Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-09

AUTHORS

Robert R Graham, Chris Cotsapas, Leela Davies, Rachel Hackett, Christopher J Lessard, Joanlise M Leon, Noel P Burtt, Candace Guiducci, Melissa Parkin, Casey Gates, Robert M Plenge, Timothy W Behrens, Joan E Wither, John D Rioux, Paul R Fortin, Deborah Cunninghame Graham, Andrew K Wong, Timothy J Vyse, Mark J Daly, David Altshuler, Kathy L Moser, Patrick M Gaffney

ABSTRACT

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA. More... »

PAGES

1059-1061

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.200

DOI

http://dx.doi.org/10.1038/ng.200

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043158572

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19165918


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.200'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.200'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.200'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.200'


 

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