Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04

AUTHORS

Jian Yang, Teresa Ferreira, Andrew P Morris, Sarah E Medland, Genetic Investigation of ANthropometric Traits Consortium, DIAbetes Genetics Replication And Meta-analysis Consortium, Pamela A F Madden, Andrew C Heath, Nicholas G Martin, Grant W Montgomery, Michael N Weedon, Ruth J Loos, Timothy M Frayling, Mark I McCarthy, Joel N Hirschhorn, Michael E Goddard, Peter M Visscher

ABSTRACT

We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with multiple associated variants for height (38 leading and 49 additional SNPs, 87 in total) via a genome-wide SNP selection procedure. The 49 new SNPs explain approximately 1.3% of variance, nearly doubling the heritability explained at the 36 loci. We did not find any locus showing multiple associated SNPs for BMI. The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium. More... »

PAGES

369

References to SciGraph publications

  • 2002-09. Familial resemblance of body mass index and familial risk of high and low body mass index. A study of young men in Sweden in INTERNATIONAL JOURNAL OF OBESITY
  • 2007-10-18. A second generation human haplotype map of over 3.1 million SNPs in NATURE
  • 2011-06. Genome partitioning of genetic variation for complex traits using common SNPs in NATURE GENETICS
  • 2010-12. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation in NATURE GENETICS
  • 2009-06. Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap–CEU populations in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2010-12. The use of communal rearing of families and DNA pooling in aquaculture genomic selection schemes in GENETICS SELECTION EVOLUTION
  • 2010-07. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis in NATURE GENETICS
  • 2008-04. Heritability in the genomics era — concepts and misconceptions in NATURE REVIEWS GENETICS
  • 2010-10. Hundreds of variants clustered in genomic loci and biological pathways affect human height in NATURE
  • 2010-06. Genome-wide association study identifies five new breast cancer susceptibility loci in NATURE GENETICS
  • 2011-07. Genomic inflation factors under polygenic inheritance in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2010-11. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index in NATURE GENETICS
  • 2010-07. Common SNPs explain a large proportion of the heritability for human height in NATURE GENETICS
  • 2011-10. Genome-wide association study identifies five new schizophrenia loci in NATURE GENETICS
  • 2011-08. Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction in NATURE GENETICS
  • 2011-12. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease in NATURE GENETICS
  • 2011-10. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.2213

    DOI

    http://dx.doi.org/10.1038/ng.2213

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006110604

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22426310


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Algorithms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Body Height", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Body Mass Index", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin-Dependent Kinase Inhibitor p15", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Data Interpretation, Statistical", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetes Mellitus, Type 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Loci", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Variation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Linkage Disequilibrium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Meta-Analysis as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "QIMR Berghofer Medical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.1049.c", 
              "name": [
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia.", 
                "University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Jian", 
            "id": "sg:person.0730724336.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730724336.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Centre for Human Genetics", 
              "id": "https://www.grid.ac/institutes/grid.270683.8", 
              "name": [
                "Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferreira", 
            "givenName": "Teresa", 
            "id": "sg:person.01072615434.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072615434.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Centre for Human Genetics", 
              "id": "https://www.grid.ac/institutes/grid.270683.8", 
              "name": [
                "Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morris", 
            "givenName": "Andrew P", 
            "id": "sg:person.012061250547.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012061250547.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "QIMR Berghofer Medical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.1049.c", 
              "name": [
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Medland", 
            "givenName": "Sarah E", 
            "id": "sg:person.01074226355.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074226355.01"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Consortium", 
            "givenName": "Genetic Investigation of ANthropometric Traits", 
            "id": "sg:person.015453206135.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015453206135.55"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Consortium", 
            "givenName": "DIAbetes Genetics Replication And Meta-analysis", 
            "id": "sg:person.012006162345.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012006162345.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Psychiatry, Washington University, Saint Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Madden", 
            "givenName": "Pamela A F", 
            "id": "sg:person.014470155357.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014470155357.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Psychiatry, Washington University, Saint Louis, Missouri, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heath", 
            "givenName": "Andrew C", 
            "id": "sg:person.015043215017.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015043215017.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "QIMR Berghofer Medical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.1049.c", 
              "name": [
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martin", 
            "givenName": "Nicholas G", 
            "id": "sg:person.010700366647.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010700366647.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "QIMR Berghofer Medical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.1049.c", 
              "name": [
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Montgomery", 
            "givenName": "Grant W", 
            "id": "sg:person.01117721120.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117721120.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Exeter", 
              "id": "https://www.grid.ac/institutes/grid.8391.3", 
              "name": [
                "Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weedon", 
            "givenName": "Michael N", 
            "id": "sg:person.01310534155.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310534155.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Loos", 
            "givenName": "Ruth J", 
            "id": "sg:person.012266613364.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012266613364.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Exeter", 
              "id": "https://www.grid.ac/institutes/grid.8391.3", 
              "name": [
                "Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Frayling", 
            "givenName": "Timothy M", 
            "id": "sg:person.012766272254.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012766272254.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford Centre for Diabetes, Endocrinology and Metabolism", 
              "id": "https://www.grid.ac/institutes/grid.470392.b", 
              "name": [
                "Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.", 
                "Oxford Centre for Diabetes, Endocrinology and Metabolism, Headington, Oxford, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCarthy", 
            "givenName": "Mark I", 
            "id": "sg:person.016704245502.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016704245502.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Program in Genomics, Children's Hospital, Boston, Massachusetts, USA.", 
                "Division of Genetics, Children's Hospital, Boston, Massachusetts, USA.", 
                "Division of Endocrinology, Children's Hospital, Boston, Massachusetts, USA.", 
                "Broad Institute, Cambridge, Massachusetts, USA.", 
                "Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirschhorn", 
            "givenName": "Joel N", 
            "id": "sg:person.0675500473.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675500473.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Environment, Land, Water and Planning", 
              "id": "https://www.grid.ac/institutes/grid.452205.4", 
              "name": [
                "Department of Food and Agricultural Systems, The University of Melbourne, Parkville, Victoria, Australia.", 
                "Biosciences Research Division, Department of Primary Industries, Bundoora, Victoria, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goddard", 
            "givenName": "Michael E", 
            "id": "sg:person.0623730357.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623730357.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Queensland", 
              "id": "https://www.grid.ac/institutes/grid.1003.2", 
              "name": [
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia.", 
                "University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.", 
                "The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Visscher", 
            "givenName": "Peter M", 
            "id": "sg:person.01033044533.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033044533.08"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1093/hmg/ddr328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004256904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004754761", 
              "https://doi.org/10.1038/ng.707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005097773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0905980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006094606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006256853", 
              "https://doi.org/10.1038/ng.586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006256853", 
              "https://doi.org/10.1038/ng.586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007102431", 
              "https://doi.org/10.1038/ng.998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007907762", 
              "https://doi.org/10.1038/ng.823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2010.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009497006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010608717", 
              "https://doi.org/10.1038/nature09534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010608717", 
              "https://doi.org/10.1038/nature09534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1375/twin.6.5.409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012190721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2009.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012473188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddh294", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013030166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013643799", 
              "https://doi.org/10.1038/ng.686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013643799", 
              "https://doi.org/10.1038/ng.686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014682139", 
              "https://doi.org/10.1038/ng.943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015057090", 
              "https://doi.org/10.1038/ng.608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015057090", 
              "https://doi.org/10.1038/ng.608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0903103106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020299353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0006-341x.1999.00997.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021081768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025506940", 
              "https://doi.org/10.1038/ng.871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0802041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027247192", 
              "https://doi.org/10.1038/sj.ijo.0802041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0802041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027247192", 
              "https://doi.org/10.1038/sj.ijo.0802041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037714920", 
              "https://doi.org/10.1038/nature09410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037714920", 
              "https://doi.org/10.1038/nature09410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039500245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039500245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041224776", 
              "https://doi.org/10.1038/ng.609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041224776", 
              "https://doi.org/10.1038/ng.609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(91)90542-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044403756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(91)90542-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044403756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046913669", 
              "https://doi.org/10.1038/nrg2322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.092189.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048316418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049458939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049458939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051134045", 
              "https://doi.org/10.1038/nature06258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2011.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051554988", 
              "https://doi.org/10.1038/ejhg.2011.39"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2008.248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052237094", 
              "https://doi.org/10.1038/ejhg.2008.248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053172161", 
              "https://doi.org/10.1038/ng.940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053172161", 
              "https://doi.org/10.1038/ng.940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1297-9686-42-41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078304275", 
              "https://doi.org/10.1186/1297-9686-42-41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1297-9686-42-41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078304275", 
              "https://doi.org/10.1186/1297-9686-42-41"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-04", 
        "datePublishedReg": "2012-04-01", 
        "description": "We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with multiple associated variants for height (38 leading and 49 additional SNPs, 87 in total) via a genome-wide SNP selection procedure. The 49 new SNPs explain approximately 1.3% of variance, nearly doubling the heritability explained at the 36 loci. We did not find any locus showing multiple associated SNPs for BMI. The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ng.2213", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3578761", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2666997", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3636942", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345564", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345497", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2691245", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6714548", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345522", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6720675", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345504", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6733431", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6728038", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345510", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6713576", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6713568", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6726634", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2484886", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6716411", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2775540", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6715021", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2536122", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2442672", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6712976", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6715143", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541398", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345491", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2443777", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6718843", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345526", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541272", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6722666", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2408001", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2443780", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2443778", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345516", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2705143", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3570887", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2443909", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "44"
          }
        ], 
        "name": "Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits", 
        "pagination": "369", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "1d1bd1f8c03d60f088b03c227b2398d2215e8fbbae3951ce956b658a5f16ddad"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22426310"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.2213"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1006110604"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.2213", 
          "https://app.dimensions.ai/details/publication/pub.1006110604"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/ng.2213"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.2213'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.2213'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.2213'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.2213'


     

    This table displays all metadata directly associated to this object as RDF triples.

    469 TRIPLES      21 PREDICATES      78 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.2213 schema:about N0f252c9fca984baf88b5541e4676785c
    2 N1116c3fc266440109cc56c3b444f8039
    3 N2094280dd662444992cf7f6832deab28
    4 N29f4b5bfe6ec4247a9b764003a5a6f7e
    5 N2c5ba7c116f7488496e4f5a7d7d41203
    6 N44bf45ba0a0b4d5f8744706847ca2c46
    7 N50e55c0eb09a4d4f93bbcfbd8571380c
    8 N5abae527c95d47f9b5538f8295644d7e
    9 N71456d183b1f491a8f92f3b2dc8d6eaf
    10 N88b5bb913da44a879e15328e3835460b
    11 N8a626ee1bda74bdb8a32f118176f7a16
    12 N91bca2aa8e6a43c0bc5d7b9b858ffa20
    13 Nb6f83899904e4a0fbe105dd020166dec
    14 Nb97b4433fde447d6a326aa51b7c077fb
    15 Ndc7d48a320594f4bb39348a9599c2435
    16 Ne9fb1be182af44dea4bf969f57539a41
    17 Nea4bcb678b3d4e0693bd70e5d32d6098
    18 anzsrc-for:06
    19 anzsrc-for:0604
    20 schema:author N12b70672050f42f1b303399b4e9028b2
    21 schema:citation sg:pub.10.1038/ejhg.2008.248
    22 sg:pub.10.1038/ejhg.2011.39
    23 sg:pub.10.1038/nature06258
    24 sg:pub.10.1038/nature09410
    25 sg:pub.10.1038/nature09534
    26 sg:pub.10.1038/ng.586
    27 sg:pub.10.1038/ng.608
    28 sg:pub.10.1038/ng.609
    29 sg:pub.10.1038/ng.686
    30 sg:pub.10.1038/ng.707
    31 sg:pub.10.1038/ng.823
    32 sg:pub.10.1038/ng.871
    33 sg:pub.10.1038/ng.940
    34 sg:pub.10.1038/ng.943
    35 sg:pub.10.1038/ng.998
    36 sg:pub.10.1038/nrg2322
    37 sg:pub.10.1038/sj.ijo.0802041
    38 sg:pub.10.1186/1297-9686-42-41
    39 https://doi.org/10.1002/gepi.20516
    40 https://doi.org/10.1002/gepi.20533
    41 https://doi.org/10.1016/0140-6736(91)90542-w
    42 https://doi.org/10.1016/j.ajhg.2009.10.009
    43 https://doi.org/10.1016/j.ajhg.2010.11.011
    44 https://doi.org/10.1056/nejmra0905980
    45 https://doi.org/10.1073/pnas.0903103106
    46 https://doi.org/10.1086/519795
    47 https://doi.org/10.1093/hmg/ddh294
    48 https://doi.org/10.1093/hmg/ddr328
    49 https://doi.org/10.1101/gr.092189.109
    50 https://doi.org/10.1111/j.0006-341x.1999.00997.x
    51 https://doi.org/10.1371/journal.pgen.1002198
    52 https://doi.org/10.1375/twin.6.5.409
    53 schema:datePublished 2012-04
    54 schema:datePublishedReg 2012-04-01
    55 schema:description We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with multiple associated variants for height (38 leading and 49 additional SNPs, 87 in total) via a genome-wide SNP selection procedure. The 49 new SNPs explain approximately 1.3% of variance, nearly doubling the heritability explained at the 36 loci. We did not find any locus showing multiple associated SNPs for BMI. The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium.
    56 schema:genre research_article
    57 schema:inLanguage en
    58 schema:isAccessibleForFree true
    59 schema:isPartOf N9ce8efd329e24946865dad954c86e012
    60 Nec53f15c7e5a4e13bc101544d1526f5d
    61 sg:journal.1103138
    62 schema:name Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
    63 schema:pagination 369
    64 schema:productId N2c42575ad7b44530b44eb1a363a3feb9
    65 N472518a71aaf42f896fb0f9f6273e602
    66 N653d7181f6a54f1196ddb5f3a4431cb2
    67 N9468b1c5e956483abd5374491dae1a5b
    68 Na8226f3a58b842378dabe83166652304
    69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006110604
    70 https://doi.org/10.1038/ng.2213
    71 schema:sdDatePublished 2019-04-11T00:05
    72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    73 schema:sdPublisher N48f049d67d5049a3817bab58ab435562
    74 schema:url https://www.nature.com/articles/ng.2213
    75 sgo:license sg:explorer/license/
    76 sgo:sdDataset articles
    77 rdf:type schema:ScholarlyArticle
    78 N068abedeac14415f8b4f2db0d30fdb4f rdf:first sg:person.01074226355.01
    79 rdf:rest N5c701e67308c45a09530cd49bcf8b5d9
    80 N0f252c9fca984baf88b5541e4676785c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    81 schema:name Humans
    82 rdf:type schema:DefinedTerm
    83 N10c35017dc7d46d289ea5ba9fca52595 schema:name Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
    84 rdf:type schema:Organization
    85 N1116c3fc266440109cc56c3b444f8039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Diabetes Mellitus, Type 2
    87 rdf:type schema:DefinedTerm
    88 N12b70672050f42f1b303399b4e9028b2 rdf:first sg:person.0730724336.65
    89 rdf:rest N3338c4966368427a914d0841293eb918
    90 N1feaeb9224b741e6b12b758bddab0d9d rdf:first sg:person.01117721120.30
    91 rdf:rest N5b5b278fe8fc4718afb941d72bd8da6e
    92 N2094280dd662444992cf7f6832deab28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Genetic Loci
    94 rdf:type schema:DefinedTerm
    95 N29f4b5bfe6ec4247a9b764003a5a6f7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Genotype
    97 rdf:type schema:DefinedTerm
    98 N2b79fdf24b8741feab93e23f0076a1b9 rdf:first sg:person.016704245502.43
    99 rdf:rest N88cb0ec61ed648d6a8024d92bce0cf8e
    100 N2c42575ad7b44530b44eb1a363a3feb9 schema:name nlm_unique_id
    101 schema:value 9216904
    102 rdf:type schema:PropertyValue
    103 N2c5ba7c116f7488496e4f5a7d7d41203 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Case-Control Studies
    105 rdf:type schema:DefinedTerm
    106 N3338c4966368427a914d0841293eb918 rdf:first sg:person.01072615434.97
    107 rdf:rest Neb233c7e45d8428483e62591a489248c
    108 N44bf45ba0a0b4d5f8744706847ca2c46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Meta-Analysis as Topic
    110 rdf:type schema:DefinedTerm
    111 N472518a71aaf42f896fb0f9f6273e602 schema:name pubmed_id
    112 schema:value 22426310
    113 rdf:type schema:PropertyValue
    114 N48a2ff0a27d549b4889f0b0914af39c9 rdf:first sg:person.012766272254.47
    115 rdf:rest N2b79fdf24b8741feab93e23f0076a1b9
    116 N48f049d67d5049a3817bab58ab435562 schema:name Springer Nature - SN SciGraph project
    117 rdf:type schema:Organization
    118 N4c8d629d9fe847ecab3673f3188b16a8 rdf:first sg:person.010700366647.17
    119 rdf:rest N1feaeb9224b741e6b12b758bddab0d9d
    120 N50e55c0eb09a4d4f93bbcfbd8571380c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Genome, Human
    122 rdf:type schema:DefinedTerm
    123 N5abae527c95d47f9b5538f8295644d7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Phenotype
    125 rdf:type schema:DefinedTerm
    126 N5b5b278fe8fc4718afb941d72bd8da6e rdf:first sg:person.01310534155.68
    127 rdf:rest Nf93c55dbe7074f809565389c8a920f73
    128 N5c701e67308c45a09530cd49bcf8b5d9 rdf:first sg:person.015453206135.55
    129 rdf:rest N5dcf09a1c2e34468b7827e91e688ae30
    130 N5dcf09a1c2e34468b7827e91e688ae30 rdf:first sg:person.012006162345.57
    131 rdf:rest N73dee5c14fee492588e3c161f3e3033a
    132 N653d7181f6a54f1196ddb5f3a4431cb2 schema:name readcube_id
    133 schema:value 1d1bd1f8c03d60f088b03c227b2398d2215e8fbbae3951ce956b658a5f16ddad
    134 rdf:type schema:PropertyValue
    135 N65cad3e51f4a4b93972968c08be2e7a3 rdf:first sg:person.015043215017.69
    136 rdf:rest N4c8d629d9fe847ecab3673f3188b16a8
    137 N68d35ccff2aa48caaa49c9ea246ff030 rdf:first sg:person.01033044533.08
    138 rdf:rest rdf:nil
    139 N71456d183b1f491a8f92f3b2dc8d6eaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Linkage Disequilibrium
    141 rdf:type schema:DefinedTerm
    142 N73dee5c14fee492588e3c161f3e3033a rdf:first sg:person.014470155357.63
    143 rdf:rest N65cad3e51f4a4b93972968c08be2e7a3
    144 N8190952d5f8b42a0902d922c252bc8f8 rdf:first sg:person.0623730357.31
    145 rdf:rest N68d35ccff2aa48caaa49c9ea246ff030
    146 N88b5bb913da44a879e15328e3835460b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Polymorphism, Single Nucleotide
    148 rdf:type schema:DefinedTerm
    149 N88cb0ec61ed648d6a8024d92bce0cf8e rdf:first sg:person.0675500473.09
    150 rdf:rest N8190952d5f8b42a0902d922c252bc8f8
    151 N8a626ee1bda74bdb8a32f118176f7a16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Genetic Variation
    153 rdf:type schema:DefinedTerm
    154 N91bca2aa8e6a43c0bc5d7b9b858ffa20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Algorithms
    156 rdf:type schema:DefinedTerm
    157 N9468b1c5e956483abd5374491dae1a5b schema:name dimensions_id
    158 schema:value pub.1006110604
    159 rdf:type schema:PropertyValue
    160 N9ce8efd329e24946865dad954c86e012 schema:issueNumber 4
    161 rdf:type schema:PublicationIssue
    162 Na8226f3a58b842378dabe83166652304 schema:name doi
    163 schema:value 10.1038/ng.2213
    164 rdf:type schema:PropertyValue
    165 Nb6f83899904e4a0fbe105dd020166dec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Data Interpretation, Statistical
    167 rdf:type schema:DefinedTerm
    168 Nb97b4433fde447d6a326aa51b7c077fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Cyclin-Dependent Kinase Inhibitor p15
    170 rdf:type schema:DefinedTerm
    171 Ndc7d48a320594f4bb39348a9599c2435 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Body Height
    173 rdf:type schema:DefinedTerm
    174 Ne9fb1be182af44dea4bf969f57539a41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Body Mass Index
    176 rdf:type schema:DefinedTerm
    177 Nea4bcb678b3d4e0693bd70e5d32d6098 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Genome-Wide Association Study
    179 rdf:type schema:DefinedTerm
    180 Neb233c7e45d8428483e62591a489248c rdf:first sg:person.012061250547.34
    181 rdf:rest N068abedeac14415f8b4f2db0d30fdb4f
    182 Nec53f15c7e5a4e13bc101544d1526f5d schema:volumeNumber 44
    183 rdf:type schema:PublicationVolume
    184 Nf93c55dbe7074f809565389c8a920f73 rdf:first sg:person.012266613364.42
    185 rdf:rest N48a2ff0a27d549b4889f0b0914af39c9
    186 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Biological Sciences
    188 rdf:type schema:DefinedTerm
    189 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    190 schema:name Genetics
    191 rdf:type schema:DefinedTerm
    192 sg:grant.2345491 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    193 rdf:type schema:MonetaryGrant
    194 sg:grant.2345497 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    195 rdf:type schema:MonetaryGrant
    196 sg:grant.2345504 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    197 rdf:type schema:MonetaryGrant
    198 sg:grant.2345510 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    199 rdf:type schema:MonetaryGrant
    200 sg:grant.2345516 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    201 rdf:type schema:MonetaryGrant
    202 sg:grant.2345522 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    203 rdf:type schema:MonetaryGrant
    204 sg:grant.2345526 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.2345564 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    207 rdf:type schema:MonetaryGrant
    208 sg:grant.2408001 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.2442672 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.2443777 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    213 rdf:type schema:MonetaryGrant
    214 sg:grant.2443778 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    215 rdf:type schema:MonetaryGrant
    216 sg:grant.2443780 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    217 rdf:type schema:MonetaryGrant
    218 sg:grant.2443909 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    219 rdf:type schema:MonetaryGrant
    220 sg:grant.2484886 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    221 rdf:type schema:MonetaryGrant
    222 sg:grant.2536122 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    223 rdf:type schema:MonetaryGrant
    224 sg:grant.2541272 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    225 rdf:type schema:MonetaryGrant
    226 sg:grant.2541398 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    227 rdf:type schema:MonetaryGrant
    228 sg:grant.2666997 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    229 rdf:type schema:MonetaryGrant
    230 sg:grant.2691245 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    231 rdf:type schema:MonetaryGrant
    232 sg:grant.2705143 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    233 rdf:type schema:MonetaryGrant
    234 sg:grant.2775540 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.3570887 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.3578761 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.3636942 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.6712976 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.6713568 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.6713576 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    247 rdf:type schema:MonetaryGrant
    248 sg:grant.6714548 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    249 rdf:type schema:MonetaryGrant
    250 sg:grant.6715021 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    251 rdf:type schema:MonetaryGrant
    252 sg:grant.6715143 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    253 rdf:type schema:MonetaryGrant
    254 sg:grant.6716411 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    255 rdf:type schema:MonetaryGrant
    256 sg:grant.6718843 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    257 rdf:type schema:MonetaryGrant
    258 sg:grant.6720675 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    259 rdf:type schema:MonetaryGrant
    260 sg:grant.6722666 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    261 rdf:type schema:MonetaryGrant
    262 sg:grant.6726634 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    263 rdf:type schema:MonetaryGrant
    264 sg:grant.6728038 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    265 rdf:type schema:MonetaryGrant
    266 sg:grant.6733431 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.2213
    267 rdf:type schema:MonetaryGrant
    268 sg:journal.1103138 schema:issn 1061-4036
    269 1546-1718
    270 schema:name Nature Genetics
    271 rdf:type schema:Periodical
    272 sg:person.01033044533.08 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
    273 schema:familyName Visscher
    274 schema:givenName Peter M
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033044533.08
    276 rdf:type schema:Person
    277 sg:person.010700366647.17 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
    278 schema:familyName Martin
    279 schema:givenName Nicholas G
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010700366647.17
    281 rdf:type schema:Person
    282 sg:person.01072615434.97 schema:affiliation https://www.grid.ac/institutes/grid.270683.8
    283 schema:familyName Ferreira
    284 schema:givenName Teresa
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072615434.97
    286 rdf:type schema:Person
    287 sg:person.01074226355.01 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
    288 schema:familyName Medland
    289 schema:givenName Sarah E
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074226355.01
    291 rdf:type schema:Person
    292 sg:person.01117721120.30 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
    293 schema:familyName Montgomery
    294 schema:givenName Grant W
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117721120.30
    296 rdf:type schema:Person
    297 sg:person.012006162345.57 schema:familyName Consortium
    298 schema:givenName DIAbetes Genetics Replication And Meta-analysis
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012006162345.57
    300 rdf:type schema:Person
    301 sg:person.012061250547.34 schema:affiliation https://www.grid.ac/institutes/grid.270683.8
    302 schema:familyName Morris
    303 schema:givenName Andrew P
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012061250547.34
    305 rdf:type schema:Person
    306 sg:person.012266613364.42 schema:affiliation N10c35017dc7d46d289ea5ba9fca52595
    307 schema:familyName Loos
    308 schema:givenName Ruth J
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012266613364.42
    310 rdf:type schema:Person
    311 sg:person.012766272254.47 schema:affiliation https://www.grid.ac/institutes/grid.8391.3
    312 schema:familyName Frayling
    313 schema:givenName Timothy M
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012766272254.47
    315 rdf:type schema:Person
    316 sg:person.01310534155.68 schema:affiliation https://www.grid.ac/institutes/grid.8391.3
    317 schema:familyName Weedon
    318 schema:givenName Michael N
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310534155.68
    320 rdf:type schema:Person
    321 sg:person.014470155357.63 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    322 schema:familyName Madden
    323 schema:givenName Pamela A F
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014470155357.63
    325 rdf:type schema:Person
    326 sg:person.015043215017.69 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    327 schema:familyName Heath
    328 schema:givenName Andrew C
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015043215017.69
    330 rdf:type schema:Person
    331 sg:person.015453206135.55 schema:familyName Consortium
    332 schema:givenName Genetic Investigation of ANthropometric Traits
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015453206135.55
    334 rdf:type schema:Person
    335 sg:person.016704245502.43 schema:affiliation https://www.grid.ac/institutes/grid.470392.b
    336 schema:familyName McCarthy
    337 schema:givenName Mark I
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016704245502.43
    339 rdf:type schema:Person
    340 sg:person.0623730357.31 schema:affiliation https://www.grid.ac/institutes/grid.452205.4
    341 schema:familyName Goddard
    342 schema:givenName Michael E
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623730357.31
    344 rdf:type schema:Person
    345 sg:person.0675500473.09 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    346 schema:familyName Hirschhorn
    347 schema:givenName Joel N
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675500473.09
    349 rdf:type schema:Person
    350 sg:person.0730724336.65 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
    351 schema:familyName Yang
    352 schema:givenName Jian
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730724336.65
    354 rdf:type schema:Person
    355 sg:pub.10.1038/ejhg.2008.248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052237094
    356 https://doi.org/10.1038/ejhg.2008.248
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/ejhg.2011.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051554988
    359 https://doi.org/10.1038/ejhg.2011.39
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/nature06258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051134045
    362 https://doi.org/10.1038/nature06258
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/nature09410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037714920
    365 https://doi.org/10.1038/nature09410
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/nature09534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010608717
    368 https://doi.org/10.1038/nature09534
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/ng.586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006256853
    371 https://doi.org/10.1038/ng.586
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/ng.608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015057090
    374 https://doi.org/10.1038/ng.608
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/ng.609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041224776
    377 https://doi.org/10.1038/ng.609
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/ng.686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013643799
    380 https://doi.org/10.1038/ng.686
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/ng.707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004754761
    383 https://doi.org/10.1038/ng.707
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/ng.823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007907762
    386 https://doi.org/10.1038/ng.823
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/ng.871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025506940
    389 https://doi.org/10.1038/ng.871
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/ng.940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053172161
    392 https://doi.org/10.1038/ng.940
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/ng.943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014682139
    395 https://doi.org/10.1038/ng.943
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/ng.998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007102431
    398 https://doi.org/10.1038/ng.998
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/nrg2322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046913669
    401 https://doi.org/10.1038/nrg2322
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/sj.ijo.0802041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027247192
    404 https://doi.org/10.1038/sj.ijo.0802041
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1186/1297-9686-42-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078304275
    407 https://doi.org/10.1186/1297-9686-42-41
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1002/gepi.20516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049458939
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1002/gepi.20533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039500245
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1016/0140-6736(91)90542-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1044403756
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/j.ajhg.2009.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012473188
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/j.ajhg.2010.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009497006
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1056/nejmra0905980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006094606
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1073/pnas.0903103106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020299353
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1093/hmg/ddh294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013030166
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1093/hmg/ddr328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004256904
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1101/gr.092189.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048316418
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1111/j.0006-341x.1999.00997.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021081768
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1371/journal.pgen.1002198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005097773
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1375/twin.6.5.409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012190721
    436 rdf:type schema:CreativeWork
    437 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
    438 schema:name Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
    439 The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
    440 University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
    441 rdf:type schema:Organization
    442 https://www.grid.ac/institutes/grid.1049.c schema:alternateName QIMR Berghofer Medical Research Institute
    443 schema:name Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
    444 University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
    445 rdf:type schema:Organization
    446 https://www.grid.ac/institutes/grid.270683.8 schema:alternateName Wellcome Centre for Human Genetics
    447 schema:name Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
    448 rdf:type schema:Organization
    449 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    450 schema:name Broad Institute, Cambridge, Massachusetts, USA.
    451 Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
    452 Division of Endocrinology, Children's Hospital, Boston, Massachusetts, USA.
    453 Division of Genetics, Children's Hospital, Boston, Massachusetts, USA.
    454 Program in Genomics, Children's Hospital, Boston, Massachusetts, USA.
    455 rdf:type schema:Organization
    456 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
    457 schema:name Department of Psychiatry, Washington University, Saint Louis, Missouri, USA.
    458 rdf:type schema:Organization
    459 https://www.grid.ac/institutes/grid.452205.4 schema:alternateName Department of Environment, Land, Water and Planning
    460 schema:name Biosciences Research Division, Department of Primary Industries, Bundoora, Victoria, Australia.
    461 Department of Food and Agricultural Systems, The University of Melbourne, Parkville, Victoria, Australia.
    462 rdf:type schema:Organization
    463 https://www.grid.ac/institutes/grid.470392.b schema:alternateName Oxford Centre for Diabetes, Endocrinology and Metabolism
    464 schema:name Oxford Centre for Diabetes, Endocrinology and Metabolism, Headington, Oxford, UK.
    465 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
    466 rdf:type schema:Organization
    467 https://www.grid.ac/institutes/grid.8391.3 schema:alternateName University of Exeter
    468 schema:name Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK.
    469 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...