Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-04

AUTHORS

Shusuke Akamatsu, Ryo Takata, Christopher A Haiman, Atsushi Takahashi, Takahiro Inoue, Michiaki Kubo, Mutsuo Furihata, Naoyuki Kamatani, Johji Inazawa, Gary K Chen, Loïc Le Marchand, Laurence N Kolonel, Takahiko Katoh, Yuko Yamano, Minoru Yamakado, Hiroyuki Takahashi, Hiroki Yamada, Shin Egawa, Tomoaki Fujioka, Brian E Henderson, Tomonori Habuchi, Osamu Ogawa, Yusuke Nakamura, Hidewaki Nakagawa

ABSTRACT

We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 × 10(-4)) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 × 10(-10); FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 × 10(-8)) and 3p11.2 (rs2055109; P = 3.94 × 10(-8)). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 × 10(-7)). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations. More... »

PAGES

426

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.1104

    DOI

    http://dx.doi.org/10.1038/ng.1104

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047671935

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22366784


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