Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06

AUTHORS

Yutaka Kondo, Lanlan Shen, Alfred S Cheng, Saira Ahmed, Yanis Boumber, Chantale Charo, Tadanori Yamochi, Takeshi Urano, Koichi Furukawa, Bernard Kwabi-Addo, David L Gold, Yoshitaka Sekido, Tim Hui-Ming Huang, Jean-Pierre J Issa

ABSTRACT

Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation. More... »

PAGES

741-750

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.159

DOI

http://dx.doi.org/10.1038/ng.159

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027745023

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18488029


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alkaline Phosphatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin Immunoprecipitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colony-Forming Units Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CpG Islands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enhancer of Zeste Homolog 2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Silencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lysine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microarray Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microfilament Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polycomb Repressive Complex 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Leukemia, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondo", 
        "givenName": "Yutaka", 
        "id": "sg:person.015444034352.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015444034352.32"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Shen", 
        "givenName": "Lanlan", 
        "id": "sg:person.013251051567.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013251051567.61"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Cheng", 
        "givenName": "Alfred S", 
        "id": "sg:person.011416266722.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011416266722.31"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ahmed", 
        "givenName": "Saira", 
        "id": "sg:person.01042064113.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042064113.36"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Boumber", 
        "givenName": "Yanis", 
        "id": "sg:person.0623110021.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623110021.64"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Charo", 
        "givenName": "Chantale", 
        "id": "sg:person.01213357777.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213357777.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yamochi", 
        "givenName": "Tadanori", 
        "id": "sg:person.01007353145.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007353145.05"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Urano", 
        "givenName": "Takeshi", 
        "id": "sg:person.011426554371.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011426554371.65"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Furukawa", 
        "givenName": "Koichi", 
        "id": "sg:person.010152206017.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010152206017.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kwabi-Addo", 
        "givenName": "Bernard", 
        "id": "sg:person.0762707361.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762707361.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gold", 
        "givenName": "David L", 
        "type": "Person"
      }, 
      {
        "familyName": "Sekido", 
        "givenName": "Yoshitaka", 
        "id": "sg:person.01016373007.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016373007.42"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Huang", 
        "givenName": "Tim Hui-Ming", 
        "id": "sg:person.013267755462.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013267755462.50"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Issa", 
        "givenName": "Jean-Pierre J", 
        "id": "sg:person.01311723006.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311723006.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng1950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005618296", 
          "https://doi.org/10.1038/ng1950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005618296", 
          "https://doi.org/10.1038/ng1950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1933744100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006013665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006220349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008729213", 
          "https://doi.org/10.1038/nature02385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008729213", 
          "https://doi.org/10.1038/nature02385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(02)00335-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010730649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013027025", 
          "https://doi.org/10.1038/nature04431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013027025", 
          "https://doi.org/10.1038/nature04431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013027025", 
          "https://doi.org/10.1038/nature04431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.15.2990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013818512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80604-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014526993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.15.8681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014931389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0306641101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015014744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.14.12.8191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015166868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.6417007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015967722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1063127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018041139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.17.6070-6078.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019770892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-2688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019863370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.11.2702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022351955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025096861", 
          "https://doi.org/10.1038/nature01075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025096861", 
          "https://doi.org/10.1038/nature01075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m304072200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027130309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029576413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029813380", 
          "https://doi.org/10.1038/ng1941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029813380", 
          "https://doi.org/10.1038/ng1941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.943102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030092845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.02.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030427346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(04)00128-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032708543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:jomg.0000037157.94207.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033158625", 
          "https://doi.org/10.1023/b:jomg.0000037157.94207.33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1200204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033924535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033930047", 
          "https://doi.org/10.1038/nrc1507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033930047", 
          "https://doi.org/10.1038/nrc1507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.06.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035389950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra023075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035903614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2004.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038965664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1084274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042001662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1084274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042001662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046563787", 
          "https://doi.org/10.1038/ng1972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046563787", 
          "https://doi.org/10.1038/ng1972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0394-236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050834353", 
          "https://doi.org/10.1038/ng0394-236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051534342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-329-1:155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053206306", 
          "https://doi.org/10.1385/1-59259-329-1:155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074464995", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/03351md01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075317008"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-06", 
    "datePublishedReg": "2008-06-01", 
    "description": "Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.159", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2476354", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2631631", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440137", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440197", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation", 
    "pagination": "741-750", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "842b97f14e31a04afadbf07ecc773dea4dfe2d5d29b1d9767bed1cff37c1decf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18488029"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.159"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027745023"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.159", 
      "https://app.dimensions.ai/details/publication/pub.1027745023"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ng/journal/v40/n6/full/ng.159.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.159'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.159'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.159'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.159'


 

This table displays all metadata directly associated to this object as RDF triples.

386 TRIPLES      21 PREDICATES      94 URIs      49 LITERALS      37 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.159 schema:about N115bca7aa05148ca9fac7c549e964a4d
2 N12445314bef141aea3401e13f81d4601
3 N14cd048a145a4238a31a617d953228bc
4 N19d34841e86c4edcb898630404ecd7bb
5 N238f7476c1a5479fa7504d1939b2c04a
6 N2525cbb1e99c4f348407b721d2591df3
7 N287b23fd55804303899f583df774f950
8 N314f200077f44842929ac6f2b079062f
9 N46003210b10548fa90d8a4e6c6e4debd
10 N46e924525c9c432d81dd1f0a5f1508f0
11 N5b931b5f09ff419a91123267329c3ff1
12 N5cbbd126258c417bbf4f1bd06b167131
13 N5f612cfb94ed41708f248a2b0305f91c
14 N6273294023e34b2d801ea192a77b9db2
15 N82894e6979cf4716865d47d22e6892d1
16 N884cbad621d340ebb0e39bf316bfa677
17 N89408568fe654da8bdbc06128062b6c4
18 N91b57f587c7f4dd19c15647718680c19
19 N98c9cac5c4134ff1b3352c0b099dc000
20 Na005d49752bf42ad82c63530849f7e4d
21 Nd0d679521e34496f97953fc0a330797a
22 Ne04c931ad7574aeeb75f0da707e3332a
23 Ne58f325c6c6846929459188cd2022d98
24 Neadf453567814a1d9431c0fd2c0e1f85
25 Neb6af587fd8549ac9c684cb129679e65
26 Nf6f3325fd59a40f791deb70372b4f76f
27 Nf6feb199e68140feaeda161a3257c85b
28 Nf7e8d846570c4d54ad4d5f9cac5f814f
29 anzsrc-for:06
30 anzsrc-for:0604
31 schema:author N4f80992574b841d6b3f8c53f21ba56ca
32 schema:citation sg:pub.10.1023/b:jomg.0000037157.94207.33
33 sg:pub.10.1038/nature01075
34 sg:pub.10.1038/nature02385
35 sg:pub.10.1038/nature04431
36 sg:pub.10.1038/ng0394-236
37 sg:pub.10.1038/ng1941
38 sg:pub.10.1038/ng1950
39 sg:pub.10.1038/ng1972
40 sg:pub.10.1038/nrc1507
41 sg:pub.10.1385/1-59259-329-1:155
42 https://app.dimensions.ai/details/publication/pub.1074464995
43 https://doi.org/10.1016/j.cell.2005.06.026
44 https://doi.org/10.1016/j.cell.2005.08.020
45 https://doi.org/10.1016/j.cell.2006.02.041
46 https://doi.org/10.1016/j.gde.2004.02.001
47 https://doi.org/10.1016/s0092-8674(00)80604-2
48 https://doi.org/10.1016/s0955-0674(02)00335-6
49 https://doi.org/10.1016/s1097-2765(04)00128-5
50 https://doi.org/10.1038/sj.emboj.7600545
51 https://doi.org/10.1056/nejmra023075
52 https://doi.org/10.1073/pnas.0306641101
53 https://doi.org/10.1073/pnas.1933744100
54 https://doi.org/10.1073/pnas.96.15.8681
55 https://doi.org/10.1074/jbc.m304072200
56 https://doi.org/10.1093/emboj/20.11.2702
57 https://doi.org/10.1093/emboj/cdg542
58 https://doi.org/10.1093/nar/22.15.2990
59 https://doi.org/10.1101/gad.1200204
60 https://doi.org/10.1101/gad.943102
61 https://doi.org/10.1101/gr.6417007
62 https://doi.org/10.1126/science.1063127
63 https://doi.org/10.1126/science.1084274
64 https://doi.org/10.1128/mcb.14.12.8191
65 https://doi.org/10.1128/mcb.22.17.6070-6078.2002
66 https://doi.org/10.1158/0008-5472.can-04-2688
67 https://doi.org/10.1371/journal.pgen.0030181
68 https://doi.org/10.2144/03351md01
69 schema:datePublished 2008-06
70 schema:datePublishedReg 2008-06-01
71 schema:description Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree false
75 schema:isPartOf N5f5580a908d944b9bf1b0b536a30f3b1
76 N9d14e07f721e4cfaac3d60ae563f2a81
77 sg:journal.1103138
78 schema:name Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
79 schema:pagination 741-750
80 schema:productId N16c0d0c0b6fc4820a8217b2c5788e10a
81 N5778fb00d0a94ba1abd00d0fd44b7aed
82 N92e4866f0ad44543b00adc13b4ddd62d
83 Na073b8e49837453cb74de473d9655dcb
84 Na4d89605dc76499c874b8326494f9d52
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027745023
86 https://doi.org/10.1038/ng.159
87 schema:sdDatePublished 2019-04-10T18:56
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher Nc911d11a8416475984875402fdf2af09
90 schema:url http://www.nature.com/ng/journal/v40/n6/full/ng.159.html
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N09e6cff1fcc045f4b06a16265eec2e23 rdf:first sg:person.01311723006.34
95 rdf:rest rdf:nil
96 N115bca7aa05148ca9fac7c549e964a4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Lysine
98 rdf:type schema:DefinedTerm
99 N12445314bef141aea3401e13f81d4601 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Colony-Forming Units Assay
101 rdf:type schema:DefinedTerm
102 N12486367e3f5491192d05c10d46d2050 schema:familyName Gold
103 schema:givenName David L
104 rdf:type schema:Person
105 N14cd048a145a4238a31a617d953228bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Biomarkers, Tumor
107 rdf:type schema:DefinedTerm
108 N16c0d0c0b6fc4820a8217b2c5788e10a schema:name doi
109 schema:value 10.1038/ng.159
110 rdf:type schema:PropertyValue
111 N19d34841e86c4edcb898630404ecd7bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name RNA, Messenger
113 rdf:type schema:DefinedTerm
114 N238f7476c1a5479fa7504d1939b2c04a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Gene Silencing
116 rdf:type schema:DefinedTerm
117 N2525cbb1e99c4f348407b721d2591df3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Cells, Cultured
119 rdf:type schema:DefinedTerm
120 N287b23fd55804303899f583df774f950 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Histones
122 rdf:type schema:DefinedTerm
123 N31181d645e764b7f8c904539c1561811 rdf:first sg:person.013267755462.50
124 rdf:rest N09e6cff1fcc045f4b06a16265eec2e23
125 N314f200077f44842929ac6f2b079062f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Prostatic Neoplasms
127 rdf:type schema:DefinedTerm
128 N34a45c9615f8408797df0a789f8789d0 rdf:first sg:person.0623110021.64
129 rdf:rest Nd38e96f939b64150948c5aa0b6296bb7
130 N46003210b10548fa90d8a4e6c6e4debd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name DNA Methylation
132 rdf:type schema:DefinedTerm
133 N46e924525c9c432d81dd1f0a5f1508f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Phosphatidylinositol 3-Kinases
135 rdf:type schema:DefinedTerm
136 N4f80992574b841d6b3f8c53f21ba56ca rdf:first sg:person.015444034352.32
137 rdf:rest N5f59b46cc80b4fe184e1f2b1ef38b736
138 N5778fb00d0a94ba1abd00d0fd44b7aed schema:name nlm_unique_id
139 schema:value 9216904
140 rdf:type schema:PropertyValue
141 N5b931b5f09ff419a91123267329c3ff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Breast Neoplasms
143 rdf:type schema:DefinedTerm
144 N5cbbd126258c417bbf4f1bd06b167131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name DNA-Binding Proteins
146 rdf:type schema:DefinedTerm
147 N5f5580a908d944b9bf1b0b536a30f3b1 schema:issueNumber 6
148 rdf:type schema:PublicationIssue
149 N5f59b46cc80b4fe184e1f2b1ef38b736 rdf:first sg:person.013251051567.61
150 rdf:rest N79609b15ca0246788918e82a8dc90019
151 N5f612cfb94ed41708f248a2b0305f91c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Microarray Analysis
153 rdf:type schema:DefinedTerm
154 N6273294023e34b2d801ea192a77b9db2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Reverse Transcriptase Polymerase Chain Reaction
156 rdf:type schema:DefinedTerm
157 N6447efad310d435daf767e2c8be17c89 rdf:first sg:person.01042064113.36
158 rdf:rest N34a45c9615f8408797df0a789f8789d0
159 N64e0bce3bb104b3cb6fd519487be5e88 rdf:first sg:person.01016373007.42
160 rdf:rest N31181d645e764b7f8c904539c1561811
161 N79609b15ca0246788918e82a8dc90019 rdf:first sg:person.011416266722.31
162 rdf:rest N6447efad310d435daf767e2c8be17c89
163 N82894e6979cf4716865d47d22e6892d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Transcription Factors
165 rdf:type schema:DefinedTerm
166 N884cbad621d340ebb0e39bf316bfa677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Acetylation
168 rdf:type schema:DefinedTerm
169 N89408568fe654da8bdbc06128062b6c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Microfilament Proteins
171 rdf:type schema:DefinedTerm
172 N91b57f587c7f4dd19c15647718680c19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Humans
174 rdf:type schema:DefinedTerm
175 N92e4866f0ad44543b00adc13b4ddd62d schema:name pubmed_id
176 schema:value 18488029
177 rdf:type schema:PropertyValue
178 N98c9cac5c4134ff1b3352c0b099dc000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Female
180 rdf:type schema:DefinedTerm
181 N9b75184bb594413c80b59db4a1e047ec rdf:first N12486367e3f5491192d05c10d46d2050
182 rdf:rest N64e0bce3bb104b3cb6fd519487be5e88
183 N9d14e07f721e4cfaac3d60ae563f2a81 schema:volumeNumber 40
184 rdf:type schema:PublicationVolume
185 Na005d49752bf42ad82c63530849f7e4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Lung Neoplasms
187 rdf:type schema:DefinedTerm
188 Na073b8e49837453cb74de473d9655dcb schema:name dimensions_id
189 schema:value pub.1027745023
190 rdf:type schema:PropertyValue
191 Na4d89605dc76499c874b8326494f9d52 schema:name readcube_id
192 schema:value 842b97f14e31a04afadbf07ecc773dea4dfe2d5d29b1d9767bed1cff37c1decf
193 rdf:type schema:PropertyValue
194 Nabc52575b67e458f8a25d78b9ca75716 rdf:first sg:person.01007353145.05
195 rdf:rest Nf15b65f336d84879a8c7c68d296a7ce2
196 Nb2ed780fd5724371a6193d2e783838bd rdf:first sg:person.0762707361.25
197 rdf:rest N9b75184bb594413c80b59db4a1e047ec
198 Nc911d11a8416475984875402fdf2af09 schema:name Springer Nature - SN SciGraph project
199 rdf:type schema:Organization
200 Nd0d679521e34496f97953fc0a330797a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Enhancer of Zeste Homolog 2 Protein
202 rdf:type schema:DefinedTerm
203 Nd38e96f939b64150948c5aa0b6296bb7 rdf:first sg:person.01213357777.26
204 rdf:rest Nabc52575b67e458f8a25d78b9ca75716
205 Ne04c931ad7574aeeb75f0da707e3332a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Polycomb Repressive Complex 2
207 rdf:type schema:DefinedTerm
208 Ne58f325c6c6846929459188cd2022d98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Chromatin Immunoprecipitation
210 rdf:type schema:DefinedTerm
211 Neadf453567814a1d9431c0fd2c0e1f85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Alkaline Phosphatase
213 rdf:type schema:DefinedTerm
214 Neb6af587fd8549ac9c684cb129679e65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name CpG Islands
216 rdf:type schema:DefinedTerm
217 Nef3e607f9b8f4f43974ac15c0e273d38 rdf:first sg:person.010152206017.09
218 rdf:rest Nb2ed780fd5724371a6193d2e783838bd
219 Nf15b65f336d84879a8c7c68d296a7ce2 rdf:first sg:person.011426554371.65
220 rdf:rest Nef3e607f9b8f4f43974ac15c0e273d38
221 Nf6f3325fd59a40f791deb70372b4f76f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Male
223 rdf:type schema:DefinedTerm
224 Nf6feb199e68140feaeda161a3257c85b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Promoter Regions, Genetic
226 rdf:type schema:DefinedTerm
227 Nf7e8d846570c4d54ad4d5f9cac5f814f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Prostate
229 rdf:type schema:DefinedTerm
230 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
231 schema:name Biological Sciences
232 rdf:type schema:DefinedTerm
233 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
234 schema:name Genetics
235 rdf:type schema:DefinedTerm
236 sg:grant.2440137 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.159
237 rdf:type schema:MonetaryGrant
238 sg:grant.2440197 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.159
239 rdf:type schema:MonetaryGrant
240 sg:grant.2476354 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.159
241 rdf:type schema:MonetaryGrant
242 sg:grant.2631631 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.159
243 rdf:type schema:MonetaryGrant
244 sg:journal.1103138 schema:issn 1061-4036
245 1546-1718
246 schema:name Nature Genetics
247 rdf:type schema:Periodical
248 sg:person.01007353145.05 schema:familyName Yamochi
249 schema:givenName Tadanori
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007353145.05
251 rdf:type schema:Person
252 sg:person.010152206017.09 schema:familyName Furukawa
253 schema:givenName Koichi
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010152206017.09
255 rdf:type schema:Person
256 sg:person.01016373007.42 schema:familyName Sekido
257 schema:givenName Yoshitaka
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016373007.42
259 rdf:type schema:Person
260 sg:person.01042064113.36 schema:familyName Ahmed
261 schema:givenName Saira
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042064113.36
263 rdf:type schema:Person
264 sg:person.011416266722.31 schema:familyName Cheng
265 schema:givenName Alfred S
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011416266722.31
267 rdf:type schema:Person
268 sg:person.011426554371.65 schema:familyName Urano
269 schema:givenName Takeshi
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011426554371.65
271 rdf:type schema:Person
272 sg:person.01213357777.26 schema:familyName Charo
273 schema:givenName Chantale
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213357777.26
275 rdf:type schema:Person
276 sg:person.01311723006.34 schema:familyName Issa
277 schema:givenName Jean-Pierre J
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311723006.34
279 rdf:type schema:Person
280 sg:person.013251051567.61 schema:familyName Shen
281 schema:givenName Lanlan
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013251051567.61
283 rdf:type schema:Person
284 sg:person.013267755462.50 schema:familyName Huang
285 schema:givenName Tim Hui-Ming
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013267755462.50
287 rdf:type schema:Person
288 sg:person.015444034352.32 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
289 schema:familyName Kondo
290 schema:givenName Yutaka
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015444034352.32
292 rdf:type schema:Person
293 sg:person.0623110021.64 schema:familyName Boumber
294 schema:givenName Yanis
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623110021.64
296 rdf:type schema:Person
297 sg:person.0762707361.25 schema:familyName Kwabi-Addo
298 schema:givenName Bernard
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762707361.25
300 rdf:type schema:Person
301 sg:pub.10.1023/b:jomg.0000037157.94207.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033158625
302 https://doi.org/10.1023/b:jomg.0000037157.94207.33
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nature01075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025096861
305 https://doi.org/10.1038/nature01075
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/nature02385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008729213
308 https://doi.org/10.1038/nature02385
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nature04431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013027025
311 https://doi.org/10.1038/nature04431
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/ng0394-236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050834353
314 https://doi.org/10.1038/ng0394-236
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/ng1941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029813380
317 https://doi.org/10.1038/ng1941
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/ng1950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005618296
320 https://doi.org/10.1038/ng1950
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/ng1972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046563787
323 https://doi.org/10.1038/ng1972
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/nrc1507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033930047
326 https://doi.org/10.1038/nrc1507
327 rdf:type schema:CreativeWork
328 sg:pub.10.1385/1-59259-329-1:155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053206306
329 https://doi.org/10.1385/1-59259-329-1:155
330 rdf:type schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1074464995 schema:CreativeWork
332 https://doi.org/10.1016/j.cell.2005.06.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035389950
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.cell.2005.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049638413
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/j.cell.2006.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427346
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/j.gde.2004.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038965664
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/s0092-8674(00)80604-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014526993
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/s0955-0674(02)00335-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010730649
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/s1097-2765(04)00128-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032708543
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1038/sj.emboj.7600545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051534342
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1056/nejmra023075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035903614
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1073/pnas.0306641101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015014744
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1073/pnas.1933744100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006013665
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1073/pnas.96.15.8681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014931389
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1074/jbc.m304072200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027130309
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1093/emboj/20.11.2702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022351955
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1093/emboj/cdg542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029576413
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1093/nar/22.15.2990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013818512
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1101/gad.1200204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033924535
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1101/gad.943102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030092845
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1101/gr.6417007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015967722
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1126/science.1063127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018041139
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1126/science.1084274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042001662
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1128/mcb.14.12.8191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015166868
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1128/mcb.22.17.6070-6078.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019770892
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1158/0008-5472.can-04-2688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019863370
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1371/journal.pgen.0030181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006220349
381 rdf:type schema:CreativeWork
382 https://doi.org/10.2144/03351md01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075317008
383 rdf:type schema:CreativeWork
384 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
385 schema:name Department of Leukemia, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
386 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...