Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-09

AUTHORS

Stacy L Musone, Kimberly E Taylor, Timothy T Lu, Joanne Nititham, Ricardo C Ferreira, Ward Ortmann, Nataliya Shifrin, Michelle A Petri, M Ilyas Kamboh, Susan Manzi, Michael F Seldin, Peter K Gregersen, Timothy W Behrens, Averil Ma, Pui-Yan Kwok, Lindsey A Criswell

ABSTRACT

The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between A20 and the etiology of SLE. More... »

PAGES

1062-1064

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.202

DOI

http://dx.doi.org/10.1038/ng.202

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007885108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19165919


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