Ontology type: schema:ScholarlyArticle Open Access: True
2012-11
AUTHORSLambert Busque, Jay P Patel, Maria E Figueroa, Aparna Vasanthakumar, Sylvie Provost, Zineb Hamilou, Luigina Mollica, Juan Li, Agnes Viale, Adriana Heguy, Maryam Hassimi, Nicholas Socci, Parva K Bhatt, Mithat Gonen, Christopher E Mason, Ari Melnick, Lucy A Godley, Cameron W Brennan, Omar Abdel-Wahab, Ross L Levine
ABSTRACTAging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated by X-inactivation analysis, identified somatic TET2 mutations. Recurrence testing identified TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematological malignancies and were associated with alterations in DNA methylation. More... »
PAGES1179
http://scigraph.springernature.com/pub.10.1038/ng.2413
DOIhttp://dx.doi.org/10.1038/ng.2413
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1032784004
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23001125
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "5-Methylcytosine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Methylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA-Binding Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Exome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoiesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "X Chromosome Inactivation",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Montreal",
"id": "https://www.grid.ac/institutes/grid.14848.31",
"name": [
"Research Centre, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.",
"Department of Hematology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.",
"University of Montreal, Montreal, Quebec, Canada."
],
"type": "Organization"
},
"familyName": "Busque",
"givenName": "Lambert",
"id": "sg:person.01251145723.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251145723.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Patel",
"givenName": "Jay P",
"id": "sg:person.0641713177.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641713177.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Michigan\u2013Ann Arbor",
"id": "https://www.grid.ac/institutes/grid.214458.e",
"name": [
"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA."
],
"type": "Organization"
},
"familyName": "Figueroa",
"givenName": "Maria E",
"id": "sg:person.01011627614.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011627614.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Chicago",
"id": "https://www.grid.ac/institutes/grid.170205.1",
"name": [
"Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois, USA."
],
"type": "Organization"
},
"familyName": "Vasanthakumar",
"givenName": "Aparna",
"id": "sg:person.01057743014.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057743014.24"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada."
],
"type": "Organization"
},
"familyName": "Provost",
"givenName": "Sylvie",
"id": "sg:person.01213570477.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213570477.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Montreal",
"id": "https://www.grid.ac/institutes/grid.14848.31",
"name": [
"Department of Hematology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.",
"University of Montreal, Montreal, Quebec, Canada."
],
"type": "Organization"
},
"familyName": "Hamilou",
"givenName": "Zineb",
"id": "sg:person.01174171414.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174171414.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Montreal",
"id": "https://www.grid.ac/institutes/grid.14848.31",
"name": [
"Research Centre, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.",
"Department of Hematology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.",
"University of Montreal, Montreal, Quebec, Canada."
],
"type": "Organization"
},
"familyName": "Mollica",
"givenName": "Luigina",
"id": "sg:person.0614760736.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614760736.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Genomics Core Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Juan",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Genomics Core Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Viale",
"givenName": "Agnes",
"id": "sg:person.0712021032.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712021032.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Heguy",
"givenName": "Adriana",
"id": "sg:person.015614157607.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015614157607.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Bioinformatics Core, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Hassimi",
"givenName": "Maryam",
"id": "sg:person.01241442752.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241442752.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Bioinformatics Core, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Socci",
"givenName": "Nicholas",
"id": "sg:person.010357032237.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010357032237.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Bhatt",
"givenName": "Parva K",
"id": "sg:person.01015470714.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015470714.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Gonen",
"givenName": "Mithat",
"id": "sg:person.0721426211.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721426211.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cornell University",
"id": "https://www.grid.ac/institutes/grid.5386.8",
"name": [
"Department of Physiology and Biophysics and the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York, USA.",
"Graduate School of Biomedical Sciences, Weill Medical College of Cornell University, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Mason",
"givenName": "Christopher E",
"id": "sg:person.010541301357.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010541301357.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cornell University",
"id": "https://www.grid.ac/institutes/grid.5386.8",
"name": [
"Graduate School of Biomedical Sciences, Weill Medical College of Cornell University, New York, New York, USA.",
"Division of Hematology/Oncology, Weill Medical College of Cornell University, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Melnick",
"givenName": "Ari",
"id": "sg:person.01364576130.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364576130.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Chicago",
"id": "https://www.grid.ac/institutes/grid.170205.1",
"name": [
"Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois, USA."
],
"type": "Organization"
},
"familyName": "Godley",
"givenName": "Lucy A",
"id": "sg:person.01154534615.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154534615.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.",
"Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Brennan",
"givenName": "Cameron W",
"id": "sg:person.01062522214.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062522214.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.",
"Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Abdel-Wahab",
"givenName": "Omar",
"id": "sg:person.0617064720.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617064720.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.",
"Graduate School of Biomedical Sciences, Weill Medical College of Cornell University, New York, New York, USA.",
"Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Levine",
"givenName": "Ross L",
"id": "sg:person.01004503566.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004503566.84"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1073/pnas.1000834107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004497675"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2010.11.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010196923"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2011.06.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017224423"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2011.06.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018476707"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2141.1997.2573078.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019742264"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2141.1997.2573078.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019742264"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400936",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022871876",
"https://doi.org/10.1038/sj.leu.2400936"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400936",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022871876",
"https://doi.org/10.1038/sj.leu.2400936"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2010-12-325241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023888047"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.coi.2010.06.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023918486"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09586",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028352751",
"https://doi.org/10.1038/nature09586"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09586",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028352751",
"https://doi.org/10.1038/nature09586"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1112317108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041424096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa0810069",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045634206"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2009.47",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050147090",
"https://doi.org/10.1038/leu.2009.47"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082916679",
"type": "CreativeWork"
}
],
"datePublished": "2012-11",
"datePublishedReg": "2012-11-01",
"description": "Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated by X-inactivation analysis, identified somatic TET2 mutations. Recurrence testing identified TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematological malignancies and were associated with alterations in DNA methylation.",
"genre": "research_article",
"id": "sg:pub.10.1038/ng.2413",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2699070",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2479550",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2376598",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2480265",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1103138",
"issn": [
"1061-4036",
"1546-1718"
],
"name": "Nature Genetics",
"type": "Periodical"
},
{
"issueNumber": "11",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "44"
}
],
"name": "Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis",
"pagination": "1179",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9c2dad3f98a61a3bdeab0f28c3669dc58c16d538216f429890eb2de2aae670fc"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"23001125"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9216904"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ng.2413"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1032784004"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ng.2413",
"https://app.dimensions.ai/details/publication/pub.1032784004"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T00:23",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000550.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/ng.2413"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2413'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2413'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2413'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2413'
This table displays all metadata directly associated to this object as RDF triples.
314 TRIPLES
21 PREDICATES
52 URIs
31 LITERALS
19 BLANK NODES