Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-09

AUTHORS

Steven A McCarroll, Alan Huett, Petric Kuballa, Shannon D Chilewski, Aimee Landry, Philippe Goyette, Michael C Zody, Jennifer L Hall, Steven R Brant, Judy H Cho, Richard H Duerr, Mark S Silverberg, Kent D Taylor, John D Rioux, David Altshuler, Mark J Daly, Ramnik J Xavier

ABSTRACT

Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated loci influences cellular and disease processes. Crohn's disease (CD) is associated with SNPs around IRGM, but coding-sequence variation has been excluded as a source of this association. We identified a common, 20-kb deletion polymorphism, immediately upstream of IRGM and in perfect linkage disequilibrium (r2 = 1.0) with the most strongly CD-associated SNP, that causes IRGM to segregate in the population with two distinct upstream sequences. The deletion (CD risk) and reference (CD protective) haplotypes of IRGM showed distinct expression patterns. Manipulation of IRGM expression levels modulated cellular autophagy of internalized bacteria, a process implicated in CD. These results suggest that the CD association at IRGM arises from an alteration in IRGM regulation that affects the efficacy of autophagy and identify a common deletion polymorphism as a likely causal variant. More... »

PAGES

1107-1112

References to SciGraph publications

  • 2007-06-07. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2007-07. The population genetics of structural variation in NATURE GENETICS
  • 2006-11. A worldwide survey of haplotype variation and linkage disequilibrium in the human genome in NATURE GENETICS
  • 2007-05. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis in NATURE GENETICS
  • 2006-01. Common deletion polymorphisms in the human genome in NATURE GENETICS
  • 2007-02. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 in NATURE GENETICS
  • 2005-11. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage in GENOME BIOLOGY
  • 2006-01. Common deletions and SNPs are in linkage disequilibrium in the human genome in NATURE GENETICS
  • 2006-01. A high-resolution survey of deletion polymorphism in the human genome in NATURE GENETICS
  • 2006-11. Global variation in copy number in the human genome in NATURE
  • 2007-10. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis in NATURE CELL BIOLOGY
  • 2002-11. Detection of regulatory variation in mouse genes in NATURE GENETICS
  • 2007-07. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility in NATURE GENETICS
  • 2006-05. A distal enhancer and an ultraconserved exon are derived from a novel retroposon in NATURE
  • 2007-07. Copy-number variation and association studies of human disease in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.215

    DOI

    http://dx.doi.org/10.1038/ng.215

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034479065

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19165925


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