Meta-analysis identifies six new susceptibility loci for atrial fibrillation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04-29

AUTHORS

Patrick T Ellinor, Kathryn L Lunetta, Christine M Albert, Nicole L Glazer, Marylyn D Ritchie, Albert V Smith, Dan E Arking, Martina Müller-Nurasyid, Bouwe P Krijthe, Steven A Lubitz, Joshua C Bis, Mina K Chung, Marcus Dörr, Kouichi Ozaki, Jason D Roberts, J Gustav Smith, Arne Pfeufer, Moritz F Sinner, Kurt Lohman, Jingzhong Ding, Nicholas L Smith, Jonathan D Smith, Michiel Rienstra, Kenneth M Rice, David R Van Wagoner, Jared W Magnani, Reza Wakili, Sebastian Clauss, Jerome I Rotter, Gerhard Steinbeck, Lenore J Launer, Robert W Davies, Matthew Borkovich, Tamara B Harris, Honghuang Lin, Uwe Völker, Henry Völzke, David J Milan, Albert Hofman, Eric Boerwinkle, Lin Y Chen, Elsayed Z Soliman, Benjamin F Voight, Guo Li, Aravinda Chakravarti, Michiaki Kubo, Usha B Tedrow, Lynda M Rose, Paul M Ridker, David Conen, Tatsuhiko Tsunoda, Tetsushi Furukawa, Nona Sotoodehnia, Siyan Xu, Naoyuki Kamatani, Daniel Levy, Yusuke Nakamura, Babar Parvez, Saagar Mahida, Karen L Furie, Jonathan Rosand, Raafia Muhammad, Bruce M Psaty, Thomas Meitinger, Siegfried Perz, H-Erich Wichmann, Jacqueline C M Witteman, W H Linda Kao, Sekar Kathiresan, Dan M Roden, Andre G Uitterlinden, Fernando Rivadeneira, Barbara McKnight, Marketa Sjögren, Anne B Newman, Yongmei Liu, Michael H Gollob, Olle Melander, Toshihiro Tanaka, Bruno H Ch Stricker, Stephan B Felix, Alvaro Alonso, Dawood Darbar, John Barnard, Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Vilmundur Gudnason, Stefan Kääb

ABSTRACT

Patrick Ellinor and colleagues report a meta-analysis of genome-wide association studies for atrial fibrillation in European populations. They identify six newly associated loci, four of which were replicated in a Japanese study.

PAGES

670-675

Journal

TITLE

Nature Genetics

ISSUE

6

VOLUME

44

Author Affiliations

  • Harvard Medical School, Boston, Massachusetts, USA
  • National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
  • Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
  • Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
  • Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA
  • Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  • McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  • Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
  • Netherlands Consortium for Healthy Aging (NCHA), The Netherlands
  • Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
  • Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
  • Department of Internal Medicine B, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Laboratory for Cardiovascular Diseases, RIKEN Center for Genomic Medicine, Kanagawa, Japan
  • Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
  • Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
  • Institute of Human Genetics, Technische Universität (TU) München, Klinikum Rechts der Isar, Munich, Germany
  • Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany
  • Department of Biostatistical Sciences, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
  • Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
  • Department of Epidemiology, University of Washington, Seattle, Washington, USA
  • Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
  • Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  • Department of Biostatistics, University of Washington, Seattle, Washington, USA
  • Department of Medicine, Cardiology Section, Boston University School of Medicine, Boston, Massachusetts, USA
  • Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
  • Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA
  • Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
  • Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA
  • Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
  • Cardiovascular Division, Department of Medicine, Cardiac Arrhythmia Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
  • Epidemiological Cardiology Research Center (EPICARE), Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
  • Laboratory for Genotyping Development, RIKEN Center for Genomic Medicine, Kanagawa, Japan
  • Department of Medicine, University Hospital, Basel, Switzerland
  • Laboratory for Medical Informatics, RIKEN Center for Genomic Medicine, Kanagawa, Japan
  • Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
  • Division of Cardiology, University of Washington, Seattle, Washington, USA
  • Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts, USA
  • Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Kanagawa, Japan
  • Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
  • Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
  • Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
  • Department of Health Services, University of Washington, Seattle, Washington, USA
  • Institute for Biological and Medical Imaging, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
  • Klinikum Grosshadern, Munich, Germany
  • The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
  • Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
  • Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
  • Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
  • Department of Clinical Sciences, Lund University, Malmo, Sweden
  • Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  • Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
  • Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands
  • Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
  • Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
  • Department of Medicine, Preventive Medicine Section, Boston University School of Medicine, Boston, Massachusetts, USA
  • Munich Heart Alliance, Munich, Germany
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2261

    DOI

    http://dx.doi.org/10.1038/ng.2261

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050255522

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22544366


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    961 grid-institutes:grid.452197.c schema:alternateName Netherlands Consortium for Healthy Aging (NCHA), The Netherlands
    962