Ontology type: schema:ScholarlyArticle Open Access: True
2008-04-27
AUTHORSPeter J Campbell, Philip J Stephens, Erin D Pleasance, Sarah O'Meara, Heng Li, Thomas Santarius, Lucy A Stebbings, Catherine Leroy, Sarah Edkins, Claire Hardy, Jon W Teague, Andrew Menzies, Ian Goodhead, Daniel J Turner, Christopher M Clee, Michael A Quail, Antony Cox, Clive Brown, Richard Durbin, Matthew E Hurles, Paul A W Edwards, Graham R Bignell, Michael R Stratton, P Andrew Futreal
ABSTRACTHuman cancers often carry many somatically acquired genomic rearrangements, some of which may be implicated in cancer development. However, conventional strategies for characterizing rearrangements are laborious and low-throughput and have low sensitivity or poor resolution. We used massively parallel sequencing to generate sequence reads from both ends of short DNA fragments derived from the genomes of two individuals with lung cancer. By investigating read pairs that did not align correctly with respect to each other on the reference human genome, we characterized 306 germline structural variants and 103 somatic rearrangements to the base-pair level of resolution. The patterns of germline and somatic rearrangement were markedly different. Many somatic rearrangements were from amplicons, although rearrangements outside these regions, notably including tandem duplications, were also observed. Some somatic rearrangements led to abnormal transcripts, including two from internal tandem duplications and two fusion transcripts created by interchromosomal rearrangements. Germline variants were predominantly mediated by retrotransposition, often involving AluY and LINE elements. The results demonstrate the feasibility of systematic, genome-wide characterization of rearrangements in complex human cancer genomes, raising the prospect of a new harvest of genes associated with cancer using this strategy. More... »
PAGES722-729
http://scigraph.springernature.com/pub.10.1038/ng.128
DOIhttp://dx.doi.org/10.1038/ng.128
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1047246435
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18438408
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Base Pairing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosome Mapping",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Computational Biology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Dosage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Rearrangement",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Variation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genome, Human",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lung Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Repetitive Sequences, Nucleic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reverse Transcriptase Polymerase Chain Reaction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sequence Analysis, DNA",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Campbell",
"givenName": "Peter J",
"id": "sg:person.0716350025.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716350025.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Stephens",
"givenName": "Philip J",
"id": "sg:person.013646440737.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013646440737.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Pleasance",
"givenName": "Erin D",
"id": "sg:person.0757417552.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757417552.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "O'Meara",
"givenName": "Sarah",
"id": "sg:person.01215214760.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215214760.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Heng",
"id": "sg:person.01043045063.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043045063.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurosurgery, University of Cambridge, Hills Road, CB2 2QQ, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"Department of Neurosurgery, University of Cambridge, Hills Road, CB2 2QQ, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Santarius",
"givenName": "Thomas",
"id": "sg:person.012750216707.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012750216707.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Stebbings",
"givenName": "Lucy A",
"id": "sg:person.0610440537.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610440537.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Leroy",
"givenName": "Catherine",
"id": "sg:person.0630267257.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630267257.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Edkins",
"givenName": "Sarah",
"id": "sg:person.0744515657.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744515657.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Hardy",
"givenName": "Claire",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Teague",
"givenName": "Jon W",
"id": "sg:person.01177240404.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177240404.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Menzies",
"givenName": "Andrew",
"id": "sg:person.01311421257.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311421257.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Goodhead",
"givenName": "Ian",
"id": "sg:person.01103710365.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103710365.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Turner",
"givenName": "Daniel J",
"id": "sg:person.01352235517.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352235517.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Clee",
"givenName": "Christopher M",
"id": "sg:person.01146456301.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146456301.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Quail",
"givenName": "Michael A",
"id": "sg:person.01346001520.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346001520.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Cox",
"givenName": "Antony",
"id": "sg:person.01323037456.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323037456.61"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Brown",
"givenName": "Clive",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Durbin",
"givenName": "Richard",
"id": "sg:person.012246531224.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012246531224.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Hurles",
"givenName": "Matthew E",
"id": "sg:person.015724616117.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015724616117.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hutchison/Medical Research Council Research Centre and Department of Pathology, University of Cambridge, Hills Road, CB2 0XZ, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"Hutchison/Medical Research Council Research Centre and Department of Pathology, University of Cambridge, Hills Road, CB2 0XZ, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Edwards",
"givenName": "Paul A W",
"id": "sg:person.011341701362.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011341701362.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Bignell",
"givenName": "Graham R",
"id": "sg:person.0641077014.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641077014.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Stratton",
"givenName": "Michael R",
"id": "sg:person.010101505177.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010101505177.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, UK"
],
"type": "Organization"
},
"familyName": "Futreal",
"givenName": "P Andrew",
"id": "sg:person.0653224107.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653224107.08"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature05945",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017221313",
"https://doi.org/10.1038/nature05945"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00335-004-2423-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001811406",
"https://doi.org/10.1007/s00335-004-2423-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1207809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049251132",
"https://doi.org/10.1038/sj.onc.1207809"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05610",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033482125",
"https://doi.org/10.1038/nature05610"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1210993",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050115868",
"https://doi.org/10.1038/sj.onc.1210993"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027447235",
"https://doi.org/10.1038/nature06024"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg798",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025444771",
"https://doi.org/10.1038/nrg798"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1299",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022731034",
"https://doi.org/10.1038/nrc1299"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1335",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051360590",
"https://doi.org/10.1038/ng1335"
],
"type": "CreativeWork"
}
],
"datePublished": "2008-04-27",
"datePublishedReg": "2008-04-27",
"description": "Human cancers often carry many somatically acquired genomic rearrangements, some of which may be implicated in cancer development. However, conventional strategies for characterizing rearrangements are laborious and low-throughput and have low sensitivity or poor resolution. We used massively parallel sequencing to generate sequence reads from both ends of short DNA fragments derived from the genomes of two individuals with lung cancer. By investigating read pairs that did not align correctly with respect to each other on the reference human genome, we characterized 306 germline structural variants and 103 somatic rearrangements to the base-pair level of resolution. The patterns of germline and somatic rearrangement were markedly different. Many somatic rearrangements were from amplicons, although rearrangements outside these regions, notably including tandem duplications, were also observed. Some somatic rearrangements led to abnormal transcripts, including two from internal tandem duplications and two fusion transcripts created by interchromosomal rearrangements. Germline variants were predominantly mediated by retrotransposition, often involving AluY and LINE elements. The results demonstrate the feasibility of systematic, genome-wide characterization of rearrangements in complex human cancer genomes, raising the prospect of a new harvest of genes associated with cancer using this strategy.",
"genre": "article",
"id": "sg:pub.10.1038/ng.128",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1103138",
"issn": [
"1061-4036",
"1546-1718"
],
"name": "Nature Genetics",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "40"
}
],
"keywords": [
"somatic rearrangements",
"tandem duplication",
"Genome-wide characterization",
"parallel paired-end sequencing",
"human cancer genomes",
"paired-end sequencing",
"reference human genome",
"germline structural variants",
"base-pair level",
"interchromosomal rearrangements",
"short DNA fragments",
"human genome",
"genomic rearrangements",
"sequence reads",
"cancer genomes",
"DNA fragments",
"parallel sequencing",
"structural variants",
"genome",
"abnormal transcripts",
"human cancers",
"cancer development",
"transcripts",
"duplication",
"sequencing",
"germline variants",
"rearrangement",
"fusion transcripts",
"new harvest",
"retrotransposition",
"germline",
"genes",
"variants",
"AluY",
"reads",
"amplicons",
"internal tandem duplication",
"fragments",
"cancer",
"harvest",
"poor resolution",
"identification",
"characterization",
"region",
"patterns",
"pairs",
"conventional strategies",
"lung cancer",
"strategies",
"line elements",
"development",
"levels",
"individuals",
"resolution",
"elements",
"end",
"sensitivity",
"results",
"prospects",
"low sensitivity",
"respect",
"feasibility"
],
"name": "Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing",
"pagination": "722-729",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1047246435"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ng.128"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"18438408"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ng.128",
"https://app.dimensions.ai/details/publication/pub.1047246435"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:56",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_464.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/ng.128"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.128'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.128'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.128'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.128'
This table displays all metadata directly associated to this object as RDF triples.
384 TRIPLES
21 PREDICATES
111 URIs
92 LITERALS
20 BLANK NODES