Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04-01

AUTHORS

Yuka Nakazawa, Kensaku Sasaki, Norisato Mitsutake, Michiko Matsuse, Mayuko Shimada, Tiziana Nardo, Yoshito Takahashi, Kaname Ohyama, Kosei Ito, Hiroyuki Mishima, Masayo Nomura, Akira Kinoshita, Shinji Ono, Katsuya Takenaka, Ritsuko Masuyama, Takashi Kudo, Hanoch Slor, Atsushi Utani, Satoshi Tateishi, Shunichi Yamashita, Miria Stefanini, Alan R Lehmann, Koh-ichiro Yoshiura, Tomoo Ogi

ABSTRACT

Tomoo Ogi and colleagues report mutations of UVSSA causing a third complementation group of the UV-sensitive syndrome. UVSSA deficiency results in defective transcription-coupled nucleotide-excision repair and failure to resolve stalled RNA polymerase IIo at DNA damage sites.

PAGES

586-592

Journal

TITLE

Nature Genetics

ISSUE

5

VOLUME

44

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.2229

DOI

http://dx.doi.org/10.1038/ng.2229

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004492893

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22466610


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