Reddy, Andrew Chang, Rodney Landrenau, Arjun Pennathur, Shuji Ogino, James D Luketich, Todd R Golub, Stacey B Gabriel, Eric S Lander, David G Beer, Tony E Godfrey, Gad Getz, Adam J Bass

ABSTRACT

Adam Bass, Gad Getz and colleagues report whole-exome sequencing of 149 esophageal adenocarcinomas (EACs) and whole-genome sequencing of 15 EACs. They identify a mutational signature defined by a high prevalence of A>C transversions, as well as 26 genes mutated at high frequency in EACs.

PAGES

478-486

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    5

    VOLUME

    45

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2591

    DOI

    http://dx.doi.org/10.1038/ng.2591

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008213220

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23525077


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