Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-06-29

AUTHORS

Jeffrey C Barrett, Sarah Hansoul, Dan L Nicolae, Judy H Cho, Richard H Duerr, John D Rioux, Steven R Brant, Mark S Silverberg, Kent D Taylor, M Michael Barmada, Alain Bitton, Themistocles Dassopoulos, Lisa Wu Datta, Todd Green, Anne M Griffiths, Emily O Kistner, Michael T Murtha, Miguel D Regueiro, Jerome I Rotter, L Philip Schumm, A Hillary Steinhart, Stephan R Targan, Ramnik J Xavier, Cécile Libioulle, Cynthia Sandor, Mark Lathrop, Jacques Belaiche, Olivier Dewit, Ivo Gut, Simon Heath, Debby Laukens, Myriam Mni, Paul Rutgeerts, André Van Gossum, Diana Zelenika, Denis Franchimont, Jean-Pierre Hugot, Martine de Vos, Severine Vermeire, Edouard Louis, Lon R Cardon, Carl A Anderson, Hazel Drummond, Elaine Nimmo, Tariq Ahmad, Natalie J Prescott, Clive M Onnie, Sheila A Fisher, Jonathan Marchini, Jilur Ghori, Suzannah Bumpstead, Rhian Gwilliam, Mark Tremelling, Panos Deloukas, John Mansfield, Derek Jewell, Jack Satsangi, Christopher G Mathew, Miles Parkes, Michel Georges, Mark J Daly

ABSTRACT

Mark Daly and colleagues present results of a combined analysis of data from three recent genome-wide association studies for Crohn's disease, followed by replication in a large independent sample collection. Their results confirm 11 previously reported risk loci and provide genome-wide significant evidence for 21 new loci associated with the disease. More... »

PAGES

955-962

References to SciGraph publications

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    8

    VOLUME

    40

    Author Affiliations

  • Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, UK
  • Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Belgium
  • Department of Medicine, University of Chicago, 5801 South Ellis, 60637, Chicago, Illinois, USA
  • Departments of Medicine and Genetics, Division of Gastroenterology, Yale University, Inflammatory Bowel Disease (IBD) Center, 300 Cedar Street, 06519, New Haven, Connecticut, USA
  • Department of Human Genetics, University of Pittsburgh, Graduate School of Public Health, 130 Desoto Street, 15261, Pittsburgh, Pennsylvania, USA
  • The Broad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA
  • Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, 615 E. Wolfe Street, 21205, Baltimore, Maryland, USA
  • Mount Sinai Hospital IBD Centre, University of Toronto, 441-600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
  • Medical Genetics Institute and Inflammatory Bowel Disease (IBD) Center, Cedars-Sinai Medical Center, 8700 W. Beverly Blvd., 90048, Los Angeles, California, USA
  • Department of Medicine, Royal Victoria Hospital, McGill University, H3A 1A1, Montreal, Quebec, Canada
  • Department of Medicine, Johns Hopkins University, Harvey M. and Lyn P. Meyerhoff Inflammatory Bowel Disease Center, 1503 East Jefferson Street, 21231, Baltimore, Maryland, USA
  • The Hospital for Sick Children, University of Toronto, 555 University Avenue, M5G 1X8, Toronto, Ontario, Canada
  • Department of Health Studies, University of Chicago, 5841 S. Maryland Avenue, 60637, Chicago, Illinois, USA
  • Department of Medicine, Division of Gastroenterology, University of Pittsburgh, School of Medicine, Hepatology and Nutrition, University of Pittsburgh Medical Center (UPMC) Presbyterian, 200 Lothrop Street, 15213, Pittsburgh, Pennsylvania, USA
  • Gastrointestinal Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, 02114, Boston, Massachusetts, USA
  • Centre National de Génotypage, Evry, France
  • Department of Clinical Sciences, Unit of Hepatology and Gastroenterology, GIGA-R, Faculty of Medicine and CHU de Liège, University of Liège, Belgium
  • Department of Gastroenterology, Clinique universitaire St Luc, UCL, Brussels, Belgium
  • Department of Hepatology and Gastroenterology, Ghent University Hospital, Belgium
  • Department of Gastroenterology, University Hospital Leuven, Belgium
  • Department of Gastroenterology, Erasmus Hospital, Free University of Brussels, Belgium
  • Université Paris Diderot, Paris, France
  • Division of Medical Sciences, Gastrointestinal Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, EH4 2XU, Edinburgh, UK
  • Peninsula Medical School, Barrack Road, EX2 5DW, Exeter, UK
  • Department of Medical and Molecular Genetics, King's College London School of Medicine, 8th Floor Guy's Tower, Guy's Hospital, SE1 9RT, London, UK
  • Department of Statistics, University of Oxford, 1 South Parks Road, OX1 3TG, Oxford, UK
  • The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, Cambridge, UK
  • IBD research group, Addenbrooke's Hospital, University of Cambridge, CB2 2QQ, Cambridge, UK
  • Department of Gastroenterology and Hepatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
  • Gastroenterology Unit, Radcliffe Infirmary, University of Oxford, OX2 6HE, Oxford, UK
  • Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, 02114, Boston, Massachusetts, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.175

    DOI

    http://dx.doi.org/10.1038/ng.175

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035894615

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18587394


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