Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-08-17

AUTHORS

Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Haruhiko Osawa, Hiroto Furuta, Yushi Hirota, Hiroyuki Mori, Anna Jonsson, Yoshifumi Sato, Kazuya Yamagata, Yoshinori Hinokio, He-Yao Wang, Toshihito Tanahashi, Naoto Nakamura, Yoshitomo Oka, Naoko Iwasaki, Yasuhiko Iwamoto, Yuichiro Yamada, Yutaka Seino, Hiroshi Maegawa, Atsunori Kashiwagi, Jun Takeda, Eiichi Maeda, Hyoung Doo Shin, Young Min Cho, Kyong Soo Park, Hong Kyu Lee, Maggie C Y Ng, Ronald C W Ma, Wing-Yee So, Juliana C N Chan, Valeriya Lyssenko, Tiinamaija Tuomi, Peter Nilsson, Leif Groop, Naoyuki Kamatani, Akihiro Sekine, Yusuke Nakamura, Ken Yamamoto, Teruhiko Yoshida, Katsushi Tokunaga, Mitsuo Itakura, Hideichi Makino, Kishio Nanjo, Takashi Kadowaki, Masato Kasuga

ABSTRACT

Masato Kasuga and colleagues and Shiro Maeda and colleagues each report the independent identification of SNPs in KCNQ1 associated with type 2 diabetes in the Japanese population. Each group replicated the associations in other populations of East Asian and European descent.

PAGES

1092-1097

References to SciGraph publications

  • 2004-11-24. Designing a multistage, SNP-based, genome screen for common diseases in JOURNAL OF HUMAN GENETICS
  • 2002-11. Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190 562 genetic variations in the human genome in JOURNAL OF HUMAN GENETICS
  • 2005-08-30. Effects of IKs channel inhibitors in insulin-secreting INS-1 cells in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1985-07. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man in DIABETOLOGIA
  • 2007-04-26. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes in NATURE GENETICS
  • 2004-10-14. Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese in JOURNAL OF HUMAN GENETICS
  • 2002-11-11. Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction in NATURE GENETICS
  • 2007-02-11. A genome-wide association study identifies novel risk loci for type 2 diabetes in NATURE
  • 2008-03-30. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes in NATURE GENETICS
  • 1996-11. KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current in NATURE
  • 2007-10-10. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population in DIABETOLOGIA
  • 2008-02-01. Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects in JOURNAL OF HUMAN GENETICS
  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2007-06-06. Replicating genotype–phenotype associations in NATURE
  • 2001-08. A high-throughput SNP typing system for genome-wide association studies in JOURNAL OF HUMAN GENETICS
  • 2006-01-15. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes in NATURE GENETICS
  • 1996-01. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias in NATURE GENETICS
  • Journal

    TITLE

    Nature Genetics

    ISSUE

    9

    VOLUME

    40

    Author Affiliations

  • Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, 162-8655, Tokyo, Japan
  • Division of Diabetes, Department of Internal Medicine, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, 650-0017, Kobe, Japan
  • Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, 501-1194, Gifu, Japan
  • Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 113-8655, Tokyo, Japan
  • Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan
  • First Department of Medicine, Wakayama Medical University, 641-8509, Wakayama, Japan
  • Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, S-205 02, Malmö, Sweden
  • Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 565-0871, Osaka, Japan
  • Present addresses: Department of Medical Biochemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8556, Japan (K. Yamagata), Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 200031, China (H.-Y.W.), Department of Internal Medicine, Akita University School of Medicine, Akita 010-8543, Japan (Y.Y.), Kansai Electric Power Hospital, Osaka 553-0003, Japan (Y. Seino) and Genome Informatics, Center for Genomic Medicine, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto 606-8501, Japan (A.S.).
  • Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 980-8574, Sendai, Japan
  • Division of Genetic Information, Institute for Genome Research, University of Tokushima, 770-8503, Tokushima, Japan
  • Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, 602-8566, Kyoto, Japan
  • Department of Medicine, Diabetes Center, Tokyo Women's Medical University, 162-8666, Tokyo, Japan
  • Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, 520-2192, Shiga, Japan
  • Clinical Genome Informatics Center, Kobe University Graduate School of Medicine, 650-0017, Kobe, Japan
  • Department of Genetic Epidemiology, SNP Genetics Inc., 110-834, Seoul, Korea
  • Department of Internal Medicine, Seoul National University College of Medicine, 110-744, Seoul, Korea
  • Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
  • Folkhaelsan Research Center, FIN-00014, Helsinki, Finland
  • Department of Clinical Sciences, Medicine Research Unit, University Hospital Malmö, Lund University, S-205 02, Malmö, Sweden
  • Department of Medicine, Helsinki University Hospital, FIN-00300, Helsinki, Finland
  • Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 162-8666, Tokyo, Japan
  • SNP Research Center, Institute of Physical and Chemical Research (RIKEN), 230-0045, Yokohama, Japan
  • Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan
  • Genetics Division, National Cancer Center Research Institute, 104-0045, Tokyo, Japan
  • Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 113-0033, Tokyo, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.207

    DOI

    http://dx.doi.org/10.1038/ng.207

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032185643

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18711367


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