Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-03

AUTHORS

S Hong Lee, Teresa R DeCandia, Stephan Ripke, Jian Yang, The Schizophrenia Psychiatric Genome-Wide Association Study Consortium, The International Schizophrenia Consortium, The Molecular Genetics of Schizophrenia Collaboration, Patrick F Sullivan, Michael E Goddard, Matthew C Keller, Peter M Visscher, Naomi R Wray

ABSTRACT

Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases. More... »

PAGES

247

References to SciGraph publications

  • 2010-06. Uncovering the roles of rare variants in common disease through whole-genome sequencing in NATURE REVIEWS GENETICS
  • 2011-06. Genome partitioning of genetic variation for complex traits using common SNPs in NATURE GENETICS
  • 2012-05. Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses in MOLECULAR PSYCHIATRY
  • 2010-11. Reconciling the analysis of IBD and IBS in complex trait studies in NATURE REVIEWS GENETICS
  • 2010-04. Variance component model to account for sample structure in genome-wide association studies in NATURE GENETICS
  • 2010-10. Hundreds of variants clustered in genomic loci and biological pathways affect human height in NATURE
  • 2006-02. An efficient variance component approach implementing an average information REML suitable for combined LD and linkage mapping with a general complex pedigree in GENETICS SELECTION EVOLUTION
  • 2010-07. Common SNPs explain a large proportion of the heritability for human height in NATURE GENETICS
  • 2009-07-01. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder in NATURE
  • 2009-03. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk in MOLECULAR PSYCHIATRY
  • 2009-07-01. Common variants on chromosome 6p22.1 are associated with schizophrenia in NATURE
  • 2011-10. Genome-wide association study identifies five new schizophrenia loci in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.1108

    DOI

    http://dx.doi.org/10.1038/ng.1108

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049441089

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22344220


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Analysis of Variance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Central Nervous System", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Computer Simulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Variation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Likelihood Functions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Linear Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Annotation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multifactorial Inheritance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Schizophrenia", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "QIMR Berghofer Medical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.1049.c", 
              "name": [
                "Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.", 
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "S Hong", 
            "id": "sg:person.01030306151.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030306151.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Colorado Boulder", 
              "id": "https://www.grid.ac/institutes/grid.266190.a", 
              "name": [
                "Department of Psychology & Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.", 
                "Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "DeCandia", 
            "givenName": "Teresa R", 
            "id": "sg:person.01203765023.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203765023.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.", 
                "Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ripke", 
            "givenName": "Stephan", 
            "id": "sg:person.01133572106.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133572106.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "QIMR Berghofer Medical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.1049.c", 
              "name": [
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia.", 
                "University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Jian", 
            "id": "sg:person.0730724336.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730724336.65"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Consortium", 
            "givenName": "The Schizophrenia Psychiatric Genome-Wide Association Study", 
            "id": "sg:person.015000465573.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015000465573.14"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Consortium", 
            "givenName": "The International Schizophrenia", 
            "id": "sg:person.010437005170.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010437005170.08"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Collaboration", 
            "givenName": "The Molecular Genetics of Schizophrenia", 
            "id": "sg:person.010521703572.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010521703572.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of North Carolina at Chapel Hill", 
              "id": "https://www.grid.ac/institutes/grid.10698.36", 
              "name": [
                "Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sullivan", 
            "givenName": "Patrick F", 
            "id": "sg:person.015012714437.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015012714437.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Environment, Land, Water and Planning", 
              "id": "https://www.grid.ac/institutes/grid.452205.4", 
              "name": [
                "Department of Agriculture and Food Systems, University of Melbourne, Melbourne, Victoria, Australia.", 
                "Biosciences Research Division, Department of Primary Industries, Melbourne, Victoria, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goddard", 
            "givenName": "Michael E", 
            "id": "sg:person.0623730357.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623730357.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Colorado Boulder", 
              "id": "https://www.grid.ac/institutes/grid.266190.a", 
              "name": [
                "Department of Psychology & Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.", 
                "Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Keller", 
            "givenName": "Matthew C", 
            "id": "sg:person.010260323777.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010260323777.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "QIMR Berghofer Medical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.1049.c", 
              "name": [
                "Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.", 
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia.", 
                "University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Visscher", 
            "givenName": "Peter M", 
            "id": "sg:person.01033044533.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033044533.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "QIMR Berghofer Medical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.1049.c", 
              "name": [
                "Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.", 
                "Queensland Institute of Medical Research, Brisbane, Queensland, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wray", 
            "givenName": "Naomi R", 
            "id": "sg:person.01024027537.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024027537.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/mp.2011.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000632110", 
              "https://doi.org/10.1038/mp.2011.65"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1192/bjp.bp.106.033761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006141697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007907762", 
              "https://doi.org/10.1038/ng.823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2010.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009497006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2011.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009526716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2008.133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010935179", 
              "https://doi.org/10.1038/mp.2008.133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1000579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013654736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015057090", 
              "https://doi.org/10.1038/ng.608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015057090", 
              "https://doi.org/10.1038/ng.608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016055940", 
              "https://doi.org/10.1038/ng.548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016055940", 
              "https://doi.org/10.1038/ng.548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(09)60072-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017806629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018043090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018043090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2010.869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018576038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.03.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018859206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021265732", 
              "https://doi.org/10.1038/nrg2865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021265732", 
              "https://doi.org/10.1038/nrg2865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.60.12.1187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021973462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022261447", 
              "https://doi.org/10.1038/nature08192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022261447", 
              "https://doi.org/10.1038/nature08192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025133227", 
              "https://doi.org/10.1038/nature08185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025133227", 
              "https://doi.org/10.1038/nature08185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027811451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027811451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1375/twin.8.2.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029178731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-8628(200021)97:1<12::aid-ajmg3>3.0.co;2-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032671336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/09540261.2010.515205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037592668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037714920", 
              "https://doi.org/10.1038/nature09410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037714920", 
              "https://doi.org/10.1038/nature09410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1297-9686-38-1-25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040980514", 
              "https://doi.org/10.1186/1297-9686-38-1-25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1192/bjp.bp.106.025585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043507183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1001097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050556066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050625874", 
              "https://doi.org/10.1038/nrg2779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050625874", 
              "https://doi.org/10.1038/nrg2779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053172161", 
              "https://doi.org/10.1038/ng.940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053172161", 
              "https://doi.org/10.1038/ng.940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01621459.1987.10478472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058303449"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-03", 
        "datePublishedReg": "2012-03-01", 
        "description": "Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 \u00d7 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 \u00d7 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ng.1108", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2692478", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549522", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2424054", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549339", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4137489", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440944", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6720675", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2550804", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2550976", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2551818", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6728038", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6713568", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2551938", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549051", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6715021", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2419893", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439408", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2692316", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2432488", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549052", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2692477", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549054", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549060", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2551591", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2550366", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2551477", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549062", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3578761", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549061", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2551940", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3561863", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2548892", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699530", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2551179", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2551277", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2551402", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2692322", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3570887", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2405168", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549342", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6722666", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2549488", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2692320", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2692505", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2548211", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "44"
          }
        ], 
        "name": "Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs", 
        "pagination": "247", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "eb86ba81c74b5e3cfa8f2dc75d15f9d5e9a04b196863324616a33385b72168ff"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22344220"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng.1108"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1049441089"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng.1108", 
          "https://app.dimensions.ai/details/publication/pub.1049441089"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000436.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/ng.1108"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.1108'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.1108'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.1108'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.1108'


     

    This table displays all metadata directly associated to this object as RDF triples.

    414 TRIPLES      21 PREDICATES      74 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng.1108 schema:about N0d002a3b99524de193f8340ce77ca844
    2 N12e2ac0b92704ed3828d9ac6b53b1dad
    3 N34f3487ad4184f5e871b34b48ce78cbc
    4 N36cd9102696f44f7be17a406dfd3cd14
    5 N3cab1e50a3f54fb492502afe493c1d0c
    6 N4986af0591e04f87b300772998283f3c
    7 N4a88587094d44cd388ee37c0cdea59a3
    8 N86812141840d4c469e2a326b6cc0cf1d
    9 N8a77d3bed7f94000a4822189ac99487f
    10 N9c518434655e448e981e12dddb785f0f
    11 Na24c979bb195431c9d524e460ebc103d
    12 Na3f06ee02e5c48b7aeba83c77c2ef4c1
    13 Nc0a538ac34c3406a86648ae91cfcb47b
    14 Ncc053ac7af5046cfb390ad6615699e89
    15 Nd89104387a364178a480ab1c7b1c5ee8
    16 Ndec8cdcfa6c9473f93a97d243c439586
    17 Ne4dbec35db4b499e8db3bdcd5fae06ae
    18 anzsrc-for:06
    19 anzsrc-for:0604
    20 schema:author N033d757e09d7451c828db1e6673b899e
    21 schema:citation sg:pub.10.1038/mp.2008.133
    22 sg:pub.10.1038/mp.2011.65
    23 sg:pub.10.1038/nature08185
    24 sg:pub.10.1038/nature08192
    25 sg:pub.10.1038/nature09410
    26 sg:pub.10.1038/ng.548
    27 sg:pub.10.1038/ng.608
    28 sg:pub.10.1038/ng.823
    29 sg:pub.10.1038/ng.940
    30 sg:pub.10.1038/nrg2779
    31 sg:pub.10.1038/nrg2865
    32 sg:pub.10.1186/1297-9686-38-1-25
    33 https://doi.org/10.1001/archpsyc.60.12.1187
    34 https://doi.org/10.1001/jama.2010.869
    35 https://doi.org/10.1002/(sici)1096-8628(200021)97:1<12::aid-ajmg3>3.0.co;2-u
    36 https://doi.org/10.1002/gepi.20456
    37 https://doi.org/10.1002/gepi.20497
    38 https://doi.org/10.1016/j.ajhg.2010.11.011
    39 https://doi.org/10.1016/j.ajhg.2011.02.002
    40 https://doi.org/10.1016/j.cell.2010.03.032
    41 https://doi.org/10.1016/s0140-6736(09)60072-6
    42 https://doi.org/10.1080/01621459.1987.10478472
    43 https://doi.org/10.1192/bjp.bp.106.025585
    44 https://doi.org/10.1192/bjp.bp.106.033761
    45 https://doi.org/10.1371/journal.pbio.1000579
    46 https://doi.org/10.1371/journal.pgen.1001097
    47 https://doi.org/10.1375/twin.8.2.87
    48 https://doi.org/10.3109/09540261.2010.515205
    49 schema:datePublished 2012-03
    50 schema:datePublishedReg 2012-03-01
    51 schema:description Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.
    52 schema:genre research_article
    53 schema:inLanguage en
    54 schema:isAccessibleForFree true
    55 schema:isPartOf Nd2bec106f9944e108125827e705a86be
    56 Nea0d253f77e94756b798fbe758e3de43
    57 sg:journal.1103138
    58 schema:name Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    59 schema:pagination 247
    60 schema:productId N2c9a0472b2af494193f36edf149d1aa8
    61 N5bc4c523372d493c827d087e4728a0e4
    62 N65cd3dadf12a4c4a9b8c97611e8b1886
    63 Nbca5ceb49a644db7b5af67a88d4d058b
    64 Nf4b97665ea3945edacb48373962d467e
    65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049441089
    66 https://doi.org/10.1038/ng.1108
    67 schema:sdDatePublished 2019-04-10T16:30
    68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    69 schema:sdPublisher N1e85ab9702064f9eb28af9a2aab42f23
    70 schema:url https://www.nature.com/articles/ng.1108
    71 sgo:license sg:explorer/license/
    72 sgo:sdDataset articles
    73 rdf:type schema:ScholarlyArticle
    74 N019ae2e89e4e4d6e8532fdaf51fc7c0b rdf:first sg:person.015012714437.80
    75 rdf:rest N09ca921c7a8a4fecada1b92784e980be
    76 N033d757e09d7451c828db1e6673b899e rdf:first sg:person.01030306151.83
    77 rdf:rest N54ea5257dba148e180beedb402dad29c
    78 N045b9c460c9f431498b132eca82a9507 rdf:first sg:person.010437005170.08
    79 rdf:rest Nce62a0e9dad6430384a2e9bf6f3d7715
    80 N09ca921c7a8a4fecada1b92784e980be rdf:first sg:person.0623730357.31
    81 rdf:rest N4874ff9a997541b09df9e58c6e7cd6c4
    82 N0d002a3b99524de193f8340ce77ca844 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Male
    84 rdf:type schema:DefinedTerm
    85 N12e2ac0b92704ed3828d9ac6b53b1dad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Schizophrenia
    87 rdf:type schema:DefinedTerm
    88 N1df3692db57f4e30ae09dc6d1d258f03 rdf:first sg:person.01133572106.62
    89 rdf:rest N7c71aca778fd48dfbd9270c32645d8ac
    90 N1e85ab9702064f9eb28af9a2aab42f23 schema:name Springer Nature - SN SciGraph project
    91 rdf:type schema:Organization
    92 N2c9a0472b2af494193f36edf149d1aa8 schema:name readcube_id
    93 schema:value eb86ba81c74b5e3cfa8f2dc75d15f9d5e9a04b196863324616a33385b72168ff
    94 rdf:type schema:PropertyValue
    95 N34f3487ad4184f5e871b34b48ce78cbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Genetic Variation
    97 rdf:type schema:DefinedTerm
    98 N36cd9102696f44f7be17a406dfd3cd14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Analysis of Variance
    100 rdf:type schema:DefinedTerm
    101 N3cab1e50a3f54fb492502afe493c1d0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Molecular Sequence Annotation
    103 rdf:type schema:DefinedTerm
    104 N4874ff9a997541b09df9e58c6e7cd6c4 rdf:first sg:person.010260323777.84
    105 rdf:rest N4d49f7a01f674f25b80644c5399606f7
    106 N4986af0591e04f87b300772998283f3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Female
    108 rdf:type schema:DefinedTerm
    109 N4a88587094d44cd388ee37c0cdea59a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Linear Models
    111 rdf:type schema:DefinedTerm
    112 N4d49f7a01f674f25b80644c5399606f7 rdf:first sg:person.01033044533.08
    113 rdf:rest Ndf2a8debf9d242aa8f2ae29ab1a92cc1
    114 N54ea5257dba148e180beedb402dad29c rdf:first sg:person.01203765023.03
    115 rdf:rest N1df3692db57f4e30ae09dc6d1d258f03
    116 N5bc4c523372d493c827d087e4728a0e4 schema:name pubmed_id
    117 schema:value 22344220
    118 rdf:type schema:PropertyValue
    119 N65cd3dadf12a4c4a9b8c97611e8b1886 schema:name doi
    120 schema:value 10.1038/ng.1108
    121 rdf:type schema:PropertyValue
    122 N7c71aca778fd48dfbd9270c32645d8ac rdf:first sg:person.0730724336.65
    123 rdf:rest Nac7fa7498db34e86afe7650c94c9c5bd
    124 N86812141840d4c469e2a326b6cc0cf1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Likelihood Functions
    126 rdf:type schema:DefinedTerm
    127 N8a77d3bed7f94000a4822189ac99487f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Central Nervous System
    129 rdf:type schema:DefinedTerm
    130 N9c518434655e448e981e12dddb785f0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Polymorphism, Single Nucleotide
    132 rdf:type schema:DefinedTerm
    133 Na24c979bb195431c9d524e460ebc103d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Genetic Predisposition to Disease
    135 rdf:type schema:DefinedTerm
    136 Na3f06ee02e5c48b7aeba83c77c2ef4c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Multifactorial Inheritance
    138 rdf:type schema:DefinedTerm
    139 Nac7fa7498db34e86afe7650c94c9c5bd rdf:first sg:person.015000465573.14
    140 rdf:rest N045b9c460c9f431498b132eca82a9507
    141 Nbca5ceb49a644db7b5af67a88d4d058b schema:name nlm_unique_id
    142 schema:value 9216904
    143 rdf:type schema:PropertyValue
    144 Nc0a538ac34c3406a86648ae91cfcb47b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Models, Genetic
    146 rdf:type schema:DefinedTerm
    147 Ncc053ac7af5046cfb390ad6615699e89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Humans
    149 rdf:type schema:DefinedTerm
    150 Nce62a0e9dad6430384a2e9bf6f3d7715 rdf:first sg:person.010521703572.26
    151 rdf:rest N019ae2e89e4e4d6e8532fdaf51fc7c0b
    152 Nd2bec106f9944e108125827e705a86be schema:volumeNumber 44
    153 rdf:type schema:PublicationVolume
    154 Nd89104387a364178a480ab1c7b1c5ee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Genome-Wide Association Study
    156 rdf:type schema:DefinedTerm
    157 Ndec8cdcfa6c9473f93a97d243c439586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Computer Simulation
    159 rdf:type schema:DefinedTerm
    160 Ndf2a8debf9d242aa8f2ae29ab1a92cc1 rdf:first sg:person.01024027537.42
    161 rdf:rest rdf:nil
    162 Ne4dbec35db4b499e8db3bdcd5fae06ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Chromosomes, Human
    164 rdf:type schema:DefinedTerm
    165 Nea0d253f77e94756b798fbe758e3de43 schema:issueNumber 3
    166 rdf:type schema:PublicationIssue
    167 Nf4b97665ea3945edacb48373962d467e schema:name dimensions_id
    168 schema:value pub.1049441089
    169 rdf:type schema:PropertyValue
    170 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Biological Sciences
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Genetics
    175 rdf:type schema:DefinedTerm
    176 sg:grant.2405168 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    177 rdf:type schema:MonetaryGrant
    178 sg:grant.2419893 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    179 rdf:type schema:MonetaryGrant
    180 sg:grant.2424054 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    181 rdf:type schema:MonetaryGrant
    182 sg:grant.2432488 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    183 rdf:type schema:MonetaryGrant
    184 sg:grant.2439408 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    185 rdf:type schema:MonetaryGrant
    186 sg:grant.2440944 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    187 rdf:type schema:MonetaryGrant
    188 sg:grant.2548211 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    189 rdf:type schema:MonetaryGrant
    190 sg:grant.2548892 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    191 rdf:type schema:MonetaryGrant
    192 sg:grant.2549051 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    193 rdf:type schema:MonetaryGrant
    194 sg:grant.2549052 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    195 rdf:type schema:MonetaryGrant
    196 sg:grant.2549054 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    197 rdf:type schema:MonetaryGrant
    198 sg:grant.2549060 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    199 rdf:type schema:MonetaryGrant
    200 sg:grant.2549061 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    201 rdf:type schema:MonetaryGrant
    202 sg:grant.2549062 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    203 rdf:type schema:MonetaryGrant
    204 sg:grant.2549339 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.2549342 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    207 rdf:type schema:MonetaryGrant
    208 sg:grant.2549488 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.2549522 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.2550366 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    213 rdf:type schema:MonetaryGrant
    214 sg:grant.2550804 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    215 rdf:type schema:MonetaryGrant
    216 sg:grant.2550976 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    217 rdf:type schema:MonetaryGrant
    218 sg:grant.2551179 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    219 rdf:type schema:MonetaryGrant
    220 sg:grant.2551277 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    221 rdf:type schema:MonetaryGrant
    222 sg:grant.2551402 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    223 rdf:type schema:MonetaryGrant
    224 sg:grant.2551477 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    225 rdf:type schema:MonetaryGrant
    226 sg:grant.2551591 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    227 rdf:type schema:MonetaryGrant
    228 sg:grant.2551818 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    229 rdf:type schema:MonetaryGrant
    230 sg:grant.2551938 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    231 rdf:type schema:MonetaryGrant
    232 sg:grant.2551940 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    233 rdf:type schema:MonetaryGrant
    234 sg:grant.2692316 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.2692320 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.2692322 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.2692477 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.2692478 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.2692505 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.2699530 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    247 rdf:type schema:MonetaryGrant
    248 sg:grant.3561863 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    249 rdf:type schema:MonetaryGrant
    250 sg:grant.3570887 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    251 rdf:type schema:MonetaryGrant
    252 sg:grant.3578761 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    253 rdf:type schema:MonetaryGrant
    254 sg:grant.4137489 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    255 rdf:type schema:MonetaryGrant
    256 sg:grant.6713568 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    257 rdf:type schema:MonetaryGrant
    258 sg:grant.6715021 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    259 rdf:type schema:MonetaryGrant
    260 sg:grant.6720675 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    261 rdf:type schema:MonetaryGrant
    262 sg:grant.6722666 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    263 rdf:type schema:MonetaryGrant
    264 sg:grant.6728038 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.1108
    265 rdf:type schema:MonetaryGrant
    266 sg:journal.1103138 schema:issn 1061-4036
    267 1546-1718
    268 schema:name Nature Genetics
    269 rdf:type schema:Periodical
    270 sg:person.01024027537.42 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
    271 schema:familyName Wray
    272 schema:givenName Naomi R
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024027537.42
    274 rdf:type schema:Person
    275 sg:person.010260323777.84 schema:affiliation https://www.grid.ac/institutes/grid.266190.a
    276 schema:familyName Keller
    277 schema:givenName Matthew C
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010260323777.84
    279 rdf:type schema:Person
    280 sg:person.01030306151.83 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
    281 schema:familyName Lee
    282 schema:givenName S Hong
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030306151.83
    284 rdf:type schema:Person
    285 sg:person.01033044533.08 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
    286 schema:familyName Visscher
    287 schema:givenName Peter M
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033044533.08
    289 rdf:type schema:Person
    290 sg:person.010437005170.08 schema:familyName Consortium
    291 schema:givenName The International Schizophrenia
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010437005170.08
    293 rdf:type schema:Person
    294 sg:person.010521703572.26 schema:familyName Collaboration
    295 schema:givenName The Molecular Genetics of Schizophrenia
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010521703572.26
    297 rdf:type schema:Person
    298 sg:person.01133572106.62 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    299 schema:familyName Ripke
    300 schema:givenName Stephan
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133572106.62
    302 rdf:type schema:Person
    303 sg:person.01203765023.03 schema:affiliation https://www.grid.ac/institutes/grid.266190.a
    304 schema:familyName DeCandia
    305 schema:givenName Teresa R
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203765023.03
    307 rdf:type schema:Person
    308 sg:person.015000465573.14 schema:familyName Consortium
    309 schema:givenName The Schizophrenia Psychiatric Genome-Wide Association Study
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015000465573.14
    311 rdf:type schema:Person
    312 sg:person.015012714437.80 schema:affiliation https://www.grid.ac/institutes/grid.10698.36
    313 schema:familyName Sullivan
    314 schema:givenName Patrick F
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015012714437.80
    316 rdf:type schema:Person
    317 sg:person.0623730357.31 schema:affiliation https://www.grid.ac/institutes/grid.452205.4
    318 schema:familyName Goddard
    319 schema:givenName Michael E
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623730357.31
    321 rdf:type schema:Person
    322 sg:person.0730724336.65 schema:affiliation https://www.grid.ac/institutes/grid.1049.c
    323 schema:familyName Yang
    324 schema:givenName Jian
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730724336.65
    326 rdf:type schema:Person
    327 sg:pub.10.1038/mp.2008.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010935179
    328 https://doi.org/10.1038/mp.2008.133
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/mp.2011.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000632110
    331 https://doi.org/10.1038/mp.2011.65
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nature08185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025133227
    334 https://doi.org/10.1038/nature08185
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nature08192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022261447
    337 https://doi.org/10.1038/nature08192
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nature09410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037714920
    340 https://doi.org/10.1038/nature09410
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/ng.548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016055940
    343 https://doi.org/10.1038/ng.548
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/ng.608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015057090
    346 https://doi.org/10.1038/ng.608
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/ng.823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007907762
    349 https://doi.org/10.1038/ng.823
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/ng.940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053172161
    352 https://doi.org/10.1038/ng.940
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nrg2779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050625874
    355 https://doi.org/10.1038/nrg2779
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nrg2865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021265732
    358 https://doi.org/10.1038/nrg2865
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1186/1297-9686-38-1-25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040980514
    361 https://doi.org/10.1186/1297-9686-38-1-25
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1001/archpsyc.60.12.1187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021973462
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1001/jama.2010.869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018576038
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1002/(sici)1096-8628(200021)97:1<12::aid-ajmg3>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1032671336
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1002/gepi.20456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018043090
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1002/gepi.20497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027811451
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/j.ajhg.2010.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009497006
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/j.ajhg.2011.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009526716
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/j.cell.2010.03.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018859206
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/s0140-6736(09)60072-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017806629
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1080/01621459.1987.10478472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058303449
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1192/bjp.bp.106.025585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043507183
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1192/bjp.bp.106.033761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006141697
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1371/journal.pbio.1000579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013654736
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1371/journal.pgen.1001097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050556066
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1375/twin.8.2.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029178731
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.3109/09540261.2010.515205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037592668
    394 rdf:type schema:CreativeWork
    395 https://www.grid.ac/institutes/grid.1049.c schema:alternateName QIMR Berghofer Medical Research Institute
    396 schema:name Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
    397 Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
    398 University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
    399 rdf:type schema:Organization
    400 https://www.grid.ac/institutes/grid.10698.36 schema:alternateName University of North Carolina at Chapel Hill
    401 schema:name Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
    402 rdf:type schema:Organization
    403 https://www.grid.ac/institutes/grid.266190.a schema:alternateName University of Colorado Boulder
    404 schema:name Department of Psychology & Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
    405 Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA.
    406 rdf:type schema:Organization
    407 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    408 schema:name Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
    409 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA.
    410 rdf:type schema:Organization
    411 https://www.grid.ac/institutes/grid.452205.4 schema:alternateName Department of Environment, Land, Water and Planning
    412 schema:name Biosciences Research Division, Department of Primary Industries, Melbourne, Victoria, Australia.
    413 Department of Agriculture and Food Systems, University of Melbourne, Melbourne, Victoria, Australia.
    414 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...