Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-06

AUTHORS

Peter J Campbell, Philip J Stephens, Erin D Pleasance, Sarah O'Meara, Heng Li, Thomas Santarius, Lucy A Stebbings, Catherine Leroy, Sarah Edkins, Claire Hardy, Jon W Teague, Andrew Menzies, Ian Goodhead, Daniel J Turner, Christopher M Clee, Michael A Quail, Antony Cox, Clive Brown, Richard Durbin, Matthew E Hurles, Paul A W Edwards, Graham R Bignell, Michael R Stratton, P Andrew Futreal

ABSTRACT

Human cancers often carry many somatically acquired genomic rearrangements, some of which may be implicated in cancer development. However, conventional strategies for characterizing rearrangements are laborious and low-throughput and have low sensitivity or poor resolution. We used massively parallel sequencing to generate sequence reads from both ends of short DNA fragments derived from the genomes of two individuals with lung cancer. By investigating read pairs that did not align correctly with respect to each other on the reference human genome, we characterized 306 germline structural variants and 103 somatic rearrangements to the base-pair level of resolution. The patterns of germline and somatic rearrangement were markedly different. Many somatic rearrangements were from amplicons, although rearrangements outside these regions, notably including tandem duplications, were also observed. Some somatic rearrangements led to abnormal transcripts, including two from internal tandem duplications and two fusion transcripts created by interchromosomal rearrangements. Germline variants were predominantly mediated by retrotransposition, often involving AluY and LINE elements. The results demonstrate the feasibility of systematic, genome-wide characterization of rearrangements in complex human cancer genomes, raising the prospect of a new harvest of genes associated with cancer using this strategy. More... »

PAGES

722-729

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.128

DOI

http://dx.doi.org/10.1038/ng.128

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047246435

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18438408


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Pairing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computational Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repetitive Sequences, Nucleic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Campbell", 
        "givenName": "Peter J", 
        "id": "sg:person.0716350025.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716350025.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stephens", 
        "givenName": "Philip J", 
        "id": "sg:person.013646440737.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013646440737.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pleasance", 
        "givenName": "Erin D", 
        "id": "sg:person.0757417552.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757417552.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Meara", 
        "givenName": "Sarah", 
        "id": "sg:person.01215214760.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215214760.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Heng", 
        "id": "sg:person.01043045063.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043045063.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.", 
            "Department of Neurosurgery, University of Cambridge, Hills Road, Cambridge CB2 2QQ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santarius", 
        "givenName": "Thomas", 
        "id": "sg:person.01171331557.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171331557.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stebbings", 
        "givenName": "Lucy A", 
        "id": "sg:person.0610440537.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610440537.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leroy", 
        "givenName": "Catherine", 
        "id": "sg:person.0630267257.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630267257.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Edkins", 
        "givenName": "Sarah", 
        "id": "sg:person.0744515657.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744515657.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hardy", 
        "givenName": "Claire", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teague", 
        "givenName": "Jon W", 
        "id": "sg:person.01177240404.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177240404.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menzies", 
        "givenName": "Andrew", 
        "id": "sg:person.01311421257.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311421257.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goodhead", 
        "givenName": "Ian", 
        "id": "sg:person.01103710365.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103710365.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turner", 
        "givenName": "Daniel J", 
        "id": "sg:person.01352235517.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352235517.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clee", 
        "givenName": "Christopher M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quail", 
        "givenName": "Michael A", 
        "id": "sg:person.01346001520.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346001520.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cox", 
        "givenName": "Antony", 
        "id": "sg:person.01323037456.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323037456.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brown", 
        "givenName": "Clive", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Durbin", 
        "givenName": "Richard", 
        "id": "sg:person.012246531224.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012246531224.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hurles", 
        "givenName": "Matthew E", 
        "id": "sg:person.015724616117.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015724616117.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Hutchison/Medical Research Council Research Centre and Department of Pathology, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Edwards", 
        "givenName": "Paul A W", 
        "id": "sg:person.011341701362.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011341701362.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bignell", 
        "givenName": "Graham R", 
        "id": "sg:person.0641077014.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641077014.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stratton", 
        "givenName": "Michael R", 
        "id": "sg:person.010101505177.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010101505177.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Futreal", 
        "givenName": "P Andrew", 
        "id": "sg:person.0653224107.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653224107.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00335-004-2423-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001811406", 
          "https://doi.org/10.1007/s00335-004-2423-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.194201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008144266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1232418100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016952083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017221313", 
          "https://doi.org/10.1038/nature05945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022731034", 
          "https://doi.org/10.1038/nrc1299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022731034", 
          "https://doi.org/10.1038/nrc1299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025444771", 
          "https://doi.org/10.1038/nrg798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025444771", 
          "https://doi.org/10.1038/nrg798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027447235", 
          "https://doi.org/10.1038/nature06024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910590623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027803646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1117679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028743308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.240630502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029910863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.240630502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029910863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci25546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030619263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btl646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031224678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033482125", 
          "https://doi.org/10.1038/nature05610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.6522707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042731982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2006.06301.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046576202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049251132", 
          "https://doi.org/10.1038/sj.onc.1207809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049251132", 
          "https://doi.org/10.1038/sj.onc.1207809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050115868", 
          "https://doi.org/10.1038/sj.onc.1210993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.6018607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050522544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051360590", 
          "https://doi.org/10.1038/ng1335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051360590", 
          "https://doi.org/10.1038/ng1335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cancergencyto.2005.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052870920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1149504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062456540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/1938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070914225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074712909", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1985.tb03682.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080037116"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-06", 
    "datePublishedReg": "2008-06-01", 
    "description": "Human cancers often carry many somatically acquired genomic rearrangements, some of which may be implicated in cancer development. However, conventional strategies for characterizing rearrangements are laborious and low-throughput and have low sensitivity or poor resolution. We used massively parallel sequencing to generate sequence reads from both ends of short DNA fragments derived from the genomes of two individuals with lung cancer. By investigating read pairs that did not align correctly with respect to each other on the reference human genome, we characterized 306 germline structural variants and 103 somatic rearrangements to the base-pair level of resolution. The patterns of germline and somatic rearrangement were markedly different. Many somatic rearrangements were from amplicons, although rearrangements outside these regions, notably including tandem duplications, were also observed. Some somatic rearrangements led to abnormal transcripts, including two from internal tandem duplications and two fusion transcripts created by interchromosomal rearrangements. Germline variants were predominantly mediated by retrotransposition, often involving AluY and LINE elements. The results demonstrate the feasibility of systematic, genome-wide characterization of rearrangements in complex human cancer genomes, raising the prospect of a new harvest of genes associated with cancer using this strategy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.128", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3639747", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing", 
    "pagination": "722-729", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e1115966a3abaf395ef2e44a6d01b4daa58278674bb0f6f9d316e50c88e4500e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18438408"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.128"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047246435"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.128", 
      "https://app.dimensions.ai/details/publication/pub.1047246435"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ng.128"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.128'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.128'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.128'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.128'


 

This table displays all metadata directly associated to this object as RDF triples.

366 TRIPLES      21 PREDICATES      66 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.128 schema:about N2bb584b7a0a14a84baccc27dac42d38b
2 N2ce9f2175d3b4ce0a3a4dae5a63ee1a8
3 N2e924cc92981472ea300d3a66ee11780
4 N36a2a1e4b4bc48db9d796db881057ad3
5 N4ed7c183f3c54289988b06e852dd700a
6 N514d5f5753cd4566bb81d84b37fafc9d
7 N6fb884064a2d45288be7b36bb0fc2efc
8 N7e523f429f42440393290ca2b3bba425
9 N9b2c77f5e28f4a519f574a4e0007e06d
10 Na97becd4f37743beb9c6a205a63d84f8
11 Nb636f986a89846619bc2993935f03346
12 Ndfcdeab754be43b6b1754df95f65a4cc
13 Nf48825a0e8444be9937d17212219ef1b
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author Nb381de95e9f44636962c66152860da17
17 schema:citation sg:pub.10.1007/s00335-004-2423-z
18 sg:pub.10.1038/nature05610
19 sg:pub.10.1038/nature05945
20 sg:pub.10.1038/nature06024
21 sg:pub.10.1038/ng1335
22 sg:pub.10.1038/nrc1299
23 sg:pub.10.1038/nrg798
24 sg:pub.10.1038/sj.onc.1207809
25 sg:pub.10.1038/sj.onc.1210993
26 https://app.dimensions.ai/details/publication/pub.1074712909
27 https://doi.org/10.1002/ijc.2910590623
28 https://doi.org/10.1002/j.1460-2075.1985.tb03682.x
29 https://doi.org/10.1002/jcb.240630502
30 https://doi.org/10.1016/j.cancergencyto.2005.03.007
31 https://doi.org/10.1073/pnas.1232418100
32 https://doi.org/10.1093/bioinformatics/btl646
33 https://doi.org/10.1101/gr.194201
34 https://doi.org/10.1101/gr.6018607
35 https://doi.org/10.1101/gr.6522707
36 https://doi.org/10.1111/j.1365-2141.2006.06301.x
37 https://doi.org/10.1126/science.1117679
38 https://doi.org/10.1126/science.1149504
39 https://doi.org/10.1172/jci25546
40 https://doi.org/10.2741/1938
41 schema:datePublished 2008-06
42 schema:datePublishedReg 2008-06-01
43 schema:description Human cancers often carry many somatically acquired genomic rearrangements, some of which may be implicated in cancer development. However, conventional strategies for characterizing rearrangements are laborious and low-throughput and have low sensitivity or poor resolution. We used massively parallel sequencing to generate sequence reads from both ends of short DNA fragments derived from the genomes of two individuals with lung cancer. By investigating read pairs that did not align correctly with respect to each other on the reference human genome, we characterized 306 germline structural variants and 103 somatic rearrangements to the base-pair level of resolution. The patterns of germline and somatic rearrangement were markedly different. Many somatic rearrangements were from amplicons, although rearrangements outside these regions, notably including tandem duplications, were also observed. Some somatic rearrangements led to abnormal transcripts, including two from internal tandem duplications and two fusion transcripts created by interchromosomal rearrangements. Germline variants were predominantly mediated by retrotransposition, often involving AluY and LINE elements. The results demonstrate the feasibility of systematic, genome-wide characterization of rearrangements in complex human cancer genomes, raising the prospect of a new harvest of genes associated with cancer using this strategy.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree true
47 schema:isPartOf N4a131a56ccac4943995400c6030755f5
48 N99d6f92ade114432b26a0d6da3f29bfd
49 sg:journal.1103138
50 schema:name Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
51 schema:pagination 722-729
52 schema:productId Nbfcd695cc7d5413494bf859e69cc3a09
53 Nd56f7b273802465fb29e92f9c8929aea
54 Ne19a187acbe045dba24a14c3d64ae2ca
55 Ne55da0dabd564ea6bba61ec1a972da9f
56 Nfff9f0d2ae654f3d9d12c01b9b521ac4
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047246435
58 https://doi.org/10.1038/ng.128
59 schema:sdDatePublished 2019-04-10T15:39
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N49205959da4341ffa5e499eb478e6299
62 schema:url http://www.nature.com/articles/ng.128
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N0339305eb9d44fe1b7650a958ff3d014 rdf:first sg:person.0757417552.08
67 rdf:rest Nb1ba87b53f114a46bc92673dd718c65f
68 N036764cb25c84a429ff90d700217228f rdf:first sg:person.0641077014.15
69 rdf:rest N2297c0f6e81449069d52a17b816f012a
70 N1090dfd085aa4257be5ed8941f7684aa rdf:first sg:person.01043045063.88
71 rdf:rest N5d4f9c44cc9e4701a3c088b5d99ad51b
72 N2297c0f6e81449069d52a17b816f012a rdf:first sg:person.010101505177.49
73 rdf:rest Nd728898aafff4c1dae405e11c5882715
74 N248c40d1a32e480995d5afa9c0990249 rdf:first sg:person.013646440737.20
75 rdf:rest N0339305eb9d44fe1b7650a958ff3d014
76 N2567cf30e67d492099b564eeabc77307 rdf:first sg:person.0630267257.87
77 rdf:rest Nf0b9628c521c49db9e55c3af41e5a521
78 N292dff31a85c4422b6b3dbd6d2b7ad78 rdf:first sg:person.01323037456.61
79 rdf:rest Nd626e785904d4de99b1b0b472d701e4d
80 N2bb584b7a0a14a84baccc27dac42d38b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Repetitive Sequences, Nucleic Acid
82 rdf:type schema:DefinedTerm
83 N2ce9f2175d3b4ce0a3a4dae5a63ee1a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Reverse Transcriptase Polymerase Chain Reaction
85 rdf:type schema:DefinedTerm
86 N2e924cc92981472ea300d3a66ee11780 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Genetic Variation
88 rdf:type schema:DefinedTerm
89 N36a2a1e4b4bc48db9d796db881057ad3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Gene Rearrangement
91 rdf:type schema:DefinedTerm
92 N3d43d0bc2d09448388d83760c52ce5bb rdf:first N983432e7a7e3434e969f02f0064d432f
93 rdf:rest N844ab217e0094b0ea862364e40d1cdbd
94 N49205959da4341ffa5e499eb478e6299 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N4a131a56ccac4943995400c6030755f5 schema:volumeNumber 40
97 rdf:type schema:PublicationVolume
98 N4ed7c183f3c54289988b06e852dd700a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Computational Biology
100 rdf:type schema:DefinedTerm
101 N5009ca23dcd54a608e4b122098c09a38 rdf:first sg:person.01352235517.68
102 rdf:rest N3d43d0bc2d09448388d83760c52ce5bb
103 N514d5f5753cd4566bb81d84b37fafc9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N5817113b273a49e486a3416e37590ee4 rdf:first sg:person.011341701362.19
107 rdf:rest N036764cb25c84a429ff90d700217228f
108 N59de405d5aa14e86b55d4601d46d2d13 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
109 schema:familyName Brown
110 schema:givenName Clive
111 rdf:type schema:Person
112 N5c3d157f56ec4069a01f29e0b89e9049 rdf:first sg:person.012246531224.10
113 rdf:rest N8d1d43f438344384b900027d052474d2
114 N5d4f9c44cc9e4701a3c088b5d99ad51b rdf:first sg:person.01171331557.47
115 rdf:rest Ncdcfd207dc1540de9b9b7afaaa088946
116 N6fb884064a2d45288be7b36bb0fc2efc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Lung Neoplasms
118 rdf:type schema:DefinedTerm
119 N7e523f429f42440393290ca2b3bba425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Chromosome Mapping
121 rdf:type schema:DefinedTerm
122 N80cfcbeef59c4f9783191b66c0949edd rdf:first Ncd8a7f3d6f7f47f2b5548a2b238f330a
123 rdf:rest Nc8324619c6904012a831b229966a8a96
124 N844ab217e0094b0ea862364e40d1cdbd rdf:first sg:person.01346001520.94
125 rdf:rest N292dff31a85c4422b6b3dbd6d2b7ad78
126 N8d1d43f438344384b900027d052474d2 rdf:first sg:person.015724616117.08
127 rdf:rest N5817113b273a49e486a3416e37590ee4
128 N983432e7a7e3434e969f02f0064d432f schema:affiliation https://www.grid.ac/institutes/grid.10306.34
129 schema:familyName Clee
130 schema:givenName Christopher M
131 rdf:type schema:Person
132 N99d6f92ade114432b26a0d6da3f29bfd schema:issueNumber 6
133 rdf:type schema:PublicationIssue
134 N9b2c77f5e28f4a519f574a4e0007e06d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Genome, Human
136 rdf:type schema:DefinedTerm
137 Na97becd4f37743beb9c6a205a63d84f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Base Pairing
139 rdf:type schema:DefinedTerm
140 Nb1ba87b53f114a46bc92673dd718c65f rdf:first sg:person.01215214760.29
141 rdf:rest N1090dfd085aa4257be5ed8941f7684aa
142 Nb381de95e9f44636962c66152860da17 rdf:first sg:person.0716350025.21
143 rdf:rest N248c40d1a32e480995d5afa9c0990249
144 Nb636f986a89846619bc2993935f03346 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Sequence Analysis, DNA
146 rdf:type schema:DefinedTerm
147 Nbfcd695cc7d5413494bf859e69cc3a09 schema:name nlm_unique_id
148 schema:value 9216904
149 rdf:type schema:PropertyValue
150 Nc8324619c6904012a831b229966a8a96 rdf:first sg:person.01177240404.72
151 rdf:rest Nf52cb7a0d88249d59493226a5411867e
152 Ncd8a7f3d6f7f47f2b5548a2b238f330a schema:affiliation https://www.grid.ac/institutes/grid.10306.34
153 schema:familyName Hardy
154 schema:givenName Claire
155 rdf:type schema:Person
156 Ncdcfd207dc1540de9b9b7afaaa088946 rdf:first sg:person.0610440537.14
157 rdf:rest N2567cf30e67d492099b564eeabc77307
158 Nd242de0b0f2046139c938ccf72a1c8d0 rdf:first sg:person.01103710365.23
159 rdf:rest N5009ca23dcd54a608e4b122098c09a38
160 Nd56f7b273802465fb29e92f9c8929aea schema:name readcube_id
161 schema:value e1115966a3abaf395ef2e44a6d01b4daa58278674bb0f6f9d316e50c88e4500e
162 rdf:type schema:PropertyValue
163 Nd626e785904d4de99b1b0b472d701e4d rdf:first N59de405d5aa14e86b55d4601d46d2d13
164 rdf:rest N5c3d157f56ec4069a01f29e0b89e9049
165 Nd728898aafff4c1dae405e11c5882715 rdf:first sg:person.0653224107.08
166 rdf:rest rdf:nil
167 Ndfcdeab754be43b6b1754df95f65a4cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name RNA, Messenger
169 rdf:type schema:DefinedTerm
170 Ne19a187acbe045dba24a14c3d64ae2ca schema:name doi
171 schema:value 10.1038/ng.128
172 rdf:type schema:PropertyValue
173 Ne55da0dabd564ea6bba61ec1a972da9f schema:name pubmed_id
174 schema:value 18438408
175 rdf:type schema:PropertyValue
176 Nf0b9628c521c49db9e55c3af41e5a521 rdf:first sg:person.0744515657.65
177 rdf:rest N80cfcbeef59c4f9783191b66c0949edd
178 Nf48825a0e8444be9937d17212219ef1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Gene Dosage
180 rdf:type schema:DefinedTerm
181 Nf52cb7a0d88249d59493226a5411867e rdf:first sg:person.01311421257.29
182 rdf:rest Nd242de0b0f2046139c938ccf72a1c8d0
183 Nfff9f0d2ae654f3d9d12c01b9b521ac4 schema:name dimensions_id
184 schema:value pub.1047246435
185 rdf:type schema:PropertyValue
186 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
187 schema:name Biological Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
190 schema:name Genetics
191 rdf:type schema:DefinedTerm
192 sg:grant.3639747 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.128
193 rdf:type schema:MonetaryGrant
194 sg:journal.1103138 schema:issn 1061-4036
195 1546-1718
196 schema:name Nature Genetics
197 rdf:type schema:Periodical
198 sg:person.010101505177.49 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
199 schema:familyName Stratton
200 schema:givenName Michael R
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010101505177.49
202 rdf:type schema:Person
203 sg:person.01043045063.88 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
204 schema:familyName Li
205 schema:givenName Heng
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043045063.88
207 rdf:type schema:Person
208 sg:person.01103710365.23 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
209 schema:familyName Goodhead
210 schema:givenName Ian
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103710365.23
212 rdf:type schema:Person
213 sg:person.011341701362.19 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
214 schema:familyName Edwards
215 schema:givenName Paul A W
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011341701362.19
217 rdf:type schema:Person
218 sg:person.01171331557.47 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
219 schema:familyName Santarius
220 schema:givenName Thomas
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171331557.47
222 rdf:type schema:Person
223 sg:person.01177240404.72 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
224 schema:familyName Teague
225 schema:givenName Jon W
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177240404.72
227 rdf:type schema:Person
228 sg:person.01215214760.29 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
229 schema:familyName O'Meara
230 schema:givenName Sarah
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215214760.29
232 rdf:type schema:Person
233 sg:person.012246531224.10 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
234 schema:familyName Durbin
235 schema:givenName Richard
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012246531224.10
237 rdf:type schema:Person
238 sg:person.01311421257.29 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
239 schema:familyName Menzies
240 schema:givenName Andrew
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311421257.29
242 rdf:type schema:Person
243 sg:person.01323037456.61 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
244 schema:familyName Cox
245 schema:givenName Antony
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323037456.61
247 rdf:type schema:Person
248 sg:person.01346001520.94 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
249 schema:familyName Quail
250 schema:givenName Michael A
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346001520.94
252 rdf:type schema:Person
253 sg:person.01352235517.68 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
254 schema:familyName Turner
255 schema:givenName Daniel J
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352235517.68
257 rdf:type schema:Person
258 sg:person.013646440737.20 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
259 schema:familyName Stephens
260 schema:givenName Philip J
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013646440737.20
262 rdf:type schema:Person
263 sg:person.015724616117.08 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
264 schema:familyName Hurles
265 schema:givenName Matthew E
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015724616117.08
267 rdf:type schema:Person
268 sg:person.0610440537.14 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
269 schema:familyName Stebbings
270 schema:givenName Lucy A
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610440537.14
272 rdf:type schema:Person
273 sg:person.0630267257.87 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
274 schema:familyName Leroy
275 schema:givenName Catherine
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630267257.87
277 rdf:type schema:Person
278 sg:person.0641077014.15 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
279 schema:familyName Bignell
280 schema:givenName Graham R
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641077014.15
282 rdf:type schema:Person
283 sg:person.0653224107.08 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
284 schema:familyName Futreal
285 schema:givenName P Andrew
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653224107.08
287 rdf:type schema:Person
288 sg:person.0716350025.21 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
289 schema:familyName Campbell
290 schema:givenName Peter J
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716350025.21
292 rdf:type schema:Person
293 sg:person.0744515657.65 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
294 schema:familyName Edkins
295 schema:givenName Sarah
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744515657.65
297 rdf:type schema:Person
298 sg:person.0757417552.08 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
299 schema:familyName Pleasance
300 schema:givenName Erin D
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757417552.08
302 rdf:type schema:Person
303 sg:pub.10.1007/s00335-004-2423-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1001811406
304 https://doi.org/10.1007/s00335-004-2423-z
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nature05610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033482125
307 https://doi.org/10.1038/nature05610
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/nature05945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017221313
310 https://doi.org/10.1038/nature05945
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/nature06024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027447235
313 https://doi.org/10.1038/nature06024
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/ng1335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051360590
316 https://doi.org/10.1038/ng1335
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/nrc1299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022731034
319 https://doi.org/10.1038/nrc1299
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/nrg798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025444771
322 https://doi.org/10.1038/nrg798
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/sj.onc.1207809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049251132
325 https://doi.org/10.1038/sj.onc.1207809
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/sj.onc.1210993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050115868
328 https://doi.org/10.1038/sj.onc.1210993
329 rdf:type schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1074712909 schema:CreativeWork
331 https://doi.org/10.1002/ijc.2910590623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027803646
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1002/j.1460-2075.1985.tb03682.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1080037116
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1002/jcb.240630502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029910863
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.cancergencyto.2005.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052870920
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1073/pnas.1232418100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016952083
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1093/bioinformatics/btl646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031224678
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1101/gr.194201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008144266
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1101/gr.6018607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050522544
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1101/gr.6522707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042731982
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1111/j.1365-2141.2006.06301.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046576202
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/science.1117679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028743308
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1126/science.1149504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062456540
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1172/jci25546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030619263
356 rdf:type schema:CreativeWork
357 https://doi.org/10.2741/1938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070914225
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.10306.34 schema:alternateName Wellcome Sanger Institute
360 schema:name Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
361 rdf:type schema:Organization
362 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
363 schema:name Department of Neurosurgery, University of Cambridge, Hills Road, Cambridge CB2 2QQ, UK.
364 Hutchison/Medical Research Council Research Centre and Department of Pathology, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.
365 Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
366 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...