Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-05

AUTHORS

Lei Sun, Johanna M Rommens, Harriet Corvol, Weili Li, Xin Li, Theodore A Chiang, Fan Lin, Ruslan Dorfman, Pierre-François Busson, Rashmi V Parekh, Diana Zelenika, Scott M Blackman, Mary Corey, Vishal K Doshi, Lindsay Henderson, Kathleen M Naughton, Wanda K O'Neal, Rhonda G Pace, Jaclyn R Stonebraker, Sally D Wood, Fred A Wright, Julian Zielenski, Annick Clement, Mitchell L Drumm, Pierre-Yves Boëlle, Garry R Cutting, Michael R Knowles, Peter R Durie, Lisa J Strug

ABSTRACT

Variants associated with meconium ileus in cystic fibrosis were identified in 3,763 affected individuals by genome-wide association study (GWAS). Five SNPs at two loci near SLC6A14 at Xq23-24 (minimum P = 1.28 × 10(-12) at rs3788766) and SLC26A9 at 1q32.1 (minimum P = 9.88 × 10(-9) at rs4077468) accounted for ~5% of phenotypic variability and were replicated in an independent sample of affected individuals (n = 2,372; P = 0.001 and 0.0001, respectively). By incorporating the knowledge that disease-causing mutations in CFTR alter electrolyte and fluid flux across surface epithelium into a hypothesis-driven GWAS (GWAS-HD), we identified associations with the same SNPs in SLC6A14 and SLC26A9 and established evidence for the involvement of SNPs in a third solute carrier gene, SLC9A3. In addition, GWAS-HD provided evidence of association between meconium ileus and multiple genes encoding constituents of the apical plasma membrane where CFTR resides (P = 0.0002; testing of 155 apical membrane genes jointly and in replication, P = 0.022). These findings suggest that modulating activities of apical membrane constituents could complement current therapeutic paradigms for cystic fibrosis. More... »

PAGES

562

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.2221

DOI

http://dx.doi.org/10.1038/ng.2221

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053601402

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22466613


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Transport Systems, Neutral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiporters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystic Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystic Fibrosis Transmembrane Conductance Regulator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ileus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Obstruction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meconium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium-Hydrogen Exchanger 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium-Hydrogen Exchangers", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.", 
            "Department of Statistics, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Lei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.", 
            "Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rommens", 
        "givenName": "Johanna M", 
        "id": "sg:person.01355172356.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355172356.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Pediatric Pulmonary Department, Hospital Trousseau, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Institut National de la Sant\u00e9 et la Recherche M\u00e9dicale (INSERM), U938, Paris, France.", 
            "Pierre et Marie Curie University\u2013Paris 6, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corvol", 
        "givenName": "Harriet", 
        "id": "sg:person.01115423145.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115423145.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.", 
            "Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Weili", 
        "id": "sg:person.01214514044.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214514044.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xin", 
        "id": "sg:person.0647060602.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647060602.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiang", 
        "givenName": "Theodore A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Fan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dorfman", 
        "givenName": "Ruslan", 
        "id": "sg:person.0645745062.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645745062.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Biostatistics Department, AP-HP, Saint-Antoine Hospital, INSERM, Unit\u00e9 Mixte de Recherche (UMR) S707, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Busson", 
        "givenName": "Pierre-Fran\u00e7ois", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parekh", 
        "givenName": "Rashmi V", 
        "id": "sg:person.01333666420.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333666420.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre National de G\u00e9notypage", 
          "id": "https://www.grid.ac/institutes/grid.418135.a", 
          "name": [
            "Centre National de G\u00e9notypage (CNG), Commisariat \u00e0 l'Energie Atomique (CEA), Evry, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zelenika", 
        "givenName": "Diana", 
        "id": "sg:person.0676436141.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676436141.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blackman", 
        "givenName": "Scott M", 
        "id": "sg:person.07636650254.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07636650254.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corey", 
        "givenName": "Mary", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Doshi", 
        "givenName": "Vishal K", 
        "id": "sg:person.0735065117.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735065117.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henderson", 
        "givenName": "Lindsay", 
        "id": "sg:person.07516601617.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07516601617.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naughton", 
        "givenName": "Kathleen M", 
        "id": "sg:person.01306105532.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306105532.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Cystic Fibrosis\u2013Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Neal", 
        "givenName": "Wanda K", 
        "id": "sg:person.01371501332.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371501332.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Cystic Fibrosis\u2013Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pace", 
        "givenName": "Rhonda G", 
        "id": "sg:person.0700202706.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700202706.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Cystic Fibrosis\u2013Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stonebraker", 
        "givenName": "Jaclyn R", 
        "id": "sg:person.0746316106.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746316106.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Cystic Fibrosis\u2013Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wood", 
        "givenName": "Sally D", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wright", 
        "givenName": "Fred A", 
        "id": "sg:person.01145130774.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145130774.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zielenski", 
        "givenName": "Julian", 
        "id": "sg:person.0770547130.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770547130.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Pediatric Pulmonary Department, Hospital Trousseau, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Institut National de la Sant\u00e9 et la Recherche M\u00e9dicale (INSERM), U938, Paris, France.", 
            "Pierre et Marie Curie University\u2013Paris 6, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clement", 
        "givenName": "Annick", 
        "id": "sg:person.01326316322.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326316322.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Case Western Reserve University", 
          "id": "https://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.", 
            "Department of Genetics, Case Western Reserve University, Cleveland, Ohio, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drumm", 
        "givenName": "Mitchell L", 
        "id": "sg:person.01101417301.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101417301.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Pierre et Marie Curie University\u2013Paris 6, Paris, France.", 
            "Biostatistics Department, AP-HP, Saint-Antoine Hospital, INSERM, Unit\u00e9 Mixte de Recherche (UMR) S707, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bo\u00eblle", 
        "givenName": "Pierre-Yves", 
        "id": "sg:person.01217105733.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217105733.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.", 
            "McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cutting", 
        "givenName": "Garry R", 
        "id": "sg:person.0752157206.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752157206.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina System", 
          "id": "https://www.grid.ac/institutes/grid.410711.2", 
          "name": [
            "Cystic Fibrosis\u2013Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knowles", 
        "givenName": "Michael R", 
        "id": "sg:person.015517451472.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015517451472.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.", 
            "Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Durie", 
        "givenName": "Peter R", 
        "id": "sg:person.014042101074.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014042101074.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.", 
            "Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strug", 
        "givenName": "Lisa J", 
        "id": "sg:person.0776774476.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776774476.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/nar/gkp1018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002756370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci24898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002939764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biomet/73.1.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005412165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005913886", 
          "https://doi.org/10.1038/nature05874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006536603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006536603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2006.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009020750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010608717", 
          "https://doi.org/10.1038/nature09534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010608717", 
          "https://doi.org/10.1038/nature09534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00052.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013415896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btn615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015664076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2010.01502.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016757390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2010.01502.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016757390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genom.9.081307.164242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018499775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/519795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019061180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ppul.21372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024114915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024667482", 
          "https://doi.org/10.1038/ng.838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.08.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024930923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025133227", 
          "https://doi.org/10.1038/nature08185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025133227", 
          "https://doi.org/10.1038/nature08185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-7364-4-1-21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028682180", 
          "https://doi.org/10.1186/1479-7364-4-1-21"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.90520.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028990519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029102123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029102123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00232-009-9165-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030309418", 
          "https://doi.org/10.1007/s00232-009-9165-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00232-009-9165-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030309418", 
          "https://doi.org/10.1007/s00232-009-9165-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00232-009-9165-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030309418", 
          "https://doi.org/10.1007/s00232-009-9165-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031377769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031429813", 
          "https://doi.org/10.1038/ng1847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031429813", 
          "https://doi.org/10.1038/ng1847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1085/jgp.200810097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034482687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039500245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039500245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043639889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044135237", 
          "https://doi.org/10.1038/75556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044135237", 
          "https://doi.org/10.1038/75556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2009.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045407083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.001669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050632906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052087865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/500026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058782523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/522374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058793537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biomet/78.3.691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059420201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/pdb.top065581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060415376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2570460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062544667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/132.4.733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075023827"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-05", 
    "datePublishedReg": "2012-05-01", 
    "description": "Variants associated with meconium ileus in cystic fibrosis were identified in 3,763 affected individuals by genome-wide association study (GWAS). Five SNPs at two loci near SLC6A14 at Xq23-24 (minimum P = 1.28 \u00d7 10(-12) at rs3788766) and SLC26A9 at 1q32.1 (minimum P = 9.88 \u00d7 10(-9) at rs4077468) accounted for ~5% of phenotypic variability and were replicated in an independent sample of affected individuals (n = 2,372; P = 0.001 and 0.0001, respectively). By incorporating the knowledge that disease-causing mutations in CFTR alter electrolyte and fluid flux across surface epithelium into a hypothesis-driven GWAS (GWAS-HD), we identified associations with the same SNPs in SLC6A14 and SLC26A9 and established evidence for the involvement of SNPs in a third solute carrier gene, SLC9A3. In addition, GWAS-HD provided evidence of association between meconium ileus and multiple genes encoding constituents of the apical plasma membrane where CFTR resides (P = 0.0002; testing of 155 apical membrane genes jointly and in replication, P = 0.022). These findings suggest that modulating activities of apical membrane constituents could complement current therapeutic paradigms for cystic fibrosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.2221", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2575667", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2498185", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2538341", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2923039", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2418955", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438979", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2538331", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2958383", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2587221", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2542416", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "name": "Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis", 
    "pagination": "562", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ff4f833b4100836de0349a71581252605dae6cb4de3492a71883cc968268444e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22466613"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.2221"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053601402"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.2221", 
      "https://app.dimensions.ai/details/publication/pub.1053601402"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ng.2221"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2221'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2221'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2221'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2221'


 

This table displays all metadata directly associated to this object as RDF triples.

484 TRIPLES      21 PREDICATES      79 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.2221 schema:about N0e1abd605acd4e2c8bb6fc2f063d0091
2 N0f6e6ec82f2b4392b66bf7a0555f70ca
3 N32ad2079282d4616b3a4b865fb275b34
4 N458e7e9a28a04fe1ba506e3d64cb2ff1
5 N72660da888884519a99046bb9c1dba05
6 N77642047cd60491eaf82688fac5468dc
7 N877c75e2471043208dfd05d8a69ceb96
8 Nc855f6006c134559a79f04d59316f00b
9 Nc9fe047cf3694494bee7ec67f69b260d
10 Nd450add4a57c4ba3b1f82a4394679b7b
11 Ne877a3ea62de4f61ae6a4a5ed79b0e8b
12 Nf00ff420a6d44e52929f466a7a42663e
13 Nf1f391dfa6e14e63841376b76f1920d4
14 Nf230f6256c1340529f66d4acf09881e4
15 Nf80ad64f0799488698863dd43d5d3873
16 anzsrc-for:06
17 anzsrc-for:0604
18 schema:author N58fbf160c27546b5b0be8bf1ad5634c6
19 schema:citation sg:pub.10.1007/s00232-009-9165-5
20 sg:pub.10.1038/75556
21 sg:pub.10.1038/nature05874
22 sg:pub.10.1038/nature08185
23 sg:pub.10.1038/nature09534
24 sg:pub.10.1038/ng.838
25 sg:pub.10.1038/ng1847
26 sg:pub.10.1186/1479-7364-4-1-21
27 https://doi.org/10.1002/gepi.20164
28 https://doi.org/10.1002/gepi.20297
29 https://doi.org/10.1002/gepi.20422
30 https://doi.org/10.1002/gepi.20438
31 https://doi.org/10.1002/gepi.20533
32 https://doi.org/10.1002/ppul.21372
33 https://doi.org/10.1016/j.ajhg.2009.11.017
34 https://doi.org/10.1016/j.bbrc.2005.08.048
35 https://doi.org/10.1053/j.gastro.2006.07.016
36 https://doi.org/10.1074/jbc.m109.001669
37 https://doi.org/10.1085/jgp.200810097
38 https://doi.org/10.1086/500026
39 https://doi.org/10.1086/519795
40 https://doi.org/10.1086/522374
41 https://doi.org/10.1093/bioinformatics/btn615
42 https://doi.org/10.1093/biomet/73.1.13
43 https://doi.org/10.1093/biomet/78.3.691
44 https://doi.org/10.1093/jn/132.4.733
45 https://doi.org/10.1093/nar/gkp1018
46 https://doi.org/10.1101/pdb.top065581
47 https://doi.org/10.1111/j.1399-0004.2010.01502.x
48 https://doi.org/10.1126/science.2570460
49 https://doi.org/10.1146/annurev.genom.9.081307.164242
50 https://doi.org/10.1152/ajpgi.00052.2011
51 https://doi.org/10.1152/ajpgi.90520.2008
52 https://doi.org/10.1172/jci24898
53 https://doi.org/10.1371/journal.pbio.1001046
54 schema:datePublished 2012-05
55 schema:datePublishedReg 2012-05-01
56 schema:description Variants associated with meconium ileus in cystic fibrosis were identified in 3,763 affected individuals by genome-wide association study (GWAS). Five SNPs at two loci near SLC6A14 at Xq23-24 (minimum P = 1.28 × 10(-12) at rs3788766) and SLC26A9 at 1q32.1 (minimum P = 9.88 × 10(-9) at rs4077468) accounted for ~5% of phenotypic variability and were replicated in an independent sample of affected individuals (n = 2,372; P = 0.001 and 0.0001, respectively). By incorporating the knowledge that disease-causing mutations in CFTR alter electrolyte and fluid flux across surface epithelium into a hypothesis-driven GWAS (GWAS-HD), we identified associations with the same SNPs in SLC6A14 and SLC26A9 and established evidence for the involvement of SNPs in a third solute carrier gene, SLC9A3. In addition, GWAS-HD provided evidence of association between meconium ileus and multiple genes encoding constituents of the apical plasma membrane where CFTR resides (P = 0.0002; testing of 155 apical membrane genes jointly and in replication, P = 0.022). These findings suggest that modulating activities of apical membrane constituents could complement current therapeutic paradigms for cystic fibrosis.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N6d18fd9eb09f42f6abb71ae311586ac6
61 Na68e45b4f2a04ae9b78028ee23d533fc
62 sg:journal.1103138
63 schema:name Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis
64 schema:pagination 562
65 schema:productId N00f35d02add54135b6546abffe411842
66 N908c02d6d0dc4833a232ddaa0ac0ab98
67 Nbd0749b9faae429390a8aa6a23f1479b
68 Nd46f0f8814d34a98917c44f4d0c5af0f
69 Ne124b383b122493abcaa85e3f675dc30
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053601402
71 https://doi.org/10.1038/ng.2221
72 schema:sdDatePublished 2019-04-10T16:30
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N9244fe33921b4a5ca61d749244a0153d
75 schema:url https://www.nature.com/articles/ng.2221
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N00f35d02add54135b6546abffe411842 schema:name readcube_id
80 schema:value ff4f833b4100836de0349a71581252605dae6cb4de3492a71883cc968268444e
81 rdf:type schema:PropertyValue
82 N0549318d9d4047a0936c3b55f090367e rdf:first sg:person.015517451472.41
83 rdf:rest N8899c8285ea9432cb3303d3e9dbd3be0
84 N073c31f2c39b4444b4f80f87bf88c691 rdf:first sg:person.0776774476.26
85 rdf:rest rdf:nil
86 N0e1abd605acd4e2c8bb6fc2f063d0091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Intestinal Obstruction
88 rdf:type schema:DefinedTerm
89 N0f6e6ec82f2b4392b66bf7a0555f70ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Amino Acid Transport Systems, Neutral
91 rdf:type schema:DefinedTerm
92 N16b18eca0c3646ba88bf14fbe195ea9f rdf:first sg:person.01371501332.03
93 rdf:rest N4c05e8329d874076adb6736d7af8d6e5
94 N1798c47fb5054b06b856217f9c1494a8 rdf:first N375e4ac100314d1a973fb292be2b0d7f
95 rdf:rest N5048e40eaf5249f6b86b6bee3776094b
96 N1e87e66ee1344d529b81cf2ea491c7a2 rdf:first sg:person.0735065117.57
97 rdf:rest N4deec646da9044b39108ae06cfd8a3a6
98 N2416c2962f044ecb9a5a2366cb184190 rdf:first Nda13e22cdc7e440199fefe9cad69fb45
99 rdf:rest N1e87e66ee1344d529b81cf2ea491c7a2
100 N284d74bda90a4eea9f367793d2a7d813 rdf:first sg:person.0746316106.45
101 rdf:rest N1798c47fb5054b06b856217f9c1494a8
102 N2ffa1a713afd4dcf9657e38f6d94e6f2 schema:affiliation N72067d3444244f9e81e04d218172e3b8
103 schema:familyName Busson
104 schema:givenName Pierre-François
105 rdf:type schema:Person
106 N3046eede11ca4e9eb65d47f97e123f7a schema:affiliation https://www.grid.ac/institutes/grid.42327.30
107 schema:familyName Lin
108 schema:givenName Fan
109 rdf:type schema:Person
110 N30ad24011aec4bc4bf4ff4cfa01e11d0 rdf:first sg:person.07636650254.30
111 rdf:rest N2416c2962f044ecb9a5a2366cb184190
112 N32ad2079282d4616b3a4b865fb275b34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Ileus
114 rdf:type schema:DefinedTerm
115 N375e4ac100314d1a973fb292be2b0d7f schema:affiliation https://www.grid.ac/institutes/grid.410711.2
116 schema:familyName Wood
117 schema:givenName Sally D
118 rdf:type schema:Person
119 N458e7e9a28a04fe1ba506e3d64cb2ff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cystic Fibrosis Transmembrane Conductance Regulator
121 rdf:type schema:DefinedTerm
122 N4c05e8329d874076adb6736d7af8d6e5 rdf:first sg:person.0700202706.10
123 rdf:rest N284d74bda90a4eea9f367793d2a7d813
124 N4deec646da9044b39108ae06cfd8a3a6 rdf:first sg:person.07516601617.16
125 rdf:rest N54102231a42646f18e4ea9e920a6d34f
126 N5048e40eaf5249f6b86b6bee3776094b rdf:first sg:person.01145130774.66
127 rdf:rest N7a47ff19cdb64baba579f958d1fe1481
128 N54102231a42646f18e4ea9e920a6d34f rdf:first sg:person.01306105532.03
129 rdf:rest N16b18eca0c3646ba88bf14fbe195ea9f
130 N545e73654c3d444b95b2d05d4a9cfffb rdf:first N2ffa1a713afd4dcf9657e38f6d94e6f2
131 rdf:rest N7d7dd44de2974c4288f593b8c0ec5cb0
132 N58fbf160c27546b5b0be8bf1ad5634c6 rdf:first N5c9aa1324f6143ceb41656a5859679c8
133 rdf:rest N86f077ec3dbf4744a76a84915ec70158
134 N5c9aa1324f6143ceb41656a5859679c8 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
135 schema:familyName Sun
136 schema:givenName Lei
137 rdf:type schema:Person
138 N6d18fd9eb09f42f6abb71ae311586ac6 schema:issueNumber 5
139 rdf:type schema:PublicationIssue
140 N6fb802b9bcf040c9a70f93f1bee52119 rdf:first N3046eede11ca4e9eb65d47f97e123f7a
141 rdf:rest N8240ef28c276487291130bf4493cf466
142 N72067d3444244f9e81e04d218172e3b8 schema:name Biostatistics Department, AP-HP, Saint-Antoine Hospital, INSERM, Unité Mixte de Recherche (UMR) S707, Paris, France.
143 rdf:type schema:Organization
144 N72660da888884519a99046bb9c1dba05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Genotype
146 rdf:type schema:DefinedTerm
147 N77642047cd60491eaf82688fac5468dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cystic Fibrosis
149 rdf:type schema:DefinedTerm
150 N7a47ff19cdb64baba579f958d1fe1481 rdf:first sg:person.0770547130.88
151 rdf:rest Na8098cf312be4cb7bc6bdfe020c77bd9
152 N7d7dd44de2974c4288f593b8c0ec5cb0 rdf:first sg:person.01333666420.02
153 rdf:rest N8654202e88e7402e82632bbb3d29a2ba
154 N8240ef28c276487291130bf4493cf466 rdf:first sg:person.0645745062.03
155 rdf:rest N545e73654c3d444b95b2d05d4a9cfffb
156 N8451972da44e47f3bc853ec38b928f3b rdf:first sg:person.01217105733.78
157 rdf:rest Naf02dfb91cbe4db5bc0819f6fc9f94f0
158 N8654202e88e7402e82632bbb3d29a2ba rdf:first sg:person.0676436141.13
159 rdf:rest N30ad24011aec4bc4bf4ff4cfa01e11d0
160 N86f077ec3dbf4744a76a84915ec70158 rdf:first sg:person.01355172356.46
161 rdf:rest N9ee7a34d97ad4340a2124cf1e8b23204
162 N877c75e2471043208dfd05d8a69ceb96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Genome-Wide Association Study
164 rdf:type schema:DefinedTerm
165 N8899c8285ea9432cb3303d3e9dbd3be0 rdf:first sg:person.014042101074.40
166 rdf:rest N073c31f2c39b4444b4f80f87bf88c691
167 N908c02d6d0dc4833a232ddaa0ac0ab98 schema:name doi
168 schema:value 10.1038/ng.2221
169 rdf:type schema:PropertyValue
170 N9244fe33921b4a5ca61d749244a0153d schema:name Springer Nature - SN SciGraph project
171 rdf:type schema:Organization
172 N9ee7a34d97ad4340a2124cf1e8b23204 rdf:first sg:person.01115423145.99
173 rdf:rest Nf3edeb386c1843d8be39b99b03319f52
174 Na68e45b4f2a04ae9b78028ee23d533fc schema:volumeNumber 44
175 rdf:type schema:PublicationVolume
176 Na8098cf312be4cb7bc6bdfe020c77bd9 rdf:first sg:person.01326316322.38
177 rdf:rest Nf36646534db44038876b6b266f801215
178 Naf02dfb91cbe4db5bc0819f6fc9f94f0 rdf:first sg:person.0752157206.07
179 rdf:rest N0549318d9d4047a0936c3b55f090367e
180 Nbd0749b9faae429390a8aa6a23f1479b schema:name dimensions_id
181 schema:value pub.1053601402
182 rdf:type schema:PropertyValue
183 Nbe5c93d6d8ad4550896745fbbad3488c rdf:first sg:person.0647060602.60
184 rdf:rest Nc8e3244b37674dd4bf3d024a7bf950c0
185 Nc855f6006c134559a79f04d59316f00b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Sodium-Hydrogen Exchangers
187 rdf:type schema:DefinedTerm
188 Nc8e3244b37674dd4bf3d024a7bf950c0 rdf:first Ncd8eb2ba1cd6493a856acc2e4b618e38
189 rdf:rest N6fb802b9bcf040c9a70f93f1bee52119
190 Nc9fe047cf3694494bee7ec67f69b260d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Genetic Predisposition to Disease
192 rdf:type schema:DefinedTerm
193 Ncd8eb2ba1cd6493a856acc2e4b618e38 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
194 schema:familyName Chiang
195 schema:givenName Theodore A
196 rdf:type schema:Person
197 Nd450add4a57c4ba3b1f82a4394679b7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Humans
199 rdf:type schema:DefinedTerm
200 Nd46f0f8814d34a98917c44f4d0c5af0f schema:name nlm_unique_id
201 schema:value 9216904
202 rdf:type schema:PropertyValue
203 Nda13e22cdc7e440199fefe9cad69fb45 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
204 schema:familyName Corey
205 schema:givenName Mary
206 rdf:type schema:Person
207 Ne124b383b122493abcaa85e3f675dc30 schema:name pubmed_id
208 schema:value 22466613
209 rdf:type schema:PropertyValue
210 Ne877a3ea62de4f61ae6a4a5ed79b0e8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Cell Membrane
212 rdf:type schema:DefinedTerm
213 Nf00ff420a6d44e52929f466a7a42663e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Sodium-Hydrogen Exchanger 3
215 rdf:type schema:DefinedTerm
216 Nf1f391dfa6e14e63841376b76f1920d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Antiporters
218 rdf:type schema:DefinedTerm
219 Nf230f6256c1340529f66d4acf09881e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Polymorphism, Single Nucleotide
221 rdf:type schema:DefinedTerm
222 Nf36646534db44038876b6b266f801215 rdf:first sg:person.01101417301.47
223 rdf:rest N8451972da44e47f3bc853ec38b928f3b
224 Nf3edeb386c1843d8be39b99b03319f52 rdf:first sg:person.01214514044.87
225 rdf:rest Nbe5c93d6d8ad4550896745fbbad3488c
226 Nf80ad64f0799488698863dd43d5d3873 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Meconium
228 rdf:type schema:DefinedTerm
229 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
230 schema:name Biological Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
233 schema:name Genetics
234 rdf:type schema:DefinedTerm
235 sg:grant.2418955 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
236 rdf:type schema:MonetaryGrant
237 sg:grant.2438979 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
238 rdf:type schema:MonetaryGrant
239 sg:grant.2498185 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
240 rdf:type schema:MonetaryGrant
241 sg:grant.2538331 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
242 rdf:type schema:MonetaryGrant
243 sg:grant.2538341 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
244 rdf:type schema:MonetaryGrant
245 sg:grant.2542416 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
246 rdf:type schema:MonetaryGrant
247 sg:grant.2575667 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
248 rdf:type schema:MonetaryGrant
249 sg:grant.2587221 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
250 rdf:type schema:MonetaryGrant
251 sg:grant.2923039 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
252 rdf:type schema:MonetaryGrant
253 sg:grant.2958383 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2221
254 rdf:type schema:MonetaryGrant
255 sg:journal.1103138 schema:issn 1061-4036
256 1546-1718
257 schema:name Nature Genetics
258 rdf:type schema:Periodical
259 sg:person.01101417301.47 schema:affiliation https://www.grid.ac/institutes/grid.67105.35
260 schema:familyName Drumm
261 schema:givenName Mitchell L
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101417301.47
263 rdf:type schema:Person
264 sg:person.01115423145.99 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
265 schema:familyName Corvol
266 schema:givenName Harriet
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115423145.99
268 rdf:type schema:Person
269 sg:person.01145130774.66 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
270 schema:familyName Wright
271 schema:givenName Fred A
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145130774.66
273 rdf:type schema:Person
274 sg:person.01214514044.87 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
275 schema:familyName Li
276 schema:givenName Weili
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214514044.87
278 rdf:type schema:Person
279 sg:person.01217105733.78 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
280 schema:familyName Boëlle
281 schema:givenName Pierre-Yves
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217105733.78
283 rdf:type schema:Person
284 sg:person.01306105532.03 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
285 schema:familyName Naughton
286 schema:givenName Kathleen M
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306105532.03
288 rdf:type schema:Person
289 sg:person.01326316322.38 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
290 schema:familyName Clement
291 schema:givenName Annick
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326316322.38
293 rdf:type schema:Person
294 sg:person.01333666420.02 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
295 schema:familyName Parekh
296 schema:givenName Rashmi V
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333666420.02
298 rdf:type schema:Person
299 sg:person.01355172356.46 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
300 schema:familyName Rommens
301 schema:givenName Johanna M
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355172356.46
303 rdf:type schema:Person
304 sg:person.01371501332.03 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
305 schema:familyName O'Neal
306 schema:givenName Wanda K
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371501332.03
308 rdf:type schema:Person
309 sg:person.014042101074.40 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
310 schema:familyName Durie
311 schema:givenName Peter R
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014042101074.40
313 rdf:type schema:Person
314 sg:person.015517451472.41 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
315 schema:familyName Knowles
316 schema:givenName Michael R
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015517451472.41
318 rdf:type schema:Person
319 sg:person.0645745062.03 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
320 schema:familyName Dorfman
321 schema:givenName Ruslan
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645745062.03
323 rdf:type schema:Person
324 sg:person.0647060602.60 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
325 schema:familyName Li
326 schema:givenName Xin
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647060602.60
328 rdf:type schema:Person
329 sg:person.0676436141.13 schema:affiliation https://www.grid.ac/institutes/grid.418135.a
330 schema:familyName Zelenika
331 schema:givenName Diana
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676436141.13
333 rdf:type schema:Person
334 sg:person.0700202706.10 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
335 schema:familyName Pace
336 schema:givenName Rhonda G
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700202706.10
338 rdf:type schema:Person
339 sg:person.0735065117.57 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
340 schema:familyName Doshi
341 schema:givenName Vishal K
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735065117.57
343 rdf:type schema:Person
344 sg:person.0746316106.45 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
345 schema:familyName Stonebraker
346 schema:givenName Jaclyn R
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746316106.45
348 rdf:type schema:Person
349 sg:person.07516601617.16 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
350 schema:familyName Henderson
351 schema:givenName Lindsay
352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07516601617.16
353 rdf:type schema:Person
354 sg:person.0752157206.07 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
355 schema:familyName Cutting
356 schema:givenName Garry R
357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752157206.07
358 rdf:type schema:Person
359 sg:person.07636650254.30 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
360 schema:familyName Blackman
361 schema:givenName Scott M
362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07636650254.30
363 rdf:type schema:Person
364 sg:person.0770547130.88 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
365 schema:familyName Zielenski
366 schema:givenName Julian
367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770547130.88
368 rdf:type schema:Person
369 sg:person.0776774476.26 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
370 schema:familyName Strug
371 schema:givenName Lisa J
372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776774476.26
373 rdf:type schema:Person
374 sg:pub.10.1007/s00232-009-9165-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030309418
375 https://doi.org/10.1007/s00232-009-9165-5
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/75556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044135237
378 https://doi.org/10.1038/75556
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/nature05874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005913886
381 https://doi.org/10.1038/nature05874
382 rdf:type schema:CreativeWork
383 sg:pub.10.1038/nature08185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025133227
384 https://doi.org/10.1038/nature08185
385 rdf:type schema:CreativeWork
386 sg:pub.10.1038/nature09534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010608717
387 https://doi.org/10.1038/nature09534
388 rdf:type schema:CreativeWork
389 sg:pub.10.1038/ng.838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024667482
390 https://doi.org/10.1038/ng.838
391 rdf:type schema:CreativeWork
392 sg:pub.10.1038/ng1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031429813
393 https://doi.org/10.1038/ng1847
394 rdf:type schema:CreativeWork
395 sg:pub.10.1186/1479-7364-4-1-21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028682180
396 https://doi.org/10.1186/1479-7364-4-1-21
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1002/gepi.20164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043639889
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1002/gepi.20297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052087865
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1002/gepi.20422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006536603
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1002/gepi.20438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029102123
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1002/gepi.20533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039500245
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1002/ppul.21372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024114915
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1016/j.ajhg.2009.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045407083
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1016/j.bbrc.2005.08.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024930923
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1053/j.gastro.2006.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009020750
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1074/jbc.m109.001669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050632906
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1085/jgp.200810097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034482687
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1086/500026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058782523
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1086/522374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058793537
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1093/bioinformatics/btn615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015664076
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1093/biomet/73.1.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005412165
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1093/biomet/78.3.691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059420201
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1093/jn/132.4.733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075023827
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1093/nar/gkp1018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002756370
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1101/pdb.top065581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060415376
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1111/j.1399-0004.2010.01502.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016757390
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1126/science.2570460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062544667
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1146/annurev.genom.9.081307.164242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018499775
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1152/ajpgi.00052.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013415896
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1152/ajpgi.90520.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028990519
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1172/jci24898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002939764
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1371/journal.pbio.1001046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031377769
451 rdf:type schema:CreativeWork
452 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
453 schema:name Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
454 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
455 Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
456 Department of Statistics, University of Toronto, Toronto, Ontario, Canada.
457 Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
458 Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
459 rdf:type schema:Organization
460 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
461 schema:name Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
462 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
463 rdf:type schema:Organization
464 https://www.grid.ac/institutes/grid.410711.2 schema:alternateName University of North Carolina System
465 schema:name Cystic Fibrosis–Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina, USA.
466 Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA.
467 rdf:type schema:Organization
468 https://www.grid.ac/institutes/grid.418135.a schema:alternateName Centre National de Génotypage
469 schema:name Centre National de Génotypage (CNG), Commisariat à l'Energie Atomique (CEA), Evry, France.
470 rdf:type schema:Organization
471 https://www.grid.ac/institutes/grid.42327.30 schema:alternateName Hospital for Sick Children
472 schema:name Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
473 Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
474 Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
475 rdf:type schema:Organization
476 https://www.grid.ac/institutes/grid.462844.8 schema:alternateName Sorbonne University
477 schema:name Biostatistics Department, AP-HP, Saint-Antoine Hospital, INSERM, Unité Mixte de Recherche (UMR) S707, Paris, France.
478 Pediatric Pulmonary Department, Hospital Trousseau, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut National de la Santé et la Recherche Médicale (INSERM), U938, Paris, France.
479 Pierre et Marie Curie University–Paris 6, Paris, France.
480 rdf:type schema:Organization
481 https://www.grid.ac/institutes/grid.67105.35 schema:alternateName Case Western Reserve University
482 schema:name Department of Genetics, Case Western Reserve University, Cleveland, Ohio, USA.
483 Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.
484 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...