Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06

AUTHORS

Yutaka Kondo, Lanlan Shen, Alfred S Cheng, Saira Ahmed, Yanis Boumber, Chantale Charo, Tadanori Yamochi, Takeshi Urano, Koichi Furukawa, Bernard Kwabi-Addo, David L Gold, Yoshitaka Sekido, Tim Hui-Ming Huang, Jean-Pierre J Issa

ABSTRACT

Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation. More... »

PAGES

741-750

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.159

DOI

http://dx.doi.org/10.1038/ng.159

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027745023

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18488029


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