The paradoxical TGF-β vasculopathies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07-27

AUTHORS

Rosemary J. Akhurst

ABSTRACT

Two new studies show that haploinsufficiency for TGFB2 causes a familial syndrome of thoracic aortic aneurysms and dissections with other clinical features that overlap the Marfan, Loeys-Dietz spectrum of syndromes. Their finding of loss-of-function mutations in yet another transforming growth factor (TGF)-β pathway gene reinforces the seeming paradox of observed increases in the downstream TGF-β signaling pathway. More... »

PAGES

838-839

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.2366

DOI

http://dx.doi.org/10.1038/ng.2366

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033804701

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22836090


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