Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07-29

AUTHORS

Michael Krauthammer, Yong Kong, Byung Hak Ha, Perry Evans, Antonella Bacchiocchi, Jamie P McCusker, Elaine Cheng, Matthew J Davis, Gerald Goh, Murim Choi, Stephan Ariyan, Deepak Narayan, Ken Dutton-Regester, Ana Capatana, Edna C Holman, Marcus Bosenberg, Mario Sznol, Harriet M Kluger, Douglas E Brash, David F Stern, Miguel A Materin, Roger S Lo, Shrikant Mane, Shuangge Ma, Kenneth K Kidd, Nicholas K Hayward, Richard P Lifton, Joseph Schlessinger, Titus J Boggon, Ruth Halaban

ABSTRACT

Ruth Halaban and colleagues report exome sequences of 147 melanoma tumors. They identified a recurrent somatic activating alteration in the Rho GTPase RAC1 in sun-exposed melanomas.

PAGES

1006-1014

References to SciGraph publications

  • 2011-08-07. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma in NATURE GENETICS
  • 2011-05-24. BRAF targeted therapy changes the treatment paradigm in melanoma in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2010-08-16. Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis in ONCOGENE
  • 1982-07. UV-induced mutation hotspots occur at DNA damage hotspots in NATURE
  • 2009-12-16. A comprehensive catalogue of somatic mutations from a human cancer genome in NATURE
  • 2009-08-19. A genetically encoded photoactivatable Rac controls the motility of living cells in NATURE
  • 2010-09-07. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma in NATURE
  • 2011-12-25. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma in NATURE GENETICS
  • 2012-05-09. Melanoma genome sequencing reveals frequent PREX2 mutations in NATURE
  • 2005-08. Base stacking controls excited-state dynamics in A·T DNA in NATURE
  • 2009-08-19. Coordination of Rho GTPase activities during cell protrusion in NATURE
  • 2012-02-22. Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours in NATURE
  • 2011-12-11. DCC constrains tumour progression via its dependence receptor activity in NATURE
  • 2011-09. P-Rex1 is required for efficient melanoblast migration and melanoma metastasis in NATURE COMMUNICATIONS
  • 2012-03-28. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity in NATURE
  • 2011-04-15. Exome sequencing identifies GRIN2A as frequently mutated in melanoma in NATURE GENETICS
  • 2002-11-25. High frequency of BRAF mutations in nevi in NATURE GENETICS
  • 2011-12-25. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing in NATURE GENETICS
  • 1997-02. The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-05-16. Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo in NATURE CELL BIOLOGY
  • Journal

    TITLE

    Nature Genetics

    ISSUE

    9

    VOLUME

    44

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2359

    DOI

    http://dx.doi.org/10.1038/ng.2359

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021618497

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22842228


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