A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-10

AUTHORS

Maria Chiara Di Bernardo, Dalemari Crowther-Swanepoel, Peter Broderick, Emily Webb, Gabrielle Sellick, Ruth Wild, Kate Sullivan, Jayaram Vijayakrishnan, Yufei Wang, Alan M Pittman, Nicola J Sunter, Andrew G Hall, Martin J S Dyer, Estella Matutes, Claire Dearden, Tryfonia Mainou-Fowler, Graham H Jackson, Geoffrey Summerfield, Robert J Harris, Andrew R Pettitt, Peter Hillmen, David J Allsup, James R Bailey, Guy Pratt, Chris Pepper, Chris Fegan, James M Allan, Daniel Catovsky, Richard S Houlston

ABSTRACT

We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL. More... »

PAGES

1204-1210

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.219

DOI

http://dx.doi.org/10.1038/ng.219

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014607564

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18758461


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